LOCUS       NM_001278671            4628 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus kelch repeat and BTB (POZ) domain containing 12
            (Kbtbd12), mRNA.
ACCESSION   NM_001278671
VERSION     NM_001278671.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4628)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4628)
  AUTHORS   van der Zwaag,B., Burbach,J.P., Scharfe,C., Oefner,P.J.,
            Brunner,H.G., Padberg,G.W. and van Bokhoven,H.
  TITLE     Identifying new candidate genes for hereditary facial paresis on
            chromosome 3q21-q22 by RNA in situ hybridization in mouse
  JOURNAL   Genomics 86 (1), 55-67 (2005)
   PUBMED   15953540
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014702.1, AC154038.1 and AK016973.1.
            
            On Jun 19, 2019 this sequence version replaced NM_001278671.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no mouse transcripts were available
            for the full length of the gene. The genomic coordinates used for
            the transcript record were based on orthologous transcript
            alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.8834.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01766820
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               AK014702.1         17-446
            431-839             AC154038.1         192150-192558       c
            840-1480            AK016973.1         858-1498
            1481-1631           AC154038.1         185288-185438       c
            1632-1829           AC154038.1         160777-160974       c
            1830-4628           AC154038.1         119114-121912       c
FEATURES             Location/Qualifiers
     source          1..4628
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.51 cM"
     gene            1..4628
                     /gene="Kbtbd12"
                     /gene_synonym="4833415F11Rik; 4933428M03Rik; Klhdc6"
                     /note="kelch repeat and BTB (POZ) domain containing 12"
                     /db_xref="GeneID:74589"
                     /db_xref="MGI:MGI:1918481"
     exon            1..33
                     /gene="Kbtbd12"
                     /gene_synonym="4833415F11Rik; 4933428M03Rik; Klhdc6"
                     /inference="alignment:Splign:2.1.0"
     exon            34..1209
                     /gene="Kbtbd12"
                     /gene_synonym="4833415F11Rik; 4933428M03Rik; Klhdc6"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..2023
                     /gene="Kbtbd12"
                     /gene_synonym="4833415F11Rik; 4933428M03Rik; Klhdc6"
                     /note="kelch domain containing 6"
                     /codon_start=1
                     /product="kelch repeat and BTB domain-containing protein
                     12"
                     /protein_id="NP_001265600.1"
                     /db_xref="CCDS:CCDS51842.2"
                     /db_xref="GeneID:74589"
                     /db_xref="MGI:MGI:1918481"
                     /translation="MECKTKGKHQHSLNLLDKIKNMKELEEMIDVVLIAEEEKFPCHR
                     LVLAAFSPYFKAMFTCGLLECTQREVILYDITAESVSVILNYMYSAVLEINNANVQTV
                     AMAAYFMQMEEVFSVCQNYMMDHMDASNCIGIYYFAKQIGAEDLSDQSKKYLYQHFAE
                     VSLHGEILDIEAHQLLALIKSDDLNISREESILDLVLRWVNHNQALRTEHLVELLKQV
                     RLELINASFLRQALRRNTMLLCDGSCIDIIQNAFKAIKTPQQHPSNLRYGMETTSLLL
                     CIGNNSSGIRSRHRSYGDASFCYDPVSHKTYFISSPKYGEGLGTVCTGVVMENNTVIV
                     AGEATATRLSRQKSKNIEIYRYHDRGNQFWEKLCTAEFRELYALGSIHNDLYVIGGQM
                     KIKNQYLITNCVDKYSVDQDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLPD
                     EEPDRLSNKLLQYDPSQDQWRERAPMRYSKYRFSAAVVNSEIYVLGGIGCVGRDKGQV
                     RKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTSAGAVDGKLYVCGGFHGADRHEV
                     ISKEILELDPWENQWNVVAINVLMHDSYDVCLVARMNPRDLIPPPSDLIEEDGDHRGQ
                     R"
     exon            1210..1480
                     /gene="Kbtbd12"
                     /gene_synonym="4833415F11Rik; 4933428M03Rik; Klhdc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1631
                     /gene="Kbtbd12"
                     /gene_synonym="4833415F11Rik; 4933428M03Rik; Klhdc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1829
                     /gene="Kbtbd12"
                     /gene_synonym="4833415F11Rik; 4933428M03Rik; Klhdc6"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..4628
                     /gene="Kbtbd12"
                     /gene_synonym="4833415F11Rik; 4933428M03Rik; Klhdc6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4609..4614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kbtbd12"
                     /gene_synonym="4833415F11Rik; 4933428M03Rik; Klhdc6"
                     /note="hexamer: AATACA"
     polyA_site      4628
                     /gene="Kbtbd12"
                     /gene_synonym="4833415F11Rik; 4933428M03Rik; Klhdc6"
                     /note="major polyA site"
ORIGIN      
        1 agtcacggcg ccatggcggc ggagcagcag cgagaatgct tcgtggcatc tccattgatt
       61 tgtgagtaat cagaaatgca aatagctcct caggaatcaa gctacgctca aagaaacctt
      121 acttaccaat ttcaaggagt ataccatgga gtgcaagact aaggggaaac accagcatag
      181 cttgaactta ctagataaaa ttaagaatat gaaagagtta gaagaaatga ttgatgtagt
      241 gctcatagca gaagaggaga aattcccttg ccacagactg gtgctcgctg cctttagtcc
      301 ttatttcaag gctatgttca cctgtggact actcgagtgc actcagagag aggtcatact
      361 ctatgacatc acagcagaaa gtgtgtcagt gatattaaac tacatgtaca gtgctgtcct
      421 ggagatcaat aacgccaacg ttcagaccgt agccatggct gcctatttta tgcagatgga
      481 agaagtcttt agtgtgtgcc aaaactatat gatggaccac atggatgcct ccaactgcat
      541 aggaatttat tactttgcaa aacaaatcgg agcagaagat ttatcggatc agtcgaagaa
      601 gtatttatac cagcacttcg ccgaggtaag ccttcatgga gaaatacttg acatcgaagc
      661 tcaccagctt ctggcactta ttaagtctga tgatctgaat atatccagag aagagagcat
      721 tctggatttg gttctgagat gggtaaacca taaccaagct ttgcgcacag agcatctcgt
      781 tgagcttttg aagcaagtca gactggaact tataaacgct tcctttctaa gacaggccct
      841 cagaaggaac acgatgctcc tttgtgatgg cagttgcatt gatataatcc agaatgcgtt
      901 caaagccatc aagacacccc agcagcaccc ctccaacctt cgctatggca tggagaccac
      961 cagccttctg ctttgcattg ggaacaattc ttctggaatc agatcaaggc acaggagcta
     1021 tggggatgcc agtttttgtt atgaccctgt gtcacacaag acctatttta tctcatcacc
     1081 caagtatggg gagggtttgg gaactgtgtg cactggggta gtcatggaaa acaatactgt
     1141 aattgtggct ggagaagcaa ctgccactag gctctctagg caaaagagca agaatattga
     1201 aatctatagg tatcatgata gaggaaacca gttttgggaa aagttatgca cagctgaatt
     1261 tcgagagctc tatgctctgg gcagcatcca taatgacctc tatgtcatag gaggacagat
     1321 gaaaattaaa aaccagtacc tcataacaaa ctgtgttgat aagtactcag tagatcaaga
     1381 caactggaaa cgagtatctc cccttccact gcagctggct tgtcatgctg tggtaacagt
     1441 gaacaataaa ctgtatgtca tcggaggctg gacccctcag atggatcttc ctgacgaaga
     1501 gcctgatcga ttaagcaaca aactgttgca gtatgacccc agccaagatc aatggagaga
     1561 gcgggcaccc atgcggtact ctaagtaccg attcagtgca gccgtcgtca acagtgagat
     1621 ctatgttctg ggtggaattg gctgtgtggg ccgagacaag ggacaagttc ggaaatgcct
     1681 tgatgtggtg gagatctaca accccgatgg ggacttctgg agggaaggcc cgcctatgcc
     1741 gagtcccctc ctctcactgc gaaccaattc caccagtgct ggcgccgtgg acgggaagct
     1801 ctatgtctgc ggtggatttc atggagcaga tcgacatgag gttatctcca aagagattct
     1861 ggagctggac ccttgggaga accagtggaa cgttgtggcc atcaatgtcc tcatgcacga
     1921 cagctatgac gtctgtctgg tagctaggat gaacccccga gacctcatcc caccaccctc
     1981 tgatctgatc gaggaagatg gtgaccacag agggcaaaga tgaggaactc gaagctggag
     2041 gagctacagc taaaggagcc atggcctggc agcgatgctt gggctgctca gaatgcaaag
     2101 cagggcatag gcatagtgtg tggtgctgac attcttatcg catgcatagc agaccctgtg
     2161 caaagtggca ctgagcggtg gtggggcggg gtcgggggga ggggtggttc agggtcttcc
     2221 ctcaggggca tcccagcatg gtaaaataga tgtggcagag cagggcagac agtgaggatt
     2281 catgggggta ggacagagtg cagaggaggg cagcaccctg ctctgctggg actcaagagt
     2341 actgccaagc aggcccatgg gtgctttttt tgatgatgag gttgggagaa aggacagtca
     2401 aaggttgtaa agtaggaaag ctggtgtgtg tctgtgtgtg tgtctagtcc agcctgccac
     2461 agagcttaca cacaggattt gctgctgaga gaaaggtaac aactaggtgt ccaatgcctg
     2521 aaagaggaag gagcataggc ctgggcctgg gtagaggagc catcgctctc agagctttgc
     2581 cccagctcag tctgtctgtt agaatagcct gaagggcata catatagcag cagagctcac
     2641 tgcggccctg cttgtgacca aacgctcacg cctagaaccc tattgccatg ggccacagtg
     2701 agcagagtat tcctggacac agaggggccc ccttgggctt aatactgagt gcgtagactg
     2761 agcttgctct cagctgtaca gaccttcctt ggatggagct gaatgcagca tgtctaaaca
     2821 cgggaaccca cagtaggctg tgaatgagga gggaagaggc atattggcta cctgatgcct
     2881 ccttcagacc cctgccctgg ctgggaaagg gagggggagc ttctcccagc ccaggcatgg
     2941 tacagtgagc tctccccaga gagctctgca attaggggta tctgcaattt tgtgtggaaa
     3001 tctatccatt ttgcttccac tcatatttct ggatgcacag ctgatccatt acgtgactgt
     3061 tctctaacat cacaaaagct tccatgtaag cagtgtggac actctgggat cttcccagag
     3121 gccagcagac cctgcacaga cacagctctt tatcaatgtg cactctccaa gttccaacct
     3181 ctccttcaca ggagaggagg actcgatcaa accagagcca ctgacaccaa ggtgttctgc
     3241 cccctgtccc tgcacagatg tacccccaga atgctacact cttagaggca cgggccacgt
     3301 ctgtctctct aaggttaccc cctgagtcct atcatagtag ctgacacatg gatggagttt
     3361 cgggtgacca gaataagtaa catttctaag ccaggatctt gtctgggact ttgagtttca
     3421 agtatcctcc ttgtgcccac cagcgcagag tggttatctg agggtttctt ttctcagagc
     3481 aaatcagagc tgctccagac aggttaggca gaagctctat agggagggtc gctgctcccc
     3541 tgagtcccca ccagaatctc ttcctgttca cccacctggg catcttagaa gctacttgtc
     3601 acctggttca cgggctgcag tgtatcttct gtaccttcct catatgcaga atgggaaggg
     3661 aaaccccaca ctctttacag agttggtgtg tggattgagt gtgaaaacac tggatggaat
     3721 acggtgttaa acacaaattc catgaagagg tcttaactgc cggctgggtt actgtcacca
     3781 tgatcagcct ttcctgggac aaagtgcaga acagaaccct ggaccttagg gaatctcaaa
     3841 tctcagggag agatgtggtt taaggtggtt ctaatttccc ctgtgcttgg ctccttcggg
     3901 ggtgaatctc ttgggtctgt aggcccttga gaccgtaagc agatgcttcg gcggcatcac
     3961 caggtaacga gagccttcct gggctaggac accattgctg cctgtgctaa ggagtatcag
     4021 aagggaactt tccagggaat gctgagggag ggaggacaaa ggagagcgac tggtctccct
     4081 ggagcggaca cagaactgcc tcagcaccag aggggaggca ggaactggga gtagtcccag
     4141 gcttattccc gacaggtaca tccaaggtct cagacgcctg ccgtgaagtc ccttctgcat
     4201 ccagaaccca gagtccaggc tcactggctc tggggctcac tttcagtgct ggggcttctc
     4261 ggctgccttt tcctatttgt gattcaaacc gacctacgct gccctcccgg agaaccattg
     4321 ttagagattc catttggaca gaccttcctg ccacccgtca ctggcattga aggtgttctg
     4381 acactcggga aggcctctta gaaatgtcta ctattggggc ttcttatctt tgtgactcag
     4441 ggttgctgga cgcctagcga aaaaacacaa tggggaagta atttggatgc tgggctgata
     4501 aaggactgca gctgtcagcc atcctgactc agtttgtgct cagcaagagg cggcattgtt
     4561 ctcaggctga ctttataatg aggagatgct ctgagtgcag acttataaaa tacatttttg
     4621 ctaatgaa
//
