LOCUS       NM_177619               5653 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus K(lysine) acetyltransferase 7 (Kat7), transcript
            variant 3, mRNA.
ACCESSION   NM_177619
VERSION     NM_177619.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5653)
  AUTHORS   Xing,Y., Qi,J., Cheng,X., Song,X., Zhang,J., Li,S., Zhao,X.,
            Gong,T., Yang,J., Zhao,C., Xin,W., Zhu,D. and Zheng,X.
  TITLE     Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to
            Govern Hypoxia-Inducible Factor-1alpha Expression
  JOURNAL   J Am Heart Assoc 12 (7), e028299 (2023)
   PUBMED   36942752
  REMARK    GeneRIF: Circ-myh8 Promotes Pulmonary Hypertension by Recruiting
            KAT7 to Govern Hypoxia-Inducible Factor-1alpha Expression.
REFERENCE   2  (bases 1 to 5653)
  AUTHORS   Zhou,Y., Jia,K., Wang,S., Li,Z., Li,Y., Lu,S., Yang,Y., Zhang,L.,
            Wang,M., Dong,Y., Zhang,L., Zhang,W., Li,N., Yu,Y., Cao,X. and
            Hou,J.
  TITLE     Malignant progression of liver cancer progenitors requires lysine
            acetyltransferase 7-acetylated and cytoplasm-translocated G protein
            GalphaS
  JOURNAL   Hepatology 77 (4), 1106-1121 (2023)
   PUBMED   35344606
REFERENCE   3  (bases 1 to 5653)
  AUTHORS   Kueh,A.J., Bergamasco,M.I., Quaglieri,A., Phipson,B.,
            Li-Wai-Suen,C.S.N., Lonnstedt,I.M., Hu,Y., Feng,Z.P., Woodruff,C.,
            May,R.E., Wilcox,S., Garnham,A.L., Snyder,M.P., Smyth,G.K.,
            Speed,T.P., Thomas,T. and Voss,A.K.
  TITLE     Stem cell plasticity, acetylation of H3K14, and de novo gene
            activation rely on KAT7
  JOURNAL   Cell Rep 42 (1), 111980 (2023)
   PUBMED   36641753
REFERENCE   4  (bases 1 to 5653)
  AUTHORS   Fan,M., Liu,Y., Shang,Y., Xue,Y., Liang,J. and Huang,Z.
  TITLE     JADE2 Is Essential for Hippocampal Synaptic Plasticity and
            Cognitive Functions in Mice
  JOURNAL   Biol Psychiatry 92 (10), 800-814 (2022)
   PUBMED   36008159
REFERENCE   5  (bases 1 to 5653)
  AUTHORS   Johmura,Y., Osada,S., Nishizuka,M. and Imagawa,M.
  TITLE     FAD24 acts in concert with histone acetyltransferase HBO1 to
            promote adipogenesis by controlling DNA replication
  JOURNAL   J Biol Chem 283 (4), 2265-2274 (2008)
   PUBMED   18029353
  REMARK    GeneRIF: FAD24 controls DNA replication by recruiting HBO1 to
            origins of DNA replication and is required for MCE during adipocyte
            differentiation.
REFERENCE   6  (bases 1 to 5653)
  AUTHORS   Iizuka,M., Sarmento,O.F., Sekiya,T., Scrable,H., Allis,C.D. and
            Smith,M.M.
  TITLE     Hbo1 Links p53-dependent stress signaling to DNA replication
            licensing
  JOURNAL   Mol Cell Biol 28 (1), 140-153 (2008)
   PUBMED   17954561
  REMARK    GeneRIF: reveal a direct regulatory connection between
            p53-responsive stress signaling and Hbo1-dependent chromatin
            pathways
REFERENCE   7  (bases 1 to 5653)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
REFERENCE   8  (bases 1 to 5653)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5653)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5653)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627222.10.
            
            On Apr 21, 2022 this sequence version replaced NM_177619.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AL627222.10        61998-62167
            171-318             AL627222.10        66006-66153
            319-558             AL627222.10        71984-72223
            559-641             AL627222.10        77557-77639
            642-740             AL627222.10        82332-82430
            741-851             AL627222.10        85762-85872
            852-1043            AL627222.10        87982-88173
            1044-1133           AL627222.10        90274-90363
            1134-1274           AL627222.10        90561-90701
            1275-1368           AL627222.10        91718-91811
            1369-1515           AL627222.10        94587-94733
            1516-1622           AL627222.10        95653-95759
            1623-5653           AL627222.10        96315-100345
FEATURES             Location/Qualifiers
     source          1..5653
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..5653
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /note="K(lysine) acetyltransferase 7"
                     /db_xref="GeneID:217127"
                     /db_xref="MGI:MGI:2182799"
     exon            1..170
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1724
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /EC_number="2.3.1.48"
                     /note="isoform 3 is encoded by transcript variant 3;
                     histone acetyltransferase MYST2; MOZ, YBF2/SAS3, SAS2 and
                     TIP60 protein 2; histone acetyltransferase binding to
                     ORC1; lysine acetyltransferase 7; histone
                     acetyltransferase KAT7; MYST histone acetyltransferase 2"
                     /codon_start=1
                     /product="histone acetyltransferase KAT7 isoform 3"
                     /protein_id="NP_808287.1"
                     /db_xref="CCDS:CCDS25275.1"
                     /db_xref="GeneID:217127"
                     /db_xref="MGI:MGI:2182799"
                     /translation="MPRRKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTR
                     SSARLSQSSQETKNTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKD
                     SGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADE
                     CKAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTSEYDL
                     DLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRL
                     YMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCL
                     LAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQY
                     MRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEI
                     SIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKT
                     MDPSCLKWTPPKGT"
     exon            171..318
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            319..558
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            559..641
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            642..740
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            741..851
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1043
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1133
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1274
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1368
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1515
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1622
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..5653
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3230..3235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /note="hexamer: AATAAA"
     polyA_site      3251
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /note="major polyA site"
     regulatory      4382..4387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /note="hexamer: AATGAA"
     polyA_site      4412
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
     regulatory      5618..5623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /note="hexamer: AATAAA"
     polyA_site      5653
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
ORIGIN      
        1 gcagaaggct ctagacgctg agaggtagga ggcacttggg atcgtccgca gggtttggga
       61 cagctacaga ggccgccacg gagcccgccg gagcccccgt tcctgctggt gctgccgccg
      121 cccgaatcgg aaccgtcggg ctgcagccgc cggcaatgcc gcgaaggaag agaaatgcag
      181 gcagtagttc agatggaacc gaagattccg atttttctac agatctcgag catacagaca
      241 gttcagagag tgatggcacc tcgcgccgat ctgcccgagt cacccgctcc tcagccaggc
      301 taagccagag ttcccaagaa actaaaaata cagctgatca tgatgagtca ccacctcgaa
      361 ctccaaccgg aaatgcacct tcttctgagt ctgacataga catctccagc cccaacgtgt
      421 ctcatgatga gagcattgcc aaggacatgt ccctgaagga ctcaggcagt gatctctctc
      481 accgtcccaa gcgacgtcga tttcacgaaa gctacaattt caacatgaag tgtcctacgc
      541 cgggctgcaa ctctctagga catcttacag gaaagcacga gagacatttc tccatctcag
      601 gatgcccgct gtatcataac ctctcagctg acgaatgcaa ggcaccaaca gagagacagc
      661 tgcggtataa ggaaaaggtg gctgaactca ggaagaaaag aaattctgga ctgagcaaag
      721 agcagaagga gaaatacatg gaacacagac agacctatgg gaacactcgg gagcctctct
      781 tggaaaacct gacaagtgaa tatgacttag atcttttccg aagagcacaa gcccgggctt
      841 ctgaggattt ggagaagtta aggcttcaag gccaaatcac agagggaagc aacatgatta
      901 aaacaattgc ttttggccgc tatgaactgg acacttggta ccactctccc tatcctgagg
      961 aatatgcgag gctgggacgt ctctacatgt gtgaattctg cttaaagtac atgaagagcc
     1021 agacaatcct ccgccgacac atggccaagt gtgtgtggaa acacccccct ggtgatgaga
     1081 tttatcgcaa aggctccatc tctgtgtttg aagtagacgg caagaagaac aagatctact
     1141 gccaaaacct ctgccttttg gcaaagcttt ttctggacca taagacgcta tactatgatg
     1201 tagaaccttt cctgttctac gttatgacag aagcggacaa tactggctgt catctgattg
     1261 gatatttttc taaggagaag aattcatttc tcaactataa tgtctcgtgc atcctcacca
     1321 tgcctcagta catgcgacag ggctacggga agatgctgat cgatttcagt tatttacttt
     1381 ccaaagtaga agagaaagtc ggctctccag agcgcccact gtcagacctg gggctcataa
     1441 gctaccgcag ctactggaag gaggtactgc tccgatacct gcacaacttc cagggcaagg
     1501 agatctccat caaagaaatt agccaggaaa cagctgtgaa tcccgtggac attgtcagca
     1561 ctctgcaagc ccttcagatg ctcaagtatt ggaaaggcaa gcacctagtt ttaaagagac
     1621 aggacctgat agatgagtgg atagccaaag aggccaaaag gtccaactcc aacaaaacca
     1681 tggatccaag ctgcttaaaa tggacccctc ccaagggcac ttaaagtgac ctatcattcc
     1741 gagccagcga gccccagcag taggaatccg taccctaggg atctgtctgt catttctgtt
     1801 gctcttgtga ttggcaagta cagtatcctt tgggaaggcc accccctcag cactgttctg
     1861 gctccagcct tcgtgtacac tgcagacact agttctgagg aactgttgtt tcggcctcag
     1921 tgaggttgcc tggacggatc tgtatgaggc tcgagtacag atccctcata gcactgaccc
     1981 aaggagttgt gttatggtac tgtacctgtc cagtcactgg ttcccacctc atgcttttta
     2041 actccgaggt ttgttgtgtc ctgacctttg tgctagtgct ttttcctgcc tggatagcag
     2101 acctccaaac atggttgcca ccaaagggcc ctttccagtt acttctaaca cattcttcat
     2161 gaaggggtgg gcaagaggca gcgcctgtgc gtgtctgctg ggagggtccg ctcaccatgg
     2221 gtttcatctc gcagtcactc atttttctcc ctttttgtca aaagacttac tacctttgat
     2281 caggatcagg ctgcccagag ctaggaacgc ctggcatttc ccaggggttc acaggcctgg
     2341 tccatctgcg tgagatggtg aagcctaaga ggtggtccca tgctttcctt tgtatttact
     2401 tgtggacact ggggcagcat tgtgtagaag gaaatgagga attctttgcc acagcagaaa
     2461 atgcccccac ttttttttct gccccctttt atgttggtag ttgccaaaat attttaacag
     2521 tcttttttca tacattaaat gaccaccctg tggatctttc cacacctgcc tctgccagtc
     2581 tggtgtaggg cagctctact ttccacacaa gttgcactga tcttgtccag agcttcctgg
     2641 gagaagtgga aactggttga aatgcttgtg tttctcagcc catgactcag caagacaggg
     2701 tggccactct gctacggttt gcttcgctct caacagtgcc tccctccccc agcagactga
     2761 agtgcttctg tctaagaact aagtccattc cctttcggga cttgccacca tcatcctgtt
     2821 ctctgggttc ctatttttgg tggtgttaag tgaaggaaga agtgttccct ctaatttctc
     2881 cctgtcccag tatataacct gctatcttgg ggcagctttt gatgtctgac atgtcaccct
     2941 tcccaagttg gtctcttcca acactgctgt cttcacgtgg caccctctta ccacaaccct
     3001 aactctggtc atttgtgcct ttctcttgtc atctctgtac actactaata ttcactgtgg
     3061 gttggggagc tgattttaag catgttcagt ggctcccctc cagtttcagt gtaactgtta
     3121 aaatgtatcc aaaagccact tcactggggg ttttcttaag gggtaaaggc cttttacaga
     3181 tgctgagccc tccccacatg tggcagaatg tgctcttctg tatctactca ataaagcatg
     3241 ttctctgctc atgtctgact gctctgaagc ttgtttatat gggaatggtg tgattggctc
     3301 agcacagtgt tagccctggg gtttggagct atggattgtt ttcccctgtg aagcaggttg
     3361 ttgacagagt gagtgttttc tctgaactca caagcggtaa aacaaattga gtctgcctcc
     3421 ctttggctcc aggaagtcgc tgtgcgcaac agcagctagc tagtgtaatt tcattcatct
     3481 gcctctggtt tggggccttg tcaaggaacc actgggaagt tagggtgggt tggggatgcc
     3541 atggaagctt gtaggaggca gaacaatgca ttcctttcct ctaagcgtgc tcaccagtat
     3601 caagccaggc cctgtctaat catcatccag cccaggttgt gcctctggaa gtagctgcag
     3661 ttgttgcttg tgtttgccca ggcaggacca gcggggcggg gcattgtcgt ctgggtgtgg
     3721 aaagggagct gtgtttgctg ggctactttt gctcactggc aaggcctctt actggagtcg
     3781 gaaaatgcag tggagaaaaa taactgccct tctgttgatc ttagaccagg gtttgctcaa
     3841 gtctctgtgt tggaaccatt tgcagcagag ggagattttg ttctctcagt ttgaagagtg
     3901 gagatgggta acatggacgg taagaattga atgccaggga gggagagatg atggttgcac
     3961 agtcctgatc ctgtcgttgc tgggtctggt tagccactca gtggaggcta acttcatttg
     4021 tgtgtggcag cctcatgtgc gctcagcact acttcctttg tcctttgtat tagctgcgtg
     4081 cagcctgctc gcactggtta tacagaagga aacctgcatc ctaccgcaac tgtgaaccaa
     4141 gaagccagaa tgctcattgt actctgttgt acttgagaat ctgtaccact tctgccattg
     4201 ccttccccag ccagcttcag ttccctggtg tttctgctca ttctttccct tcgaggcaga
     4261 tacacgctgt tagaaaccgt catgtttcta gagcagcgct tctcggcgtg tagatgtcaa
     4321 tgagcctttc ccagggttgc ctaagaccac ccggaatata gattattata tcatgatcct
     4381 gaatgaaagc cttgcttctc ttgcctccaa aacacgtggt gcagcctggt ctcttatttc
     4441 tcatgggaat agtgagccct gatgagtcat ttctagtagt gtagtatgta tgtagtatgt
     4501 acagtgtagt atgtatgtag tatgtatgca gtatgtgtag tgtagtatgt atgtagtatg
     4561 tatgcacttt gtagagcaga gatgcttcct acttggtctt ggctgtcatc aggccctgta
     4621 cttcgttctg gttgtatggc tgggattagg gactgctgga atggacctat ctgtcaggct
     4681 ggttgctcta gatcaaggtt ggggctgtgg agcatcataa aatctgtaga tgaaagtgga
     4741 gcacagtttg cttgtggcac acatatatcc cttctggaac ataaaaccaa tggaatcagc
     4801 attttgattg cccttgcaag ggtagttagt gtgtctattc ttatagcagg ttcaagcagc
     4861 agagctctga gccaccttct ccctcccctg tttgcttctg gcctttgtga agctgaaaag
     4921 actcattagg attaattttt gttgtaccta tgcaaatatg cacacattta tttacagtcc
     4981 aggaaattgc ctttggaatc tccagggatg agcatcctag agcctggttt gagacgcctc
     5041 agtagtaaag caggaagcac attctggctt cgctgctctt actcgggact ctgaactggt
     5101 ttctggaatg tgctgggatg caaagaacca aatccaatga gtgatgaagt atgaaggagg
     5161 tctggctcac cggctgccgg agcctcatag ggtttgcatg ggaagacctt tgctaaataa
     5221 tggcatgtag tctatgctag gaattggctc taacctggtt ttgcttcagg tcttttggcc
     5281 tcaggcttgc aaatgactgc ctctcccaga ctgatggggg cactgtactt gctcacttcc
     5341 tctgtggtat cttcagcaat gccagtgagt gtcactgaac tatcgacaag actcagcggt
     5401 gaggaaaatg tccgacaccc cccccccccc caagcaaagt cactatttgt cccttccctc
     5461 tcgtgcagtg ccttcagtac acgtttggac tcctggcttt gtttactcat gcatagaact
     5521 agagaaaata acctggtctg ttgatggctt tggctccctg gtgcctccca agccttcccc
     5581 gtgagttgaa cactttcttc ttgacaagtt acctgctaat aaagggccat ttctggaaat
     5641 ggcttacctt gga
//
