LOCUS       NM_001362210            3892 bp    mRNA    linear   ROD 04-APR-2024
DEFINITION  Mus musculus kelch repeat and BTB (POZ) domain containing 2
            (Kbtbd2), transcript variant 3, mRNA.
ACCESSION   NM_001362210 XM_006505844
VERSION     NM_001362210.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3892)
  AUTHORS   Ding,J., Gao,W., Yang,H., Duan,L., Sun,D., Liu,L., Qu,X., Yu,H.,
            Xu,B., Zhao,S., Wang,L. and Chai,J.
  TITLE     KBTBD2 promotes proliferation and migration of gastric cancer via
            activating EGFR signaling pathway
  JOURNAL   Pathol Res Pract 254, 155095 (2024)
   PUBMED   38237399
  REMARK    GeneRIF: KBTBD2 promotes proliferation and migration of gastric
            cancer via activating EGFR signaling pathway.
REFERENCE   2  (bases 1 to 3892)
  AUTHORS   Zhang,Z., Gallagher,T., Scherer,P.E. and Beutler,B.
  TITLE     Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic
            and -extrinsic features of the teeny lipodystrophy syndrome
  JOURNAL   Proc Natl Acad Sci U S A 117 (21), 11829-11835 (2020)
   PUBMED   32381739
  REMARK    GeneRIF: Tissue-specific disruption of Kbtbd2 uncovers
            adipocyte-intrinsic and -extrinsic features of the teeny
            lipodystrophy syndrome.
REFERENCE   3  (bases 1 to 3892)
  AUTHORS   Dai,K., Huang,Y., Chen,Z., Sun,X., Yang,L. and Jiang,Y.
  TITLE     Kbtbd2 inhibits the cytotoxic activity of immortalized NK cells
            through down-regulating mTOR signaling in a mouse hepatocellular
            carcinoma model
  JOURNAL   Eur J Immunol 48 (4), 683-695 (2018)
   PUBMED   29331106
  REMARK    GeneRIF: This investigation indicates that Kbtbd2 is an inhibitory
            molecule for the tumoricidal activity of KIL C.2 Natural killer
            cells and perhaps intratumoral Natural killer cells.
REFERENCE   4  (bases 1 to 3892)
  AUTHORS   Zhang,Z., Turer,E., Li,X., Zhan,X., Choi,M., Tang,M., Press,A.,
            Smith,S.R., Divoux,A., Moresco,E.M. and Beutler,B.
  TITLE     Insulin resistance and diabetes caused by genetic or diet-induced
            KBTBD2 deficiency in mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (42), E6418-E6426 (2016)
   PUBMED   27708159
  REMARK    GeneRIF: KBTBD2 is an essential regulator of the insulin-signaling
            pathway, modulating insulin sensitivity by limiting p85alpha
            abundance.
REFERENCE   5  (bases 1 to 3892)
  AUTHORS   Wang,T., Zhan,X., Bu,C.H., Lyon,S., Pratt,D., Hildebrand,S.,
            Choi,J.H., Zhang,Z., Zeng,M., Wang,K.W., Turer,E., Chen,Z.,
            Zhang,D., Yue,T., Wang,Y., Shi,H., Wang,J., Sun,L., SoRelle,J.,
            McAlpine,W., Hutchins,N., Zhan,X., Fina,M., Gobert,R., Quan,J.,
            Kreutzer,M., Arnett,S., Hawkins,K., Leach,A., Tate,C., Daniel,C.,
            Reyna,C., Prince,L., Davis,S., Purrington,J., Bearden,R.,
            Weatherly,J., White,D., Russell,J., Sun,Q., Tang,M., Li,X.,
            Scott,L., Moresco,E.M., McInerney,G.M., Karlsson Hedestam,G.B.,
            Xie,Y. and Beutler,B.
  TITLE     Real-time resolution of point mutations that cause phenovariance in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 112 (5), E440-E449 (2015)
   PUBMED   25605905
REFERENCE   6  (bases 1 to 3892)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 3892)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115003.18.
            
            On Apr 7, 2018 this sequence version replaced XM_006505844.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1-5 all encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028396.1, SRR7974084.18515.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415130 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               AC115003.18        129791-130145       c
            356-837             AC115003.18        121551-122032       c
            838-1003            AC115003.18        114133-114298       c
            1004-3892           AC115003.18        109857-112745       c
FEATURES             Location/Qualifiers
     source          1..3892
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.73 cM"
     gene            1..3892
                     /gene="Kbtbd2"
                     /gene_synonym="Bklhd1; mKIAA1489"
                     /note="kelch repeat and BTB (POZ) domain containing 2"
                     /db_xref="GeneID:210973"
                     /db_xref="MGI:MGI:2384811"
     exon            1..355
                     /gene="Kbtbd2"
                     /gene_synonym="Bklhd1; mKIAA1489"
                     /inference="alignment:Splign:2.1.0"
     exon            356..837
                     /gene="Kbtbd2"
                     /gene_synonym="Bklhd1; mKIAA1489"
                     /inference="alignment:Splign:2.1.0"
     CDS             668..2539
                     /gene="Kbtbd2"
                     /gene_synonym="Bklhd1; mKIAA1489"
                     /note="isoform a is encoded by transcript variant 3; BTB
                     and kelch domain containing 1; kelch repeat and BTB
                     domain-containing protein 2"
                     /codon_start=1
                     /product="kelch repeat and BTB domain-containing protein 2
                     isoform a"
                     /protein_id="NP_001349139.1"
                     /db_xref="CCDS:CCDS51790.1"
                     /db_xref="GeneID:210973"
                     /db_xref="MGI:MGI:2384811"
                     /translation="MSTQEERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPC
                     HKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAAALQMIIAYAYTGNLAVNDSTVE
                     QLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKF
                     TAVYRQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLS
                     QIRIDALSEVTQRAWFQGLPPNDKSVVVQGLYKSMPKFFKPRLGMTKEEMMIFIEASS
                     ENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNH
                     SKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRVKPSLVCCEGYIYAIGGDSVGG
                     ELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVMTLNLMYCYFPRSDSWV
                     EMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNE
                     WKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNERAKYVTYQYDLELDRWSLRQH
                     ISERVLWDLGRDFRCTVGKLYPSCLEESPWKPPTYLFSPDGTEEFELDGEMVALPPV"
     exon            838..1003
                     /gene="Kbtbd2"
                     /gene_synonym="Bklhd1; mKIAA1489"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..3892
                     /gene="Kbtbd2"
                     /gene_synonym="Bklhd1; mKIAA1489"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagcgtca cctcgcgccg cctccgccct tcctgctttc cgtttccttc ccgcgcctgc
       61 gcggctccga ttgttttggc tttccggtgg ggcagaggaa aagggcgcgg tgagccagat
      121 gaaggcgggg tccagccgcg ggcacccggg agcccgcaga gccgctgctg gagcgggcgc
      181 gggcactggc gcgggcggca ggccgtgacg gcccagccca ggaggcgcga ggaagcggaa
      241 gcgggggcgg aagcgagcgg cccggatccc cgcagcgcca cgcccccgcc gtgcgtgcgg
      301 ccgcgtgagt gcagcccggc ggagcggcgc ggtgagctgg gcgaccgggg acgagttctg
      361 cagaagacct actgaacata agatgttgca acaaaatcta cctcctgtat tttccctatt
      421 catgagcttc ccaggtgcaa atttgagcag gatgtttgga gaatctgttg aaaaactgta
      481 gctcaggatg acctagcaaa gattgtgagc ctgtaacaag atattcagag cggctgtgtg
      541 ggttctgttc tgaatgctgc agataacagc aagtgaactc cctcctttgc ttttgaagta
      601 ttcatttgac cttccatcaa gacggacttt tctaatctgt tcttggagat attaatggaa
      661 tacaatcatg tccactcaag aggaaaggca gatcaatacc gaatatgctg tgtccttatt
      721 ggaacagttg aaactgtttt atgaacaaca gttatttact gacatagtgt taattgttga
      781 gggcactgaa ttcccttgtc ataagatggt tcttgcaaca tgtagctcct atttcagggc
      841 catgttcatg agtggactaa gtgaaagcaa gcagacacat gtacacctga ggaatgtgga
      901 cgctgccgcc ttgcagatga taatagctta cgcgtacaca gggaacttgg cagtaaacga
      961 cagcactgtg gagcagctct atgaaacagc ttgcttcctg caggtagaag atgtgttaca
     1021 gcgttgccga gaatatttaa ttaaaaaaat taatgcagag aactgtgtgc ggctgctgag
     1081 ttttgctgac ctcttcagtt gtgaagaatt aaagcagagt gcaaagagga tggtggagca
     1141 caagttcacg gctgtgtacc gccaggaagc cttcatgcag ctgtcccacg acctcctcat
     1201 agacatcctc agcagcgaca acttaaatgt agaaaaggag gaaaccgtgc gagaggctgc
     1261 catgctctgg ctagagtaca acacagagtc acgatcccag tatttgtctt cagttcttag
     1321 ccagatcaga attgatgctc tttcagaagt cacacaaaga gcttggtttc aaggtctccc
     1381 acccaacgat aagtctgttg tggttcaggg tctttataag tctatgccca agttcttcaa
     1441 acccagactt gggatgacta aggaggaaat gatgattttc attgaagcat cctcagaaaa
     1501 cccttgtagt ctttactctt ctgtctgtta tagcccccag gcagaaaaag tttacaagtt
     1561 atgcagccca cccgctgatt tgcataaggt tgggacagtt gtaactccgg ataatgatat
     1621 ttacatagca gggggccaag tgcccttgaa aaacacaaaa acaaatcaca gtaaaacaag
     1681 taaactgcag actgccttcc gaactgtgaa ttgcttttac tggtttgatg cacaacaaaa
     1741 tacctggttt ccaaagacac caatgctttt tgtccgtgtg aagccatctt tggtttgctg
     1801 tgaaggctat atctatgcaa tcggaggaga tagtgttggt ggagaactta accggaggac
     1861 tgtagaaaga tacgacactg agaaggatga gtggacaatg gtgagccctt tgccttgtgc
     1921 atggcagtgg agtgcagcag ttgtagttca cgactgcatc tatgtgatga cattaaacct
     1981 catgtactgt tactttccaa gatctgactc atgggtagaa atggccatga ggcagactag
     2041 cagatctttt gcttcagctg cagcttttgg tgataaaatt ttctatattg gagggttgca
     2101 tattgctacc aattctggca taagactccc ctctggcact gtagatgggt cttcagtaac
     2161 tgtggaaatt tatgatgtga ataaaaatga atggaagatg gctgccaaca tccctgctaa
     2221 aaggtattct gatccctgtg ttagagctgt tgtgatctca aattctcttt gtgtgtttat
     2281 gcgagaaacc cacttaaatg aacgagctaa gtatgtcacc taccagtatg atttggaact
     2341 tgaccggtgg tctctgcggc agcatatatc tgaacgtgta ctgtgggacc tagggagaga
     2401 ttttcggtgc actgtgggga aactttatcc atcctgtctt gaagaatctc catggaagcc
     2461 accaacttac cttttttcac cagatggaac agaggagttt gaactggatg gggaaatggt
     2521 tgcacttccg cctgtatagg ggacttgagg gagtgccacg tgctgaactt gtgatatcct
     2581 ttgctaaacc agaggataaa aaaggagagt atgagtacat aaaaatctat ctttgataca
     2641 ttttattttt atgccctact taatatttgc atcagtataa tatatatcag tgtgtcatac
     2701 agaaagatat gcttctgtaa tatgaaatag gttatttgat aactgagaaa ctttaaatgt
     2761 atcatgtgag cataagagtc tggattatct aacattgtta gccctgtgta tgtacagtcc
     2821 agaacttcac tttttttaga aaattttttt gtttgtttat cttgtttttg gtttttttgt
     2881 tttttgtttt tttccgagac agggtttctt tgtatagccc tggctgccct ggaactcact
     2941 ttgcagacca ggctggcctc gaactcagaa atccgcctgc ctctgcctcc caagtgctgg
     3001 gattaaaggc gtgcgccacc tccgcccagc tcagaacttc acttttaaaa gtaatctgtt
     3061 cccagtgtgg tatctcaaaa ttgtgctgag attatcttag tatatgtatt ggattcctgt
     3121 acttccaaag tcctggaata tagttttttt agtataattc cactgcactt aacactaatg
     3181 ttcatgttgg tatagaaatg tcttttaaat cctattgttg agcaagatct gctctctgtc
     3241 tatggtatta cacagggaaa gctgtgactg caggatcagt ctcattcttc tactaggtgc
     3301 atggactccc ttcccactga cttacactcg tctatctaga atacaggttg tccaggcagc
     3361 tggtcactta ccaggtgtgg acttacgttg ctgggcttgc aaatgaattg ctagtccctc
     3421 attgtgcggg tctatgtgga gctttaatca gtaaatgtct ccacttccta tattacatta
     3481 acgttggctc atgcatataa ccacctgctg ctgatgtact tctccatctt aaaaagattt
     3541 agagtggatt aaccaggtca ttacatctta atttaataac aagcattact gtagagtgat
     3601 tgtgtgtagg tatctaatag gtgtgttttt tttttaactt gatgtgtgta tgtttggggg
     3661 gctaggatta ggaaggtgaa ctgtgcagga attgtctgca ctgtgcagaa gagcagatcc
     3721 tagtgctgct ctggcattaa tcccaggaac cactagcagt agtggggcgc caccaatgta
     3781 acatgagcac aggtgcctca tggcaaacat ggctggcatg ttcaactgca taatgctctg
     3841 gcactgtatt ttgaatgaca ttaatttatt aaataaattg tatataatca gt
//
