LOCUS       NM_144531               4898 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus kazrin, periplakin interacting protein (Kazn),
            transcript variant 1, mRNA.
ACCESSION   NM_144531 XM_983459
VERSION     NM_144531.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4898)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4898)
  AUTHORS   Hernandez-Perez,I., Rubio,J., Baumann,A., Girao,H., Ferrando,M.,
            Rebollo,E., Aragay,A.M. and Geli,M.I.
  TITLE     Kazrin promotes dynein/dynactin-dependent traffic from early to
            recycling endosomes
  JOURNAL   Elife 12, e83793 (2023)
   PUBMED   37096882
  REMARK    GeneRIF: Kazrin promotes dynein/dynactin-dependent traffic from
            early to recycling endosomes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4898)
  AUTHORS   Youlten,S.E., Kemp,J.P., Logan,J.G., Ghirardello,E.J., Sergio,C.M.,
            Dack,M.R.G., Guilfoyle,S.E., Leitch,V.D., Butterfield,N.C.,
            Komla-Ebri,D., Chai,R.C., Corr,A.P., Smith,J.T., Mohanty,S.T.,
            Morris,J.A., McDonald,M.M., Quinn,J.M.W., McGlade,A.R.,
            Bartonicek,N., Jansson,M., Hatzikotoulas,K., Irving,M.D.,
            Beleza-Meireles,A., Rivadeneira,F., Duncan,E., Richards,J.B.,
            Adams,D.J., Lelliott,C.J., Brink,R., Phan,T.G., Eisman,J.A.,
            Evans,D.M., Zeggini,E., Baldock,P.A., Bassett,J.H.D., Williams,G.R.
            and Croucher,P.I.
  TITLE     Osteocyte transcriptome mapping identifies a molecular landscape
            controlling skeletal homeostasis and susceptibility to skeletal
            disease
  JOURNAL   Nat Commun 12 (1), 2444 (2021)
   PUBMED   33953184
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4898)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4898)
  AUTHORS   Miller,J.A., Nathanson,J., Franjic,D., Shim,S., Dalley,R.A.,
            Shapouri,S., Smith,K.A., Sunkin,S.M., Bernard,A., Bennett,J.L.,
            Lee,C.K., Hawrylycz,M.J., Jones,A.R., Amaral,D.G., Sestan,N.,
            Gage,F.H. and Lein,E.S.
  TITLE     Conserved molecular signatures of neurogenesis in the hippocampal
            subgranular zone of rodents and primates
  JOURNAL   Development 140 (22), 4633-4644 (2013)
   PUBMED   24154525
REFERENCE   6  (bases 1 to 4898)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   7  (bases 1 to 4898)
  AUTHORS   Chhatriwala,M.K., Cipolat,S., Sevilla,L.M., Nachat,R. and Watt,F.M.
  TITLE     Exons 5-15 of kazrin are dispensable for murine epidermal
            morphogenesis and homeostasis
  JOURNAL   J Invest Dermatol 132 (8), 1977-1987 (2012)
   PUBMED   22513779
  REMARK    GeneRIF: exons 5-15 of kazrin, encoding the nuclear localization
            signal and C-terminal domain, are not required for epidermal
            development and function
REFERENCE   8  (bases 1 to 4898)
  AUTHORS   Gallicano,G.I., Foshay,K., Pengetnze,Y. and Zhou,X.
  TITLE     Dynamics and unexpected localization of the plakin binding protein,
            kazrin, in mouse eggs and early embryos
  JOURNAL   Dev Dyn 234 (1), 201-214 (2005)
   PUBMED   16086310
REFERENCE   9  (bases 1 to 4898)
  AUTHORS   Groot,K.R., Sevilla,L.M., Nishi,K., DiColandrea,T. and Watt,F.M.
  TITLE     Kazrin, a novel periplakin-interacting protein associated with
            desmosomes and the keratinocyte plasma membrane
  JOURNAL   J Cell Biol 166 (5), 653-659 (2004)
   PUBMED   15337775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            MF597748.1 and AL663037.13.
            
            On Jan 5, 2023 this sequence version replaced NM_144531.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173090.1, SRR17784648.286505.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-399               MF597748.1         13432-13830         c
            400-591             AL663037.13        224053-224244       c
            592-728             AL663037.13        173082-173218       c
            729-899             AL663037.13        168468-168638       c
            900-1089            AL663037.13        164884-165073       c
            1090-1217           AL663037.13        161056-161183       c
            1218-1268           AL663037.13        157332-157382       c
            1269-1392           AL663037.13        155711-155834       c
            1393-1598           AL663037.13        132113-132318       c
            1599-1717           AL663037.13        131123-131241       c
            1718-1949           AL663037.13        126146-126377       c
            1950-2051           AL663037.13        123315-123416       c
            2052-2218           AL663037.13        122584-122750       c
            2219-2333           AL663037.13        120850-120964       c
            2334-4898           AL663037.13        116428-118992       c
FEATURES             Location/Qualifiers
     source          1..4898
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 75.46 cM"
     gene            1..4898
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /note="kazrin, periplakin interacting protein"
                     /db_xref="GeneID:71529"
                     /db_xref="MGI:MGI:1918779"
     exon            1..399
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..2498
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="kazrin isoform 1"
                     /protein_id="NP_653114.3"
                     /db_xref="GeneID:71529"
                     /db_xref="MGI:MGI:1918779"
                     /translation="MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGG
                     GGPGSGPGAATSASAAAVTVADSAVATMENHQHGAQVLLREEVVQLQEEVHLLRQMKE
                     MLAKDLEESQGGKCSEVLSATELRVQLVQKEQELARAKEALQAMKADRKRLKGEKTDL
                     VSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAK
                     EATDHAAALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGN
                     QEWVVQADLPLTAAIRQSQQTLYHSHPPHPADRQVRVSPCHSRQPSVISDASAAEGDR
                     SSTPSDINSPRHRTHSLCNGDSPGPVQKSLHNPIVQSLEDLEDQKRKKKKEKMGFGSI
                     SRVFARGKQRKSLDPGLFDDSDSQCSPTRHSLSLSEGEEQMDRLQHVELVRTTPMSHW
                     KAGTVQAWLEVVMAMPMYVKACAENVKSGKVLLSLSDEDLELGLGVCSSLHRRKLRLA
                     IEDYRDAEAGRSLSKAADLDHHWVAKAWLNDIGLSQYSQAFQNHLVDGRMLNSLMKRD
                     LEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRARCETQNTDPVVWTNQRVLKW
                     VRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGIPSGKHILRRHLAEEMSTI
                     FHPSNSTGIRESERFGTPPGRASSITRAGREDSGGNSKHRAGRLPLGKIGRGFSSKEP
                     DFHDDYGSLENEDCGDEDLQGRPEQCRLEGYGSLEVTNV"
     exon            400..591
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /inference="alignment:Splign:2.1.0"
     exon            592..728
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /inference="alignment:Splign:2.1.0"
     exon            729..899
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1089
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1217
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1268
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1392
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1598
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1717
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1949
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2051
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2218
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2333
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..4898
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4875..4880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /note="hexamer: AATAAA"
     polyA_site      4898
                     /gene="Kazn"
                     /gene_synonym="2310007B04Rik; 9030409G11Rik; Kaz; Kazrin"
                     /note="major polyA site"
ORIGIN      
        1 gccggcgctt gccggtgccc gggggtcggg gcgcggggaa acccgggccg ctgtggtgac
       61 ccaacaggta gagccggggc cacggccggc cacgcgcccc ccgcgtgcat catgcagctc
      121 tttgtcacct ctctcgcccc caggccaaaa tcctgagcat gatggaagac aataagcagc
      181 tcgcgctccg catcgatggg gcggtccagt cggccagcca ggaggtgacc aacctgcgag
      241 ccgaactcac ggccaccaac cggagactgg cggaattgag cggcggaggc ggcggccccg
      301 gctcgggccc gggagctgcg accagcgcct cggcagcagc ggtgacggtg gctgactcgg
      361 cagtggcgac catggagaac catcagcacg gagctcaagt gctcctgcgg gaggaagtgg
      421 tccagcttca agaggaagtg caccttctcc ggcagatgaa ggaaatgctg gcgaaggacc
      481 tggaggagtc acagggcggc aagtgctctg aggtcctctc agccactgag ctccgggtgc
      541 agctggtaca gaaggagcag gaactggcca gagccaaaga agccttgcaa gccatgaaag
      601 ctgaccggaa gcgcttaaag ggcgagaaga ctgacctggt gagccagatg cagcagctgt
      661 acgccacgct ggagagccgc gaggagcagt tgcgagactt catccgcaac tatgagcagc
      721 accgcaagga gagtgaagac gcagtcaaag cactggccaa ggagaaggac ctgctggagc
      781 gagagaagtg ggagcttcga cggcaggcca aggaagccac agaccatgct gcggccctgc
      841 gctcccagct ggacctcaag gacaaccgca tgaaggagct ggaggcggag ctcgccatgg
      901 ccaagcagtc cttagccact ctgaccaagg atgtccccaa gaggcattcc ctcgccatgc
      961 ccggtgagac ggtgctcaat ggcaaccagg aatgggtggt gcaggctgac ctcccactga
     1021 ctgctgccat ccggcaaagc caacagactc tctaccactc acaccctccc caccctgcag
     1081 accggcaagt cagggtgagc ccctgccact caagacagcc ctccgtcatc tctgatgctt
     1141 ctgctgctga aggtgaccgg tcatctacac caagcgacat caactcccca agacaccgga
     1201 cacactccct ctgcaacggc gacagtcccg gcccagttca gaagagccta cacaacccta
     1261 ttgtacagtc actagaggat cttgaagacc aaaaacggaa aaagaagaag gagaagatgg
     1321 gattcggctc catctctcga gtcttcgcca gagggaagca acggaagtcc ctcgacccgg
     1381 gcctctttga tgactccgac agccagtgca gccccacacg ccacagcctc agcctgtctg
     1441 agggagagga gcagatggac cgtctgcagc acgtggagct ggtgaggacc acgcccatgt
     1501 cgcactggaa ggctggcaca gtgcaggcct ggctggaggt ggtgatggcc atgcccatgt
     1561 acgtcaaggc ctgtgcagaa aatgtcaaga gtgggaaggt gcttctcagc ctgagtgacg
     1621 aggacctgga gttgggcctg ggagtgtgca gctccttgca caggcgcaag ctccgcctgg
     1681 ccattgagga ctaccgagat gctgaggcag gccgcagcct gtccaaagct gccgacctgg
     1741 accatcactg ggtggccaag gcctggctga atgacattgg cctgtcccag tattcccagg
     1801 ccttccagaa ccacctggtt gatgggagga tgctgaattc actgatgaag cgggacctgg
     1861 agaaacacct gaacgtgtcc aagaagttcc accaagttag catcttgctg ggaattgagc
     1921 tgctgtacca agtgaacttc agcagggagg ctctccagga gcgcagagcc cgctgtgaaa
     1981 cacagaacac agaccctgtg gtctggacca accagcgggt gctcaagtgg gtgcgcgata
     2041 tcgacctgaa ggagtatgca gacaacctga ccaatagcgg tgtccatggt gctgtgctgg
     2101 tcctggagcc cacattcaat gccgaggcca tggccaccgc cctgggcatc cccagcggga
     2161 agcacatact caggagacac ctggcagagg agatgagcac catcttccat ccatccaact
     2221 ccacaggcat ccgggagtct gagcgctttg ggacaccacc tggcagggcc tctagcatca
     2281 ccagagctgg gagagaggac agtgggggca atagcaagca cagagctggc cggctgcccc
     2341 tggggaagat aggaaggggc ttcagcagca aagagcccga tttccatgat gactatggct
     2401 ctctggagaa cgaggactgt ggggatgagg acctccaagg caggccggaa cagtgccgtc
     2461 tggagggata cggcagcttg gaggtcacca atgtgtaaga aagccgcgtg actcaactcc
     2521 agaagagaac agggagaagg gacagcccaa cgtcccagag ccgtccatcc ccactgtaca
     2581 gcatgacccg gagccgagga cagacagggt gtcagaacag agttcccaga gatggtcaca
     2641 atttccaggg gggcaccaag gacagagaat gcccacctag gtatcttgta tctctgagga
     2701 agtatcccca gctgcgcgac ccagcaggtg gccctggggc tgctgttcaa agtagaagtc
     2761 aggtgccact ggtattttac actggtcaag gaggggcagt cagtctttgg gcctggaaca
     2821 ccctgctaag aggagcaggg aaacccccag cctgccttgg caaagccagg gccgctggga
     2881 tccggtggca aagccagcta gcagcggcca ggtggtgatt gttgactgtc agcccgctgg
     2941 gcagagaact tgaactctga cctcactcac tccagaagga ggcggaacgg cctgggcatc
     3001 ccttccactt taagggtgga catgttggga gcaggagggg gaatctctgc agggcacagg
     3061 tgcctgacag cagcagccct aggggctaca gacatcctgt caccagaatg aatgtgactt
     3121 caagagtggg aggggggtgg ttgctgtgct ctgtcccaaa cagctattcc gagtgtgcgc
     3181 atgacatggg agacagcctg tcattaatct gacaaacctc tcttgtgatg tccctgtcag
     3241 ctgagacagg taagctcacc catgagctaa cggaggtgca aatcctacaa aacaaggtca
     3301 ccccggttgt cagagtaggg cctttctagc cgctgtcctg atctgccagt gtttttgctg
     3361 tgtggcttcc cctcaatggc ctcacctctc tgtgcctcag tgtcttacct gtcatacttc
     3421 cggttcctcc cagaggagct gtgaggatta acattcacta acatttgtcc cgagctttga
     3481 acctctcagg aaacagctgg aagggatggg gcaggggagg aaggagccta acttccatcc
     3541 acaacattgg cagacaccgg gcgagttcac cccatttttg gatagggaga taagcaagag
     3601 gggcttgcag aaagtttaat atcgagagtt tccaaaagcc atcggtgagg tctgggagag
     3661 ccaccagcac agcctgcggg cctactgggt gcagggtcca agctgactga gcagagcctg
     3721 cctattgatg atagggagga tttcggtgta gctgtgctca gtcagtacca gctctcctca
     3781 gattcccaca gctgacggca gtcggtgggg gtgggggtgg ggcactgcct ctgagtcacc
     3841 aaagccagtc ttctgcattg tttctgagag cttccctttg cgggaagacc acaggaagcc
     3901 tgagaacttg gaggaggatt ccctgagtcc cccaggtcca gtctccttcc caacctgagt
     3961 ccagggccct cggggactgg gaggaacctc tctgtctgag tgtcagcctc cgaaggacac
     4021 acggcggaca ccaggacttg cagggtcaac ctctggggta gaatccagct tggctcaggc
     4081 tccacatccc tgagtgttta taacacgcat tcccctgccc ctggaatcct gaagctacaa
     4141 atcccttagc ccagcaaaga gaggggaaga aggtcctctt ctaattgaag ccagctgtca
     4201 ctttcacacc aagtccccaa agggtgacaa agcttctgga gccaggagga tactgagagc
     4261 cttcctggaa atgtcgctgg cgatgtgggc tcctttcaag ggccaaggtc taggtaggga
     4321 gagactcaca ctttcttccc acgggctcgg aggcccacgg catctgaagg ctccttccca
     4381 atggactctg ggcttcagtc ctgggcacct ctgtcagtct ccatccacat ccagtgtcac
     4441 ttttagcaga ttctctgtct tgactcctca ccacaggatg caggggttgt caggggacta
     4501 gagtcagaag tggagagagg ggctctctcc taagcccacc ctgcataggg cacttagaac
     4561 agggaacccc gccaaagacc gaggtcatga aaaggggtgg ggtcctggca gatgtaaatt
     4621 cggacggcag gatcacgatg aagaactcta agagaattat gacagccctt cccagaaggc
     4681 caaggaccac gtcacaggtt gtgggggaac gtggctcctg agtggtggca ccttctgggt
     4741 gtcactttac agaagccagc atggatggtg acgatgtccc tccctgaccc atggagggtt
     4801 tgtaaaatgc acggcaaatg aacagtgaac tgcagtgtcc catgccttcc cagagggaat
     4861 tttaacaatg taacaataaa tgcttggcct tgaagcta
//
