LOCUS       NM_178929               1432 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus Kazal-type serine peptidase inhibitor domain 1
            (Kazald1), transcript variant 2, mRNA.
ACCESSION   NM_178929
VERSION     NM_178929.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1432)
  AUTHORS   Morrison,J.A., Pushel,I., McLennan,R., McKinney,M.C., Gogol,M.M.,
            Scott,A., Krumlauf,R. and Kulesa,P.M.
  TITLE     Comparative analysis of neural crest development in the chick and
            mouse
  JOURNAL   Dev Biol 519, 142-149 (2025)
   PUBMED   39716593
REFERENCE   2  (bases 1 to 1432)
  AUTHORS   Whiley,P.A.F., O'Donnell,L., Moody,S.C., Handelsman,D.J.,
            Young,J.C., Richards,E.A., Almstrup,K., Western,P.S. and
            Loveland,K.L.
  TITLE     Activin A Determines Steroid Levels and Composition in the Fetal
            Testis
  JOURNAL   Endocrinology 161 (7) (2020)
   PUBMED   32274496
REFERENCE   3  (bases 1 to 1432)
  AUTHORS   Suto,J.
  TITLE     Quantitative trait locus mapping of genes that control body length
            and plasma insulin-like growth factor 1 level in mice
  JOURNAL   BMC Res Notes 5, 547 (2012)
   PUBMED   23031221
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1432)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1432)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 1432)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   7  (bases 1 to 1432)
  AUTHORS   James,M.J., Jarvinen,E., Wang,X.P. and Thesleff,I.
  TITLE     Different roles of Runx2 during early neural crest-derived bone and
            tooth development
  JOURNAL   J Bone Miner Res 21 (7), 1034-1044 (2006)
   PUBMED   16813524
REFERENCE   8  (bases 1 to 1432)
  AUTHORS   Shibata,Y., Tsukazaki,T., Hirata,K., Xin,C. and Yamaguchi,A.
  TITLE     Role of a new member of IGFBP superfamily, IGFBP-rP10, in
            proliferation and differentiation of osteoblastic cells
  JOURNAL   Biochem Biophys Res Commun 325 (4), 1194-1200 (2004)
   PUBMED   15555553
  REMARK    GeneRIF: These results suggest that IGFBP-rP10 is involved in the
            proliferation of osteoblasts during bone formation and bone
            regeneration.
REFERENCE   9  (bases 1 to 1432)
  AUTHORS   James,M.J., Jarvinen,E. and Thesleff,I.
  TITLE     Bono1: a gene associated with regions of deposition of bone and
            dentine
  JOURNAL   Gene Expr Patterns 4 (5), 595-599 (2004)
   PUBMED   15261838
  REMARK    GeneRIF: Expression of Bono1 was detected in osteoblasts and
            secretory odontoblasts by in situ hybridization.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB869960.1, BB871162.1, BB618180.1, BC115642.1, AI842353.1 and
            AI847274.1.
            
            On Apr 14, 2018 this sequence version replaced NM_178929.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030678.1, BC115642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BB869960.1         2-53
            53-106              BB871162.1         33-86
            107-366             BB618180.1         54-313
            367-1208            BC115642.1         306-1147
            1209-1428           AI842353.1         11-230              c
            1429-1432           AI847274.1         17-20               c
FEATURES             Location/Qualifiers
     source          1..1432
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.32 cM"
     gene            1..1432
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /note="Kazal-type serine peptidase inhibitor domain 1"
                     /db_xref="GeneID:107250"
                     /db_xref="MGI:MGI:2147606"
     exon            1..150
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /inference="alignment:Splign:2.1.0"
     exon            151..700
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1110
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; Kazal-type serine protease inhibitor domain 1;
                     kazal-type serine protease inhibitor domain-containing
                     protein 1; IGFBP-related protein 10; bone and
                     odontoblast-expressed protein 1; insulin-like growth
                     factor-binding-related protein 4; insulin-like growth
                     factor-binding-related protein 10"
                     /codon_start=1
                     /product="kazal-type serine protease inhibitor
                     domain-containing protein 1 isoform 1 precursor"
                     /protein_id="NP_849260.2"
                     /db_xref="CCDS:CCDS29857.1"
                     /db_xref="GeneID:107250"
                     /db_xref="MGI:MGI:2147606"
                     /translation="MPRVFTGLPANYAAPTLALSLLLPLLLVVWTQLPVSARPSTGPD
                     YLRRGWLRLLAEGEGCAPCRPEECAAPRGCLAGRVRDACGCCWECANLEGQLCDLDPS
                     ANFYGRCGEQLECRLDAGGDLSRGEVPEPLCVCRSQRPLCGSDGRTYAQICRLQEAAR
                     ARLDANLTVVHPGPCESEPQILSQPHNIWNVTGQDVIFGCEVFAYPMASIEWRKDGLD
                     IQLPGDDPHISVQFRGGPQKFEVTGWLQIQALRPSDEGTYRCLARNALGQAEASATLT
                     VLTPEQLNATGFSQLQSRSLFPEEEEEAESEELGDYY"
     exon            701..861
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1009
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1432
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1407..1412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /note="hexamer: AATAAA"
     polyA_site      1432
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /note="major polyA site"
ORIGIN      
        1 gtgggctgcc agcgatcccc tgacagaagc aggggtggcc tgcgggtctg gctggccgtg
       61 catgcgactc ttcgttccct accgtttttt tttttttttt ttttttaggt tggaaatccc
      121 agctgttaag ggcctagtcc aaggcactag ggtgccacct acgcgccgat gccccgagtg
      181 ttcacagggc ttccagctaa ctatgctgca cctaccttgg cgctgtcctt gctactacca
      241 ttattgctgg tggtgtggac ccagctaccc gttagcgcga ggccgtccac aggccccgat
      301 tacctgcggc gaggctggct gcggctgcta gccgagggcg agggttgtgc tccctgccgg
      361 ccagaagagt gcgctgcgcc gcggggatgc ctagcaggcc gggtgcggga tgcgtgcggc
      421 tgctgctggg aatgcgcaaa cctggagggc cagctctgcg atctggaccc cagcgctaac
      481 ttctacgggc gctgcggcga gcagctcgag tgcaggctgg acgcgggcgg tgacctgagt
      541 cgaggagagg tgccggagcc gctgtgtgtc tgccgctcgc agcgcccgct ctgtggttcg
      601 gacggccgaa cctacgcgca gatctgtcgc ctgcaggagg ccgcccgcgc tcggctggac
      661 gctaacctca ctgtggtgca tccggggccc tgcgaatcgg agccccagat cctgtcgcag
      721 cctcacaata tttggaatgt gaccggacag gatgtgatct ttggctgtga ggtgtttgcc
      781 taccccatgg cctcgattga gtggaggaaa gatggcttgg acatccagct gccgggggat
      841 gaccctcata tctctgtgca gtttaggggt ggacctcaga agtttgaggt gactggctgg
      901 ctacagattc aagctttgcg ccctagtgat gagggcacct accgttgcct tgcccggaat
      961 gctctgggcc aagcggaagc ttctgcaacc ctcacagtgc tcacaccaga gcagctgaac
     1021 gccacgggat tctcccagct gcaatcacgg agtttgtttc ctgaggagga ggaggaggca
     1081 gaaagtgaag agttgggcga ttactactag gtccagatct ctgctttgca ggtgtgggca
     1141 tgtggacaga gccctgcatc cttgctgtct agaaagcccg gagaagactg gaaaaggcga
     1201 gcagggtcct tacatggatt gtttaatgct cagtgtagcc tcagctcatc tttcctcaaa
     1261 actcatcttt cagaagcgtc cgcggtagag atgagcgcag cggaactgat ttagttcagt
     1321 acagggagag gggtggggta gctccgtgtc ttatacactc taggggacaa aacccaccta
     1381 gcatacgact agacacagtg ggcaccaata aaaaaatata taaacaaacc ga
//
