LOCUS       NM_001362398            1625 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus Kazal-type serine peptidase inhibitor domain 1
            (Kazald1), transcript variant 1, mRNA.
ACCESSION   NM_001362398 XM_006526568
VERSION     NM_001362398.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1625)
  AUTHORS   Morrison,J.A., Pushel,I., McLennan,R., McKinney,M.C., Gogol,M.M.,
            Scott,A., Krumlauf,R. and Kulesa,P.M.
  TITLE     Comparative analysis of neural crest development in the chick and
            mouse
  JOURNAL   Dev Biol 519, 142-149 (2025)
   PUBMED   39716593
REFERENCE   2  (bases 1 to 1625)
  AUTHORS   Whiley,P.A.F., O'Donnell,L., Moody,S.C., Handelsman,D.J.,
            Young,J.C., Richards,E.A., Almstrup,K., Western,P.S. and
            Loveland,K.L.
  TITLE     Activin A Determines Steroid Levels and Composition in the Fetal
            Testis
  JOURNAL   Endocrinology 161 (7) (2020)
   PUBMED   32274496
REFERENCE   3  (bases 1 to 1625)
  AUTHORS   Suto,J.
  TITLE     Quantitative trait locus mapping of genes that control body length
            and plasma insulin-like growth factor 1 level in mice
  JOURNAL   BMC Res Notes 5, 547 (2012)
   PUBMED   23031221
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1625)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1625)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 1625)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   7  (bases 1 to 1625)
  AUTHORS   James,M.J., Jarvinen,E., Wang,X.P. and Thesleff,I.
  TITLE     Different roles of Runx2 during early neural crest-derived bone and
            tooth development
  JOURNAL   J Bone Miner Res 21 (7), 1034-1044 (2006)
   PUBMED   16813524
REFERENCE   8  (bases 1 to 1625)
  AUTHORS   Shibata,Y., Tsukazaki,T., Hirata,K., Xin,C. and Yamaguchi,A.
  TITLE     Role of a new member of IGFBP superfamily, IGFBP-rP10, in
            proliferation and differentiation of osteoblastic cells
  JOURNAL   Biochem Biophys Res Commun 325 (4), 1194-1200 (2004)
   PUBMED   15555553
  REMARK    GeneRIF: These results suggest that IGFBP-rP10 is involved in the
            proliferation of osteoblasts during bone formation and bone
            regeneration.
REFERENCE   9  (bases 1 to 1625)
  AUTHORS   James,M.J., Jarvinen,E. and Thesleff,I.
  TITLE     Bono1: a gene associated with regions of deposition of bone and
            dentine
  JOURNAL   Gene Expr Patterns 4 (5), 595-599 (2004)
   PUBMED   15261838
  REMARK    GeneRIF: Expression of Bono1 was detected in osteoblasts and
            secretory odontoblasts by in situ hybridization.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132957.3.
            
            On Apr 14, 2018 this sequence version replaced XM_006526568.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               AC132957.3         182514-182791
            279-320             AC132957.3         183468-183509
            321-893             AC132957.3         183914-184486
            894-1054            AC132957.3         185569-185729
            1055-1202           AC132957.3         185834-185981
            1203-1625           AC132957.3         186140-186562
FEATURES             Location/Qualifiers
     source          1..1625
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.32 cM"
     gene            1..1625
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /note="Kazal-type serine peptidase inhibitor domain 1"
                     /db_xref="GeneID:107250"
                     /db_xref="MGI:MGI:2147606"
     exon            1..278
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /inference="alignment:Splign:2.1.0"
     exon            279..320
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /inference="alignment:Splign:2.1.0"
     exon            321..893
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..1303
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Kazal-type serine protease inhibitor domain 1;
                     kazal-type serine protease inhibitor domain-containing
                     protein 1; IGFBP-related protein 10; bone and
                     odontoblast-expressed protein 1; insulin-like growth
                     factor-binding-related protein 4; insulin-like growth
                     factor-binding-related protein 10"
                     /codon_start=1
                     /product="kazal-type serine protease inhibitor
                     domain-containing protein 1 isoform 1 precursor"
                     /protein_id="NP_001349327.1"
                     /db_xref="CCDS:CCDS29857.1"
                     /db_xref="GeneID:107250"
                     /db_xref="MGI:MGI:2147606"
                     /translation="MPRVFTGLPANYAAPTLALSLLLPLLLVVWTQLPVSARPSTGPD
                     YLRRGWLRLLAEGEGCAPCRPEECAAPRGCLAGRVRDACGCCWECANLEGQLCDLDPS
                     ANFYGRCGEQLECRLDAGGDLSRGEVPEPLCVCRSQRPLCGSDGRTYAQICRLQEAAR
                     ARLDANLTVVHPGPCESEPQILSQPHNIWNVTGQDVIFGCEVFAYPMASIEWRKDGLD
                     IQLPGDDPHISVQFRGGPQKFEVTGWLQIQALRPSDEGTYRCLARNALGQAEASATLT
                     VLTPEQLNATGFSQLQSRSLFPEEEEEAESEELGDYY"
     exon            894..1054
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1202
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1625
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1600..1605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /note="hexamer: AATAAA"
     polyA_site      1625
                     /gene="Kazald1"
                     /gene_synonym="Bono1; IGFBP-rP10"
                     /note="major polyA site"
ORIGIN      
        1 ggtttccttc tgctcctcct cctcctagga gcttggattg cggtttttgg aagctgtttg
       61 ggggccggcg ggggcggggc ctgccattct cggggtggtg ggcgggcctc cggggatgct
      121 ttgcttcctg cccctaaccc aaaagtgcca ccgtggcgtt ggcggaggtc tccagactga
      181 acacttttgg ccccgacatg ctcgaatttt gcaacctgta atccggagcc cagagacgcc
      241 ctatggggag tcacccgccg gccttgctgc ggccgctagt tggaaatccc agctgttaag
      301 ggcctagtcc aaggcactag acctggcttc cctctcctgg cagggtgcca cctacgcgcc
      361 gatgccccga gtgttcacag ggcttccagc taactatgct gcacctacct tggcgctgtc
      421 cttgctacta ccattattgc tggtggtgtg gacccagcta cccgttagcg cgaggccgtc
      481 cacaggcccc gattacctgc ggcgaggctg gctgcggctg ctagccgagg gcgagggttg
      541 tgctccctgc cggccagaag agtgcgctgc gccgcgggga tgcctagcag gccgggtgcg
      601 ggatgcgtgc ggctgctgct gggaatgcgc aaacctggag ggccagctct gcgatctgga
      661 ccccagcgct aacttctacg ggcgctgcgg cgagcagctc gagtgcaggc tggacgcggg
      721 cggtgacctg agtcgaggag aggtgccgga gccgctgtgt gtctgccgct cgcagcgccc
      781 gctctgtggt tcggacggcc gaacctacgc gcagatctgt cgcctgcagg aggccgcccg
      841 cgctcggctg gacgctaacc tcactgtggt gcatccgggg ccctgcgaat cggagcccca
      901 gatcctgtcg cagcctcaca atatttggaa tgtgaccgga caggatgtga tctttggctg
      961 tgaggtgttt gcctacccca tggcctcgat tgagtggagg aaagatggct tggacatcca
     1021 gctgccgggg gatgaccctc atatctctgt gcagtttagg ggtggacctc agaagtttga
     1081 ggtgactggc tggctacaga ttcaagcttt gcgccctagt gatgagggca cctaccgttg
     1141 ccttgcccgg aatgctctgg gccaagcgga agcttctgca accctcacag tgctcacacc
     1201 agagcagctg aacgccacgg gattctccca gctgcaatca cggagtttgt ttcctgagga
     1261 ggaggaggag gcagaaagtg aagagttggg cgattactac taggtccaga tctctgcttt
     1321 gcaggtgtgg gcatgtggac agagccctgc atccttgctg tctagaaagc ccggagaaga
     1381 ctggaaaagg cgagcagggt ccttacatgg attgtttaat gctcagtgta gcctcagctc
     1441 atctttcctc aaaactcatc tttcagaagc gtccgcggta gagatgagcg cagcggaact
     1501 gatttagttc agtacaggga gaggggtggg gtagctccgt gtcttataca ctctagggga
     1561 caaaacccac ctagcatacg actagacaca gtgggcacca ataaaaaaat atataaacaa
     1621 accga
//
