LOCUS       NM_011835               1770 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus katanin p60 (ATPase-containing) subunit A1 (Katna1),
            mRNA.
ACCESSION   NM_011835
VERSION     NM_011835.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1770)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1770)
  AUTHORS   Dunleavy,J.E.M., Graffeo,M., Wozniak,K., O'Connor,A.E.,
            Merriner,D.J., Nguyen,J., Schittenhelm,R.B., Houston,B.J. and
            O'Bryan,M.K.
  TITLE     The katanin A-subunits KATNA1 and KATNAL1 act co-operatively in
            mammalian meiosis and spermiogenesis to achieve male fertility
  JOURNAL   Development 150 (22) (2023)
   PUBMED   37882691
  REMARK    GeneRIF: The katanin A-subunits KATNA1 and KATNAL1 act
            co-operatively in mammalian meiosis and spermiogenesis to achieve
            male fertility.
REFERENCE   3  (bases 1 to 1770)
  AUTHORS   Liu,H., Zheng,J., Zhu,L., Xie,L., Chen,Y., Zhang,Y., Zhang,W.,
            Yin,Y., Peng,C., Zhou,J., Zhu,X. and Yan,X.
  TITLE     Wdr47, Camsaps, and Katanin cooperate to generate ciliary central
            microtubules
  JOURNAL   Nat Commun 12 (1), 5796 (2021)
   PUBMED   34608154
  REMARK    GeneRIF: Wdr47, Camsaps, and Katanin cooperate to generate ciliary
            central microtubules.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1770)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1770)
  AUTHORS   Ho,U.Y., Feng,C.A., Yeap,Y.Y., Bain,A.L., Wei,Z., Shohayeb,B.,
            Reichelt,M.E., Homer,H., Khanna,K.K., Bowles,J. and Ng,D.C.H.
  TITLE     WDR62 is required for centriole duplication in spermatogenesis and
            manchette removal in spermiogenesis
  JOURNAL   Commun Biol 4 (1), 645 (2021)
   PUBMED   34059773
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1770)
  AUTHORS   Yu,W., Solowska,J.M., Qiang,L., Karabay,A., Baird,D. and Baas,P.W.
  TITLE     Regulation of microtubule severing by katanin subunits during
            neuronal development
  JOURNAL   J Neurosci 25 (23), 5573-5583 (2005)
   PUBMED   15944385
REFERENCE   7  (bases 1 to 1770)
  AUTHORS   Karabay,A., Yu,W., Solowska,J.M., Baird,D.H. and Baas,P.W.
  TITLE     Axonal growth is sensitive to the levels of katanin, a protein that
            severs microtubules
  JOURNAL   J Neurosci 24 (25), 5778-5788 (2004)
   PUBMED   15215300
REFERENCE   8  (bases 1 to 1770)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1770)
  AUTHORS   Vale,R.D.
  TITLE     AAA proteins. Lords of the ring
  JOURNAL   J Cell Biol 150 (1), F13-F19 (2000)
   PUBMED   10893253
  REMARK    Review article
REFERENCE   10 (bases 1 to 1770)
  AUTHORS   Syu,L.J. and Saltiel,A.R.
  TITLE     Lipotransin: a novel docking protein for hormone-sensitive lipase
  JOURNAL   Mol Cell 4 (1), 109-115 (1999)
   PUBMED   10445032
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156391.6.
            
            On Dec 21, 2021 this sequence version replaced NM_011835.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF153197.1, AK041900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC156391.6         50267-50386         c
            121-295             AC156391.6         37493-37667         c
            296-453             AC156391.6         34825-34982         c
            454-634             AC156391.6         32654-32834         c
            635-756             AC156391.6         27493-27614         c
            757-862             AC156391.6         24741-24846         c
            863-1021            AC156391.6         23488-23646         c
            1022-1148           AC156391.6         16567-16693         c
            1149-1283           AC156391.6         15521-15655         c
            1284-1410           AC156391.6         15021-15147         c
            1411-1770           AC156391.6         13241-13600         c
FEATURES             Location/Qualifiers
     source          1..1770
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 2.32 cM"
     gene            1..1770
                     /gene="Katna1"
                     /note="katanin p60 (ATPase-containing) subunit A1"
                     /db_xref="GeneID:23924"
                     /db_xref="MGI:MGI:1344353"
     exon            1..120
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            121..295
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1609
                     /gene="Katna1"
                     /EC_number="5.6.1.1"
                     /note="lipotransin; p60 katanin; katanin p60 subunit A1"
                     /codon_start=1
                     /product="katanin p60 ATPase-containing subunit A1"
                     /protein_id="NP_035965.3"
                     /db_xref="CCDS:CCDS23689.2"
                     /db_xref="GeneID:23924"
                     /db_xref="MGI:MGI:1344353"
                     /translation="MSLQMIVENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVK
                     DTHLRQKWQQVWQEINVEAKQVKDIMKTLESFKLDITSLQAAQHEFPAAEGEVWSLPV
                     PVERRPLPGPRKRQSSQHSDPKPHSNRPSTVVRAHRPSPQNLHNDRGKAVRSREKKEQ
                     SKGREEKNKLPAAVTEPEANKFDGTGYDKDLVEALERDIISQNPNVRWYDIADLVEAK
                     KLLQEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSS
                     TLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRMKAELL
                     VQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLR
                     ISLRELELADDVNLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSR
                     EAMHMPTTMEDFEMALKKISKSVSAADIERYEKWIVEFGSC"
     exon            296..453
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            454..634
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..756
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..862
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1021
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1148
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1283
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1410
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1770
                     /gene="Katna1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1748..1753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Katna1"
                     /note="hexamer: AATAAA"
     polyA_site      1770
                     /gene="Katna1"
                     /note="major polyA site"
ORIGIN      
        1 acgcacttcc ggggcgtgtc cccgccggtg cgggaactat ccttttaaga ggggctttcc
       61 cggtttcatt tcaacttggt cccgacccgg agctgcggcg ggtagcctgg gctgcgctag
      121 cttacatatg accatgagtc ttcaaatgat tgttgagaat gtaaaattgg ctcgtgaata
      181 tgcactgctg ggaaactatg actctgcaat ggtctactat cagggagttc ttgaccaaat
      241 gaacaagtac ctgtactcag tcaaagatac acacctccgt cagaaatggc aacaggtttg
      301 gcaggaaata aatgtggaag ctaagcaagt taaggatatc atgaaaacac tcgagagctt
      361 caaactagac atcacttctt tgcaagctgc acaacatgaa tttccagctg ctgaaggaga
      421 agtctggtcc ttgcctgtac ctgttgagcg aagaccctta ccaggaccta ggaaacgcca
      481 gtcttctcag cacagtgacc ctaagccaca cagtaaccgg ccaagcacag tcgtcagagc
      541 tcatcggccg tctccacaga atcttcacaa tgacagaggg aaagctgttc gtagtcgtga
      601 aaagaaagaa cagagtaagg gaagagagga aaagaacaaa ttacctgctg cagttacaga
      661 accagaggca aataagtttg atggcactgg gtatgacaag gacttagtag aagctttgga
      721 aagagatatc atttctcaga atcccaacgt tcggtggtat gatattgctg atttagtaga
      781 agccaaaaag ttgcttcagg aagcagtggt gttaccaatg tggatgccag aattctttaa
      841 gggcattagg agaccatgga aaggtgtgct gatggttggc ccacctggca ctggaaagac
      901 ccttctagct aaagcagttg ccacggaatg caagacaacg ttcttcaatg tctcttcatc
      961 aactctgacg tccaaataca gaggagagtc tgagaagctt gtccgtcttc tgtttgaaat
     1021 ggctcggttt tactccccag ctaccatatt tattgatgag atagattcca tttgcagccg
     1081 ccgaggaact tctgaagagc atgaagccag ccgaaggatg aaagctgagc tgctggttca
     1141 aatggacggt gttggaggtg cctcagagaa cgatgaccct tccaaaatgg ttatggttct
     1201 ggcggctact aatttcccat gggacataga tgaggcttta aggcgtcgtc tggagaaaag
     1261 aatctatatt ccattaccat cagcaaaagg cagggaagaa ctgttgagaa taagtctgcg
     1321 agagctggaa ttggctgatg atgtcaacct tgcgagcata gcagaaaaca tggaaggcta
     1381 ctcgggtgca gacattacca atgtatgcag ggacgcatcg ttgatggcca tgagacggcg
     1441 tattgagggt ctaaccccag aagaaatccg gaacctttca agagaagcaa tgcacatgcc
     1501 taccaccatg gaggattttg aaatggcttt aaagaagatt tctaaatcag tatcagctgc
     1561 agatattgaa agatacgaga aatggatagt tgagtttgga tcatgctagc tatgttctca
     1621 catgtaagct gtgaggaatc tgccttaagt ctttgaaaaa taattaaatg tagaatttca
     1681 gtgtacggag tgctatattt ttttaaactt tcataatggt gtgatttgga aattctttct
     1741 ggttctgaat aaagactatt tttaagctgc
//
