LOCUS       NM_001408696            7662 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus K(lysine) acetyltransferase 6B (Kat6b), transcript
            variant 4, mRNA.
ACCESSION   NM_001408696 XM_006519268
VERSION     NM_001408696.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7662)
  AUTHORS   Bergamasco,M.I., Abeysekera,W., Garnham,A.L., Hu,Y.,
            Li-Wai-Suen,C.S., Sheikh,B.N., Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     KAT6B is required for histone 3 lysine 9 acetylation and SOX gene
            expression in the developing brain
  JOURNAL   Life Sci Alliance 8 (2), e202402969 (2024)
   PUBMED   39537341
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7662)
  AUTHORS   Bergamasco,M.I., Ranathunga,N., Abeysekera,W., Li-Wai-Suen,C.S.N.,
            Garnham,A.L., Willis,S.N., McRae,H.M., Yang,Y., D'Amico,A., Di
            Rago,L., Wilcox,S., Nutt,S.L., Alexander,W.S., Smyth,G.K.,
            Voss,A.K. and Thomas,T.
  TITLE     The histone acetyltransferase KAT6B is required for hematopoietic
            stem cell development and function
  JOURNAL   Stem Cell Reports 19 (4), 469-485 (2024)
   PUBMED   38518784
  REMARK    GeneRIF: The histone acetyltransferase KAT6B is required for
            hematopoietic stem cell development and function.
REFERENCE   3  (bases 1 to 7662)
  AUTHORS   Bergamasco,M.I., Vanyai,H.K., Garnham,A.L., Geoghegan,N.D.,
            Vogel,A.P., Eccles,S., Rogers,K.L., Smyth,G.K., Blewitt,M.E.,
            Hannan,A.J., Thomas,T. and Voss,A.K.
  TITLE     Increasing histone acetylation improves sociability and restores
            learning and memory in KAT6B-haploinsufficient mice
  JOURNAL   J Clin Invest 134 (7), e167672 (2024)
   PUBMED   38557491
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7662)
  AUTHORS   Cui,J., Liu,X., Dong,W., Liu,Y., Ruan,X., Zhang,M., Wang,P., Liu,L.
            and Xue,Y.
  TITLE     SNORD17-mediated KAT6B mRNA 2'-O-methylation regulates vasculogenic
            mimicry in glioblastoma cells
  JOURNAL   Cell Biol Toxicol 39 (6), 2841-2860 (2023)
   PUBMED   37058271
  REMARK    GeneRIF: SNORD17-mediated KAT6B mRNA 2'-O-methylation regulates
            vasculogenic mimicry in glioblastoma cells.
REFERENCE   5  (bases 1 to 7662)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7662)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 7662)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 7662)
  AUTHORS   Thomas,T. and Voss,A.K.
  TITLE     Querkopf, a histone acetyltransferase, is essential for embryonic
            neurogenesis
  JOURNAL   Front Biosci 9, 24-31 (2004)
   PUBMED   14766340
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 7662)
  AUTHORS   Hobbs,C.A., Paul,B.A. and Gilmour,S.K.
  TITLE     Deregulation of polyamine biosynthesis alters intrinsic histone
            acetyltransferase and deacetylase activities in murine skin and
            tumors
  JOURNAL   Cancer Res 62 (1), 67-74 (2002)
   PUBMED   11782361
  REMARK    GeneRIF: Deregulation of polyamine biosynthesis alters intrinsic
            histone acetyltransferase and deacetylase activities in murine skin
            and tumors.
REFERENCE   10 (bases 1 to 7662)
  AUTHORS   Thomas,T., Voss,A.K., Chowdhury,K. and Gruss,P.
  TITLE     Querkopf, a MYST family histone acetyltransferase, is required for
            normal cerebral cortex development
  JOURNAL   Development 127 (12), 2537-2548 (2000)
   PUBMED   10821753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115122.4 and AC148978.3.
            
            On Jun 22, 2022 this sequence version replaced XM_006519268.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.9687948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AC115122.4         92949-93138         c
            191-1063            AC115122.4         76529-77401         c
            1064-1172           AC148978.3         71141-71249         c
            1173-1288           AC148978.3         61997-62112         c
            1289-1370           AC148978.3         61704-61785         c
            1371-1503           AC148978.3         58916-59048         c
            1504-1886           AC148978.3         55788-56170         c
            1887-2008           AC148978.3         54163-54284         c
            2009-2124           AC148978.3         52075-52190         c
            2125-2266           AC148978.3         49540-49681         c
            2267-2428           AC148978.3         46366-46527         c
            2429-2522           AC148978.3         43363-43456         c
            2523-2754           AC148978.3         20029-20260         c
            2755-2914           AC148978.3         19416-19575         c
            2915-3223           AC148978.3         18537-18845         c
            3224-3515           AC148978.3         16255-16546         c
            3516-7662           AC148978.3         8526-12672          c
FEATURES             Location/Qualifiers
     source          1..7662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 11.73 cM"
     gene            1..7662
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /note="K(lysine) acetyltransferase 6B"
                     /db_xref="GeneID:54169"
                     /db_xref="MGI:MGI:1858746"
     exon            1..190
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     exon            191..1063
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     CDS             440..6058
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /EC_number="2.3.1.48"
                     /note="isoform 2 is encoded by transcript variant 4;
                     histone acetyltransferase MYST4; histone acetyltransferase
                     querkopf; protein querkopf; MOZ, YBF2/SAS3, SAS2 and TIP60
                     protein 4; monocytic leukemia; histone acetyltransferase
                     KAT6B; MYST histone acetyltransferase monocytic leukemia
                     4"
                     /codon_start=1
                     /product="histone acetyltransferase KAT6B isoform 2"
                     /protein_id="NP_001395625.1"
                     /db_xref="GeneID:54169"
                     /db_xref="MGI:MGI:1858746"
                     /translation="MVKLANPLYTEWILEAVQKIKKQKQRPSEERICHAVSTSHGLDK
                     KTVSEQLELSVQDGSVLKVTNKGLASYKDPDNPGRFSSVKPGTFPKPTKGSKGPPCND
                     LRNVDWNKLLKRAIEGLEEPNGSSLKNIEKYLRSQSDLTGTTNHPAFQQRLRLGAKRA
                     VNNGRLLKEGPQYRVNSGSSDGKGAPQYPSAFPSSLPPVSLLPHEKDQPRADPIPICS
                     FCLGTKESNREKKPEELLSCADCGSSGHPSCLKFCPELTANVKALRWQCIECKTCSAC
                     RVQGKNADNMLFCDSCDRGFHMECCDPPLSRMPKGMWICQVCRPKKKGRKLLHEKAAQ
                     IKRRYAKPIGRPKNKLKQRLLSVTSDEGSMSAFTGRGSPGRGQKTKVSTTPSSGHAAS
                     GKHSSSRLAVTDPTRPGATTKTTTSSTYISASTLKVNKKTKGLIDGLTKFFTPSPDGR
                     RSRGEIIDFSKHYRPRKKVSQKQSCTSHVLATDTDIKISIKQESADVSLVGNKELVTE
                     EDLDVFKQAQELSWEKIECESGVEDCGRYPSVIEFGKYEIQTWYSSPYPQEYARLPKL
                     YLCEFCLKYMKSKNILLRHSKKCGWFHPPANEIYRRKDLSVFEVDGNMSKIYCQNLCL
                     LAKLFLDHKTLYYDVEPFLFYVLTKNDEKGCHLVGYFSKEKLCQQKYNVSCIMIMPQH
                     QRQGFGRFLIDFSYLLSRREGQAGSPEKPLSDLGRLSYLAYWKSVILEYLYRHHERHI
                     SIKAISRATGMCPHDIATTLQHLHMIDRRDGRFVIIRREKLILGHMEKLKNCSRPNEL
                     DPESLRWTPMLISNAVVSEEEREAEKEAERLMEQASCWEKEEQEILSSRVSSRQSSAK
                     VQSKNKYLHSPERRPVAGERGQLLELSKESSEEEEEEEEEDDEEEEEEEEEESIQTSP
                     PRLTKPQSVSIKRKRPFVVKKKRGRKRRRINSSVTTETISETTEVLNEPFDNSDEERP
                     MPQLEPTCEIPVEEGGRKPVLRKAFPHQPGKKRQTEEEEGEDNHFFKTAALCRKDVDD
                     DAEHLKEGSKDNPEPLKCRQVWPKGAKRGLSKWKQSKERKTGFKLNLYTPPETPMEPE
                     DQVTIEEQKELSEDKGSPVGMEREVTETVDALLPQEGSRREETGIPVSPHKSPGGKVD
                     EEDLIRGEEEGEEEGEEEGEREEQEEEEEVTTEKDLDGAKSKENPEPEISMEKEDPVH
                     LGDHEEDEDEEEEPSHNEDHDADDEDDGHMEAANMERGDLPRETFKDALEGQEAFLDL
                     SIQPSHSNPEVLMNCGVDLTMSCNSEPKELAGDTGTAPESDAEPPEEQTQKQDQKNSD
                     GVDAELEEGGPAAVEIDSETAQAVQSLTQENREHDDTFPDCAETQEACRSLQNYTHTD
                     QSPQIATTLDECQQSDHSSPVSSVHSHPGQSVRSVNSPSVPALENSYAQISPDQTAIT
                     VPPLQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIESTTENYENPSSYDSTMGGSIC
                     GNGSSQNSCSYSSLTSSNLTQNSCAVTQQMSNISGSCSMLQQTSISSPPTCSVKSPQG
                     CVVERPPSSSQQLAQCSMAANFTPPMQLADIPETSNANIGLYERMGQSDFGAGHYPQP
                     SATFSLAKLQQLTNTLIDHSLPYSHSAAVTSYANSASLSTPLSNTGLVQLSQSPHSVP
                     GGPQAQATMTPPPNLTPPPMNLPPPLLQRNMAASNIGISHSQRLQTQIASKGHVSMRT
                     KAASLSPAAATHQSQIYGRSQTVAMQGPARTLTMQRGMNMSVNLMPAPAYNVNSVNMN
                     MNTLNAMNGYSMSQPMMNSGYHSNHGYMNQTPQYPMQMQMGMMGSQPYAQQPMQTPPH
                     ANMMYTAPGHHGYMNTGMSKQSLNGSYMRR"
     exon            1064..1172
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1288
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1370
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1503
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1886
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2008
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2124
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2266
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2428
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2522
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2754
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2914
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..3223
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3515
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     exon            3516..7662
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7294..7299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /note="hexamer: AATAAA"
     polyA_site      7318
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /note="major polyA site"
     regulatory      7411..7416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /note="hexamer: AATAAA"
     polyA_site      7435
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
     regulatory      7545..7550
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /note="hexamer: AATAAA"
     polyA_site      7565
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
     regulatory      7636..7641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
                     /note="hexamer: AATAAA"
     polyA_site      7662
                     /gene="Kat6b"
                     /gene_synonym="B130044K16Rik; mKIAA0383; Morf; MYST-4;
                     Myst4; qkf; querkopf"
ORIGIN      
        1 agtgtcatgt cggattcatg tcaacgacaa caacaggggg acacaaaatg gcggcggctt
       61 agctcctacc cctggcggcg gcggcagcgg tggcgggcgc tacggcacct cctccaggcg
      121 gcagccgtag cttctttctc aggcagattc agcgcccccg gcaggcgcgg tggtggtggc
      181 gcgcggccag gtcttggttt cctaaagatg tctttcactt gaagagtgca gtccttccca
      241 ttggtgaact aagacaactc tccacgttgc ctggcagtca gtcctctctt taaggatggt
      301 tgtccctatg ctgttgcttc acatgggctg ggatcctctg cccttgtgtt gaattgtgac
      361 tttggaatgt gcaggttgtg ttaagtacaa ggcgaatctc tatgggtaac gtctgtgttg
      421 gagaagccat ttgtcaacca tggtaaaact tgcaaaccca ctttacacag agtggattct
      481 tgaagcagtg cagaaaatca agaagcagaa gcagcggccc tcagaagaga ggatctgcca
      541 tgcggtcagc acgtcccatg ggttggacaa gaaaacagtc tcggaacagc tggaacttag
      601 tgttcaggat ggctccgttc tcaaagtcac caacaaaggc cttgcttcat ataaggaccc
      661 agacaatcct gggcgttttt catcggttaa accgggcact ttccccaagc caaccaaggg
      721 gtccaaagga ccgccgtgta atgatctacg caatgtggat tggaataaac ttttaaagag
      781 agcaatcgaa ggccttgagg agccaaacgg ctcctccttg aagaacattg agaagtatct
      841 gagaagccag agtgatctta caggcaccac caaccatcca gcctttcagc agaggttgcg
      901 gctaggggcc aagcgtgctg tgaacaatgg gaggttactg aaggaaggac cacagtacag
      961 ggtcaatagt gggagctcag atggcaaagg ggcgccccag taccccagtg cttttccgtc
     1021 ctcactcccg cccgtcagcc ttctacccca tgagaaagac cagccccgtg ccgatcccat
     1081 tccaatatgt agcttctgtt tggggactaa agagtcaaat cgtgaaaaga aaccagaaga
     1141 actcctgtct tgtgcagatt gtggcagtag tggacaccca tcctgtctga agttttgtcc
     1201 tgagttaacc gcaaatgtga aggccttgag gtggcagtgc atcgagtgca agacgtgcag
     1261 cgcatgtcga gtccagggca aaaatgcaga taacatgctt ttttgtgatt cctgtgatag
     1321 aggattccat atggagtgct gtgacccacc actttccaga atgccaaaag ggatgtggat
     1381 ttgccaagtc tgcagaccaa agaaaaaggg aagaaaacta cttcatgaga aagctgcaca
     1441 aataaaacgg cgatatgcaa aacccattgg acgaccgaaa aataaattaa agcaacgatt
     1501 gttgtctgta accagtgatg aaggatccat gagtgcattc acaggaaggg ggtcacctgg
     1561 taggggtcaa aagactaaag tcagtaccac accttcatct ggtcatgctg cgtctgggaa
     1621 gcactcaagc agcagattgg ctgttacaga ccccacccgg cctggtgcca ccaccaaaac
     1681 caccacctcc tccacctaca tttctgcctc tacacttaaa gttaacaaga aaaccaaagg
     1741 gctcattgat ggccttacta agttttttac accatcacct gatggtcgca gatcccgagg
     1801 tgaaataata gacttttcaa agcactatcg tccaaggaaa aaggtctctc agaaacagtc
     1861 atgcacttct catgtgttgg ctacagatac tgatattaaa ataagcatca aacaagaaag
     1921 tgcagatgtg agtctggtgg gaaacaagga gctcgtgact gaagaggatc tggacgtttt
     1981 taagcaggcc caggaactgt cttgggagaa aatagagtgt gaaagtggag tggaagactg
     2041 tggtcggtac ccctcagtaa tagagttcgg gaaatacgag atccaaacct ggtactcctc
     2101 gccttaccca caggaatatg caagattacc aaagctttac ctgtgtgaat tctgtcttaa
     2161 atatatgaag agtaaaaata ttttgctaag acactcaaag aagtgtggat ggtttcatcc
     2221 tccggccaat gagatttacc gaaggaaaga cctttcagta ttcgaggttg atgggaatat
     2281 gagtaaaatt tattgccaaa acctttgctt gttagccaag ctcttcctgg accacaaaac
     2341 attgtattat gatgttgagc cattcctttt ttatgtcctt acaaaaaatg atgaaaaagg
     2401 ctgtcatctg gttggatact tctccaagga aaagctctgc cagcagaagt ataatgtgtc
     2461 ctgcataatg atcatgcccc agcaccaaag gcaaggattt ggacgctttc tcattgattt
     2521 cagctatttg ctttctcgaa gagaaggcca agcagggtct cccgaaaagc cgctctctga
     2581 cctgggccgg ctctcctacc tggcctactg gaaaagtgtc atcttggaat acctctaccg
     2641 ccaccacgag aggcacatca gcatcaaggc cattagcaga gccacaggca tgtgcccaca
     2701 tgacatcgcc accactctgc agcacctcca catgattgac aggagggatg gcaggtttgt
     2761 catcattaga agggaaaagt tgatattggg ccacatggaa aagctgaaga actgttcccg
     2821 acccaatgaa cttgatccgg agagtctaag atggacccca atgttaattt ctaatgctgt
     2881 ggtttctgag gaagagcgag aagctgagaa ggaggctgaa cgactaatgg aacaagccag
     2941 ctgctgggag aaggaggagc aagagatcct gtcgtccaga gttagcagta ggcaatcgtc
     3001 tgcaaaagta caatcaaaga ataagtacct gcactcccca gagaggcggc cagtggccgg
     3061 ggagcgagga cagttgttag agctgtccaa agagagcagt gaggaagagg aggaggagga
     3121 ggaggaagat gatgaggaag aggaggagga ggaagaggag gagagcattc agacatctcc
     3181 ccctcggttg actaagccac agtcagtttc cattaaaaga aagaggcctt ttgtagtaaa
     3241 gaagaaaagg ggtcgtaaac gcaggaggat caacagcagt gtcaccaccg agaccatttc
     3301 cgagacgaca gaagtgctca atgagccctt cgacaactcg gatgaggaga ggccaatgcc
     3361 gcagctggag cctacctgtg agatcccagt ggaggagggc ggcaggaagc cagttctgag
     3421 gaaagcattc ccacatcagc cagggaagaa aaggcagaca gaggaagagg aaggggaaga
     3481 caatcatttc ttcaagaccg ctgccctttg tagaaaagat gtagatgatg atgcagaaca
     3541 cttgaaagaa ggcagcaaag acaatcctga gcctctaaag tgcagacaag tgtggccaaa
     3601 aggagcgaag cgagggctct ccaagtggaa gcaaagcaag gagaggaaga cgggcttcaa
     3661 gctgaacctg tacaccccac cagagacacc catggagcca gaggaccagg tgacgatcga
     3721 agagcagaag gagctttcag aggacaaggg cagccccgtg gggatggaac gggaggtgac
     3781 agagaccgtg gatgccttgc tgcctcagga ggggagcaga agggaagaga caggcatacc
     3841 cgtgagtcca cataaatcac caggtggaaa ggtagatgag gaggacctca tcagaggtga
     3901 ggaggaggga gaggaagagg gagaggagga gggagaacga gaagaacagg aagaggaaga
     3961 agaagtaact acagaaaaag acctagatgg tgctaaaagt aaagagaacc cggagcctga
     4021 gatctccatg gaaaaggaag accctgtgca tctgggtgac catgaagagg acgaggatga
     4081 ggaggaagag ccatctcaca atgaggacca tgatgcagat gatgaagatg atggccacat
     4141 ggaggctgcc aacatggaga ggggagacct cccaagagaa accttcaaag acgcactaga
     4201 gggccaggag gcttttttag acctgagcat tcagccgagt cactcgaacc ctgaagtctt
     4261 gatgaactgc ggtgttgatc tcacaatgtc ctgtaacagt gagccaaagg agcttgctgg
     4321 ggacactgga actgcacctg agtctgacgc ggagcccccg gaagaacaga cacagaagca
     4381 ggaccaaaag aacagcgatg gtgtggatgc tgagctcgaa gagggaggcc cagccgctgt
     4441 ggaaattgac tccgagaccg cccaggctgt tcagtctttg acccaagaaa acagggagca
     4501 cgatgacacc tttccagatt gtgctgagac tcaagaggcc tgtagaagcc tgcagaacta
     4561 tacacacaca gaccaaagtc ctcaaattgc caccacgctg gacgagtgcc aacagtcaga
     4621 ccacagtagc ccagtttcat ctgtccattc ccatcctggc cagtcagttc gttctgtcaa
     4681 tagccccagt gtccctgccc tagagaatag ctatgcccaa atcagccccg atcagactgc
     4741 catcacagtg ccacctctgc agaacatgga gaccagtcca atgatggacg tcccgtcagt
     4801 gtcagatcac tcacagcagg tcgttgacag cggattcagt gacctgggca gtattgagag
     4861 cacaacagag aactatgaga acccaagcag ctatgactca accatgggag gcagtatctg
     4921 tggaaacggc tcttcccaga acagctgctc ctacagcagt ctcacctcta gcaatctgac
     4981 acagaacagc tgtgctgtca cccagcagat gtccaacatc agtgggagct gcagcatgct
     5041 gcagcagacc agcatcagct cccctccaac ctgcagcgtc aagtctcccc aaggctgtgt
     5101 ggtggagagg cctcccagta gcagccagca gctggctcag tgcagcatgg ccgccaattt
     5161 caccccaccc atgcagctgg ctgacatccc cgagaccagc aatgccaaca ttggcttata
     5221 tgagcgaatg ggtcaaagtg attttggggc tgggcactac ccacagccat ctgccacctt
     5281 cagccttgcc aaactgcagc agttaactaa tacacttatt gatcattcat tgccttacag
     5341 ccattccgct gctgtgacct cctatgcaaa cagtgcctct ttgtccacac cattaagtaa
     5401 cacagggctt gttcagcttt cgcagtctcc acactctgtc cctggagggc cccaagcaca
     5461 agctaccatg accccacccc ctaacctgac tcctcctccc atgaatctgc caccacctct
     5521 cctgcagcgg aacatggctg catcaaatat tggcatctcc cacagccaaa gactgcaaac
     5581 tcagattgcc agcaagggcc acgtctccat gagaaccaag gcggcatctc tgtcaccagc
     5641 tgccgccacc catcagtcac aaatctatgg gcgttcccag actgtagcca tgcagggtcc
     5701 tgcacggact ttaacgatgc aaagaggcat gaacatgagt gtgaacttga tgccagcgcc
     5761 agcctacaat gtcaactcgg tgaacatgaa catgaacact ctgaatgcca tgaatgggta
     5821 tagcatgtcc cagccgatga tgaacagtgg ttaccacagc aaccacggct atatgaatca
     5881 aaccccccag taccctatgc agatgcagat gggcatgatg ggaagccagc catacgccca
     5941 gcagccaatg cagaccccac cccacgctaa catgatgtac acggcccccg gacaccacgg
     6001 ctacatgaac acaggcatgt ccaaacagtc tctcaatggg tcctacatga gaaggtagac
     6061 agcctggcag cccacccagc ccactgggcc ccactattgg attgatctgc acaaatacct
     6121 ttgaagagta cgatttcaaa accagcattg gtgtgaatgc aaaaacattt gttggcacca
     6181 tttatttaaa aaaaaaaaag ctgtatgcag cagaaagaaa gccttataca agttgttttt
     6241 cttttttcct ttttttcttt tttggtacct ttatttctgt tacttttata taaaattctc
     6301 tgcaaaggaa ggcctctctt aggactctag ttggcagcgg ccacacgtcg tgcctgcttc
     6361 cattaaacag tgtggataca agcccctccc caaatcacct gttttaatac tgaacctcca
     6421 gcttttctcc ttcctgtcta ctccatggaa atgcctttag catttcaatt actgtatatt
     6481 ttgtttaagg tgacccttca gcatgccgct aatgtctttg ttagtgacag tgcattttgt
     6541 agtactgtac aagtgttgtg ctaacggtaa gccatttctt aagttttttg ccttgattag
     6601 ggtaccctaa tttgagggtt aaaaaaaaca aaacaaaaca aagctctatt tttgttaatt
     6661 ataaaactgt aaagagctac agagctatcc ccgtctggtt agtgaagggg gtttatcgct
     6721 aaatgtttgg tgtaaagttg agaagacctt tttccatttt ggtggcaggc tcctttgggg
     6781 ggaggcagct ttctgtttta taaatgcaca cttctgttta ttgaatgaag catatctcag
     6841 tgtttatctg tcaggttttg aagcatttca tatatgtcca aatacttggc aggatttaaa
     6901 aaaaaatagt gaatttggtg taaagttgct attttatgga aatgcctcta actttacatt
     6961 ttcattccat ctgtagattt ttctatcttt ataaaatatt ggagttattt tttaaggaaa
     7021 aatagaaaag tagcttgtga atagctcaaa ctaagcttac aaatcgcatg taaaaaagca
     7081 gaaaagttat ttgtgtctgt ttctattgcg tcctttttta gcctttgtac ctggacaggt
     7141 gacagtaagg gccaagcagg agaggcgggc gcggccttgt ataaaatagg agccagcggg
     7201 actcttgtat ctacctgttc tctttttagt cagttacttc aaaaaaaaga aaaagcaaaa
     7261 acaaaaaaac aaaagctgta cattttaaca taaaataaat tatgatgagc catttctagc
     7321 ctctcgtgtc ctgtcatgtt atgattgatg gagaatgacc agctgagctg tgtcatgtgt
     7381 cacatttcag aacacataca cgatggggga aataaattat ttagtgtaaa ttgaagttat
     7441 gagatttttt ttttctgatt tgttttgact ttgggggagg ggttggcaat aagtatgaat
     7501 gagtactatc taataaaacc atcacctata ccaaatacct atttaataaa ttaatttata
     7561 atggatttta atgcttttcc atgaaagttg actttatgct ggtgcatacc ttctgtatgc
     7621 caatcattgt ctttaaataa agtgagtttg gttttttctt tt
//
