LOCUS       NM_026370               1579 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus K(lysine) acetyltransferase 8 (Kat8), transcript
            variant 1, mRNA.
ACCESSION   NM_026370
VERSION     NM_026370.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1579)
  AUTHORS   Hu,Y., Zheng,Y., Liu,C., You,Y., Wu,Y., Wang,P., Wu,Y., Ba,H.,
            Lu,J., Yuan,Y., Liu,P. and Mao,Y.
  TITLE     Mitochondrial MOF regulates energy metabolism in heart failure via
            ATP5B hyperacetylation
  JOURNAL   Cell Rep 43 (10), 114839 (2024)
   PUBMED   39392752
  REMARK    GeneRIF: Mitochondrial MOF regulates energy metabolism in heart
            failure via ATP5B hyperacetylation.
REFERENCE   2  (bases 1 to 1579)
  AUTHORS   Bi,S., Huang,L., Chen,Y., Hu,Z., Li,S., Wang,Y., Huang,B.,
            Zhang,L., Huang,Y., Dai,B., Du,L., Tu,Z., Wang,Y., Xu,D., Xu,X.,
            Sun,W., Kzhyshkowska,J., Wang,H., Chen,D., Wang,F. and Zhang,S.
  TITLE     KAT8-mediated H4K16ac is essential for sustaining trophoblast
            self-renewal and proliferation via regulating CDX2
  JOURNAL   Nat Commun 15 (1), 5602 (2024)
   PUBMED   38961108
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1579)
  AUTHORS   Wu,X., Wang,S., Guo,Y. and Zeng,S.
  TITLE     Overexpression of KAT8 induces a failure in early embryonic
            development in mice
  JOURNAL   Theriogenology 221, 31-37 (2024)
   PUBMED   38537319
  REMARK    GeneRIF: Overexpression of KAT8 induces a failure in early
            embryonic development in mice.
REFERENCE   4  (bases 1 to 1579)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1579)
  AUTHORS   Wu,X., Wang,S., Guo,Y., Song,S. and Zeng,S.
  TITLE     KAT8 functions in redox homeostasis and mitochondrial dynamics
            during mouse oocyte meiosis progression
  JOURNAL   FASEB J 38 (2), e23435 (2024)
   PUBMED   38243686
  REMARK    GeneRIF: KAT8 functions in redox homeostasis and mitochondrial
            dynamics during mouse oocyte meiosis progression.
REFERENCE   6  (bases 1 to 1579)
  AUTHORS   Gupta,A., Guerin-Peyrou,T.G., Sharma,G.G., Park,C., Agarwal,M.,
            Ganju,R.K., Pandita,S., Choi,K., Sukumar,S., Pandita,R.K.,
            Ludwig,T. and Pandita,T.K.
  TITLE     The mammalian ortholog of Drosophila MOF that acetylates histone H4
            lysine 16 is essential for embryogenesis and oncogenesis
  JOURNAL   Mol Cell Biol 28 (1), 397-409 (2008)
   PUBMED   17967868
  REMARK    GeneRIF: MOF is an essential factor for embryogenesis and
            oncogenesis
REFERENCE   7  (bases 1 to 1579)
  AUTHORS   Thomas,T., Loveland,K.L. and Voss,A.K.
  TITLE     The genes coding for the MYST family histone acetyltransferases,
            Tip60 and Mof, are expressed at high levels during sperm
            development
  JOURNAL   Gene Expr Patterns 7 (6), 657-665 (2007)
   PUBMED   17517537
REFERENCE   8  (bases 1 to 1579)
  AUTHORS   Dmitriev,R.I., Korneenko,T.V., Bessonov,A.A., Shakhparonov,M.I.,
            Modyanov,N.N. and Pestov,N.B.
  TITLE     Characterization of hampin/MSL1 as a node in the nuclear
            interactome
  JOURNAL   Biochem Biophys Res Commun 355 (4), 1051-1057 (2007)
   PUBMED   17335777
REFERENCE   9  (bases 1 to 1579)
  AUTHORS   Craig,J.M., Earle,E., Canham,P., Wong,L.H., Anderson,M. and
            Choo,K.H.
  TITLE     Analysis of mammalian proteins involved in chromatin modification
            reveals new metaphase centromeric proteins and distinct chromosomal
            distribution patterns
  JOURNAL   Hum Mol Genet 12 (23), 3109-3121 (2003)
   PUBMED   14519686
REFERENCE   10 (bases 1 to 1579)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146710.1 and AK132000.1.
            
            On Feb 9, 2018 this sequence version replaced NM_026370.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132000.1, AK018002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1503              AK146710.1         3-1505
            1504-1579           AK132000.1         1505-1580
FEATURES             Location/Qualifiers
     source          1..1579
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.83 cM"
     gene            1..1579
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
                     /note="K(lysine) acetyltransferase 8"
                     /db_xref="GeneID:67773"
                     /db_xref="MGI:MGI:1915023"
     exon            1..226
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1392
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
                     /EC_number="2.3.1.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     histone acetyltransferase Myst1; protein acetyltransferase
                     KAT8; protein propionyltransferase KAT8; males-absent on
                     the first protein homolog; probable histone
                     acetyltransferase MYST1; MOZ, YBF2/SAS3, SAS2 and TIP60
                     protein 1; lysine acetyltransferase 8; MYST histone
                     acetyltransferase 1; histone acetyltransferase KAT8"
                     /codon_start=1
                     /product="histone acetyltransferase KAT8 isoform 1"
                     /protein_id="NP_080646.1"
                     /db_xref="CCDS:CCDS21885.1"
                     /db_xref="GeneID:67773"
                     /db_xref="MGI:MGI:1915023"
                     /translation="MAAQGATAAVAATTSGTVGEGEPGPGENAAVEGPARSPGRVSPP
                     TPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDE
                     WVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMD
                     PTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMK
                     FEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTL
                     YFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIA
                     FSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSIT
                     QNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKH
                     KQVKLSKK"
     exon            227..301
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..477
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            478..531
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..696
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..786
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..927
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1021
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1172
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1327
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1579
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1481..1486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
                     /note="hexamer: AGTAAA"
     polyA_site      1504
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
                     /note="major polyA site"
     polyA_site      1530
                     /gene="Kat8"
                     /gene_synonym="2010203C02Rik; 5830450F21Rik; D7Ertd629e;
                     mMof; MOF; MYST-1; Myst1"
ORIGIN      
        1 acttccggca cagcaatggc ggcacaggga gctacagctg cagttgctgc aacaacttca
       61 ggaactgtag gggagggaga gcccggcccg ggggaaaatg cagcagtcga ggggcctgcc
      121 cggtccccgg gccgggtctc tccgccgact ccggcgcgtg gcgaaccaga agtcaccgtg
      181 gagatcggag aaacgtacct gtgccggcgg ccggatagca cctggcattc agcagaagtg
      241 atccagtctc gagtgaatga ccaggaaggc cgagaagaat tctatgttca ctatgtgggc
      301 tttaacaggc gactggacga atgggtggac aagaaccgac tcgcactgac caagacagtg
      361 aaggatgccg tgcagaagaa ctctgagaaa tacctgagtg agctggccga gcagccagag
      421 cgcaagatca ctcgaaacca aaagcgaaag catgatgaga tcaaccatgt gcagaagacc
      481 tatgcagaga tggaccccac cacagcagcc ttggaaaagg aacacgaggc gatcaccaaa
      541 gtgaagtatg tagacaagat ccacattggg aactatgaaa tcgatgcctg gtatttctca
      601 cctttcccag aggactatgg gaagcagccc aagctttggc tctgcgagta ctgcctcaaa
      661 tacatgaagt tcgagaagag ctaccgcttc cacctgggcc agtgtcagtg gcggcagccc
      721 ccagggaagg agatctatcg aaagagcaac atctctgtgt atgaagtgga tggcaaagac
      781 cacaagatat actgtcagaa cctgtgtcta ctggccaagc ttttcctgga ccacaagacc
      841 ttgtattttg atgtggagcc ctttgtcttt tacattctga cagaagtaga taggcaaggg
      901 gctcacattg ttggctactt ttctaaggag aaggaatccc cagatggaaa caacgtggcc
      961 tgcatcttga ccctgcctcc ctaccagcgg cgtggctatg ggaagtttct catcgccttc
     1021 agttatgagc tctctaagct cgagagtact gtaggctccc cagagaagcc actgagtgac
     1081 ctgggcaaac tcagctacag aagctactgg tcatgggtct tgctggagat cctgcgagac
     1141 ttccggggca cattgtctat caaagatctt agccagatga ccagcatcac ccagaatgac
     1201 atcatcagca ccctgcagtc cctcaacatg gtcaagtact ggaagggcca gcatgttatc
     1261 tgtgtcacac ctaagctggt agaggaacac ctcaaaagtg cccagtataa gaaaccacct
     1321 atcacagtgg actctgtctg cctcaagtgg gcacccccga agcacaaaca agtcaagctt
     1381 tccaagaagt gagtggcctg tgccctgctt gggatctggg tttcctggcc tctaacctgt
     1441 aaatatgtgt acagacctgt tttgtgtcat ttattcataa agtaaaatct gctggtgcac
     1501 tggactttgg aggtacgcag agatgccaaa gggtggtatt cttcatttca tctcacagac
     1561 agccagctgt gttaaaaac
//
