LOCUS       NM_001405194            5792 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus K(lysine) acetyltransferase 7 (Kat7), transcript
            variant 4, mRNA.
ACCESSION   NM_001405194 XM_006533013
VERSION     NM_001405194.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5792)
  AUTHORS   Xing,Y., Qi,J., Cheng,X., Song,X., Zhang,J., Li,S., Zhao,X.,
            Gong,T., Yang,J., Zhao,C., Xin,W., Zhu,D. and Zheng,X.
  TITLE     Circ-myh8 Promotes Pulmonary Hypertension by Recruiting KAT7 to
            Govern Hypoxia-Inducible Factor-1alpha Expression
  JOURNAL   J Am Heart Assoc 12 (7), e028299 (2023)
   PUBMED   36942752
  REMARK    GeneRIF: Circ-myh8 Promotes Pulmonary Hypertension by Recruiting
            KAT7 to Govern Hypoxia-Inducible Factor-1alpha Expression.
REFERENCE   2  (bases 1 to 5792)
  AUTHORS   Zhou,Y., Jia,K., Wang,S., Li,Z., Li,Y., Lu,S., Yang,Y., Zhang,L.,
            Wang,M., Dong,Y., Zhang,L., Zhang,W., Li,N., Yu,Y., Cao,X. and
            Hou,J.
  TITLE     Malignant progression of liver cancer progenitors requires lysine
            acetyltransferase 7-acetylated and cytoplasm-translocated G protein
            GalphaS
  JOURNAL   Hepatology 77 (4), 1106-1121 (2023)
   PUBMED   35344606
REFERENCE   3  (bases 1 to 5792)
  AUTHORS   Kueh,A.J., Bergamasco,M.I., Quaglieri,A., Phipson,B.,
            Li-Wai-Suen,C.S.N., Lonnstedt,I.M., Hu,Y., Feng,Z.P., Woodruff,C.,
            May,R.E., Wilcox,S., Garnham,A.L., Snyder,M.P., Smyth,G.K.,
            Speed,T.P., Thomas,T. and Voss,A.K.
  TITLE     Stem cell plasticity, acetylation of H3K14, and de novo gene
            activation rely on KAT7
  JOURNAL   Cell Rep 42 (1), 111980 (2023)
   PUBMED   36641753
REFERENCE   4  (bases 1 to 5792)
  AUTHORS   Fan,M., Liu,Y., Shang,Y., Xue,Y., Liang,J. and Huang,Z.
  TITLE     JADE2 Is Essential for Hippocampal Synaptic Plasticity and
            Cognitive Functions in Mice
  JOURNAL   Biol Psychiatry 92 (10), 800-814 (2022)
   PUBMED   36008159
REFERENCE   5  (bases 1 to 5792)
  AUTHORS   Johmura,Y., Osada,S., Nishizuka,M. and Imagawa,M.
  TITLE     FAD24 acts in concert with histone acetyltransferase HBO1 to
            promote adipogenesis by controlling DNA replication
  JOURNAL   J Biol Chem 283 (4), 2265-2274 (2008)
   PUBMED   18029353
  REMARK    GeneRIF: FAD24 controls DNA replication by recruiting HBO1 to
            origins of DNA replication and is required for MCE during adipocyte
            differentiation.
REFERENCE   6  (bases 1 to 5792)
  AUTHORS   Iizuka,M., Sarmento,O.F., Sekiya,T., Scrable,H., Allis,C.D. and
            Smith,M.M.
  TITLE     Hbo1 Links p53-dependent stress signaling to DNA replication
            licensing
  JOURNAL   Mol Cell Biol 28 (1), 140-153 (2008)
   PUBMED   17954561
  REMARK    GeneRIF: reveal a direct regulatory connection between
            p53-responsive stress signaling and Hbo1-dependent chromatin
            pathways
REFERENCE   7  (bases 1 to 5792)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
REFERENCE   8  (bases 1 to 5792)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5792)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5792)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627222.10.
            
            On Apr 21, 2022 this sequence version replaced XM_006533013.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3571552.1,
                                           SRR13422601.1712261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AL627222.10        62624-62665
            43-190              AL627222.10        66006-66153
            191-367             AL627222.10        68893-69069
            368-607             AL627222.10        71984-72223
            608-690             AL627222.10        77557-77639
            691-780             AL627222.10        80593-80682
            781-879             AL627222.10        82332-82430
            880-990             AL627222.10        85762-85872
            991-1182            AL627222.10        87982-88173
            1183-1272           AL627222.10        90274-90363
            1273-1413           AL627222.10        90561-90701
            1414-1507           AL627222.10        91718-91811
            1508-1654           AL627222.10        94587-94733
            1655-1761           AL627222.10        95653-95759
            1762-5792           AL627222.10        96315-100345
FEATURES             Location/Qualifiers
     source          1..5792
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..5792
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /note="K(lysine) acetyltransferase 7"
                     /db_xref="GeneID:217127"
                     /db_xref="MGI:MGI:2182799"
     exon            1..42
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1863
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /EC_number="2.3.1.48"
                     /note="isoform 4 is encoded by transcript variant 4;
                     histone acetyltransferase MYST2; MOZ, YBF2/SAS3, SAS2 and
                     TIP60 protein 2; histone acetyltransferase binding to
                     ORC1; lysine acetyltransferase 7; histone
                     acetyltransferase KAT7; MYST histone acetyltransferase 2"
                     /codon_start=1
                     /product="histone acetyltransferase KAT7 isoform 4"
                     /protein_id="NP_001392123.1"
                     /db_xref="GeneID:217127"
                     /db_xref="MGI:MGI:2182799"
                     /translation="MAIGVVKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARV
                     TRSSARLSQSSQDSSPVRNLPSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSS
                     GSETEQVVDFSDRETKNTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMS
                     LKDSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLS
                     ADECKVRAQSRDKQIEERMLSHRQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSG
                     LSKEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITE
                     GSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVW
                     KHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTE
                     ADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGS
                     PERPLSDLGLISYRSYWKEVLLRYLHNFQGKEISIKEISQETAVNPVDIVSTLQALQM
                     LKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTPPKGT"
     exon            43..190
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            191..367
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..607
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..690
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            691..780
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            781..879
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..990
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1182
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1272
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1413
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1507
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1654
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1761
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..5792
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3369..3374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /note="hexamer: AATAAA"
     polyA_site      3390
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /note="major polyA site"
     regulatory      4521..4526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /note="hexamer: AATGAA"
     polyA_site      4551
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
     regulatory      5757..5762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
                     /note="hexamer: AATAAA"
     polyA_site      5792
                     /gene="Kat7"
                     /gene_synonym="Hbo1; Hboa; Myst2"
ORIGIN      
        1 gccccgccct tccggataga gatggcgata ggtgttgtaa agagaaatgc aggcagtagt
       61 tcagatggaa ccgaagattc cgatttttct acagatctcg agcatacaga cagttcagag
      121 agtgatggca cctcgcgccg atctgcccga gtcacccgct cctcagccag gctaagccag
      181 agttcccaag attccagccc tgttcgaaat ttgccgtctt tcggcactga ggagcctgcc
      241 tattctacca gaagggtgac ccgtagtcag cagcagccca cgccagtgac tccaaaaaag
      301 taccctcttc gacagactcg ctcatctggc tctgaaacgg agcaggtggt ggacttttca
      361 gatagagaaa ctaaaaatac agctgatcat gatgagtcac cacctcgaac tccaaccgga
      421 aatgcacctt cttctgagtc tgacatagac atctccagcc ccaacgtgtc tcatgatgag
      481 agcattgcca aggacatgtc cctgaaggac tcaggcagtg atctctctca ccgtcccaag
      541 cgacgtcgat ttcacgaaag ctacaatttc aacatgaagt gtcctacgcc gggctgcaac
      601 tctctaggac atcttacagg aaagcacgag agacatttct ccatctcagg atgcccgctg
      661 tatcataacc tctcagctga cgaatgcaag gtgagagcac agagccggga taagcagata
      721 gaagaaagga tgctgtccca caggcaagat gacaacaaca ggcatgcaac caggcaccag
      781 gcaccaacag agagacagct gcggtataag gaaaaggtgg ctgaactcag gaagaaaaga
      841 aattctggac tgagcaaaga gcagaaggag aaatacatgg aacacagaca gacctatggg
      901 aacactcggg agcctctctt ggaaaacctg acaagtgaat atgacttaga tcttttccga
      961 agagcacaag cccgggcttc tgaggatttg gagaagttaa ggcttcaagg ccaaatcaca
     1021 gagggaagca acatgattaa aacaattgct tttggccgct atgaactgga cacttggtac
     1081 cactctccct atcctgagga atatgcgagg ctgggacgtc tctacatgtg tgaattctgc
     1141 ttaaagtaca tgaagagcca gacaatcctc cgccgacaca tggccaagtg tgtgtggaaa
     1201 cacccccctg gtgatgagat ttatcgcaaa ggctccatct ctgtgtttga agtagacggc
     1261 aagaagaaca agatctactg ccaaaacctc tgccttttgg caaagctttt tctggaccat
     1321 aagacgctat actatgatgt agaacctttc ctgttctacg ttatgacaga agcggacaat
     1381 actggctgtc atctgattgg atatttttct aaggagaaga attcatttct caactataat
     1441 gtctcgtgca tcctcaccat gcctcagtac atgcgacagg gctacgggaa gatgctgatc
     1501 gatttcagtt atttactttc caaagtagaa gagaaagtcg gctctccaga gcgcccactg
     1561 tcagacctgg ggctcataag ctaccgcagc tactggaagg aggtactgct ccgatacctg
     1621 cacaacttcc agggcaagga gatctccatc aaagaaatta gccaggaaac agctgtgaat
     1681 cccgtggaca ttgtcagcac tctgcaagcc cttcagatgc tcaagtattg gaaaggcaag
     1741 cacctagttt taaagagaca ggacctgata gatgagtgga tagccaaaga ggccaaaagg
     1801 tccaactcca acaaaaccat ggatccaagc tgcttaaaat ggacccctcc caagggcact
     1861 taaagtgacc tatcattccg agccagcgag ccccagcagt aggaatccgt accctaggga
     1921 tctgtctgtc atttctgttg ctcttgtgat tggcaagtac agtatccttt gggaaggcca
     1981 ccccctcagc actgttctgg ctccagcctt cgtgtacact gcagacacta gttctgagga
     2041 actgttgttt cggcctcagt gaggttgcct ggacggatct gtatgaggct cgagtacaga
     2101 tccctcatag cactgaccca aggagttgtg ttatggtact gtacctgtcc agtcactggt
     2161 tcccacctca tgctttttaa ctccgaggtt tgttgtgtcc tgacctttgt gctagtgctt
     2221 tttcctgcct ggatagcaga cctccaaaca tggttgccac caaagggccc tttccagtta
     2281 cttctaacac attcttcatg aaggggtggg caagaggcag cgcctgtgcg tgtctgctgg
     2341 gagggtccgc tcaccatggg tttcatctcg cagtcactca tttttctccc tttttgtcaa
     2401 aagacttact acctttgatc aggatcaggc tgcccagagc taggaacgcc tggcatttcc
     2461 caggggttca caggcctggt ccatctgcgt gagatggtga agcctaagag gtggtcccat
     2521 gctttccttt gtatttactt gtggacactg gggcagcatt gtgtagaagg aaatgaggaa
     2581 ttctttgcca cagcagaaaa tgcccccact tttttttctg ccccctttta tgttggtagt
     2641 tgccaaaata ttttaacagt cttttttcat acattaaatg accaccctgt ggatctttcc
     2701 acacctgcct ctgccagtct ggtgtagggc agctctactt tccacacaag ttgcactgat
     2761 cttgtccaga gcttcctggg agaagtggaa actggttgaa atgcttgtgt ttctcagccc
     2821 atgactcagc aagacagggt ggccactctg ctacggtttg cttcgctctc aacagtgcct
     2881 ccctccccca gcagactgaa gtgcttctgt ctaagaacta agtccattcc ctttcgggac
     2941 ttgccaccat catcctgttc tctgggttcc tatttttggt ggtgttaagt gaaggaagaa
     3001 gtgttccctc taatttctcc ctgtcccagt atataacctg ctatcttggg gcagcttttg
     3061 atgtctgaca tgtcaccctt cccaagttgg tctcttccaa cactgctgtc ttcacgtggc
     3121 accctcttac cacaacccta actctggtca tttgtgcctt tctcttgtca tctctgtaca
     3181 ctactaatat tcactgtggg ttggggagct gattttaagc atgttcagtg gctcccctcc
     3241 agtttcagtg taactgttaa aatgtatcca aaagccactt cactgggggt tttcttaagg
     3301 ggtaaaggcc ttttacagat gctgagccct ccccacatgt ggcagaatgt gctcttctgt
     3361 atctactcaa taaagcatgt tctctgctca tgtctgactg ctctgaagct tgtttatatg
     3421 ggaatggtgt gattggctca gcacagtgtt agccctgggg tttggagcta tggattgttt
     3481 tcccctgtga agcaggttgt tgacagagtg agtgttttct ctgaactcac aagcggtaaa
     3541 acaaattgag tctgcctccc tttggctcca ggaagtcgct gtgcgcaaca gcagctagct
     3601 agtgtaattt cattcatctg cctctggttt ggggccttgt caaggaacca ctgggaagtt
     3661 agggtgggtt ggggatgcca tggaagcttg taggaggcag aacaatgcat tcctttcctc
     3721 taagcgtgct caccagtatc aagccaggcc ctgtctaatc atcatccagc ccaggttgtg
     3781 cctctggaag tagctgcagt tgttgcttgt gtttgcccag gcaggaccag cggggcgggg
     3841 cattgtcgtc tgggtgtgga aagggagctg tgtttgctgg gctacttttg ctcactggca
     3901 aggcctctta ctggagtcgg aaaatgcagt ggagaaaaat aactgccctt ctgttgatct
     3961 tagaccaggg tttgctcaag tctctgtgtt ggaaccattt gcagcagagg gagattttgt
     4021 tctctcagtt tgaagagtgg agatgggtaa catggacggt aagaattgaa tgccagggag
     4081 ggagagatga tggttgcaca gtcctgatcc tgtcgttgct gggtctggtt agccactcag
     4141 tggaggctaa cttcatttgt gtgtggcagc ctcatgtgcg ctcagcacta cttcctttgt
     4201 cctttgtatt agctgcgtgc agcctgctcg cactggttat acagaaggaa acctgcatcc
     4261 taccgcaact gtgaaccaag aagccagaat gctcattgta ctctgttgta cttgagaatc
     4321 tgtaccactt ctgccattgc cttccccagc cagcttcagt tccctggtgt ttctgctcat
     4381 tctttccctt cgaggcagat acacgctgtt agaaaccgtc atgtttctag agcagcgctt
     4441 ctcggcgtgt agatgtcaat gagcctttcc cagggttgcc taagaccacc cggaatatag
     4501 attattatat catgatcctg aatgaaagcc ttgcttctct tgcctccaaa acacgtggtg
     4561 cagcctggtc tcttatttct catgggaata gtgagccctg atgagtcatt tctagtagtg
     4621 tagtatgtat gtagtatgta cagtgtagta tgtatgtagt atgtatgcag tatgtgtagt
     4681 gtagtatgta tgtagtatgt atgcactttg tagagcagag atgcttccta cttggtcttg
     4741 gctgtcatca ggccctgtac ttcgttctgg ttgtatggct gggattaggg actgctggaa
     4801 tggacctatc tgtcaggctg gttgctctag atcaaggttg gggctgtgga gcatcataaa
     4861 atctgtagat gaaagtggag cacagtttgc ttgtggcaca catatatccc ttctggaaca
     4921 taaaaccaat ggaatcagca ttttgattgc ccttgcaagg gtagttagtg tgtctattct
     4981 tatagcaggt tcaagcagca gagctctgag ccaccttctc cctcccctgt ttgcttctgg
     5041 cctttgtgaa gctgaaaaga ctcattagga ttaatttttg ttgtacctat gcaaatatgc
     5101 acacatttat ttacagtcca ggaaattgcc tttggaatct ccagggatga gcatcctaga
     5161 gcctggtttg agacgcctca gtagtaaagc aggaagcaca ttctggcttc gctgctctta
     5221 ctcgggactc tgaactggtt tctggaatgt gctgggatgc aaagaaccaa atccaatgag
     5281 tgatgaagta tgaaggaggt ctggctcacc ggctgccgga gcctcatagg gtttgcatgg
     5341 gaagaccttt gctaaataat ggcatgtagt ctatgctagg aattggctct aacctggttt
     5401 tgcttcaggt cttttggcct caggcttgca aatgactgcc tctcccagac tgatgggggc
     5461 actgtacttg ctcacttcct ctgtggtatc ttcagcaatg ccagtgagtg tcactgaact
     5521 atcgacaaga ctcagcggtg aggaaaatgt ccgacacccc cccccccccc aagcaaagtc
     5581 actatttgtc ccttccctct cgtgcagtgc cttcagtaca cgtttggact cctggctttg
     5641 tttactcatg catagaacta gagaaaataa cctggtctgt tgatggcttt ggctccctgg
     5701 tgcctcccaa gccttccccg tgagttgaac actttcttct tgacaagtta cctgctaata
     5761 aagggccatt tctggaaatg gcttaccttg ga
//
