LOCUS       NM_001024135            4529 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus kelch repeat and BTB (POZ) domain containing 7
            (Kbtbd7), mRNA.
ACCESSION   NM_001024135 XM_139159
VERSION     NM_001024135.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4529)
  AUTHORS   Li,X., Lin,Z., Xu,S., Zhang,N., Zhou,J. and Liao,B.
  TITLE     Knockdown of KBTBD7 attenuates septic lung injury by inhibiting
            ferroptosis and improving mitochondrial dysfunction
  JOURNAL   Int Immunopharmacol 133, 112129 (2024)
   PUBMED   38652964
  REMARK    GeneRIF: Knockdown of KBTBD7 attenuates septic lung injury by
            inhibiting ferroptosis and improving mitochondrial dysfunction.
REFERENCE   2  (bases 1 to 4529)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4529)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 4529)
  AUTHORS   Makeyev,A.V. and Bayarsaihan,D.
  TITLE     New TFII-I family target genes involved in embryonic development
  JOURNAL   Biochem Biophys Res Commun 386 (4), 554-558 (2009)
   PUBMED   19527686
  REMARK    GeneRIF: Kbtbd7 encodes an adapter protein with BTB/POZ, BACK, and
            Kelch motifs, previously shown to recruit substrates to the
            enzymatic complexes of the histone modifying or E3 ubiquitin ligase
            activities.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC096019.1 and CO045548.1.
            
            On Jul 21, 2009 this sequence version replaced NM_001024135.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC096019.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-600               BC096019.1         1-600
            601-605             CO045548.1         92-96
            606-4529            BC096019.1         606-4529
FEATURES             Location/Qualifiers
     source          1..4529
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 42.65 cM"
     gene            1..4529
                     /gene="Kbtbd7"
                     /gene_synonym="1110008P08Rik; Gm295"
                     /note="kelch repeat and BTB (POZ) domain containing 7"
                     /db_xref="GeneID:211255"
                     /db_xref="MGI:MGI:2685141"
     exon            1..4529
                     /gene="Kbtbd7"
                     /gene_synonym="1110008P08Rik; Gm295"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..2292
                     /gene="Kbtbd7"
                     /gene_synonym="1110008P08Rik; Gm295"
                     /codon_start=1
                     /product="kelch repeat and BTB domain-containing protein
                     7"
                     /protein_id="NP_001019306.2"
                     /db_xref="CCDS:CCDS27298.1"
                     /db_xref="GeneID:211255"
                     /db_xref="MGI:MGI:2685141"
                     /translation="MQSREDAPRSRRLASPRGGRRPKRISKPSVSAFFTGPEELKDAA
                     HSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTG
                     GMYESQQASVTIHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREAC
                     ASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSFIAHNFKQLSRMGSIREETLADLT
                     LAQLLAVLRLDSLDVESEKTVCHVAVQWLEAAPKERGPSAAEVFKCIRWAHFPAEEQD
                     YLGGLLSKPIVKKYCLDIIEGALRQLRFGDRLYKSVVAKPNSSHSSDSNNSSNSSSSS
                     SSVVSVAENPPQRLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTMPSPLTSLAHTKTI
                     TSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWHQLADRLLCREGMDVAYLNGYIYIL
                     GGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSKRMLCYD
                     PSHNMWLNCASLKRSDFQEACVFKEEIYCICDIPVMKVYNPARGEWRRISNIPLDSET
                     HNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGTMLGLLQFDSGFICL
                     CDRVYPSCLEPGQSFITEEDDARSESSTEWDLDGFSELDSESGSSSSFSDDEVWVQVA
                     PQRNAPDQ"
     regulatory      4507..4512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kbtbd7"
                     /gene_synonym="1110008P08Rik; Gm295"
                     /note="hexamer: AATAAA"
     polyA_site      4529
                     /gene="Kbtbd7"
                     /gene_synonym="1110008P08Rik; Gm295"
                     /note="major polyA site"
ORIGIN      
        1 gctaagggct gagaaagggc gtgaagggaa acagtgagtc agccggggac tacgcgataa
       61 aggcagacgg ctccgccccg aaggcccagc tgagtaattg cggccgcgag ccgagtttgt
      121 tctgggacgc cgctgagtcg gcgtcggcga gggaggcgtg aggaggagcc gggcgtctgc
      181 agccgttctc gccctcggcg ccccgccgcc atctccacca tgcagtcccg ggaagacgcc
      241 ccgcgctctc gccgcctcgc cagcccccgc ggcgggaggc ggcccaagag gatttccaag
      301 ccctcggtgt cggccttttt cacgggcccg gaggaattaa aggacgcggc ccattccgca
      361 gccctcctgg cacagctcaa gtctttctac gacgcgcggc tgctgtgcga tgtgaccatc
      421 gaggtggtga cgcctggcag cgggccgggc acggggcgcc tcttctcgtg caaccgcaac
      481 gtgctggcgg ccgcttgccc ctacttcaag agcatgttca cggggggcat gtacgagagc
      541 cagcaggcca gcgtgacgat ccacgacgtg gatgccgagt ccttcgaggt cttggtggac
      601 tactgctaca ctggtcgcgt gtcgctcagc gaggccaacg tgcagcgcct gtacgcggcc
      661 tcggatatgc tgcagctgga gtacgtgcgc gaagcctgtg cctccttcct ggctcgccgc
      721 cttgacctga ccaattgcac tgccatcctc aagtttgccg atgcctttga ccaccacaag
      781 ctgcgatctc aggcccagtc cttcatagct cacaacttca agcagctcag caggatgggg
      841 tccattcggg aggagacgct ggcagatctg accctggccc agctgctggc cgtcctgcgt
      901 ctggacagct tggatgtaga gagtgagaag actgtgtgtc atgtggcggt gcagtggctg
      961 gaggctgctc cgaaagagcg gggtcccagt gctgcggaag tctttaagtg tattcgttgg
     1021 gcgcacttcc ctgcagaaga gcaggactac ctgggagggc tactgagcaa gcctattgtg
     1081 aagaaatact gcctggacat tattgaaggg gctctccggc agctgcgatt tggtgatagg
     1141 ttgtacaagt cagtggttgc caagccaaat agcagccaca gcagtgatag caataatagc
     1201 agcaatagca gcagcagcag tagctcagtt gtatcggtag cagaaaatcc accccaaagg
     1261 ttgggtatgt gtgccaaaga gatggtaata ttttttgggc acccccgaga tccatttctc
     1321 tgttacgacc cttattccgg agatatttac acaatgccgt ctcctttgac tagcttggca
     1381 cacactaaga ccattacatc ttcagctgtt tgtgtctctc cagaccatga catctatctt
     1441 gctgcccagc ccaggaaaga cctatgggtg tataaaccag cccaaaatag ttggcatcag
     1501 ctggcagacc gcttgctgtg tcgagagggt atggatgtag cctatctgaa tggctacatt
     1561 tacatcttgg gtgggagaga cccgattact ggagttaaat tgaaggaagt ggaatgctac
     1621 agtgtccaga ggaaccaatg ggcattggtg gctcctgtac cacattcctt ttattcattt
     1681 gaactaatag tggttcagaa ttatctttac gctgtcaaca gtaagcgcat gctctgctat
     1741 gatcctagcc ataatatgtg gctgaattgt gcatctctca aacgaagtga ctttcaagaa
     1801 gcctgtgtct tcaaagagga aatctattgt atctgtgaca tcccagtcat gaaggtctac
     1861 aaccctgcta gaggagagtg gaggcggatt agtaatatcc cactggactc agaaacccac
     1921 aactaccaga ttgtcaatca tgaccaaaag ttgctgctca tcacctctac caccccacag
     1981 tggaaaaaga accgagtcac agtatatgag tatgatacta gggaagacca atggattaat
     2041 ataggcacca tgttaggcct tttgcagttt gactctggct ttatttgcct gtgtgatcga
     2101 gtttatcctt cctgtcttga acctggtcag agtttcatca ctgaggaaga tgatgcaagg
     2161 agtgagtcta gcactgaatg ggacttagat ggattcagtg aactggactc tgagtcagga
     2221 agttcaagtt ctttttctga tgatgaagtc tgggtacaag ttgcgcctca gcgaaatgca
     2281 ccagatcagt agggttcttt gtaaatattt tgagacaata agatgttgtt tctactgtat
     2341 ggaatatatc ttaaaatgat accccttttc ctgaaaagac aaagttgatt aggactggag
     2401 atttggttta gaaagggtag caatttgaaa tagtaatgca atatgcaaaa ttcatacagt
     2461 ccctgaaatc cgattatttc aataatttgc tgtgctaaaa gtccatgatt aatatatgca
     2521 tagtgaacta cataaattaa ttaaggtgtt tagtggattt tgttttgcag ttaattagta
     2581 tgtttatatt ttgatttctc tagtttttgt taaattttgc ctagagctat gaggtcttgt
     2641 ttattactag aaaaactgga ctgagaattg ttgtattttg aaggtaataa cattttcctt
     2701 cagaataatg aaagatgaca ttttttaaag taaattttta gttatcagtt atagtttgtt
     2761 aaaactctag tatgctctcc ttcctttctg caaagaaaga aacattaagg ttactaagta
     2821 gtgactccat actgataatg tgttcagtgg acttacaagg tcacaggaaa cttaaaaaat
     2881 caggattcca ctgtttccaa agaatttaaa tttttacttt aaaatttaaa aatatatatt
     2941 ggtaaatatg acctgtttct cacccaccac tttcttgaaa agaaaccact ctagtaatgt
     3001 catcaattat ttaagcacct ttctaacccc ccccccaaaa tgtgagaggt aatttgcttt
     3061 ataaattcac agttttgatc ggtatatgtt aaatgctttg ttgactcaga agaacaaccc
     3121 ttcactggac atgatttaaa taatgtacat ttttcttcat tggtcatgca ctgtcttaaa
     3181 aagtttgctt ccctaaaata ttttggctat atagttttag tattcatctt agaggcttta
     3241 tcagcagaaa gtgatttatt cttcaatgtt ttgtgacgta atattggttt tgaaaatatg
     3301 tataagctaa aggcagtatt ttattgagat cagtagctat agtgtttatc aactcaagtt
     3361 aagtgccagc aaagaccttt aaaacttcaa gctgtgtata gaactgtcct gtgtagtatt
     3421 gaaatattgt cagtttttta agttactaga aatgttcttg atttgcagct tgaacatatt
     3481 tttgtattaa aagttgactc ttaaggaact taagtggatg gtgggtggtg gcatttgggg
     3541 ccagtagtta aagtatgttt cttcagttct ttccttaatc agtggtatac atggccattt
     3601 tattatggtg tctgtatcca gtttatattt ctctgtaagt tatactctag tttctgtctc
     3661 agtcaccata tgtaaaggaa agtccagaag tagtaaacta cacaaaacag gcattataac
     3721 gttataggtg cttacctttt gaaggtttat taatacatat ggttgtcata tatacatgac
     3781 aaatggtgta catatacaga tgttttatgc tatataaagt tttctatact ctttcagaat
     3841 tatcttccgc agtctttatt caataccatg caaattcctc tttattctct agtggcaaat
     3901 gcttaagttt ttacactctg gtagaggata gagtctggtc caagatgggg aagtgacttt
     3961 ttgaatgaaa agtgaaagat aaaatgacaa aagcaaaaca aaataccacg aataatgtgt
     4021 tattcattat tttgattggc taggtgaaga ctgtaagata gtcagctcag caatatttct
     4081 gttaagagtc tgctgatttc tgaaatgtag tcaggctttc aagtctaaat tctattccat
     4141 ttgtactagg gaatgttata agaactattt atttagaaag ttatttttcc ctgtttgggg
     4201 gccaactttt tcttccccac taacttctgt tgatagcctt tttgttctgt aaggtggaaa
     4261 cttggcaatg cttgtcacaa cccgattatt catctgcaca attaaggtct gcaactgatg
     4321 tataaaagtc atattctcaa attcatcatt ctcaactctt gagttaaagc ttaggctaaa
     4381 tattagtaat agcttcgctt actgtcacat tttcttggga aggattttga ttttgtgaaa
     4441 catttgtgaa ttagagacta gatgttatta ttttatagat aaatgatttg tatgttgctt
     4501 gttccaaata aaactgggtt taaactaaa
//
