LOCUS       NM_001038010            3045 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus K(lysine) acetyltransferase 2A (Kat2a), transcript
            variant 2, mRNA.
ACCESSION   NM_001038010
VERSION     NM_001038010.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3045)
  AUTHORS   Walters,B.W., Tan,T.J., Tan,C.T., Dube,C.T., Lee,K.T., Koh,J.,
            Ong,Y.H.B., Tan,V.X.H., Jahan,F.R.S., Lim,X.N., Wan,Y. and Lim,C.Y.
  TITLE     Divergent functions of histone acetyltransferases KAT2A and KAT2B
            in keratinocyte self-renewal and differentiation
  JOURNAL   J Cell Sci 136 (12) (2023)
   PUBMED   37259855
REFERENCE   2  (bases 1 to 3045)
  AUTHORS   Gupta,S., Dovey,O.M., Domingues,A.F., Cyran,O.W., Cash,C.M.,
            Giotopoulos,G., Rak,J., Cooper,J., Gozdecka,M., Dijkhuis,L.,
            Asby,R.J., Al-Jabery,N., Hernandez-Hernandez,V., Prabakaran,S.,
            Huntly,B.J., Vassiliou,G.S. and Pina,C.
  TITLE     Transcriptional variability accelerates preleukemia by cell
            diversification and perturbation of protein synthesis
  JOURNAL   Sci Adv 8 (31), eabn4886 (2022)
   PUBMED   35921412
REFERENCE   3  (bases 1 to 3045)
  AUTHORS   Li,J., Yan,C., Wang,Y., Chen,C., Yu,H., Liu,D., Huang,K. and Han,Y.
  TITLE     GCN5-mediated regulation of pathological cardiac hypertrophy via
            activation of the TAK1-JNK/p38 signaling pathway
  JOURNAL   Cell Death Dis 13 (4), 421 (2022)
   PUBMED   35490166
  REMARK    GeneRIF: GCN5-mediated regulation of pathological cardiac
            hypertrophy via activation of the TAK1-JNK/p38 signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3045)
  AUTHORS   Addicks,G.C., Zhang,H., Ryu,D., Vasam,G., Green,A.E.,
            Marshall,P.L., Patel,S., Kang,B.E., Kim,D., Katsyuba,E.,
            Williams,E.G., Renaud,J.M., Auwerx,J. and Menzies,K.J.
  TITLE     GCN5 maintains muscle integrity by acetylating YY1 to promote
            dystrophin expression
  JOURNAL   J Cell Biol 221 (2) (2022)
   PUBMED   35024765
  REMARK    GeneRIF: GCN5 maintains muscle integrity by acetylating YY1 to
            promote dystrophin expression.
REFERENCE   5  (bases 1 to 3045)
  AUTHORS   Oksenych,V., Su,D. and Daniel,J.A.
  TITLE     Acetyltransferases GCN5 and PCAF Are Required for B Lymphocyte
            Maturation in Mice
  JOURNAL   Biomolecules 12 (1), 61 (2021)
   PUBMED   35053209
  REMARK    GeneRIF: Acetyltransferases GCN5 and PCAF Are Required for B
            Lymphocyte Maturation in Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3045)
  AUTHORS   Miyoshi,K., Cui,Y., Riedlinger,G., Robinson,P., Lehoczky,J.,
            Zon,L., Oka,T., Dewar,K. and Hennighausen,L.
  TITLE     Structure of the mouse Stat 3/5 locus: evolution from Drosophila to
            zebrafish to mouse
  JOURNAL   Genomics 71 (2), 150-155 (2001)
   PUBMED   11161808
REFERENCE   7  (bases 1 to 3045)
  AUTHORS   Yamauchi,T., Yamauchi,J., Kuwata,T., Tamura,T., Yamashita,T.,
            Bae,N., Westphal,H., Ozato,K. and Nakatani,Y.
  TITLE     Distinct but overlapping roles of histone acetylase PCAF and of the
            closely related PCAF-B/GCN5 in mouse embryogenesis
  JOURNAL   Proc Natl Acad Sci U S A 97 (21), 11303-11306 (2000)
   PUBMED   11027331
REFERENCE   8  (bases 1 to 3045)
  AUTHORS   Xu,W., Edmondson,D.G., Evrard,Y.A., Wakamiya,M., Behringer,R.R. and
            Roth,S.Y.
  TITLE     Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects
            during mouse development
  JOURNAL   Nat Genet 26 (2), 229-232 (2000)
   PUBMED   11017084
REFERENCE   9  (bases 1 to 3045)
  AUTHORS   Brand,M., Yamamoto,K., Staub,A. and Tora,L.
  TITLE     Identification of TATA-binding protein-free TAFII-containing
            complex subunits suggests a role in nucleosome acetylation and
            signal transduction
  JOURNAL   J Biol Chem 274 (26), 18285-18289 (1999)
   PUBMED   10373431
REFERENCE   10 (bases 1 to 3045)
  AUTHORS   Xu,W., Edmondson,D.G. and Roth,S.Y.
  TITLE     Mammalian GCN5 and P/CAF acetyltransferases have homologous
            amino-terminal domains important for recognition of nucleosomal
            substrates
  JOURNAL   Mol Cell Biol 18 (10), 5659-5669 (1998)
   PUBMED   9742083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK155842.1, AL591469.9 and AV014576.1.
            
            On Jul 3, 2010 this sequence version replaced NM_001038010.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. This
            results in a shorter protein (isoform b), compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155842.1, AK155791.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1514              AK155842.1         2-1515
            1515-1515           AL591469.9         119623-119623       c
            1516-3041           AK155842.1         1517-3042
            3042-3045           AV014576.1         266-269
FEATURES             Location/Qualifiers
     source          1..3045
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.53 cM"
     gene            1..3045
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /note="K(lysine) acetyltransferase 2A"
                     /db_xref="GeneID:14534"
                     /db_xref="MGI:MGI:1343101"
     exon            1..387
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2553
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /EC_number="2.3.1.48"
                     /note="isoform b is encoded by transcript variant 2;
                     general control of amino acid synthesis 5-like 2; histone
                     acetyltransferase KAT2A; lysine acetyltransferase 2A;
                     histone acetyltransferase GCN5; general control of amino
                     acid synthesis protein 5-like 2; general control of amino
                     acid synthesis, yeast homolog-like 2; PCAF-B/GCN5; GCN5
                     general control of amino acid synthesis-like 2; histone
                     succinyltransferase KAT2A; histone glutaryltransferase
                     KAT2A"
                     /codon_start=1
                     /product="histone acetyltransferase KAT2A isoform b"
                     /protein_id="NP_001033099.1"
                     /db_xref="CCDS:CCDS25432.1"
                     /db_xref="GeneID:14534"
                     /db_xref="MGI:MGI:1343101"
                     /translation="MAEPSQAPNPVPAAQPRPLHSPAPAPTSTPAPSPASASTPAPTP
                     APAPAPAAAPAGSTGSGGAGVGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEKLG
                     VFSACKANETCKCNGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVS
                     EDEINRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGS
                     PPFEKPNIEQGVLNFVQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQ
                     SEDVATYKVNYTRWLCYCHVPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRV
                     EKDKLVPEKRTLILTHFPKFLSMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPATVS
                     ATVVPSFSPSMGGGSNSSLSLDSAGTEPMPGEKRKLPENLTLEDAKRLRVMGDIPMEL
                     VNEVMLTITDPAAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSLTPKANRRV
                     LLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFT
                     EIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHSILYFLTYADEYAIGYFKKQGFSKDIK
                     VPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKKQKEIIKKLIERKQAQIRKVY
                     PGLSCFKEGVRQIPVESVPGIRETGWKPLGKEKGKELKDPDQLYTTLKNLLAQIKSHP
                     SAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCRE
                     YNPPDSEYCRCASALEKFFYFKLKEGGLIDK"
     exon            388..511
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            512..657
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            658..747
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            748..929
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1121
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1228
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1330
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1467
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1676
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1803
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1914
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2058
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2173
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2210
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2274
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2359
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..3045
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3023..3028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /note="hexamer: AATAAA"
     polyA_site      3045
                     /gene="Kat2a"
                     /gene_synonym="1110051E14Rik; Gcn5; Gcn5l2; mmGCN5"
                     /note="major polyA site"
ORIGIN      
        1 gcgccggttg cccatgcggc cctagggctg ggagcgcggc gccgctccgc tgcgggggag
       61 gccatggcgg aaccttccca ggccccaaac ccggtcccgg cagcgcagcc ccggcccctt
      121 cactccccag cccctgcccc aacttcgact cctgcgccca gtccggcttc agcctccact
      181 ccggctccga ctccggcacc agcccctgcc ccagctgcag ccccagctgg gagcacaggg
      241 agtgggggcg ccggggtagg aagtgggggg gatccggctc gacctggcct gagccagcag
      301 cagcgcgcta gccagaggaa ggcgcaagtc cggggtctgc cgcgtgccaa gaagcttgag
      361 aaactagggg tcttctcagc ttgcaaggcc aatgaaacct gcaagtgtaa tggctggaaa
      421 aaccccaagc cccccaccgc accccgcatg gacctccagc agccagctgc caacctgagc
      481 gagttgtgcc gtagctgtga gcaccctttg gcggaccatg tgtcccacct ggagaatgtg
      541 tcagaggacg agattaaccg gctcttggga atggtagtag atgtagaaaa tctgttcatg
      601 tctgttcaca aggaagagga cacagacacc aaacaagtct atttctacct cttcaagctc
      661 ttgcggaagt gcattctgca gatgacacgg ccagtggtgg aggggtctct aggcagcccc
      721 ccatttgaga agcctaacat tgaacagggt gtactgaact ttgtgcagta caaatttagc
      781 cacctggccc cccgagagcg ccagacaatg tttgagctct caaagatgtt cctgctctgc
      841 cttaactact ggaagctgga gacccctgct caattccggc agcggtccca gtctgaggat
      901 gtcgctacct acaaagtcaa ttataccaga tggctctgtt actgccacgt gccccagagc
      961 tgcgacagcc tcccccgcta cgagaccacc cacgtgtttg gccgaagcct tctacggtcc
     1021 attttcactg tcacccgccg gcagctactg gaaaaatttc gggtggaaaa ggacaaactg
     1081 gtgcctgaga agaggaccct catcctcact cacttcccca aattcctgtc catgcttgag
     1141 gaagagatct acggggcaaa ttctcccatc tgggagtcag gcttcaccat gccaccttcg
     1201 gaggggacac agctggtgcc ccggccagcc acggtcagtg caacagttgt acccagcttc
     1261 agtccttcca tgggaggagg cagcaacagc tccctgagcc tagattccgc agggactgag
     1321 cccatgccag gggagaagag gaagcttcct gagaacctga ccctggagga tgccaagcgg
     1381 ctccgcgtga tgggggacat ccccatggag ctggtcaatg aggtcatgct gacgatcact
     1441 gaccccgctg ccatgctggg gcctgagaca agcctgcttt cggccaacgc agctcgagat
     1501 gagacggctc gcctggaaga acggcgagga atcatcgagt tccacgtcat tggcaactcc
     1561 ctgacgccca aggccaaccg gcgcgtgctg ctctggctcg tggggctgca gaatgtcttt
     1621 tcccaccagc tgccaagaat gcccaaggaa tatatcgccc gcctcgtctt tgacccgaag
     1681 cacaagaccc tggccctgat caaggatggg cgggtcatcg gtggcatttg cttccgcatg
     1741 tttcccactc agggcttcac ggaaatcgtc ttctgtgccg tcacctcaaa tgagcaggtc
     1801 aagggctatg gcacccacct gatgaaccac ctaaaggagt accacatcaa acacagcatc
     1861 ctttactttc tcacctatgc tgacgagtac gccattggct acttcaaaaa gcagggcttc
     1921 tccaaagaca tcaaggtgcc caagagccgc tatctgggct acatcaagga ctatgaagga
     1981 gcgacgctga tggagtgtga gctgaatccc cgaatcccct acacagagct gtcccacatc
     2041 atcaagaaac agaaagagat catcaagaag ttgattgagc gcaaacaggc acagatccgc
     2101 aaggtctacc ctggactcag ctgcttcaaa gagggagtga ggcagatccc ggtggagagc
     2161 gtccctggca ttcgagagac aggctggaag ccactgggaa aggagaaggg caaggagctt
     2221 aaggatcctg atcagctata tacgaccctc aaaaacctgc tggctcagat caagtcacac
     2281 cccagtgcct ggcccttcat ggaacctgtg aagaagtcag aggctcctga ctactacgag
     2341 gttatccgtt tccccattga cctgaagacc atgacagaac ggttgcgcag tcgctactat
     2401 gtgacccgga agctcttcgt agctgacctg cagcgggtca tcgccaactg ccgggagtac
     2461 aatcccccag acagcgaata ctgtcgctgc gccagtgccc tggagaagtt cttctacttc
     2521 aagctcaaag agggagggct catcgacaag tagcccccag ctgggatccg caacatccac
     2581 ctccatctcc tcagatccgt ttgggggctc ccggccccct ctcccggact cagctggaga
     2641 aactccagcc agggacccca gatcttacag actttctggc cagcaggcac tcactcccaa
     2701 gccagcagct ctctttccac cttccttgca tcccaccttg gggagacgtc tggtctgggg
     2761 ccagcccgtt gtagaatgtc tggtggccag ggcatgaact gttggtcctt atagagccat
     2821 gcaggctgag catcctgagc ctggtcccca tgcctgtttc ccagggccag gactattcag
     2881 tgagtagcct tcacatggaa acagcccaga ctggaggaac catgaggggc cttggcttat
     2941 cctacactgt tgtctatctg tccctccagg attgggggca ggaggaccat tcattccttg
     3001 gcattaatcc ctcggaggga acaataaagc tttttttttc ccctg
//
