LOCUS       NM_001081140            1826 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus potassium voltage-gated channel, shaker-related
            subfamily, member 10 (Kcna10), mRNA.
ACCESSION   NM_001081140 XM_143471
VERSION     NM_001081140.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1826)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1826)
  AUTHORS   Khan,M.N., Cherukuri,P., Negro,F., Rajput,A., Fabrowski,P.,
            Bansal,V., Lancelin,C., Lee,T.I., Bian,Y., Mayer,W.P., Akay,T.,
            Muller,D., Bonn,S., Farina,D. and Marquardt,T.
  TITLE     ERR2 and ERR3 promote the development of gamma motor neuron
            functional properties required for proprioceptive movement control
  JOURNAL   PLoS Biol 20 (12), e3001923 (2022)
   PUBMED   36542664
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1826)
  AUTHORS   Kwon,S.H., Oh,S., Nacke,M., Mostov,K.E. and Lipschutz,J.H.
  TITLE     Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome
            Cargo Protein Trafficking through the Golgi Complex
  JOURNAL   J Biol Chem 291 (49), 25462-25475 (2016)
   PUBMED   27765817
  REMARK    Erratum:[J Biol Chem. 2017 Oct 6;292(40):16523. doi:
            10.1074/jbc.A116.729202.. PMID: 28986432]
REFERENCE   4  (bases 1 to 1826)
  AUTHORS   Lee,S.I., Conrad,T., Jones,S.M., Lagziel,A., Starost,M.F.,
            Belyantseva,I.A., Friedman,T.B. and Morell,R.J.
  TITLE     A null mutation of mouse Kcna10 causes significant vestibular and
            mild hearing dysfunction
  JOURNAL   Hear Res 300, 1-9 (2013)
   PUBMED   23528307
  REMARK    GeneRIF: Kcna10 is expressed primarily in hair cells of the inner
            ear and null mutations cause significant vestibular/mild hearing
            dysfunction.
            Erratum:[Hear Res. 2013 Aug;302:83]
REFERENCE   5  (bases 1 to 1826)
  AUTHORS   Carlisle,F.A., Steel,K.P. and Lewis,M.A.
  TITLE     Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti
  JOURNAL   Gene Expr Patterns 12 (5-6), 172-179 (2012)
   PUBMED   22446089
  REMARK    GeneRIF: Kcna10 is most strikingly expressed in the hair cells in
            late embryonic stage however, at adult stages, however, Kcna10
            expression is no longer specific to hair cells.
REFERENCE   6  (bases 1 to 1826)
  AUTHORS   Koza,R.A., Hohmann,S.M., Guerra,C., Rossmeisl,M. and Kozak,L.P.
  TITLE     Synergistic gene interactions control the induction of the
            mitochondrial uncoupling protein (Ucp1) gene in white fat tissue
  JOURNAL   J Biol Chem 275 (44), 34486-34492 (2000)
   PUBMED   10931824
REFERENCE   7  (bases 1 to 1826)
  AUTHORS   Street,V.A. and Tempel,B.L.
  TITLE     Physical mapping of potassium channel gene clusters on mouse
            chromosomes three and six
  JOURNAL   Genomics 44 (1), 110-117 (1997)
   PUBMED   9286706
REFERENCE   8  (bases 1 to 1826)
  AUTHORS   Lock,L.F., Gilbert,D.J., Street,V.A., Migeon,M.B., Jenkins,N.A.,
            Copeland,N.G. and Tempel,B.L.
  TITLE     Voltage-gated potassium channel genes are clustered in paralogous
            regions of the mouse genome
  JOURNAL   Genomics 20 (3), 354-362 (1994)
   PUBMED   8034307
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC121825.3 and
            AC132405.3.
            
            On Feb 6, 2007 this sequence version replaced XM_143471.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY233472.1, AK157965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN02415122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC121825.3         164133-164235
            104-1826            AC132405.3         186200-187922       c
FEATURES             Location/Qualifiers
     source          1..1826
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.64 cM"
     gene            1..1826
                     /gene="Kcna10"
                     /gene_synonym="Gm1962; Kcna8; Kv1.8"
                     /note="potassium voltage-gated channel, shaker-related
                     subfamily, member 10"
                     /db_xref="GeneID:242151"
                     /db_xref="MGI:MGI:3037820"
     exon            1..103
                     /gene="Kcna10"
                     /gene_synonym="Gm1962; Kcna8; Kv1.8"
                     /inference="alignment:Splign:2.1.0"
     exon            104..1826
                     /gene="Kcna10"
                     /gene_synonym="Gm1962; Kcna8; Kv1.8"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1695
                     /gene="Kcna10"
                     /gene_synonym="Gm1962; Kcna8; Kv1.8"
                     /note="potassium voltage gated channel, shaker related
                     subfamily, member 8; cyclic GMP gated potassium channel;
                     voltage-gated potassium channel subunit Kv1.8"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily A
                     member 10"
                     /protein_id="NP_001074609.1"
                     /db_xref="CCDS:CCDS38587.1"
                     /db_xref="GeneID:242151"
                     /db_xref="MGI:MGI:3037820"
                     /translation="MDVCSWKEMEVALVNFDNSDEIHEEPGYATDFDPTSSKGRPGSS
                     PFSNWRVLISDNTNHETAFSKIPGEYVDPPGPEPVVLNEGNQRVIINIAGLRFETQLR
                     TLNQFPETLLGDREKRMQFFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPID
                     VFADEISFYELGSEAMDQFREDEGFIKDPETLLPTNDFHRQFWLLFEYPESSSAARGV
                     AVVSVLVVVISITIFCLETLPEFREDRELKVVRDPSINTNKTGLSQTMFTDPFFMVES
                     TCIVWFTFELVLRFVVCPSKTDFFKNIMNIIDIISIIPYFATLITELVQETEPSAQQN
                     MSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSA
                     VYFAEVDEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIA
                     LPVPVIVSNFNYFYHRETENEEKPNIPGELDKILNSMGSRMGSTESLNKTNGSCSAEK
                     SRK"
     regulatory      1803..1808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kcna10"
                     /gene_synonym="Gm1962; Kcna8; Kv1.8"
                     /note="hexamer: AATAAA"
     polyA_site      1825
                     /gene="Kcna10"
                     /gene_synonym="Gm1962; Kcna8; Kv1.8"
                     /note="major polyA site"
ORIGIN      
        1 agtcttcctg tggaccttga gaccagcaca tcccatctgc tatggccagc tgaccccagc
       61 agagctgcgg aggcccactg ggtccgagac accactcctg ctgcgtccag tgggtagcaa
      121 agactggggg tcttcatgct gttctcctga ctccctagaa tggatgtgtg tagctggaaa
      181 gaaatggagg ttgctctggt caattttgat aactcggatg aaatccatga agagccaggc
      241 tatgccacag actttgaccc aaccagctca aaaggccgcc ctggtagcag tcccttttcc
      301 aattggagag tccttatcag tgacaacacc aaccatgaaa ctgccttctc caagatccca
      361 ggagagtatg tggatccccc gggacctgag ccagtggtct tgaatgaggg aaaccaaagg
      421 gtgatcatca acattgctgg tctgagattc gagactcagc tcagaacact taatcaattc
      481 ccagagacac tcctgggaga ccgggagaaa aggatgcaat tttttgactc catgagaaat
      541 gagtatttct ttgatagaaa cagacctagt tttgatggaa tcttatatta ttaccagtct
      601 ggtgggaaaa tacggcggcc agccaacgtg cctatcgatg ttttcgctga tgagatctcc
      661 ttctatgaac tgggtagcga ggccatggac cagttccggg aggatgaagg cttcattaag
      721 gaccctgaga cactgctgcc caccaatgac tttcaccggc aattctggct tctctttgag
      781 taccccgaga gctccagtgc agctcgagga gtggctgtgg tctcggtttt ggttgtagtc
      841 atctccatca ccatcttctg cctggagaca ctcccagagt tccgagagga cagggagctg
      901 aaggtggtca gagaccccag catcaataca aacaaaacag gcctctccca gaccatgttc
      961 actgatcctt tcttcatggt ggagtccacc tgcatcgtgt ggttcacctt tgagctggtg
     1021 ctccggtttg tggtctgccc cagcaagact gacttcttca agaacatcat gaatattatt
     1081 gacatcatct ccatcatccc ctactttgca accctcataa cagagctagt acaggagacc
     1141 gagccaagtg cccagcagaa catgtccctg gccatcctga ggatcattcg tctggtgagg
     1201 gtcttccgca tcttcaagct ttctcgacac tctaaagggc tgcagatcct ggggcagacg
     1261 ctgaaggctt ccatgcggga gctggggctg ctcatcttct tcctcttcat tggggtcatc
     1321 cttttctcca gtgcagtcta ctttgctgag gtggatgagc cagagtccca tttctctagc
     1381 attcctgatg gcttctggtg ggctgtggtc accatgacaa ctgtaggcta cggtgacatg
     1441 tgcccaacca ccccaggagg aaagattgtg ggtactctgt gcgccattgc tggtgtcctc
     1501 accatcgccc tccctgtgcc tgtcattgtc tccaatttca actacttcta ccaccgtgag
     1561 actgagaacg aggagaagcc aaacatccca ggagaacttg acaaaatcct caacagcatg
     1621 ggctccagaa tggggagtac tgagtctctc aacaagacca atggcagctg ctctgcagag
     1681 aagtccagga agtgaccagc ccgaggcttc tagagtctct gaacccccct ccctcctctc
     1741 actgttttcc taagatgaaa attatgttct atggccaaga ggccatctct gtgagctgtc
     1801 ttaataaatc catgtttctg ttctat
//
