LOCUS       NM_153572               6173 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus katanin p60 subunit A-like 1 (Katnal1), mRNA.
ACCESSION   NM_153572
VERSION     NM_153572.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6173)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6173)
  AUTHORS   Dunleavy,J.E.M., Graffeo,M., Wozniak,K., O'Connor,A.E.,
            Merriner,D.J., Nguyen,J., Schittenhelm,R.B., Houston,B.J. and
            O'Bryan,M.K.
  TITLE     The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in
            mammalian meiosis and spermiogenesis to achieve male fertility
  JOURNAL   Development 150 (22) (2023)
   PUBMED   37882691
  REMARK    GeneRIF: The katanin A-subunits KATNA1 and KATNAL1 act
            co-operatively in mammalian meiosis and spermiogenesis to achieve
            male fertility.
REFERENCE   3  (bases 1 to 6173)
  AUTHORS   Kang,K., Li,N., Gao,Y., Wang,C., Chen,P., Meng,X., Yang,W., Zhao,M.
            and Yu,K.
  TITLE     circ-Katnal1 Enhances Inflammatory Pyroptosis in Sepsis-Induced
            Liver Injury through the miR-31-5p/GSDMD Axis
  JOURNAL   Mediators Inflamm 2022, 8950130 (2022)
   PUBMED   35979014
  REMARK    GeneRIF: circ-Katnal1 Enhances Inflammatory Pyroptosis in
            Sepsis-Induced Liver Injury through the miR-31-5p/GSDMD Axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6173)
  AUTHORS   Gao,L.L., Xu,F., Jin,Z., Ying,X.Y. and Liu,J.W.
  TITLE     Microtubule-severing protein Katanin p60 ATPase-containing subunit
            A-like 1 is involved in pole-based spindle organization during
            mouse oocyte meiosis
  JOURNAL   Mol Med Rep 20 (4), 3573-3582 (2019)
   PUBMED   31485656
  REMARK    GeneRIF: Katanin p60 ATPase-containing subunit A-like 1 was
            predominant in the ovaries and oocytes, indicating its essential
            roles in oocyte meiosis. It was also revealed that p60 kataninlike
            1 was concentrated at the spindle poles and colocalized and
            interacted with gammatubulin, indicating that it may be involved in
            pole organization.
REFERENCE   5  (bases 1 to 6173)
  AUTHORS   Hatakeyama,E. and Hayashi,K.
  TITLE     KATNAL1 is a more active and stable isoform of katanin, and is
            expressed dominantly in neurons
  JOURNAL   Biochem Biophys Res Commun 507 (1-4), 389-394 (2018)
   PUBMED   30448058
  REMARK    GeneRIF: more active and more stable katanin subunit, KATNAL1,
            plays more important role in process elongation.
REFERENCE   6  (bases 1 to 6173)
  AUTHORS   Banks,G., Lassi,G., Hoerder-Suabedissen,A., Tinarelli,F.,
            Simon,M.M., Wilcox,A., Lau,P., Lawson,T.N., Johnson,S., Rutman,A.,
            Sweeting,M., Chesham,J.E., Barnard,A.R., Horner,N., Westerberg,H.,
            Smith,L.B., Molnar,Z., Hastings,M.H., Hirst,R.A., Tucci,V. and
            Nolan,P.M.
  TITLE     A missense mutation in Katnal1 underlies behavioural, neurological
            and ciliary anomalies
  JOURNAL   Mol Psychiatry 23 (3), 713-722 (2018)
   PUBMED   28373692
REFERENCE   7  (bases 1 to 6173)
  AUTHORS   Smith,L.B., Milne,L., Nelson,N., Eddie,S., Brown,P., Atanassova,N.,
            O'Bryan,M.K., O'Donnell,L., Rhodes,D., Wells,S., Napper,D.,
            Nolan,P., Lalanne,Z., Cheeseman,M. and Peters,J.
  TITLE     KATNAL1 regulation of sertoli cell microtubule dynamics is
            essential for spermiogenesis and male fertility
  JOURNAL   PLoS Genet 8 (5), e1002697 (2012)
   PUBMED   22654668
  REMARK    GeneRIF: The identification of KATNAL1 as an essential regulator of
            male fertility provides a significant novel entry point into
            advancing our understanding of how SC microtubule dynamics promotes
            male fertility
REFERENCE   8  (bases 1 to 6173)
  AUTHORS   O'Leary,J. and Osborne,L.R.
  TITLE     Global analysis of gene expression in the developing brain of
            Gtf2ird1 knockout mice
  JOURNAL   PLoS One 6 (8), e23868 (2011)
   PUBMED   21909369
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE653455.1, BC030434.1, AC107720.16 and AI844773.1.
            
            On Feb 5, 2010 this sequence version replaced NM_153572.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030434.1, SRR7974084.22296.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BE653455.1         1-29
            30-1675             BC030434.1         17-1662
            1676-5839           AC107720.16        54930-59093
            5840-6173           AI844773.1         1-334               c
FEATURES             Location/Qualifiers
     source          1..6173
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 89.04 cM"
     gene            1..6173
                     /gene="Katnal1"
                     /note="katanin p60 subunit A-like 1"
                     /db_xref="GeneID:231912"
                     /db_xref="MGI:MGI:2387638"
     exon            1..122
                     /gene="Katnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            123..298
                     /gene="Katnal1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1603
                     /gene="Katnal1"
                     /EC_number="5.6.1.1"
                     /note="p60 katanin-like 1"
                     /codon_start=1
                     /product="katanin p60 ATPase-containing subunit A-like 1"
                     /protein_id="NP_705800.1"
                     /db_xref="CCDS:CCDS39404.1"
                     /db_xref="GeneID:231912"
                     /db_xref="MGI:MGI:2387638"
                     /translation="MNLAEICENAKKGREYALLGNYDSSMVYYQGVIQQIQRHCQSLR
                     DPATKAKWQQVRQELLEEYEQVKSIVSTLESFKMDKPPDFPVSCRDEPFRDPAVWPPP
                     VPAEHRAPPQIRRPNREVRPLRKDVGAGARGLVGRAHQISKSDKPASRDKDYRARGRD
                     DKARKNVQDGASDSEIPKFDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLL
                     REAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLT
                     SKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQM
                     DGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKISL
                     REVELDPDVHLEDIADKTEGYSGADITNICRDASLMAMRRRINGLSPEEIRALSKEEL
                     QMPVTRGDLELALKKIAKSVSAADLEKYEKWMVEFGSA"
     exon            299..459
                     /gene="Katnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            460..622
                     /gene="Katnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..750
                     /gene="Katnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..856
                     /gene="Katnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1015
                     /gene="Katnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1142
                     /gene="Katnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1277
                     /gene="Katnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1404
                     /gene="Katnal1"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..6157
                     /gene="Katnal1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6137..6142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Katnal1"
                     /note="hexamer: AATAAA"
     polyA_site      6157
                     /gene="Katnal1"
                     /note="major polyA site"
ORIGIN      
        1 agcgcggcga cagactgata aattgggagc tactcagatg gtgttaaagt gactctttgt
       61 ctgcaggggg ctccggggtg gtcgctggat tgggcgctgt gcgtcgggcg ggggtagcgc
      121 aggtgtctga aagaagatga atttggcgga gatttgtgag aatgcgaaga aaggccggga
      181 atatgcgctt ctgggaaatt atgactcgtc aatggtgtat taccagggag tgatacagca
      241 gatccagaga cactgccagt cactgagaga cccggccacc aaagccaagt ggcagcaggt
      301 acggcaggaa ctcttggaag aatatgaaca ggttaagagt atcgtcagca ctttagaaag
      361 ctttaagatg gacaagcccc ctgacttccc cgtgtcttgc cgagatgaac cgtttagaga
      421 ccctgcagta tggccacccc ctgtccctgc ggaacacaga gcaccccctc aaatcaggcg
      481 tccaaatcgc gaagtgaggc ctctgcggaa agacgtgggg gcaggagccc ggggactcgt
      541 gggccgagca caccagatat cgaagagtga caaacctgca agtcgggaca aggactatag
      601 agcaagaggg agagatgaca aggcaaggaa aaatgtgcaa gatggtgcaa gtgacagcga
      661 gattcccaag tttgatggcg ccgggtatga taaggatctg gtggaagccc tggagaggga
      721 cattgtgtcc aggaacccta gcattcactg ggatgacata gcagacctgg aggaggctaa
      781 gaagttgctc cgggaagctg ttgtcctgcc catgtggatg cctgactttt tcaaagggat
      841 tagaaggcca tggaagggtg tgctgatggt tggcccccca ggcactggta agactatgct
      901 ggctaaagcg gttgccactg aatgtgggac aacctttttc aacgtgtcct cttctaccct
      961 gacatctaag tacagaggcg aatctgagaa gttggtccga ctgttgtttg aaatggctag
     1021 gttctatgcc cctaccacga tcttcatcga cgaaattgat tctatctgca gtcgaagagg
     1081 gacgtctgat gagcacgagg caagccgcag agtcaagtcg gagctcctca tccagatgga
     1141 tggagttgga ggagccttag aaaatgatga cccatccaaa atggtgatgg tcctggctgc
     1201 tacgaacttt ccgtgggaca ttgatgaggc tctgcgcagg agactagaga aaaggattta
     1261 cattcctctc ccgacagcaa aaggaagagc ggagctcctg aagatcagcc tccgggaggt
     1321 agagctggac cccgatgtcc acctggagga catcgccgac aagacggagg gctactcggg
     1381 tgccgacatc actaacatct gcagggacgc ttctttgatg gcgatgaggc ggcgcatcaa
     1441 tggcttgagt ccggaagaga tccgggccct gtccaaggag gagctgcaga tgcctgtcac
     1501 cagaggggac ttggagttgg ctctgaagaa aatcgccaag tctgtctcag cggcagacct
     1561 ggagaagtac gaaaagtgga tggttgagtt tgggtctgca tgattggtca gctcttccat
     1621 ctctgggagt tttctttatg aaatgtgaag aaattcctga aattaaaaaa aaaaatctgg
     1681 aagttttaat cagaggaatc ttcacttgaa ggccaaacca aaacagaaat gccagaggta
     1741 cagagaaatg tagttgagaa acaaggtatg atcatacagt ctgctggctc caggctacca
     1801 aacctcatac ttgtgtacag aataagagag ccagtggccc gggctgaagg ggtagctctg
     1861 tgcagggagg gccttgttta caaagcattg gcagagtttt cttgcccata cgtgcactga
     1921 ctggtagttt ggaattgtca ctttgagtgg aatgatcaca agttcttcag gaataatttt
     1981 taaatctcta gaatctaata cttcctgtta gagttgaaaa tgtagttagt actcactcct
     2041 cttagcttac cagttcctct gttagctgcc gccttacatc caccagggaa gagtctctga
     2101 ccgactgctc cgttgacatt tgccctggcc tgtagtctct gtgccggggc ctctcctgct
     2161 tcctttgcaa tgatgggaag agcccttctt agttagcagc agccttcagc ctttgaagtc
     2221 ctcactcttc cttcagtact ctcaagtcaa tatggctact gttttttctc acctccaaca
     2281 ctgtgtgctt ttgtagaatt taacctgttt aggtcggtaa tctgagttcc aaacaagact
     2341 agtctcctag gcgaatgcaa aagaaccttt cccctcttct gcatgtgagc gagcattctg
     2401 ccagcacgca tgtctgtata ccacatgcat gcagtgcccg aggaggccag agaggacatt
     2461 gggtcccctg gttctggaat tacagggtgt gtgagccacc gtgtggatgc tgggaaccaa
     2521 acccaggtct ctacaagggc agccagtgtt cttaacggct gagccatccc tccaacccca
     2581 caaacagaac ctatgaactt gtgcatgcag tgggactaga gcagacagct gccatgctcg
     2641 ttagatgcgg agtaaccagg aaggaggatc tcagacaggg gccgcatgag tgtggtcaca
     2701 cgcactgtgc cctgatgtcc gttctctgtg attaattaca cctgcccttc tggatcacca
     2761 ggcaacctat gcttcaaaag tttgtctaat aatatcctga ttctcgagcc tattttaagc
     2821 tatatactat atacacctta gaggcacttt taaaaactcc tagtatgttg cttaagatat
     2881 ttgacccctt tttcttacta aaacctataa atgcatcacg ctcttttcag gagacataag
     2941 cccgactctc taaactcttg gattcatctg attactgtaa atttccccct ttcttctgag
     3001 agggagtgaa gggccccagc aggctgacca ttgcacacac agcggagcat agcagacatg
     3061 gcactgacag gttttgtcgt ttacccctct cccccactga gctgttagct tgatcctgaa
     3121 gctcactacc aaggtctggc cccttattca gtcactgact cattcctgag accgagcacc
     3181 aaggtctagc tatcagaatt cagtatttcg actaacctaa ctaacataac caaccagatc
     3241 ttaccagcac gttctcgctc actctaagac agagctcccc ctttcctctt acgattaaca
     3301 cctgcaaagc tatttactgt tgtttctgtg taattcagac tcagccacct tgtctcatct
     3361 ctctgccttg cttaataaag gatctctttg catttggctt gtgcttggac ggaggtgttt
     3421 ggatgtggtc tgtgcctaac ccggggtcca gaggggagca tcccacagtg cacaggtccc
     3481 ttcgtaagga ttataaaatt tcaaatcaaa agacatttgt aatgggacta attttaaaat
     3541 tagactgaga gactcttcct tccatgaaca aacttgcttt tatttattta ctttgaggaa
     3601 gagtctgact ctgttgccaa tgctggtctt cagctgtttc agcctcccag tagctgggac
     3661 tgattattga taaatgctta aaataaacaa ctaatgtgga aggctgatgc aggaggatcc
     3721 ataggaaaca gaaacagccc aaatgccccc cagctgctga aagtatgatg aaaatatcac
     3781 acacacacac acacacacac acacacacac acacacgaag agtctgaagc cagcttgtgt
     3841 agactagcaa ggccctatct caaaaatcaa acagaaagaa ccccattcaa tcctcttgtt
     3901 gtatttcaaa aagaaggaag gaaggaagga aggaaggaag gaaggaagga aggaaggaag
     3961 gaaggaagga aaagaaaaaa gaaaagaaaa gaaaagaaag aagaaagaga aggaaggaag
     4021 accgaccttc tctataaccc tgctggttgg cagacctttc ctggctctgg cattagttac
     4081 ctttgcataa acccattttt tttctggagt cctcatgcac ccacagtaca ggcctgcgtc
     4141 tacgctaggg taggtggtgg tctgtagtta gtaagtcaca tgtgcgctcc ctccatccct
     4201 ccctcctcac aagctgtcag tagacggcac agatctgtaa gaggccggcc actcagatgt
     4261 ctctctcctg taagacatgc tgtccacaca ttgtcactgc catggcggca ggaagcatgt
     4321 tactctgcac acagtaggaa acaggagctc tggggcagca gcacaggggc tggtgtgtgc
     4381 acagttgttt catcgtccca tcatgggcac accgtgctgg tcaccctcgc tgtgtagatg
     4441 gtgggtggag gctacgtgac ttgccaagta gtgctggacc ctgaagctgt ggctggacat
     4501 tttctccagt aactgcctct cctggctcct gctactaaag cacgagttta gtttataact
     4561 ggagagacag cgatctgtgt gtttggagaa gagaatatac agaaaggttt tcccctttgc
     4621 ttttcttttg aaacctttga ttggttttaa attgtttaaa atgagtttta aacaattaaa
     4681 cagtttgctt aaacaatcaa acaattgttt gtttaaacac accattaaaa atcaatcgat
     4741 gaaagatcta tttcagtgca cccactttat catttttgtg ccacgattat acgtgtgatt
     4801 atgcaaagca tacacgcaag taatgcgatt actgtgaaag cttccatagt ttccttttta
     4861 aagaaagtaa gataatattg gtgagatgtc ccagacaaat ggaagctgtg gcctcctagt
     4921 tacgcaggtt aggaacaggt gacatcacag gccttccacc catgagttcc atccttcagt
     4981 agagtgaccc caggcaacac atggccatca gaaatgccag actgggacat cctgccgggg
     5041 ccttcacagg agagcctggg tcacagttca gtcacacagc tgtctaactt tcagggagtt
     5101 caccaagtgg ggtggagtag ggaaaccagc acccacaagc agtcaagcag gcacacggag
     5161 gcctaaaaca agcagccgcc caggagtatg tgtgagccca gtttacagta ttaattgtcg
     5221 ctggttatcc ctgtgtgtat tgtgactctg tggggagtca ttgcctcctt agctcttggg
     5281 tatctgagtt catgaggctt ccttccttag atacactaca ggatcaggca ggagtctgcc
     5341 caggtaacct cctccttgcc tcacttgaga ggcaggcaaa gaactgggcc tgtcatttgc
     5401 atagtggtct tggctctggc ctccttagtg aggtcttttt tggtctcttc atacacacac
     5461 acacacacac gcacacaggc ccccaataat aataatagta catttctact gttttcttat
     5521 taaatataga tcacaactag ggtatgactc atgctttggg ataaaatgtt aggtgggagt
     5581 cgaccttttc taagaaaaga tctaactgtg gcgaactgga agaatctgga ctattccagc
     5641 tttctagtgt ctttgttttg ttgcttaatg tttgcatgta caatgtttta aatttgtgac
     5701 acatatgata cttatgtcaa tctaagagtc caccacaaca gaagaaaata ggaccaagtt
     5761 gaaggatgca ttgggggcaa attaaccctc accgggaccg cactgatatt aaagttgaag
     5821 gatggggggc gggggagggg actaatcctc atggggacca ctcatccaca ccgattattt
     5881 ctgcagttta tttacctcat aattattaca tgtttactta tttatgtgtt taatttaggc
     5941 tttccttatt tatttaattt ttgggtcact tgcttttgat attatttctt aatgtggaaa
     6001 ctgagtattt aaaatattag atctgtatgg tgatatgttt ttacacattt acttagtagt
     6061 aatttgaatt tttaccagtt tatttttttt tgaaaaatgt agttttgatg ataattctca
     6121 tttcaggtgc cttattaata aaagcttatt aagaggaaaa aaaaaaaaaa aaa
//
