LOCUS       NM_020005               4654 bp    mRNA    linear   ROD 11-OCT-2023
DEFINITION  Mus musculus K(lysine) acetyltransferase 2B (Kat2b), transcript
            variant 1, mRNA.
ACCESSION   NM_020005 XM_001003318
VERSION     NM_020005.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4654)
  AUTHORS   Walters BW, Tan TJ, Tan CT, Dube CT, Lee KT, Koh J, Ong YHB, Tan
            VXH, Jahan FRS, Lim XN, Wan Y and Lim CY.
  TITLE     Divergent functions of histone acetyltransferases KAT2A and KAT2B
            in keratinocyte self-renewal and differentiation
  JOURNAL   J Cell Sci 136 (12) (2023)
   PUBMED   37259855
REFERENCE   2  (bases 1 to 4654)
  AUTHORS   Kumar S, Alam SS, Bareke E, Beauchamp MC, Dong Y, Chan W, Majewski
            J and Jerome-Majewska LA.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   3  (bases 1 to 4654)
  AUTHORS   Ma J, Li Y, Chen M, Wang W, Zhao Q, He B, Zhang M and Jiang Y.
  TITLE     hMSCs-derived exosome circCDK13 inhibits liver fibrosis by
            regulating the expression of MFGE8 through miR-17-5p/KAT2B
  JOURNAL   Cell Biol Toxicol 39 (2), 1-22 (2023)
   PUBMED   35484432
  REMARK    GeneRIF: hMSCs-derived exosome circCDK13 inhibits liver fibrosis by
            regulating the expression of MFGE8 through miR-17-5p/KAT2B.
REFERENCE   4  (bases 1 to 4654)
  AUTHORS   Zhou P, Li D, Luo F and Wan X.
  TITLE     NCOA2 coordinates with the transcriptional KAT2B-NF-kappaB partner
            to trigger inflammation response in acute kidney injury
  JOURNAL   Gene 832, 146583 (2022)
   PUBMED   35597525
  REMARK    GeneRIF: NCOA2 coordinates with the transcriptional KAT2B-NF-kappaB
            partner to trigger inflammation response in acute kidney injury.
REFERENCE   5  (bases 1 to 4654)
  AUTHORS   Creighton SD, Jardine KH, Desimone A, Zmetana M, Castellano S,
            Milite C, Sbardella G and Winters BD.
  TITLE     Age-dependent attenuation of spatial memory deficits by the histone
            acetyltransferase p300/CBP-associated factor (PCAF) in 3xTG
            Alzheimer's disease mice
  JOURNAL   Learn Mem 29 (3), 71-76 (2022)
   PUBMED   35169045
  REMARK    GeneRIF: Age-dependent attenuation of spatial memory deficits by
            the histone acetyltransferase p300/CBP-associated factor (PCAF) in
            3xTG Alzheimer's disease mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4654)
  AUTHORS   Schiltz RL and Nakatani Y.
  TITLE     The PCAF acetylase complex as a potential tumor suppressor
  JOURNAL   Biochim Biophys Acta 1470 (2), M37-M53 (2000)
   PUBMED   10722926
  REMARK    Review article
REFERENCE   7  (bases 1 to 4654)
  AUTHORS   Kung AL, Rebel VI, Bronson RT, Ch'ng LE, Sieff CA, Livingston DM
            and Yao TP.
  TITLE     Gene dose-dependent control of hematopoiesis and hematologic tumor
            suppression by CBP
  JOURNAL   Genes Dev 14 (3), 272-277 (2000)
   PUBMED   10673499
REFERENCE   8  (bases 1 to 4654)
  AUTHORS   Schiltz RL, Mizzen CA, Vassilev A, Cook RG, Allis CD and Nakatani
            Y.
  TITLE     Overlapping but distinct patterns of histone acetylation by the
            human coactivators p300 and PCAF within nucleosomal substrates
  JOURNAL   J Biol Chem 274 (3), 1189-1192 (1999)
   PUBMED   9880483
REFERENCE   9  (bases 1 to 4654)
  AUTHORS   Xu W, Edmondson DG and Roth SY.
  TITLE     Mammalian GCN5 and P/CAF acetyltransferases have homologous
            amino-terminal domains important for recognition of nucleosomal
            substrates
  JOURNAL   Mol Cell Biol 18 (10), 5659-5669 (1998)
   PUBMED   9742083
REFERENCE   10 (bases 1 to 4654)
  AUTHORS   Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ,
            Howard BH, Qin J and Nakatani Y.
  TITLE     Histone-like TAFs within the PCAF histone acetylase complex
  JOURNAL   Cell 94 (1), 35-44 (1998)
   PUBMED   9674425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131785.3, BC082581.1 and AC140263.3.
            
            [WARNING] On Jan 16, 2024 this sequence was replaced by
            NM_020005.5.
            
            On Jul 3, 2010 this sequence version replaced NM_020005.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156290.1, BC082581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               AC131785.3         112618-112961
            345-3005            BC082581.1         1-2661
            3006-4654           AC140263.3         126142-127790
FEATURES             Location/Qualifiers
     source          1..4654
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 27.86 cM"
     gene            1..4654
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /note="K(lysine) acetyltransferase 2B"
                     /db_xref="GeneID:18519"
                     /db_xref="MGI:MGI:1343094"
     exon            1..608
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            609..735
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            736..881
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            882..974
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1156
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1348
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1455
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1578
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1715
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1924
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2051
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2162
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2306
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2421
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2458
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2522
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2607
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..4654
                     /gene="Kat2b"
                     /gene_synonym="A930006P13Rik; p/CAF; Pcaf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtctcggc gcgggagggt gtcaggccca gggacgccag cagcgcaggg cggcaggtgc
       61 ctgggctgca gcggcccggt ctcgcgggtc gccggtcacc tacgggccct ggcgctcccg
      121 gcgggcggct acgctcgcag cagcatgccg gaggcccagg ggagcagagc gcggccaagg
      181 cgctcgggcc cgctagcgtc ctagccgcct ggggaggcgc gggggcctgc gatcgctggc
      241 ggccgagtgc ggcgggggcg gggagggcgc agggcggcgg ccgggggggg gggagggtct
      301 cggctccgcc accagcgccc gcggggaccc tggcagctgc gggtgacagt cggggcggca
      361 tggccgaggc tggcggggcc gggtccccag cactgcctcc cgcgcccccg cacggttccc
      421 cccggaccct ggccaccgct gccgggagct ctgcttcctg cgggccagcg accgcggtgg
      481 ccgcggcggg cacggccgag ggaccgggag gaggcggctc ggcccggatc gccgtgaaga
      541 aggcgcagtt gcgctctgct ccgcgggcga agaagctgga gaaactcggc gtgtactccg
      601 cctgcaaggc agaggagtcc tgtaaatgca atggctggaa gaaccctaac ccctctccta
      661 ctccaccaag aggagacctc cagcagataa ttgtcagttt gacagaatcc tgtcgaagct
      721 gtagccatgc ccttgctgct cacgtttctc acttggagaa tgtgtcagag gaagagatgg
      781 acagactcct gggaattgtg ttggatgtgg agtacctctt cacctgcgtc cacaaagaag
      841 aagatgcaga taccaaacaa gtgtacttct acctattcaa gctcttgaga aagtcaattt
      901 tacaaagagg aaaacctgtg gttgaaggct ccttggagaa gaagccgcca tttgagaagc
      961 ccagtattga acagggtgtg aacaacttcg tgcagtacaa gtttagtcac ttgccatcga
     1021 aagagaggca gacaacgatc gagctggcca agatgtttct gaaccgcatc aactactggc
     1081 atctggaggc tccatctcag cggagactac ggtctcccaa tgatgacatc tctggataca
     1141 aggaaaacta cacaaggtgg ttgtgctact gcaatgtacc gcagttctgt gacagcttac
     1201 ctcggtacga aaccacaaag gtgtttggga gaacattgct tcgctcggtc ttcaccatca
     1261 tgagacgaca gctcttggaa caagccagac aggaaaaaga caaactgcct cttgagaaac
     1321 gcacgcttat cctcacacat ttcccaaagt ttctgtccat gttggaagaa gaagtgtata
     1381 gtcaaaattc tcctatctgg gatcaggatt ttctctcagc ctcttccaga accagcccgc
     1441 taggaatcca aacagtaatc agtcctcctg ttactgggac agcattgttc agttcaaatt
     1501 ccacttccca tgagcagatc aatggaggga gaacaagtcc tggatgcaga ggctcttctg
     1561 ggcttgaagc aaacccggga gaaaagagga aaatgaacaa ctctcatgct cccgaggagg
     1621 ccaagagatc tcgagtgatg ggggatattc ccgtggaatt gatcaatgag gtcatgtcta
     1681 ccatcacaga ccctgcaggg atgcttggac cagagaccaa ttttctgtca gcccattcgg
     1741 ccagagatga ggcggcacgg ctggaagaac gcaggggtgt cattgaattc cacgtggtgg
     1801 gcaactccct gaaccagaaa ccaaacaaga agatcctgat gtggctcgtg ggcctccaga
     1861 atgtgttttc ccaccagctg cccagaatgc ccaaagagta catcacacgg ctcgtctttg
     1921 acccgaaaca caaaaccctt gctttaatta aagatggccg tgtcattggt ggtatctgtt
     1981 tccggatgtt tccatcccag ggattcacag agattgtttt ctgtgcagta acctcaaatg
     2041 aacaagtcaa gggctatgga acccacctga tgaaccatct caaagaatac cacataaagc
     2101 acgagatcct caacttcctc acatatgcag atgagtatgc catcggctat ttcaagaagc
     2161 agggtttctc caaagaaatc aaaataccta aaaccaaata tgttggctac atcaaggatt
     2221 atgaaggggc cactttgatg ggatgtgagc tgaaccctca gatcccatac acagagttct
     2281 ctgtcatcat taaaaagcag aaggagatca ttaaaaagct gatagaaaga aaacaagccc
     2341 agattcgaaa agtctaccct ggactttcgt gtttcaaaga tggagttcgg cagattccta
     2401 tagaaagcat tcctggaatc agagagacag gctggaaacc aagtggaaaa gagaaaagta
     2461 aagagcccaa agaccctgag cagctttaca gcaccctcaa gaacatcctg cagcaggtga
     2521 agaaccatcc aaatgcttgg cctttcatgg aaccagtgaa gagaacagaa gctccgggat
     2581 attatgaagt tataaggttc cccatggatc tgaaaaccat gagtgaacgc ctcaggaaca
     2641 ggtactatgt gtctaagaag ttattcatgg cggacttgca acgagtgttc accaactgca
     2701 aggagtacaa ccctcccgag agcgagtact acaaatgcgc cagcatcctg gagaagttct
     2761 tcttcagtaa aattaaggaa gcagggttga ttgacaagtg atttctttcc cttagacaca
     2821 catcagcagt gtgcctaaaa caggtcattt aggtttttgg ttgcttttgt ttttttgttt
     2881 ttgtttttaa attgtacatc atgtgttgaa gagacttgta ataattagca cttttgaaaa
     2941 acaaacaaaa cctcctttta gcttttcaga gacgtattta aatggaaatc atagattttt
     3001 tttttatttt gagcaataga ttttaatcta tttactacta tcatgtaatt tttctctggc
     3061 atgtccagta gctgactatt gcatggtaga tgatcagggg cttcctcaaa acctgtatgt
     3121 gaggaaattg cacacagtac caagatttgg ggtaatctag agaaaagttt gaccatgaat
     3181 gtctccattt tttttctaat ggaacatgag agtttatttt attctgaagg actttaaagg
     3241 gtccgtgaca cacctgtgct gtgaatgaac tgtgtgatgt ttgaagtctc cttgtagact
     3301 ttttataagt atatattttt aaaacactca tctagatgag gtgctttgag cagttctgaa
     3361 aaaaaaaaat gcagcttcca caatagcggc tgctatgact cctaaggaag ggacttttta
     3421 taagctcctg gggctttgat cattctgtct acctattaca gacttgagag tgcacaacca
     3481 ctatttaata atatcttggc agatatgtgt ccatctcata tttgactttg cttgtgcagg
     3541 gcccaacttc taaaagatcc gttcccaggc cacaaaggtg ttagcttgaa aatatttgag
     3601 gttgagttaa tgttaagaca tgtggcctaa acatgaaccc aggggagcct tgcttcacta
     3661 tgtaaggatt ctttgtattt tctggtacat ttaaccccat caccagtgtc tatgtgaaca
     3721 tttcccattt gcacttccag agttttgttt gtctgaggtg aactgaattc tcaccaaagt
     3781 ttaggccagt attttaacac ctccattgtt ttattggtcc agggttatat cccactaaca
     3841 ttcgctgtac aatcttatta accatttttg tcttgggact ccagcttagt gcttggattt
     3901 atttcctaat tacactacat agaaaagtgg gacacctgcc agcccaactc tgggaaaaac
     3961 caactaatat acaaccatat taaatgaagg ccaccttaat ggtctcgaca ctaattttta
     4021 tgatgcaaat ttataaactg atttttttgt aaaggctgag gttttaaaaa tgtatttaat
     4081 gtatgttttc tatccgcata aattatattg ggtcactaat agtcattaaa aatagcttgc
     4141 agaggtagtg tgcttgaagg aaaatatcct ggcattgctc ccgagtgctg cttctgacat
     4201 ggaaggcatg ctgtatgttc atagtgttca ctgaagatca cactgaagat gcctcaacat
     4261 tgggaaatgt aaggaacact ttgagtggta tctagactat taatgaagag tgataataga
     4321 ggctgcatta agtgtctcag actggtttta aaacagcttt gtaccgattt cgctgaagcg
     4381 tctgtccagt ttggtatcct gtgaaagttt gttatttcct gggtagacat ccttaaagag
     4441 tattgtcttt aaaatcagat ggtctcttct atattgaaag catttttatg ttttctaatt
     4501 taaaattaat attttcttat agatattgtg caataaagca gaagtagaat gtggtttttg
     4561 caaatgcttt aacggccgac aaaaacttta catttgtaaa attaatatat tgtactggta
     4621 caaaatagtt ttaaattata ttttgaaaag ctct
//
