LOCUS       NM_001008785            4732 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kelch repeat and BTB (POZ) domain containing 8
            (Kbtbd8), transcript variant 1, mRNA.
ACCESSION   NM_001008785 XM_144916
VERSION     NM_001008785.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4732)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4732)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   3  (bases 1 to 4732)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4732)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   5  (bases 1 to 4732)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   6  (bases 1 to 4732)
  AUTHORS   Oh,B., Hwang,S., McLaughlin,J., Solter,D. and Knowles,B.B.
  TITLE     Timely translation during the mouse oocyte-to-embryo transition
  JOURNAL   Development 127 (17), 3795-3803 (2000)
   PUBMED   10934024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ046115.1, AK142080.1, BC088734.1, DV653148.1 and BF019958.1.
            
            On Nov 8, 2013 this sequence version replaced NM_001008785.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142080.1, SRR9219383.50624.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                CJ046115.1         2-27
            27-2409             AK142080.1         1-2383
            2410-2573           BC088734.1         2321-2484
            2574-3602           AK142080.1         2548-3576
            3603-4658           BC088734.1         3512-4567
            4659-4729           DV653148.1         362-432
            4730-4732           BF019958.1         1-3                 c
FEATURES             Location/Qualifiers
     source          1..4732
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 44.32 cM"
     gene            1..4732
                     /gene="Kbtbd8"
                     /gene_synonym="mKIAA1842; SSEC-51; SSEC51; Takrp"
                     /note="kelch repeat and BTB (POZ) domain containing 8"
                     /db_xref="GeneID:243574"
                     /db_xref="MGI:MGI:2661430"
     exon            1..95
                     /gene="Kbtbd8"
                     /gene_synonym="mKIAA1842; SSEC-51; SSEC51; Takrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1879
                     /gene="Kbtbd8"
                     /gene_synonym="mKIAA1842; SSEC-51; SSEC51; Takrp"
                     /note="isoform a is encoded by transcript variant 1;
                     T-cell activation kelch repeat protein; kelch repeat and
                     BTB domain-containing protein 8; SSEC 51"
                     /codon_start=1
                     /product="kelch repeat and BTB domain-containing protein 8
                     isoform a"
                     /protein_id="NP_001008785.2"
                     /db_xref="CCDS:CCDS51856.1"
                     /db_xref="GeneID:243574"
                     /db_xref="MGI:MGI:2661430"
                     /translation="MAASADLSKSSPTPNGIPSSDTANDTMDPFHACSILKQLKTMYD
                     EGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIIGVEAESMD
                     LVLNYAYTSRVILTEANVQALFTTASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFAD
                     HYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESII
                     RWFEHEQSEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIVKSCGEPSNTSGCTQ
                     RLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDND
                     IYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYA
                     IGGRVYEGDGRNSLKSVECYDSRENCWMTVCAMPVAMEFHNAVEHKEKIYVLQGEFFL
                     FYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRVFTVEAYDIELNKWT
                     RKKDFPCDQSINPYLKLVLFQNKLHLFVRATQVTVEEHIFRTSRKNSLYQYDDIADQW
                     MKVYETPDRLWDLGRHFECAVAKLYPQCLQKVL"
     exon            96..306
                     /gene="Kbtbd8"
                     /gene_synonym="mKIAA1842; SSEC-51; SSEC51; Takrp"
                     /inference="alignment:Splign:2.1.0"
     exon            307..1415
                     /gene="Kbtbd8"
                     /gene_synonym="mKIAA1842; SSEC-51; SSEC51; Takrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..4732
                     /gene="Kbtbd8"
                     /gene_synonym="mKIAA1842; SSEC-51; SSEC51; Takrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4638..4643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kbtbd8"
                     /gene_synonym="mKIAA1842; SSEC-51; SSEC51; Takrp"
                     /note="hexamer: ATTAAA"
     polyA_site      4662
                     /gene="Kbtbd8"
                     /gene_synonym="mKIAA1842; SSEC-51; SSEC51; Takrp"
                     /note="major polyA site"
     regulatory      4686..4691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kbtbd8"
                     /gene_synonym="mKIAA1842; SSEC-51; SSEC51; Takrp"
                     /note="hexamer: AATAAT"
     polyA_site      4707
                     /gene="Kbtbd8"
                     /gene_synonym="mKIAA1842; SSEC-51; SSEC51; Takrp"
ORIGIN      
        1 agcagagccg gaacccggga gcgagcgaaa cgcaatgaca tttcctcttt aaataaccgg
       61 agccggggcc cctgtagtaa tggccgcgtc ggcagattta agtaagtctt ccccaacacc
      121 gaatgggatt ccatcttcag acacagccaa cgataccatg gatcctttcc atgcttgcag
      181 tattcttaag caactcaaaa caatgtacga tgaaggacag ttgacagaca ttgtagtgga
      241 agtggatcac gggaaaacat tttcctgtca tagaaacgtt cttgctgcaa tcagccccta
      301 cttcagatcc atgttcacta gcggccttac agaaagtact cagaaagaag ttcgaatcat
      361 tggtgttgaa gctgaatcaa tggatttagt attgaattat gcctatacct ctagagttat
      421 tctgacagag gccaatgttc aagccttgtt cactacagct agcatcttcc aaattccttc
      481 catacaagac cagtgtgcta agtatatgat tagtcatttg gatccacaga attctattgg
      541 agtctttatc tttgctgatc attatggtca tcaggagctt ggagatcgat caaaagaata
      601 tatccgtaaa aagtttctgt gtgtcaccaa agaacaagag tttctccaac tgacaaaaga
      661 ccaactcata agcatactag acagtgacga tttaaatgtg gatcgggaag aacatgttta
      721 tgaaagcatt ataaggtggt ttgaacatga gcagagtgaa agagaagtac accttccaga
      781 gatttttgcc aaatgtatac gttttcctct aatggaagat acatttatcg agaaaattcc
      841 tcctcagttt gcacaggcca tagtcaaaag ttgtggagaa ccctccaaca ccagtggctg
      901 tacacagagg cttggaatga ctgcttctga aatgatcata tgttttgatg ctgcccacaa
      961 acactcagga aagaagcaaa cagtgccttg tctagatatc gtcacaggaa gagtgtttaa
     1021 actatgcaaa ccaccaaatg acctaagaga agttgggatt cttgtgtcac cagataatga
     1081 catatacatt gcaggaggct acaggccaag cagcagtgag gtgtccatcg accataaagc
     1141 agaaaatgat ttttggatgt atgaccattc caccaacaga tggctttcca agccgtcctt
     1201 gcttcgggcc agaataggct gcaagctagt atactgctgt ggtaaaatgt atgcaattgg
     1261 agggcgtgtt tacgaaggtg atggaagaaa ctcactgaag tctgtggagt gctatgatag
     1321 cagagagaat tgctggatga ctgtgtgtgc catgccagtt gcaatggagt ttcataatgc
     1381 tgtggagcac aaagagaaaa tctacgtttt acagggggaa tttttcctct tctatgagcc
     1441 tcaaaaagac tactggggat ttttaacccc catgactgtg cctcgaatcc agggcttagc
     1501 agctgtgtac aaagactcaa tctactacat agctggaacc tgtggaaatc atcagcgtgt
     1561 gtttactgtt gaagcctatg atatagagct aaataagtgg actcgtaaaa aggactttcc
     1621 gtgtgatcag tctataaatc catacctgaa gctagtactt ttccagaata aactccattt
     1681 atttgtgcga gctactcaag tgactgttga agaacatatc ttcagaacca gcaggaaaaa
     1741 ttctctttac caatacgatg acattgctga ccagtggatg aaagtgtatg agaccccaga
     1801 tcggctgtgg gaccttggcc gccattttga gtgtgcggtg gctaaactct atcctcagtg
     1861 tcttcagaaa gttctttaaa taagcagcag gccaaagcac gcccctggca tctcatactg
     1921 aggaagctgg cttaggaaat gctgtcgcca ttgaagaaag ctaacagagt cttgtattca
     1981 gaaatgggtg ctcataaaga ctgtggtgtg gagagggatt tgattttacc ttcatgatat
     2041 tttcagttca gtcaggaaag ggaacaaagt gcggttatca gcatttttcc acccctggca
     2101 taaaagtatc atcctagagt tttgtgataa atagttgctg agaaaccagg tgaattcaag
     2161 acaactatgc actcttgaaa agcagaatat tcctgggtag agacatccaa actggttaac
     2221 gtgactttct tttaactacg ggtaacaata tgaggcaata tcatttattt agctgtgatc
     2281 tctaacacag agaagcacta acctagatcc tcagtcttac tatttatatc tatttacata
     2341 tatatttttg tgtactgttt tcaagtgtac gagatttaaa tgtgctgtca gcagacggaa
     2401 gggaaactcg gttttcagag cgaactttta gtccgattgt tccatgtaac ttttaagtta
     2461 agctgcaagg ttaaagtggc agttttctgt ccataacttt ttcaagtgct aacactgtct
     2521 cattttttaa aatcccagaa agggctcaga tttgcaggtg actggtgctc gtataagttc
     2581 attcatgtgt agttagatca acttaaatgg ttaccgagtc tctgtttatc tttcaggtta
     2641 gcatgctagt tccatggtcc tggcacttta ccttgtgatt ccatgaggtc tgctatttgt
     2701 gtgataggat atggccgttg gccattggtc tagctggatt cagttttaca attccaagtt
     2761 tgcactaaca tgggctgttt tgttgcccaa actctctttc catcctctac ctttccagtc
     2821 attgttggca tcgtgaaagt taactaataa tgtgaagttt taacacctac ttataaaatt
     2881 ctgttttcta gaaacaagag tcttggagtg gtctaataat taagtggctt ataaggttca
     2941 tattatggtt acaacctctc tatttttttg cactcaacag tgatgaatat ttttatgttg
     3001 aaacacttgt agctgaaggc gatctagaag gaaggatgag tgagtgaaca ggtcaaaggt
     3061 ttctgtgctc taggtactaa ggcgctgttc atagtgaact gataagtttc tcacagttag
     3121 ttagggatat taacataaac tccttttcac ctaaggcagg tatttaggtt gataacatac
     3181 tcattactat gcctactata actgataaag aatattacac ataaggcaga gcctgtcctc
     3241 agtcaacaca ttttctttaa gagactcaat ttgattctct tgaagaaacc tggcaagatt
     3301 ttgtattgga atagaaaaaa gtcttgcaca acgtgtaagg tgatagatac tgtgaaacaa
     3361 atggaaaata ttgcctcttg catcacatac ctccttttcc agaaacttta tagactgcat
     3421 tacaaaggcc ctacaaggag agagttctcg aagcagttca agtggacagc attcacagat
     3481 tgttcatgtg tcctccacag ctggatgcgt ggcttctcct aatctctttg taaactttgt
     3541 cagccaatat ttttttaaac ctctctagtt gtcttatggt tttgtttttt ttgggttttt
     3601 ttcatgctgt tttagggtta tttctgtgaa ttttttgaat tatagttttg tattgctaat
     3661 gagagggaag agaattttta caagagatat ccatgtaatt tatttttgaa agctttgttg
     3721 agtatctaag atttcctgcc actttgacaa tctctgtatt taggaaaatt cattacttga
     3781 atacatgatg tagaacattg agttagcaat gtacatgtac cgtacgatat gtaagagaac
     3841 aatacactgt ggctaattct atactagatt tattctgttg gtctgtacaa cagttggtcc
     3901 ttttgtcata actgtgtcta ttgagggaat catttcagaa tagtgtatca aagccaaggt
     3961 ttagaatttg ctacaggagt agaatatata ttgaattttg tatgaattat ttgtttacat
     4021 tacatagctg ggatattttg ccacttttaa aatgacttta gaaaaggtcc taggaaactt
     4081 aagattagtg atgtgtgtgg gtttatgtgt agaaattcaa ggtacattct catagtctga
     4141 atataagtaa aaggcacaaa ggctacagca ggattcaaag atctaacaaa tgccaatccc
     4201 actttaacta tgtttctgca tttgaatgta cacagcactt ttcctatata gttctataca
     4261 aagaaaacag aactaggtat aactgtgttg taggattgaa gaaatcatta tttatgtctg
     4321 tctttgtttc ttgttatcct acaaagttga tgtgtaaaca tcaagttgat ttcattggtg
     4381 catgaggaaa agtggatgtg atctgtgagg aaccagagtc ccatgggaag agtttaagat
     4441 ggcattcaat attcagtgct caggtatgta gtaagtactg tagtcctatg gggcaaatgt
     4501 gtagatattt ttaaacattt tgccgtaatt gcacaatttt tgcattttta cctgatgtca
     4561 ttgtttcttg taataaaatc ttttctgatt gaaaactgcc agtgttgtaa actgatctca
     4621 agaatgaatt ttgcaaaatt aaaatttggt gaaaatcaca aactatctca tgtcatgtag
     4681 aatgaaataa tattttaacc tattaaatat ctgacttgtg gcttaaaaat ga
//
