LOCUS       NM_001405210            5576 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus K(lysine) acetyltransferase 7 (Kat7), transcript
            variant 20, mRNA.
ACCESSION   NM_001405210
VERSION     NM_001405210.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5576)
  AUTHORS   Xing,Y., Qi,J., Cheng,X., Song,X., Zhang,J., Li,S., Zhao,X.,
            Gong,T., Yang,J., Zhao,C., Xin,W., Zhu,D. and Zheng,X.
  TITLE     Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to
            Govern Hypoxia-Inducible Factor-1alpha Expression
  JOURNAL   J Am Heart Assoc 12 (7), e028299 (2023)
   PUBMED   36942752
  REMARK    GeneRIF: Circ-myh8 Promotes Pulmonary Hypertension by Recruiting
            KAT7 to Govern Hypoxia-Inducible Factor-1alpha Expression.
REFERENCE   2  (bases 1 to 5576)
  AUTHORS   Zhou,Y., Jia,K., Wang,S., Li,Z., Li,Y., Lu,S., Yang,Y., Zhang,L.,
            Wang,M., Dong,Y., Zhang,L., Zhang,W., Li,N., Yu,Y., Cao,X. and
            Hou,J.
  TITLE     Malignant progression of liver cancer progenitors requires lysine
            acetyltransferase 7-acetylated and cytoplasm-translocated G protein
            GalphaS
  JOURNAL   Hepatology 77 (4), 1106-1121 (2023)
   PUBMED   35344606
REFERENCE   3  (bases 1 to 5576)
  AUTHORS   Kueh,A.J., Bergamasco,M.I., Quaglieri,A., Phipson,B.,
            Li-Wai-Suen,C.S.N., Lonnstedt,I.M., Hu,Y., Feng,Z.P., Woodruff,C.,
            May,R.E., Wilcox,S., Garnham,A.L., Snyder,M.P., Smyth,G.K.,
            Speed,T.P., Thomas,T. and Voss,A.K.
  TITLE     Stem cell plasticity, acetylation of H3K14, and de novo gene
            activation rely on KAT7
  JOURNAL   Cell Rep 42 (1), 111980 (2023)
   PUBMED   36641753
REFERENCE   4  (bases 1 to 5576)
  AUTHORS   Fan,M., Liu,Y., Shang,Y., Xue,Y., Liang,J. and Huang,Z.
  TITLE     JADE2 Is Essential for Hippocampal Synaptic Plasticity and
            Cognitive Functions in Mice
  JOURNAL   Biol Psychiatry 92 (10), 800-814 (2022)
   PUBMED   36008159
REFERENCE   5  (bases 1 to 5576)
  AUTHORS   Johmura,Y., Osada,S., Nishizuka,M. and Imagawa,M.
  TITLE     FAD24 acts in concert with histone acetyltransferase HBO1 to
            promote adipogenesis by controlling DNA replication
  JOURNAL   J Biol Chem 283 (4), 2265-2274 (2008)
   PUBMED   18029353
  REMARK    GeneRIF: FAD24 controls DNA replication by recruiting HBO1 to
            origins of DNA replication and is required for MCE during adipocyte
            differentiation.
REFERENCE   6  (bases 1 to 5576)
  AUTHORS   Iizuka,M., Sarmento,O.F., Sekiya,T., Scrable,H., Allis,C.D. and
            Smith,M.M.
  TITLE     Hbo1 Links p53-dependent stress signaling to DNA replication
            licensing
  JOURNAL   Mol Cell Biol 28 (1), 140-153 (2008)
   PUBMED   17954561
  REMARK    GeneRIF: reveal a direct regulatory connection between
            p53-responsive stress signaling and Hbo1-dependent chromatin
            pathways
REFERENCE   7  (bases 1 to 5576)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
REFERENCE   8  (bases 1 to 5576)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5576)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5576)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627222.10.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR15390196.20730.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AL627222.10        61998-62167
            171-318             AL627222.10        66006-66153
            319-495             AL627222.10        68893-69069
            496-735             AL627222.10        71984-72223
            736-818             AL627222.10        77557-77639
            819-917             AL627222.10        82332-82430
            918-1028            AL627222.10        85762-85872
            1029-1220           AL627222.10        87982-88173
            1221-1310           AL627222.10        90274-90363
            1311-1451           AL627222.10        90561-90701
            1452-1545           AL627222.10        91718-91811
            1546-5576           AL627222.10        96315-100345
FEATURES             Location/Qualifiers
     source          1..5576
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..5576
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /note="K(lysine) acetyltransferase 7"
                     /db_xref="GeneID:217127"
                     /db_xref="MGI:MGI:2182799"
     exon            1..170
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1559
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /EC_number="2.3.1.48"
                     /note="isoform 20 is encoded by transcript variant 20;
                     histone acetyltransferase MYST2; MOZ, YBF2/SAS3, SAS2 and
                     TIP60 protein 2; histone acetyltransferase binding to
                     ORC1; lysine acetyltransferase 7; histone
                     acetyltransferase KAT7; MYST histone acetyltransferase 2"
                     /codon_start=1
                     /product="histone acetyltransferase KAT7 isoform 20"
                     /protein_id="NP_001392139.1"
                     /db_xref="GeneID:217127"
                     /db_xref="MGI:MGI:2182799"
                     /translation="MPRRKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTR
                     SSARLSQSSQDSSPVRNLPSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGS
                     ETEQVVDFSDRETKNTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLK
                     DSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSAD
                     ECKAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTSEYD
                     LDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGR
                     LYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLC
                     LLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQ
                     YMRQGYGKMLIDFRPDR"
     exon            171..318
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            319..495
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            496..735
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            736..818
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            819..917
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1028
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1220
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1310
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1451
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1545
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..5576
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3153..3158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /note="hexamer: AATAAA"
     polyA_site      3174
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /note="major polyA site"
     regulatory      4305..4310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /note="hexamer: AATGAA"
     polyA_site      4335
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
     regulatory      5541..5546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /note="hexamer: AATAAA"
     polyA_site      5576
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
ORIGIN      
        1 gcagaaggct ctagacgctg agaggtagga ggcacttggg atcgtccgca gggtttggga
       61 cagctacaga ggccgccacg gagcccgccg gagcccccgt tcctgctggt gctgccgccg
      121 cccgaatcgg aaccgtcggg ctgcagccgc cggcaatgcc gcgaaggaag agaaatgcag
      181 gcagtagttc agatggaacc gaagattccg atttttctac agatctcgag catacagaca
      241 gttcagagag tgatggcacc tcgcgccgat ctgcccgagt cacccgctcc tcagccaggc
      301 taagccagag ttcccaagat tccagccctg ttcgaaattt gccgtctttc ggcactgagg
      361 agcctgccta ttctaccaga agggtgaccc gtagtcagca gcagcccacg ccagtgactc
      421 caaaaaagta ccctcttcga cagactcgct catctggctc tgaaacggag caggtggtgg
      481 acttttcaga tagagaaact aaaaatacag ctgatcatga tgagtcacca cctcgaactc
      541 caaccggaaa tgcaccttct tctgagtctg acatagacat ctccagcccc aacgtgtctc
      601 atgatgagag cattgccaag gacatgtccc tgaaggactc aggcagtgat ctctctcacc
      661 gtcccaagcg acgtcgattt cacgaaagct acaatttcaa catgaagtgt cctacgccgg
      721 gctgcaactc tctaggacat cttacaggaa agcacgagag acatttctcc atctcaggat
      781 gcccgctgta tcataacctc tcagctgacg aatgcaaggc accaacagag agacagctgc
      841 ggtataagga aaaggtggct gaactcagga agaaaagaaa ttctggactg agcaaagagc
      901 agaaggagaa atacatggaa cacagacaga cctatgggaa cactcgggag cctctcttgg
      961 aaaacctgac aagtgaatat gacttagatc ttttccgaag agcacaagcc cgggcttctg
     1021 aggatttgga gaagttaagg cttcaaggcc aaatcacaga gggaagcaac atgattaaaa
     1081 caattgcttt tggccgctat gaactggaca cttggtacca ctctccctat cctgaggaat
     1141 atgcgaggct gggacgtctc tacatgtgtg aattctgctt aaagtacatg aagagccaga
     1201 caatcctccg ccgacacatg gccaagtgtg tgtggaaaca cccccctggt gatgagattt
     1261 atcgcaaagg ctccatctct gtgtttgaag tagacggcaa gaagaacaag atctactgcc
     1321 aaaacctctg ccttttggca aagctttttc tggaccataa gacgctatac tatgatgtag
     1381 aacctttcct gttctacgtt atgacagaag cggacaatac tggctgtcat ctgattggat
     1441 atttttctaa ggagaagaat tcatttctca actataatgt ctcgtgcatc ctcaccatgc
     1501 ctcagtacat gcgacagggc tacgggaaga tgctgatcga tttcagacct gatagatgag
     1561 tggatagcca aagaggccaa aaggtccaac tccaacaaaa ccatggatcc aagctgctta
     1621 aaatggaccc ctcccaaggg cacttaaagt gacctatcat tccgagccag cgagccccag
     1681 cagtaggaat ccgtacccta gggatctgtc tgtcatttct gttgctcttg tgattggcaa
     1741 gtacagtatc ctttgggaag gccaccccct cagcactgtt ctggctccag ccttcgtgta
     1801 cactgcagac actagttctg aggaactgtt gtttcggcct cagtgaggtt gcctggacgg
     1861 atctgtatga ggctcgagta cagatccctc atagcactga cccaaggagt tgtgttatgg
     1921 tactgtacct gtccagtcac tggttcccac ctcatgcttt ttaactccga ggtttgttgt
     1981 gtcctgacct ttgtgctagt gctttttcct gcctggatag cagacctcca aacatggttg
     2041 ccaccaaagg gccctttcca gttacttcta acacattctt catgaagggg tgggcaagag
     2101 gcagcgcctg tgcgtgtctg ctgggagggt ccgctcacca tgggtttcat ctcgcagtca
     2161 ctcatttttc tccctttttg tcaaaagact tactaccttt gatcaggatc aggctgccca
     2221 gagctaggaa cgcctggcat ttcccagggg ttcacaggcc tggtccatct gcgtgagatg
     2281 gtgaagccta agaggtggtc ccatgctttc ctttgtattt acttgtggac actggggcag
     2341 cattgtgtag aaggaaatga ggaattcttt gccacagcag aaaatgcccc cacttttttt
     2401 tctgccccct tttatgttgg tagttgccaa aatattttaa cagtcttttt tcatacatta
     2461 aatgaccacc ctgtggatct ttccacacct gcctctgcca gtctggtgta gggcagctct
     2521 actttccaca caagttgcac tgatcttgtc cagagcttcc tgggagaagt ggaaactggt
     2581 tgaaatgctt gtgtttctca gcccatgact cagcaagaca gggtggccac tctgctacgg
     2641 tttgcttcgc tctcaacagt gcctccctcc cccagcagac tgaagtgctt ctgtctaaga
     2701 actaagtcca ttccctttcg ggacttgcca ccatcatcct gttctctggg ttcctatttt
     2761 tggtggtgtt aagtgaagga agaagtgttc cctctaattt ctccctgtcc cagtatataa
     2821 cctgctatct tggggcagct tttgatgtct gacatgtcac ccttcccaag ttggtctctt
     2881 ccaacactgc tgtcttcacg tggcaccctc ttaccacaac cctaactctg gtcatttgtg
     2941 cctttctctt gtcatctctg tacactacta atattcactg tgggttgggg agctgatttt
     3001 aagcatgttc agtggctccc ctccagtttc agtgtaactg ttaaaatgta tccaaaagcc
     3061 acttcactgg gggttttctt aaggggtaaa ggccttttac agatgctgag ccctccccac
     3121 atgtggcaga atgtgctctt ctgtatctac tcaataaagc atgttctctg ctcatgtctg
     3181 actgctctga agcttgttta tatgggaatg gtgtgattgg ctcagcacag tgttagccct
     3241 ggggtttgga gctatggatt gttttcccct gtgaagcagg ttgttgacag agtgagtgtt
     3301 ttctctgaac tcacaagcgg taaaacaaat tgagtctgcc tccctttggc tccaggaagt
     3361 cgctgtgcgc aacagcagct agctagtgta atttcattca tctgcctctg gtttggggcc
     3421 ttgtcaagga accactggga agttagggtg ggttggggat gccatggaag cttgtaggag
     3481 gcagaacaat gcattccttt cctctaagcg tgctcaccag tatcaagcca ggccctgtct
     3541 aatcatcatc cagcccaggt tgtgcctctg gaagtagctg cagttgttgc ttgtgtttgc
     3601 ccaggcagga ccagcggggc ggggcattgt cgtctgggtg tggaaaggga gctgtgtttg
     3661 ctgggctact tttgctcact ggcaaggcct cttactggag tcggaaaatg cagtggagaa
     3721 aaataactgc ccttctgttg atcttagacc agggtttgct caagtctctg tgttggaacc
     3781 atttgcagca gagggagatt ttgttctctc agtttgaaga gtggagatgg gtaacatgga
     3841 cggtaagaat tgaatgccag ggagggagag atgatggttg cacagtcctg atcctgtcgt
     3901 tgctgggtct ggttagccac tcagtggagg ctaacttcat ttgtgtgtgg cagcctcatg
     3961 tgcgctcagc actacttcct ttgtcctttg tattagctgc gtgcagcctg ctcgcactgg
     4021 ttatacagaa ggaaacctgc atcctaccgc aactgtgaac caagaagcca gaatgctcat
     4081 tgtactctgt tgtacttgag aatctgtacc acttctgcca ttgccttccc cagccagctt
     4141 cagttccctg gtgtttctgc tcattctttc ccttcgaggc agatacacgc tgttagaaac
     4201 cgtcatgttt ctagagcagc gcttctcggc gtgtagatgt caatgagcct ttcccagggt
     4261 tgcctaagac cacccggaat atagattatt atatcatgat cctgaatgaa agccttgctt
     4321 ctcttgcctc caaaacacgt ggtgcagcct ggtctcttat ttctcatggg aatagtgagc
     4381 cctgatgagt catttctagt agtgtagtat gtatgtagta tgtacagtgt agtatgtatg
     4441 tagtatgtat gcagtatgtg tagtgtagta tgtatgtagt atgtatgcac tttgtagagc
     4501 agagatgctt cctacttggt cttggctgtc atcaggccct gtacttcgtt ctggttgtat
     4561 ggctgggatt agggactgct ggaatggacc tatctgtcag gctggttgct ctagatcaag
     4621 gttggggctg tggagcatca taaaatctgt agatgaaagt ggagcacagt ttgcttgtgg
     4681 cacacatata tcccttctgg aacataaaac caatggaatc agcattttga ttgcccttgc
     4741 aagggtagtt agtgtgtcta ttcttatagc aggttcaagc agcagagctc tgagccacct
     4801 tctccctccc ctgtttgctt ctggcctttg tgaagctgaa aagactcatt aggattaatt
     4861 tttgttgtac ctatgcaaat atgcacacat ttatttacag tccaggaaat tgcctttgga
     4921 atctccaggg atgagcatcc tagagcctgg tttgagacgc ctcagtagta aagcaggaag
     4981 cacattctgg cttcgctgct cttactcggg actctgaact ggtttctgga atgtgctggg
     5041 atgcaaagaa ccaaatccaa tgagtgatga agtatgaagg aggtctggct caccggctgc
     5101 cggagcctca tagggtttgc atgggaagac ctttgctaaa taatggcatg tagtctatgc
     5161 taggaattgg ctctaacctg gttttgcttc aggtcttttg gcctcaggct tgcaaatgac
     5221 tgcctctccc agactgatgg gggcactgta cttgctcact tcctctgtgg tatcttcagc
     5281 aatgccagtg agtgtcactg aactatcgac aagactcagc ggtgaggaaa atgtccgaca
     5341 cccccccccc ccccaagcaa agtcactatt tgtcccttcc ctctcgtgca gtgccttcag
     5401 tacacgtttg gactcctggc tttgtttact catgcataga actagagaaa ataacctggt
     5461 ctgttgatgg ctttggctcc ctggtgcctc ccaagccttc cccgtgagtt gaacactttc
     5521 ttcttgacaa gttacctgct aataaagggc catttctgga aatggcttac cttgga
//
