LOCUS       NM_001081149            9116 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus K(lysine) acetyltransferase 6A (Kat6a), transcript
            variant 1, mRNA.
ACCESSION   NM_001081149 XM_146248
VERSION     NM_001081149.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9116)
  AUTHORS   Sheridan,M., Maqbool,M.A., Largeot,A., Clayfield,L., Xu,J.,
            Moncaut,N., Sellers,R., Whittle,J., Paggetti,J., Iqbal,M.,
            Aucagne,R., Delva,L., Baker,S.M., Lie-A-Ling,M., Kouskoff,V. and
            Lacaud,G.
  TITLE     The small inhibitor WM-1119 effectively targets KAT6A-rearranged
            AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic
            dependency
  JOURNAL   J Hematol Oncol 17 (1), 91 (2024)
   PUBMED   39380002
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9116)
  AUTHORS   Liu,Y., Fan,M., Yang,J., Mihaljevic,L., Chen,K.H., Ye,Y., Sun,S.
            and Qiu,Z.
  TITLE     KAT6A deficiency impairs cognitive functions through suppressing
            RSPO2/Wnt signaling in hippocampal CA3
  JOURNAL   Sci Adv 10 (20), eadm9326 (2024)
   PUBMED   38758792
  REMARK    GeneRIF: KAT6A deficiency impairs cognitive functions through
            suppressing RSPO2/Wnt signaling in hippocampal CA3.
REFERENCE   3  (bases 1 to 9116)
  AUTHORS   Fu,J.Y., Huang,S.J., Wang,B.L., Yin,J.H., Chen,C.Y., Xu,J.B.,
            Chen,Y.L., Xu,S., Dong,T., Zhou,H.N., Ma,X.Y., Pu,Y.P., Li,H.,
            Yang,X.J., Xie,L.S., Wang,Z.J., Luo,Q., Shao,Y.X., Ye,L.,
            Zong,Z.R., Wei,X.D., Xiao,W.W., Niu,S.T., Liu,Y.M., Xu,H.P.,
            Yu,C.Q., Duan,S.Z. and Zheng,L.Y.
  TITLE     Lysine acetyltransferase 6A maintains CD4+ T cell response via
            epigenetic reprogramming of glucose metabolism in autoimmunity
  JOURNAL   Cell Metab 36 (3), 557-574 (2024)
   PUBMED   38237601
  REMARK    GeneRIF: Lysine acetyltransferase 6A maintains CD4[+] T cell
            response via epigenetic reprogramming of glucose metabolism in
            autoimmunity.
REFERENCE   4  (bases 1 to 9116)
  AUTHORS   Mah,S.Y.Y., Vanyai,H.K., Li-Wai-Suen,C.S.N., Garnham,A.L., Wynn,J.,
            Bergamasco,M.I., Malelang,S., Wilcox,S., Biben,C., Smyth,G.K.,
            Thomas,T. and Voss,A.K.
  TITLE     ING4 and ING5 are essential for histone H3 lysine 14 acetylation
            and epicardial cell lineage development
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38446206
REFERENCE   5  (bases 1 to 9116)
  AUTHORS   Katsumoto,T., Ogawara,Y., Yamagata,K., Aikawa,Y., Goitsuka,R.,
            Nakamura,T. and Kitabayashi,I.
  TITLE     MOZ is critical for the development of MOZ/MLL fusion-induced
            leukemia through regulation of Hoxa9/Meis1 expression
  JOURNAL   Blood Adv 6 (19), 5527-5537 (2022)
   PUBMED   35947126
  REMARK    GeneRIF: MOZ is critical for the development of MOZ/MLL
            fusion-induced leukemia through regulation of Hoxa9/Meis1
            expression.
REFERENCE   6  (bases 1 to 9116)
  AUTHORS   Katsumoto,T., Aikawa,Y., Iwama,A., Ueda,S., Ichikawa,H., Ochiya,T.
            and Kitabayashi,I.
  TITLE     MOZ is essential for maintenance of hematopoietic stem cells
  JOURNAL   Genes Dev 20 (10), 1321-1330 (2006)
   PUBMED   16702405
  REMARK    GeneRIF: MOZ is required for maintenance of hematopoietic stem
            cells, and that it plays a role in differentiation of erythroid and
            myeloid cells.
REFERENCE   7  (bases 1 to 9116)
  AUTHORS   Thomas,T., Corcoran,L.M., Gugasyan,R., Dixon,M.P., Brodnicki,T.,
            Nutt,S.L., Metcalf,D. and Voss,A.K.
  TITLE     Monocytic leukemia zinc finger protein is essential for the
            development of long-term reconstituting hematopoietic stem cells
  JOURNAL   Genes Dev 20 (9), 1175-1186 (2006)
   PUBMED   16651658
  REMARK    GeneRIF: Moz is essential for a fundamental property of
            hematopoietic stem cells, the ability to reconstitute the
            hematopoietic system of a recipient after transplantation and that
            Moz is specifically required in the stem cell compartment.
REFERENCE   8  (bases 1 to 9116)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   9  (bases 1 to 9116)
  AUTHORS   Kitabayashi,I., Aikawa,Y., Nguyen,L.A., Yokoyama,A. and Ohki,M.
  TITLE     Activation of AML1-mediated transcription by MOZ and inhibition by
            the MOZ-CBP fusion protein
  JOURNAL   EMBO J 20 (24), 7184-7196 (2001)
   PUBMED   11742995
REFERENCE   10 (bases 1 to 9116)
  AUTHORS   Misawa,K., Nosaka,T., Morita,S., Kaneko,A., Nakahata,T., Asano,S.
            and Kitamura,T.
  TITLE     A method to identify cDNAs based on localization of green
            fluorescent protein fusion products
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3062-3066 (2000)
   PUBMED   10716735
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC142414.3 and AC115361.5.
            
            On Jun 16, 2018 this sequence version replaced NM_001081149.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143408.1, AK082463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC142414.3         77829-77915         c
            88-173              AC142414.3         75859-75944         c
            174-1087            AC142414.3         74660-75573         c
            1088-1196           AC142414.3         34245-34353         c
            1197-1312           AC142414.3         29700-29815         c
            1313-1394           AC142414.3         29137-29218         c
            1395-1530           AC142414.3         27194-27329         c
            1531-1847           AC142414.3         25485-25801         c
            1848-1966           AC142414.3         23074-23192         c
            1967-2082           AC142414.3         18021-18136         c
            2083-2224           AC142414.3         13805-13946         c
            2225-2386           AC142414.3         12019-12180         c
            2387-2480           AC142414.3         10991-11084         c
            2481-2712           AC142414.3         8014-8245           c
            2713-2926           AC142414.3         7083-7296           c
            2927-3526           AC142414.3         4747-5346           c
            3527-3845           AC142414.3         1663-1981           c
            3846-9116           AC115361.5         126432-131702
FEATURES             Location/Qualifiers
     source          1..9116
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 11.42 cM"
     gene            1..9116
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /note="K(lysine) acetyltransferase 6A"
                     /db_xref="GeneID:244349"
                     /db_xref="MGI:MGI:2442415"
     exon            1..87
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            88..173
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            174..1087
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..6499
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /EC_number="2.3.1.48"
                     /note="histone acetyltransferase MYST3; monocytic leukemia
                     zinc finger homolog; monocytic leukemia zinc finger
                     protein; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; zinc
                     finger protein 220; MYST histone acetyltransferase
                     (monocytic leukemia) 3"
                     /codon_start=1
                     /product="histone acetyltransferase KAT6A"
                     /protein_id="NP_001074618.1"
                     /db_xref="CCDS:CCDS40294.1"
                     /db_xref="GeneID:244349"
                     /db_xref="MGI:MGI:2442415"
                     /translation="MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDR
                     RTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGKLDTKQSVDWNKL
                     LKRAFEGLAETGGSTLKSIERFLKSQKDVSAACGGSAAPGFHQQLRLAIKRAVGHGRL
                     LKDGPLYRLNTKAASAEGKEGCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQ
                     NREKQPEELVSCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNAD
                     NMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYANP
                     IGRPKNRLKKQNTVSKGPFSKVRTGPGRGRKRKITVSSQSASSSEEGYLERIDGLDFC
                     RDSNAPLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKKGNRKSSTSD
                     WPTDNQDGWESKQENEERLFGSQEIMTERDMELFRDIQEQALQKVGVTGPPDPQVRCP
                     SVIEFGKYEIHTWYSSPYPQEYSRLPKLYLCEFCLKYMKSRTILQQHMKKCGWFHPPA
                     NEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKG
                     CHLVGYFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPL
                     SDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLTGVCPQDITSTLHHLRMLDFRS
                     DQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEDEDEEADEGEK
                     EEPQGQERELETRVKVGKSVSREKKDQESSSLIETDKKPEVKELASSSRLSKQALPRD
                     SLPANSQPPRRGRCGRKNRKTQERFGDKDSKMLVDETLSASQEQYGDCEEKSETSQER
                     FTEMEEQLAAPQVQADGKPDIPKGRFSESVELWRGQLKKSPETLKCRLPEGNDRLPCC
                     YTDGDRAVFRGFSESSEEEEEPESPRSNSPPILTKPTLKRKKPILHRRRRVRKRKHHN
                     SSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEMEEEEEEEEEESELFPRGYFHC
                     LSSQDILRCQSSSKRPSKEEEEEEEESDDADDTPVLKPVSLLRKCDVNSASLEPDTST
                     PMKKKKGWPKGKSRKPIHWKKRPGRKPGFKLNQEIIAASAQECIVEPVVPIKPGRKPR
                     TQENEEIVEVKEDLLEERKEEMHTEPDEEAEEEEDTTSSDIRAMSPLDSSNSPEAEPK
                     EPEPEEEDEKPSDDQRQSEEEPQELEEQEQEEEDEVTTEANQNEDHDADDEDEGHLDS
                     LKTKEPEEQPAREDDKEEPGIQGSFLAANMQDSRENTKDKDEAEPDSEEDQPSHEASV
                     VSETMPGSEEDHEEDSNTKEELIELKEEEEIPHSELDLETVQAVQSLTQEESSEHEGA
                     YQDCEETLAACQTLQSYTHTDEDPQMSMVEDCHASEHNSPISSIPSHPSQSVRSVNSP
                     SMPALESGYTQISPEQGSLSAPSMQNMETSPMMDVPSVSDHSQQVVDSGFSDLGSIES
                     TTENYENPSSYDSTMGSSICGNNSSQSSCSYGGLSSSSSLTQNSCVVTQQMANMGNSC
                     SMLQQNTVQPAANCNIKSPQTCVVERPPSNQQPPPPPPPPPPPQQPQPPPQQQAAPQP
                     PPPQPQQQQQQQQQPPPPQQQPQPPPPQQQPPLSQCSMNNSFTAAPMIMEIPESGSTG
                     NISIYERIPGDFGAGSYSQPSATFSLAKLQQLTNTIMDPHAMPYSHSPAVTSYATSVS
                     LSNTGLAQLAPSHPLAGTPQAQATMTPPPNLASTTMNLTSPLLQCNMSATNIGIPHTQ
                     RLQGQMPVKGHISIRSKSAPLPSATAHQQQLYGRSPPAVAMQAGPRALAVQRGMNMGV
                     NLMPTPAYNVNSMNMNTLNAMNSYRMTQPMMNSSYHSNPAYMNQTAQYPMQMQMGMMG
                     SQAYTQQPMQPNPHGNMMYTGPSHHSYMNAAGVPKQSLNGPYMRR"
     exon            1088..1196
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1312
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1394
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1530
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1847
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1966
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2082
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2224
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2386
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2480
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2712
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2926
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..3526
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3845
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..9116
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9091..9096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /note="hexamer: AATAAA"
     polyA_site      9116
                     /gene="Kat6a"
                     /gene_synonym="1500036M03; 9930021N24Rik; MOZ; Myst3;
                     Zfp220"
                     /note="major polyA site"
ORIGIN      
        1 actgtctcca agatggcggc cgtgtcagtt tggggcatct ccgcggtccg gcccgggccc
       61 ccgggatccc ggctgtcttc cccccaggat tcttcctact aatccagata cttgttgaag
      121 tgctgaatag tttcttgggg acaatgtgga ggacgagttg accccctaga ctggcttaag
      181 atactcactt tctgcttgaa gccgggaatg agatgtgtgg aacccaggag tgtgtgtgga
      241 gtagacacca atgcgttgtg atagtgagga ttttgaagat acgacagaaa aaccaggcgt
      301 tttgatttct gaggtaaaag taggctgtaa atctattttg tgaaaggagg gaagactcag
      361 gccagaaatc ttgtatgcta tggttaactg gttcccatcc tccgagaatc ctgttttcca
      421 tggtgtaaga cttactcagc atcaggataa gggataacga ctctatggat atacagaatc
      481 cttcaccatg gtaaaactcg ctaacccgct gtacacggag tggattttgg aggccatcaa
      541 aaaagtcaag aagcagaaac agcgaccttc agaggaaagg atctgcaatg ccgtgtcctc
      601 atcccatggg ctggaccgca ggactgtgct agagcagctg gagctgagcg tcaaagacgg
      661 gacgatttta aaggtctcaa acaaaggtct caattcctac aaagatcctg ataatcctgg
      721 gcgaatagca cttcctaaac ctcggaacca tggaaaattg gatactaagc aaagtgtgga
      781 ttggaataaa ttactcaagc gggcatttga gggcttggca gagactggtg gctcaacttt
      841 gaaaagtatc gaacgttttt tgaaaagcca gaaggatgta tctgctgcct gtggaggtag
      901 tgctgcccct gggtttcacc agcagctacg attggccatc aagcgtgctg ttggtcatgg
      961 ccgactcctc aaagatggac ccctctaccg cctcaacact aaggcagcca gtgctgaagg
     1021 gaaagagggc tgtgagtcgc tctcgtgttt acctcccgtg tcactgcttc cacacgagaa
     1081 agacaagccg gttgctgaac caatccccat ctgtagcttc tgtcttggta caaaagagca
     1141 gaaccgggag aagcagcccg aggaactcgt ctcctgcgcg gactgcggca atagcggtca
     1201 tccatcgtgt ttaaagttct ccccagagct aacagtgaga gtgaaggcct tacggtggca
     1261 gtgcattgag tgtaaaacat gcagctcctg tcgtgaccaa ggcaaaaacg cagataacat
     1321 gctcttttgt gactcatgtg accgaggttt tcacatggag tgttgtgacc caccacttac
     1381 acggatgcca aaaggtatgt ggatatgtca gatatgccga cctaggaaaa aaggacggaa
     1441 acttctacaa aagaaggcgg cacagataaa acggcgctat gctaatccaa taggacgtcc
     1501 aaaaaacagg ttaaagaaac aaaacacggt atcaaaaggt ccctttagca aagttcgaac
     1561 tggtcctgga aggggtcgga aacgtaaaat cactgtctcc agccagtctg catcatcatc
     1621 agaagaaggc tatttagagc ggatagatgg cttggacttc tgcagagata gcaatgcccc
     1681 cttgaagttc aacaagaaaa ccaaagggct cattgatggc cttaccaaat tcttcacccc
     1741 ttctcctgat gggcggaaag cccgagggga agtggtagac tactctgagc aatacagaat
     1801 caggaaaaag ggcaacagga aatcaagtac ttcagattgg cccacagaca atcaggacgg
     1861 ctgggaaagc aaacaagaaa atgaggaacg gctttttggg agccaagaaa tcatgactga
     1921 aagagatatg gaattgtttc gtgatatcca agaacaagca ctgcagaagg tcggagtaac
     1981 tgggccccct gatccacaag tccgctgtcc ctctgtcatt gagtttggga agtatgaaat
     2041 ccacacctgg tattcctctc cgtaccctca ggagtactca aggctgccta aattgtatct
     2101 ttgtgagttc tgtctaaaat atatgaaaag tagaactatt ctacagcagc acatgaagaa
     2161 atgtggttgg ttccatcctc ctgccaatga gatttaccga aagaataata tttctgtctt
     2221 tgaggttgat gggaacgtga gtaccattta ttgtcaaaat ctgtgtctct tggcaaagtt
     2281 gtttcttgac cacaaaacac tctattatga cgtggagcca tttcttttct atgttctaac
     2341 acagaatgat gtcaagggct gccaccttgt tggctacttt tctaaagaaa agcactgcca
     2401 acagaaatac aatgtctcct gtataatgat tcttccccaa taccaacgta agggctacgg
     2461 caggtttctc atcgatttca gttatttgtt atcaaagcgt gaaggccaag caggctctcc
     2521 tgagaaacca ttatcagatc taggtcgtct ctcctacatg gcttactgga agagtgtgat
     2581 cctggagtgc ctttatcacc aaaatgacaa gcagatcagc atcaagaagc tgagcaagct
     2641 gactggagtc tgccctcagg acatcacgtc cacactgcac cacctacgaa tgctggactt
     2701 ccgcagtgac caatttgtga ttatccgccg ggagaaactt atccaggatc acatggcaaa
     2761 gctgcagctg aaccttcggc ctgtagatgt agatccagag tgcttacgct ggactccagt
     2821 catagtctcc aattctgtgg tctccgagga tgaagacgag gaggccgatg agggagagaa
     2881 agaagagccc caaggccaag aaagagagct agagaccagg gtaaaggtgg ggaagtctgt
     2941 gtctcgggag aaaaaagatc aggagtcttc ctctttaata gaaactgaca agaagccaga
     3001 agttaaggaa ctagccagtt cttcacgttt gagcaaacag gcccttcctc gggacagtct
     3061 tcctgcaaat agccagccac ctcggagggg ccgctgtggg aggaagaaca gaaagacaca
     3121 agaacgcttt ggtgataaag attctaagat gcttgtggat gagacactat ccgcttctca
     3181 agagcaatat ggagactgcg aggaaaagtc agaaacctcc caagaacggt tcactgagat
     3241 ggaagagcag ttggcagccc ctcaagtgca agcagacggg aaaccagaca tccccaaggg
     3301 gaggttcagt gagagcgttg agttgtggcg aggacagctg aagaaaagcc ctgagaccct
     3361 gaagtgccga ttgccagaag gaaatgaccg gcttccgtgc tgctacaccg atggtgacag
     3421 ggctgtcttt aggggcttca gcgagagcag tgaggaggag gaagagccag agagtccccg
     3481 gtcaaactcg ccaccaattc tcacgaagcc cacactgaaa agaaagaaac cgattcttca
     3541 ccgaagacga agagtccgca agcggaaaca ccacaatagc agtgtagtca cagagaccat
     3601 ctctgagacc acggaggtgt tagatgagcc ttttgaagac tctgactctg agagaccaat
     3661 gccacgactg gagcctacat ttgagatgga ggaagaggag gaggaggagg aggaggagag
     3721 tgagctcttc cccagagggt acttccattg cctgtcctca caggacatcc ttaggtgtca
     3781 gtcctcctcc aagaggccgt ctaaagagga agaggaggag gaggaggagt cagacgacgc
     3841 agatgacact cctgtcctaa agccagtatc tctcttgcga aaatgtgatg tgaacagtgc
     3901 ttcacttgag ccagatacct ctacacctat gaaaaagaaa aagggatggc ccaaaggcaa
     3961 gagccgaaaa cctatccact ggaagaaaag gcctggacgg aaaccaggat ttaaattgaa
     4021 tcaggaaatc atagctgctt ctgcacagga atgcatagtt gagcccgtag tccccattaa
     4081 accaggccgt aaacccagaa ctcaagagaa tgaagaaatt gttgaggtaa aggaggactt
     4141 gctggaagaa aggaaagaag agatgcacac agaaccagat gaggaggccg aagaggaaga
     4201 ggatacaacc agcagtgaca ttagagccat gtccccattg gacagcagca acagccctga
     4261 ggcagaacca aaagaacccg agccagagga ggaagacgag aagccttcgg acgatcagag
     4321 gcagtcagag gaagagcccc aagagctgga ggagcaggag caggaggaag aagatgaagt
     4381 gaccacagag gccaaccaga acgaagacca tgacgctgac gatgaggacg aaggccacct
     4441 ggattcgcta aagacaaaag agccagagga gcagccagct agagaagacg acaaggagga
     4501 gcctggcatc cagggatctt ttttagctgc aaacatgcag gacagtaggg agaatacaaa
     4561 ggataaagat gaggctgaac cggattctga ggaagaccag ccttcccatg aggcttctgt
     4621 ggtatcagaa accatgccag gctcagagga ggaccatgag gaagactcca acactaagga
     4681 agagttaatt gagctaaagg aggaggaaga gatcccacac agcgaactgg acctggagac
     4741 tgtacaggca gtgcaatctt tgactcaaga agaaagcagt gagcatgaag gagcctacca
     4801 ggactgtgaa gaaactcttg cagcctgcca gacactgcag agttacaccc acactgatga
     4861 ggacccccag atgtcaatgg ttgaagactg tcatgcttca gagcataata gcccgatatc
     4921 ctccattccg tctcatccta gccagtcagt ccgctctgtc aacagcccca gcatgcctgc
     4981 cctggagagt ggctacacac agatcagccc agagcaagga tccctgtccg caccctctat
     5041 gcagaacatg gagaccagcc ccatgatgga tgtgccttcc gtatcagacc actctcagca
     5101 ggtggtagac agcggcttca gtgatctggg cagcatcgag agtaccacag agaactatga
     5161 gaacccaagc agctatgatt ccaccatggg cagcagcatt tgtgggaata attcctctca
     5221 gagcagctgc tcgtatggcg gcctgtcgtc ttcaagcagc ctcacccaga acagttgtgt
     5281 tgttactcag caaatggcca acatgggcaa cagctgcagc atgctgcaac agaacactgt
     5341 ccaaccagcc gccaactgca atatcaagtc accgcagact tgtgtggtgg aaaggcctcc
     5401 cagtaaccag cagccacccc cgccaccacc cccgccgcca ccaccacagc agccgcagcc
     5461 gccgccacag caacaggcgg ccccacagcc tcccccacca cagccgcagc agcagcagca
     5521 gcaacagcag cagccccctc caccacagca gcagccccag ccccctccac cacagcagca
     5581 gccccctctg tctcagtgca gtatgaacaa cagcttcact gcagccccca tgataatgga
     5641 gatacccgag tctggaagca ctgggaatat cagtatctac gagaggattc caggggattt
     5701 tggtgcaggc agctactccc aaccatcagc caccttcagt ctagccaagc tgcagcagct
     5761 gaccaacacc atcatggacc ctcatgccat gccttacagt cattctccgg ctgtgacttc
     5821 ctatgcaacc agtgtttctc tgtccaacac gggactggct cagctagctc catctcatcc
     5881 cttagccggg acccctcaag cacaagccac catgactcca cccccaaatc tggcgtctac
     5941 tactatgaac ctcacgtcac ctctgctaca gtgcaacatg tctgccacca acatcggaat
     6001 tcctcacact cagaggttgc aagggcagat gccagtcaag gggcacattt ctatccgttc
     6061 caagtctgca cctttaccct ctgcaactgc acaccaacag cagctatatg gccgcagccc
     6121 accagcagtt gccatgcagg ctggccctcg tgcattggct gttcagcgtg gcatgaacat
     6181 gggggttaat ttaatgccca ctccagccta taatgtcaat tccatgaata tgaacacctt
     6241 gaatgccatg aacagttatc gaatgacaca gcccatgatg aacagcagtt accatagtaa
     6301 ccctgcctac atgaaccaga cagcacagta tcctatgcag atgcagatgg ggatgatggg
     6361 aagccaggcc tatacccagc agcctatgca gccaaaccct cacgggaaca tgatgtacac
     6421 tggcccctcc catcacagct acatgaatgc tgctggcgtg cccaagcagt cacttaacgg
     6481 accttacatg aggagatgag cgaggtggac cggcagtcag aagcttaaat atatataaat
     6541 aaaggaactt tttatactga caaaccagag aaaaaaatgg accttttttc caattaaaat
     6601 attactgtag agttagagga gtttttcttt ggtttattat tattactgtt tttgttttgt
     6661 ttttagaaaa cctgatctct ttttgggggt tcaactttgt tttgggtttt tgttttcttc
     6721 acagtcttga acattttaca gtagaactca tctaaagatg gatttgggta gggaaacatg
     6781 cacagaatct tttcataatt aaaaggagcc ttactttctt tatataccac atggacagaa
     6841 gttatgtcaa cgtgaattta tttttatttt acaatgtatg tttcccctca ctgtctgcag
     6901 ctcccgctgt tgtcatttta aatgttatat atacatctca agggtcaccc aggccctgtc
     6961 ctccagaccc aaccttcatt tcccacttca ttccaacagg aggcacttag gggaactggg
     7021 atggggacgt ggagaacaac ccaagctcct taaacttaat gttgttgttg ttattattca
     7081 taaagtgaag caggtaatgt ttctccttgt aaaattccct cccctcctcc ctgtgtgtgc
     7141 gcgcacacac acacacacac acacacacac cccctctgga aacttttccc caagagtgtt
     7201 tctaggtaga cttcattgaa attgtttttc cttaatcaag tataatataa ttcttttttt
     7261 tttaaaatat tcccactcag cactcagaga cacaaaaata ctgtaagtct cacttaacag
     7321 cagaatctca gaggaaagct gtttgcaatc ctactccagc ctttggagga ctcagagggt
     7381 cagctaacaa tcagaaaggg gaggtgtacc tcttggtctg taccacctgg tggaccagcc
     7441 ataacatgca cactccactc gcctctgtag tatgtacttg gaaatgtgga ctaagggtct
     7501 tgtgcttgca cctttgactc tggtaaccct cagagcaagc ccctgtgatt tgcctgtcat
     7561 atcttatcca gtctccacga acgactgtag tgtcagtgac ttagaaaacc cctggtgcag
     7621 acggagtccc aagggagatg atggtgtgac tcttgtagct gcagaagtga tgcatacctc
     7681 tcgttttcat tttgtcttga gatcctgaat tcacccccaa gaaccagtgt gcactagccc
     7741 ctctcctgtg aggatgagca aggagagacc caccaccagc atagtagggc acagctggca
     7801 gtagggcttc aggaggctca catgttgtct cactagtttg cccgttctct tcctactcgc
     7861 tccagggata ggtaaaaaac tatatatata attataatta tatatatata ttatatattc
     7921 catcattaga agatggaaac tattatacca gttggtatgt gcagtcaaat atccaaaagg
     7981 aggacataat gcttaaaaaa ttacctgtaa gcataaattc tctcctttat ttgtacattt
     8041 tatatagata aatttttaaa gtactaatta ggcattacat ttttttcaaa tgcacaggtt
     8101 tgttgggctt ttttatagac cttaattggc tttctcaatt aagtgtgtta gctagaaaag
     8161 cagaattcca cactgtcccg ctatcaactc tgagcatgcg caaggctgcg taggacccag
     8221 tttctctgta tatactgttc cggttcccag tcatctctgt agaatgtgca ccgtgctgcc
     8281 ctctcccaca tcttcagcta tgtcattgct tcctggatgg gatggggcag ggatgggagg
     8341 gagggaaggg aggtctattt gggaggaggg tgggtcaagg cagaaggaga cgctgttgaa
     8401 atgagggccg tgaattcact ttctgttggt ttgcagttgt gtttgggttt ctttgttttg
     8461 ttttgttttt aaattcaatc aggcagctcc cttttctgca agcctctttg tgactgtaga
     8521 actattgtag aaaaaaaaat atgttctttt ctatattata aaagaaaatt atccaacacg
     8581 gtaatattgg tacctgtcat tttttcactt ctgttttaaa aaaatgtatt tttagcaaga
     8641 taacttgggt aatcttctaa aaaagaaatt taaaaactca cttgttagtg actttgatgc
     8701 cttttaaaat gagagctttt tcatttcatt ccatctttaa aattttttat ctttgttgta
     8761 gaatattaaa aactatttta agaaagataa aaattctctt taaagagatg tctagagtgt
     8821 gtgaatagag ccccagatgc ctctaaaagc cgcatgtaca aaccgagtct actcccgtct
     8881 gtttatattt gctttcctgt tttgtaacct ctttgtactc tgttcctggt gacttgtaag
     8941 ccgaggggag gggcacctag acgccttggt gtttctccat gtcatacgct cctggccagg
     9001 cagcccccct ccctctcctt gtatgtaata tcttttcccc ctttctagca agtactttca
     9061 aaagaactct gtacatttta acataaaaaa aataaattat gttgagccat tttgga
//
