LOCUS       NM_028805               3425 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus katanin p80 (WD40-containing) subunit B 1 (Katnb1),
            mRNA.
ACCESSION   NM_028805 XM_134311
VERSION     NM_028805.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3425)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3425)
  AUTHORS   Dunleavy,J.E.M., O'Connor,A.E., Okuda,H., Merriner,D.J. and
            O'Bryan,M.K.
  TITLE     KATNB1 is a master regulator of multiple katanin enzymes in male
            meiosis and haploid germ cell development
  JOURNAL   Development 148 (24) (2021)
   PUBMED   34822718
  REMARK    GeneRIF: KATNB1 is a master regulator of multiple katanin enzymes
            in male meiosis and haploid germ cell development.
REFERENCE   3  (bases 1 to 3425)
  AUTHORS   Ho,U.Y., Feng,C.A., Yeap,Y.Y., Bain,A.L., Wei,Z., Shohayeb,B.,
            Reichelt,M.E., Homer,H., Khanna,K.K., Bowles,J. and Ng,D.C.H.
  TITLE     WDR62 is required for centriole duplication in spermatogenesis and
            manchette removal in spermiogenesis
  JOURNAL   Commun Biol 4 (1), 645 (2021)
   PUBMED   34059773
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3425)
  AUTHORS   Faltova,L., Jiang,K., Frey,D., Wu,Y., Capitani,G., Prota,A.E.,
            Akhmanova,A., Steinmetz,M.O. and Kammerer,R.A.
  TITLE     Crystal Structure of a Heterotetrameric Katanin p60:p80 Complex
  JOURNAL   Structure 27 (9), 1375-1383 (2019)
   PUBMED   31353241
  REMARK    GeneRIF: Study uncovered an unexpected role of the p60-MIT and
            p80-CTD domains of katanin in the oligomerization and regulation of
            the protein. p80-CTD mediates the assembly of p60-MIT:p80-CTD
            heterodimers into heterotetramers that have an impact on katanin MT
            end and lattice binding as well as on the severing activity of the
            enzyme. The heterotetrameric structure of the p60-MIT:p80-CTD
            K555A/R591A mutant revealed a domain swap.
REFERENCE   5  (bases 1 to 3425)
  AUTHORS   Rezabkova,L., Jiang,K., Capitani,G., Prota,A.E., Akhmanova,A.,
            Steinmetz,M.O. and Kammerer,R.A.
  TITLE     Structural basis of katanin p60:p80 complex formation
  JOURNAL   Sci Rep 7 (1), 14893 (2017)
   PUBMED   29097679
  REMARK    GeneRIF: This study structurally and functionally characterized the
            interaction between the two katanin subunits that is mediated by
            the p60-MIT domain and the p80 C-terminal domain (p80-CTD).
            p60-MIT and p80-CTD form a tight heterodimeric complex, whose
            high-resolution structure was determined by X-ray crystallography.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3425)
  AUTHORS   Iwaya,N., Akiyama,K., Goda,N., Tenno,T., Fujiwara,Y., Hamada,D.,
            Ikura,T., Shirakawa,M. and Hiroaki,H.
  TITLE     Effect of Ca2+ on the microtubule-severing enzyme p60-katanin.
            Insight into the substrate-dependent activation mechanism
  JOURNAL   FEBS J 279 (7), 1339-1352 (2012)
   PUBMED   22325007
REFERENCE   7  (bases 1 to 3425)
  AUTHORS   Cummings,C.M., Bentley,C.A., Perdue,S.A., Baas,P.W. and Singer,J.D.
  TITLE     The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for
            normal mitosis in mammalian cells
  JOURNAL   J Biol Chem 284 (17), 11663-11675 (2009)
   PUBMED   19261606
  REMARK    GeneRIF: Cul3-deficient cells or Ctb9/KLHDC5-deficient cells show
            an increase in p60/katanin levels, indicating that Cul3/Ctb9/KLHDC5
            is required for efficient p60/katanin removal
REFERENCE   8  (bases 1 to 3425)
  AUTHORS   Toyo-Oka,K., Sasaki,S., Yano,Y., Mori,D., Kobayashi,T.,
            Toyoshima,Y.Y., Tokuoka,S.M., Ishii,S., Shimizu,T., Muramatsu,M.,
            Hiraiwa,N., Yoshiki,A., Wynshaw-Boris,A. and Hirotsune,S.
  TITLE     Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1
            interacting protein, is essential for mitotic cell division and
            neuronal migration
  JOURNAL   Hum Mol Genet 14 (21), 3113-3128 (2005)
   PUBMED   16203747
REFERENCE   9  (bases 1 to 3425)
  AUTHORS   Yu,W., Solowska,J.M., Qiang,L., Karabay,A., Baird,D. and Baas,P.W.
  TITLE     Regulation of microtubule severing by katanin subunits during
            neuronal development
  JOURNAL   J Neurosci 25 (23), 5573-5583 (2005)
   PUBMED   15944385
REFERENCE   10 (bases 1 to 3425)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB842538.1, AK034103.1, AK031630.1 and AK136322.1.
            
            On Dec 30, 2005 this sequence version replaced NM_028805.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136322.1, AK031630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                BB842538.1         3-83
            82-2616             AK034103.1         2-2536
            2617-3154           AK031630.1         2529-3066
            3155-3425           AK136322.1         3076-3346
FEATURES             Location/Qualifiers
     source          1..3425
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.12 cM"
     gene            1..3425
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /note="katanin p80 (WD40-containing) subunit B 1"
                     /db_xref="GeneID:74187"
                     /db_xref="MGI:MGI:1921437"
     exon            1..104
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            105..400
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..2337
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /note="p80 katanin; katanin p80 subunit B1"
                     /codon_start=1
                     /product="katanin p80 WD40 repeat-containing subunit B1"
                     /protein_id="NP_083081.2"
                     /db_xref="CCDS:CCDS22555.1"
                     /db_xref="GeneID:74187"
                     /db_xref="MGI:MGI:1921437"
                     /translation="MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCR
                     VNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLM
                     GHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGK
                     WLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL
                     EKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVA
                     DLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVTQDPVQANQPLTQQTPNPGVSLR
                     RIYERPSTTCSKPQRVKHNSESERRSPSSEDDRDERESRAEIQNAEDYNEIFQPKNSI
                     SRTPPRRSEPFPAPPEDDAATVKEVSKPSPAMDVQLPQLPVPNLEVPARPSVMTSTPA
                     PKGEPDIIPATRNEPIGLKASDFLPAVKVPQQAELVDEDAMSQIRKGHDTMFVVLTSR
                     HKNLDTVRAVWTTGDIKTSVDSAVAINDLSVVVDLLNIVNQKASLWKLDLCTTVLPQI
                     EKLLQSKYESYVQTGCTSLKLILQRFLPLITDILAAPPSVGVDISREERLHKCRLCFK
                     QLKSISGLVKSKSGLSGRHGSAFRELHLLMASLD"
     exon            401..531
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            532..649
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            650..750
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            751..792
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            793..876
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            877..992
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1064
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1215
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1406
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1537
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1588
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1665
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1785
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1935
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2012
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2087
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2204
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..3425
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2588..2593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /note="hexamer: ATTAAA"
     polyA_site      2610
                     /gene="Katnb1"
                     /gene_synonym="2410003J24Rik; KAT"
                     /note="major polyA site"
ORIGIN      
        1 ttgtgagggt cggttgtcaa gcagcgacca atcagggcaa aggatggagg caagtggggg
       61 tcgcgcctgg agggaagcct tggcctccag agctacagct gcagcccagt gttgagctga
      121 gatggtccaa gcctgacatt ccatgatctg ggatcccgac ctatgtgtcc aggctgctgc
      181 ttgatagcgg atgatctaaa ccaccaggca gtcctgggcc aggagaggcg gactctctgc
      241 ctggatgtgt gggaactccc tgccaacttg attgtcggat ctggggggga tccaccccca
      301 ccccacagag aaagcacaat ctgttttgtg ggtggggtct caggcgccac cccctgaagc
      361 atggccaccc ctgtggtcac caagacagcc tggaagttgc aagagatcgt cgcccatgcc
      421 agcaatgtgt cctccttggt gctgggcaag gcctcagggc ggctgctggc cactggtggg
      481 gatgactgcc gagtcaacct gtggtccata aacaagccta actgcatcat gagcctgaca
      541 ggtcacacgt cccctgtgga gagtgtccgt ctcaacactc ctgaggagct catcgtagct
      601 ggttcccagt cgggctccat ccgcgtctgg gacctggaag ctgctaaaat tcttcgaaca
      661 ctcatgggcc acaaagccaa catctgcagc ctggatttcc acccctatgg tgaatttgtg
      721 gcctcaggct cccaggacac aaacattaag ctctgggaca tcaggaggaa aggctgtgtc
      781 ttccgatata gggggcacag ccaggctgtg cggtgtctcc ggttcagccc tgatgggaag
      841 tggctggcgt cggcagcaga tgaccacaca gtgaagcttt gggatctgac ggctggcaag
      901 atgatgtccg agttcccggg tcatacaggg cctgtcaatg tggtggagtt tcaccccaat
      961 gaatatctcc tagcttctgg cagctccgac aggacaatcc gcttctggga cctggagaag
     1021 ttccaggtgg tgagctgcat tgaaggggag cccgggcccg tcaggagtgt cctcttcaac
     1081 cccgacggct gctgcttgta cagcggctgc caggactcgc tgcgtgtcta cggctgggaa
     1141 cctgagcgct gctttgatgt ggtccttgtc aactggggca aggtggctga cctggccatc
     1201 tgcaatgacc agctgatagg tgtggctttc tcccagagta atgtctcctc ttatgtggtg
     1261 gacctgacga gagtcaccag gacgggaact gtgacccagg accctgtgca ggctaaccag
     1321 cctctgacac aacagacccc taaccctggt gtctccctcc gccgcatcta tgagcggccc
     1381 agcacgacat gcagcaagcc tcagagggta aagcacaact cagagagcga gcggcgcagc
     1441 cccagcagcg aagatgacag ggacgagcga gagtcccggg cggagatcca gaacgcggag
     1501 gactacaatg agattttcca gcccaagaac agcatcagtc ggacaccacc ccggagaagt
     1561 gagcccttcc cagcaccccc agaagatgat gcagccacag tgaaggaggt ctcaaaaccc
     1621 agcccagcca tggatgtgca gttgccgcag ttgccggtgc caaatctcga ggtcccagca
     1681 cgaccgtcag tcatgacttc cactcctgca cccaagggtg aacctgacat catccctgcc
     1741 acacggaatg agcccattgg cttaaaggcc tcggacttct tgcccgccgt gaaggtcccc
     1801 cagcaggcag agctggtgga cgaggatgcc atgtcgcaga tacgcaaagg ccacgacacc
     1861 atgtttgtgg tgctcaccag ccgccacaag aacctggaca ctgtccgagc tgtatggact
     1921 acaggagata tcaagacatc agtggactct gcagtggcca tcaatgacct gtctgtggta
     1981 gtggacctcc tgaacattgt caatcagaaa gcctccctgt ggaagctgga cctgtgcacc
     2041 acagtgctgc cccagatcga gaaactgctg cagagcaagt atgagagcta tgtccagacc
     2101 gggtgcacct ccctgaagct gatcctgcag cggttcctac ccctcatcac tgacattttg
     2161 gcagccccgc cctctgtggg tgtggacatc agccgagagg agaggttgca caagtgtcga
     2221 ctctgcttca aacaactcaa gagcatcagt ggcctcgtca agagcaagtc gggtttgagt
     2281 ggccgccatg gcagtgcctt ccgtgagctg cacctactca tggccagttt ggactgagga
     2341 gcacacggtg ggagcacccg cagccctcac acatacatac ttgctgtatg cctgtggccc
     2401 acgagcctca gcctggcctc cattcctgcc ctgctggcca tcctggaggc atggttgcca
     2461 gcctgctgac cacctcctcg gttgtggact aagctcctct ccggcagcag ctgcagtctt
     2521 gcacagccct tactgctcag ggcaactcca gcctcggggc tgctgctgta aattatcagg
     2581 cagatttatt aaatttataa ctgttcctga cttccttatg agaggaatat ccgctggctc
     2641 tcccagacac attgtggcct gcctagaggt cgctggaagc agagactgtc gtactccagg
     2701 cccagtgcag cctccatctg tggccagcag gggccagcag agtgccaggc acgaagcaag
     2761 gggctgcctg gtcagcttga cttggggaaa tggaacaggt gaggccatag atgtcacatc
     2821 ccccccaatt gtccttgggt agattggcta agagcctgtc ataactctcc ctctgacctc
     2881 tggatgccac cagagactag accacgatgg ttgcatgacc ttggaagatt ctagagtggt
     2941 tttcacaggc cacaggaaac tacttttata cttgtggcat ccctgagagt ctgcgctcca
     3001 gaacagcctg ttgatgcagc cagcaagaag ggaggagccc tagcaagccc tgttctccag
     3061 ggctgggacc ggggaccaga tacaaacgca tacatcaggt cactactagt tacagttcca
     3121 gactgggagg aaaggctggc acaggatgag caggtctttg aagcctagtt ttccttctgt
     3181 aacatgaggt gatactgcaa tgggatggaa tggttatagg ggcccgcaag gtgctagaaa
     3241 tgatataaaa agcatggggg acacagtgtc ttcagtgaca acttgtggag tctgcatggt
     3301 cagccagcaa cgggagcaac agggtacaca atgcccactc tccatagggt ctcccagtac
     3361 tgacgattca gattgcactt gtgtaaaaag acattcattt taataagtaa aaatggctaa
     3421 gcttc
//
