LOCUS       NM_001164574            2321 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kelch repeat and BTB (POZ) domain containing 3
            (Kbtbd3), transcript variant 2, mRNA.
ACCESSION   NM_001164574
VERSION     NM_001164574.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2321)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2321)
  AUTHORS   Taher,L., Collette,N.M., Murugesh,D., Maxwell,E., Ovcharenko,I. and
            Loots,G.G.
  TITLE     Global gene expression analysis of murine limb development
  JOURNAL   PLoS One 6 (12), e28358 (2011)
   PUBMED   22174793
REFERENCE   3  (bases 1 to 2321)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB264869.2 and AK078744.1.
            
            [WARNING] On Aug 9, 2024 this sequence was replaced by
            NM_001164574.2.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR, compared to variant 1. Variants 1 and 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078744.1, BB264869.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                BB264869.2         1-90
            91-2321             AK078744.1         3-2233
FEATURES             Location/Qualifiers
     source          1..2321
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 2.46 cM"
     gene            1..2321
                     /gene="Kbtbd3"
                     /gene_synonym="2200003A07Rik; Bklhd3"
                     /note="kelch repeat and BTB (POZ) domain containing 3"
                     /db_xref="GeneID:69149"
                     /db_xref="MGI:MGI:1916399"
     exon            1..192
                     /gene="Kbtbd3"
                     /gene_synonym="2200003A07Rik; Bklhd3"
                     /inference="alignment:Splign:2.1.0"
     exon            193..437
                     /gene="Kbtbd3"
                     /gene_synonym="2200003A07Rik; Bklhd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..2040
                     /gene="Kbtbd3"
                     /gene_synonym="2200003A07Rik; Bklhd3"
                     /note="BTB and kelch domain containing 3; BTB and kelch
                     domain-containing protein 3"
                     /codon_start=1
                     /product="kelch repeat and BTB domain-containing protein
                     3"
                     /protein_id="NP_001158046.1"
                     /db_xref="CCDS:CCDS22795.1"
                     /db_xref="GeneID:69149"
                     /db_xref="MGI:MGI:1916399"
                     /translation="MDNSYNLNEQSSWNGISSEKKKNYLASEDHGQKILSVLQSFREQ
                     NVFYDFKIIMKEEIIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTITNLSSKAVKAF
                     LDYAYTGKTRITDDNVEMFFQLSSFLQVSFLSKACSDFLIKSISLVNCLHLLSLSDSY
                     GSAQLFSHTLYFVQHHFHLLYKSSDFLEMNFGVLQKCLESDELNVPEEEMVLKAVLTW
                     IKYNLESRQKHLPHLITKVRLHQLSEDTLQDYLLNEEYLLKSTNCFDIIVDAIKCVQG
                     SSGLFPDARPSTTEKYIFIHKTEENGENQYTFCYNIKTDSWKILPQSHLIDLPGSSLS
                     SYGEKIFLTGGCKGKCCRRIRLHIAQSYHDATDQTWCYCPAKNEFFCVSAMKTPRTMH
                     TSVMALNRLFVIGGKTRGSQDIKSLLDVESYNPLSREWTSVSPLPRGIYYPEASACQN
                     IIYVLGSEVEIADAFNPSLDCFFKYNATTDQWSELVAEFGQFFHATLIKAVPVNCTLY
                     ICDLSTYKVYSFCPDTCVWKGEGSFECAGFNAGAIGIEDKIYILGGDYAPDEITDEVQ
                     VYHSSRSEWEEVSPMPRALTEFYCQVIQFNKYRDPWYSNHF"
     exon            438..2321
                     /gene="Kbtbd3"
                     /gene_synonym="2200003A07Rik; Bklhd3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2299..2304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kbtbd3"
                     /gene_synonym="2200003A07Rik; Bklhd3"
                     /note="hexamer: ATTAAA"
     polyA_site      2316
                     /gene="Kbtbd3"
                     /gene_synonym="2200003A07Rik; Bklhd3"
                     /note="major polyA site"
ORIGIN      
        1 agagctctgc ggcacggcgt gacgtcttgt gagcttagct cgctctcctc ggaaagggcg
       61 ggaccagagt ttctcagaac cgttttagct gctcactctg gagaaagagc taacgagaca
      121 gtcgcacaag ccaatcgcag ccggagttta caggctgggc ctgggtggag acttcaccga
      181 ctgcagttgc agctctaaga acaggtggaa ttagctatgg ataattcata caatttaaat
      241 gaacaaagct catggaatgg aatctcatct gagaagaaaa aaaattacct tgcatcagaa
      301 gatcatggac agaaaatctt aagtgtgctg cagagtttta gagaacagaa tgtcttttat
      361 gacttcaaaa taatcatgaa agaagaaata atcccatgtc atcgttgtgt gttggctgca
      421 tgcagtgact ttttcagggc tatgttcgaa gtaaacatga aagaaagaga tgacggaagt
      481 gttaccatta ctaacttgtc ctccaaagct gtaaaggcat ttcttgacta tgcctatacg
      541 ggaaaaacaa gaataacaga tgataacgtg gaaatgttct tccagttgtc atcctttctt
      601 caggtttcct tcctgtccaa agcttgcagt gactttttaa taaaaagcat tagtctggtc
      661 aactgtttgc atttgttatc tctgtcagac agctacggct ctgcccagtt gttcagtcac
      721 actttatatt ttgtgcagca tcactttcat ttgttgtata aatccagtga ctttttagaa
      781 atgaattttg gagtgctgca gaagtgtctg gaatcagatg aattgaacgt acctgaagaa
      841 gaaatggtcc taaaggctgt cctcacatgg attaagtaca acttagagtc caggcaaaaa
      901 cacctgcctc acttgattac caaagtaaga ttacatcagt tatctgagga cacacttcaa
      961 gactatttgc tcaatgaaga gtatttactc aaaagcacaa actgttttga cataatcgtg
     1021 gatgccatta agtgtgtaca aggttctagt ggcctctttc ctgatgctcg accatccaca
     1081 actgaaaaat atatattcat ccataagact gaggaaaatg gagaaaatca atatacattt
     1141 tgctataata ttaaaactga ctcctggaaa atattgccac aatcacatct gattgatttg
     1201 ccaggatcta gtctgtctag ctatggagag aaaatattct tgacaggtgg ttgcaaaggg
     1261 aagtgctgta gaaggattcg acttcatatt gcacagtctt accatgatgc cactgaccag
     1321 acctggtgct actgtccagc taaaaatgag tttttctgtg tttcagccat gaaaacccca
     1381 agaaccatgc atacatcagt catggctctc aatcgattat ttgttatagg cggaaaaact
     1441 agagggtccc aggacattaa aagtctctta gatgttgaat cttataatcc actgtccaga
     1501 gagtggacat cagttagccc tttacccaga ggcatctatt acccagaagc cagtgcatgc
     1561 cagaatatca tttatgtcct tggatctgag gtagagattg ccgatgcttt caacccatca
     1621 cttgattgct tttttaaata taatgctaca actgaccagt ggtctgaact agtagcagag
     1681 tttgggcagt tttttcacgc tactttaatt aaagctgtcc cagtaaactg caccctttat
     1741 atatgtgatc tttccaccta taaggtttat agtttttgtc ctgatacttg tgtttggaaa
     1801 ggagaagggt cttttgagtg tgcaggtttt aatgcaggtg caattggaat tgaggataag
     1861 atttacatat taggtggaga ttatgcacca gatgagatta cagatgaagt gcaggtctac
     1921 cacagtagta ggtcagagtg ggaagaggtg tcaccaatgc caagagcttt aactgaattt
     1981 tactgtcagg tcattcagtt caacaaatac agggacccat ggtattcaaa tcatttctaa
     2041 aagtaatatt tgcatgagag ctctaaaatt gcaactagta gaattggtta aaaatatgta
     2101 tatctcagca cactgaaatg ttccttatat taaagaatga ctatagatgt atgctctcaa
     2161 taaatagaca gtttccagaa gtttaaaata caaaatgcat tttatcaaag ttttgttaaa
     2221 tataaattca tgttcaataa tccagattac atagtatttt cttatataaa taaaaattac
     2281 agatttatgc ttatttacat taaacgatgg aaaaaagtct g
//
