LOCUS       NM_181417               3748 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus lysine acetyltransferase 14 (Kat14), transcript
            variant 1, mRNA.
ACCESSION   NM_181417 XM_918076
VERSION     NM_181417.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3748)
  AUTHORS   Gong,Y., Liu,M., Zhang,Q., Li,J., Cai,H., Ran,J., Ma,L., Ma,Y. and
            Quan,S.
  TITLE     Lysine acetyltransferase 14 mediates TGF-beta-induced fibrosis in
            ovarian endometrioma via co-operation with serum response factor
  JOURNAL   J Transl Med 22 (1), 561 (2024)
   PUBMED   38867256
  REMARK    GeneRIF: Lysine acetyltransferase 14 mediates TGF-beta-induced
            fibrosis in ovarian endometrioma via co-operation with serum
            response factor.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3748)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3748)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3748)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3748)
  AUTHORS   Ma,Y., Li,Q., Li,A., Wei,Y., Long,P., Jiang,X., Sun,F.,
            Weiskirchen,R., Wu,B., Liang,C., Grotzinger,J., Wei,Y., Yu,W.,
            Mercola,M., Huang,Y., Wang,J., Yu,Y. and Schwartz,R.J.
  TITLE     The CSRP2BP histone acetyltransferase drives smooth muscle gene
            expression
  JOURNAL   Nucleic Acids Res 45 (6), 3046-3058 (2017)
   PUBMED   27940555
  REMARK    GeneRIF: CSRP2BP strongly potentiates the expression of SRF smooth
            muscle target genes together with either Myocardin or CRP2
REFERENCE   6  (bases 1 to 3748)
  AUTHORS   Krebs,A.R., Demmers,J., Karmodiya,K., Chang,N.C., Chang,A.C. and
            Tora,L.
  TITLE     ATAC and Mediator coactivators form a stable complex and regulate a
            set of non-coding RNA genes
  JOURNAL   EMBO Rep 11 (7), 541-547 (2010)
   PUBMED   20508642
REFERENCE   7  (bases 1 to 3748)
  AUTHORS   Nagy,Z., Riss,A., Fujiyama,S., Krebs,A., Orpinell,M., Jansen,P.,
            Cohen,A., Stunnenberg,H.G., Kato,S. and Tora,L.
  TITLE     The metazoan ATAC and SAGA coactivator HAT complexes regulate
            different sets of inducible target genes
  JOURNAL   Cell Mol Life Sci 67 (4), 611-628 (2010)
   PUBMED   19936620
REFERENCE   8  (bases 1 to 3748)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   9  (bases 1 to 3748)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3748)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL808123.9.
            
            On Oct 30, 2009 this sequence version replaced NM_181417.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031563.1, SRR1660817.31091.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AL808123.9         108468-108590
            124-788             AL808123.9         112624-113288
            789-907             AL808123.9         115278-115396
            908-1029            AL808123.9         120140-120261
            1030-1211           AL808123.9         128608-128789
            1212-1628           AL808123.9         132737-133153
            1629-2191           AL808123.9         133249-133811
            2192-2328           AL808123.9         140119-140255
            2329-2504           AL808123.9         141828-142003
            2505-2695           AL808123.9         143432-143622
            2696-3748           AL808123.9         146056-147108
FEATURES             Location/Qualifiers
     source          1..3748
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 71.01 cM"
     gene            1..3748
                     /gene="Kat14"
                     /gene_synonym="2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e;
                     D2Wsu131e; E430020F17"
                     /note="lysine acetyltransferase 14"
                     /db_xref="GeneID:228714"
                     /db_xref="MGI:MGI:1917264"
     exon            1..123
                     /gene="Kat14"
                     /gene_synonym="2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e;
                     D2Wsu131e; E430020F17"
                     /inference="alignment:Splign:2.1.0"
     exon            124..788
                     /gene="Kat14"
                     /gene_synonym="2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e;
                     D2Wsu131e; E430020F17"
                     /inference="alignment:Splign:2.1.0"
     CDS             530..2869
                     /gene="Kat14"
                     /gene_synonym="2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e;
                     D2Wsu131e; E430020F17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cysteine-rich protein 2-binding protein; CRP2BP;
                     CRP2-binding partner; CSRP2-binding protein;
                     ADA2A-containing complex subunit 2; cysteine and
                     glycine-rich protein 2 binding protein"
                     /codon_start=1
                     /product="cysteine-rich protein 2-binding protein isoform
                     1"
                     /protein_id="NP_852082.2"
                     /db_xref="CCDS:CCDS16819.1"
                     /db_xref="GeneID:228714"
                     /db_xref="MGI:MGI:1917264"
                     /translation="MDSSIHLSGLLSRHDDDATRTSTSEGLEEGEVEGETLLIVESED
                     QASVDLSHDQSGDSLNSDEGDVSWMEEQLSYFCDKCQKWIPASQLREQLSYLKGDNFF
                     RFTCCDCSADGKEQYERLKLTWQQVVMLAMYNLSLEGSGRQGYFRWKEDICAFIEKHW
                     TFLLGNRKKTSTWWSTVAGCLSVGSPVYFRSGAQEFGEPGWWKLVHNRPPTMRPEGEK
                     LAASTLKVKASKPTLDPIITVEGLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQKE
                     AAGLLDRSTSSTPVKFISRGRRPDLILEKGEVIDFSSLSSSDRTPLTSPSPSPSLDFS
                     APGTPASHSATPSLLSEADLIPDVMPPQALFHDDDELEGDGVIDPGMEYIPPPAGSAS
                     GLLGSRKKVRAPEQIKQEVDSEEEKPDRMDGDSEDTDSNISLHTRAREKRKPPLEKDM
                     KPKGPRYTPVSIYEEKLLLKRLEACPGAVAMTPEARRLKRKLIVRQAKRDRGLPLFDL
                     DEVVNAALLLVDGIYGAKDGGASRLAAGQATYRTTCQDFRILDRYQTALPARKGFRHQ
                     TTRFLYRLVGSEDLAVDQSIISPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLHRSD
                     PHWTPGPDAPLDYCYVRPNHIPTINSMCQEFFWPGIDLSECLQYPDFSVVVLYKKVIV
                     AFGFMVPDVKYNEAYISFLLVHPEWRRAGIATFMIYHLIQTCMGKDVTLHVSASNPAM
                     LLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR"
     exon            789..907
                     /gene="Kat14"
                     /gene_synonym="2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e;
                     D2Wsu131e; E430020F17"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1029
                     /gene="Kat14"
                     /gene_synonym="2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e;
                     D2Wsu131e; E430020F17"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1211
                     /gene="Kat14"
                     /gene_synonym="2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e;
                     D2Wsu131e; E430020F17"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1628
                     /gene="Kat14"
                     /gene_synonym="2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e;
                     D2Wsu131e; E430020F17"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..2191
                     /gene="Kat14"
                     /gene_synonym="2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e;
                     D2Wsu131e; E430020F17"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2328
                     /gene="Kat14"
                     /gene_synonym="2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e;
                     D2Wsu131e; E430020F17"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2504
                     /gene="Kat14"
                     /gene_synonym="2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e;
                     D2Wsu131e; E430020F17"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2695
                     /gene="Kat14"
                     /gene_synonym="2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e;
                     D2Wsu131e; E430020F17"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..3748
                     /gene="Kat14"
                     /gene_synonym="2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e;
                     D2Wsu131e; E430020F17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3699..3704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kat14"
                     /gene_synonym="2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e;
                     D2Wsu131e; E430020F17"
                     /note="hexamer: AATAAA"
     polyA_site      3728
                     /gene="Kat14"
                     /gene_synonym="2510008M08Rik; ATAC2; Csrp2bp; D2Ertd473e;
                     D2Wsu131e; E430020F17"
                     /note="major polyA site"
ORIGIN      
        1 ggagcgagtc cgcggccggg agcgggaatg tcgaggagtt cgaaggcagt gctgggcctc
       61 tcggtgctgc tgacggcggc cacggtggcc ggcgtgcatc tgaagcagcg gcaggaccgg
      121 cagaggcttc gtgacggagt gatcagagac attgagaggc agaatcagaa aaaagaaaac
      181 attcgtcttc tgggagaaca gattattttg actaagcagc ttgaagcaga aagagagaag
      241 atgttggaga aaggatctca aaatacctga ctttcagaag ccgggggcag cgctgagttg
      301 gtgtgcgtaa ctgtgggtgt ggtgtgttgg tagagagttg ttagtgagaa gagctgcccc
      361 cccaaatcac gctccattta aactttgtta aatgaaggac agtgggccct gtcttctaaa
      421 ttgcttcttt aaagagtctg ttctgtctgg atagagtgct tgtgggcaga tgtccttctg
      481 aaggtctggg ggatcccggc agcttaggag tgcgtgtgag cagggggcga tggatagtag
      541 catccacctg agtgggctcc tcagtcggca tgacgatgac gccacgagaa cgtccacctc
      601 ggaagggctg gaggaaggcg aggtggaggg agagactctc ctaattgtgg aatcggagga
      661 tcaggcgtca gtggacttat ctcacgacca gagtggggat tccctcaaca gcgatgaagg
      721 agatgtgtcc tggatggagg aacagctgtc ttacttctgt gacaagtgcc aaaagtggat
      781 cccagccagt cagctgaggg agcagctcag ttacctgaag ggcgataact ttttcaggtt
      841 tacttgttgc gattgctctg cagacggcaa ggagcagtac gagaggctga aactgacatg
      901 gcagcaagtg gtcatgctgg caatgtacaa cctgtctctg gaaggaagtg gacgtcaagg
      961 ttatttccgg tggaaagaag atatctgtgc ttttattgag aaacattgga cttttttact
     1021 aggaaatagg aaaaagacgt cgacgtggtg gagcacagta gcaggctgcc tcagcgtggg
     1081 aagccctgtt tatttccggt caggtgctca ggagtttgga gagcccggat ggtggaaact
     1141 tgttcataac agacccccaa ccatgaggcc ggagggagag aagctggctg cctccacctt
     1201 gaaagtgaaa gcttcaaagc caacgctgga tcccatcatt actgttgagg gactcagaaa
     1261 acgggcaagc cggaatcctg tggaatctgc catggaattg aaagagaagc ggtcgcgaac
     1321 acaggaagct aaagacatca gaagagctca gaaagaagcg gctggcctcc tcgacaggag
     1381 cacctcttcc acccccgtca agttcataag ccgaggccgg aggccggatc tgattttgga
     1441 gaaaggagaa gtgatcgact tctcgtccct gagctcctca gaccgcactc ccctcacaag
     1501 cccgtctcct tctccgtctc tggatttctc cgccccgggg acgccagcct cgcactcggc
     1561 cacacctagc ttgctttccg aagcagacct catcccagac gtgatgccac cccaagccct
     1621 gtttcatgat gacgatgagc tggaaggaga tggagttata gacccaggga tggagtacat
     1681 cccaccccca gctgggtcag cgtctgggct gcttgggagc agaaagaagg tccgagctcc
     1741 ggaacagata aaacaggaag tggacagcga ggaggagaag ccagacagga tggatggaga
     1801 tagcgaagac acagattcaa acatttctct gcacactaga gctcgagaaa agaggaagcc
     1861 gccactggaa aaggacatga agcccaaggg ccccaggtat acacccgtga gcatctatga
     1921 ggagaagctg ctgctcaaga ggctggaggc gtgccccggc gccgtggcca tgactccaga
     1981 agccaggagg ctgaaacgga aactgatcgt ccggcaagcg aaaagagatc ggggtttacc
     2041 actatttgac ttggacgagg ttgtgaatgc cgcacttctg ttagtcgatg ggatttatgg
     2101 agccaaagat ggaggagctt cccggcttgc agctggacaa gctacatacc ggaccacctg
     2161 ccaggacttt cggatcctgg accggtacca gactgcctta ccagccagga aaggattccg
     2221 gcaccagacc acgagatttt tgtatcgttt ggtgggatca gaagatctgg ctgtggacca
     2281 aagtattatc agcccttata cttctcggat cttgaaacct tatatcaggc gtgattatga
     2341 gacaaagcca cccaaactac agctcctgtc acagatccgt tcccacctgc acaggagtga
     2401 ccctcactgg acacctggac ctgatgcacc cctcgattac tgctatgtcc gaccaaatca
     2461 catcccaacc atcaactcca tgtgccagga gtttttctgg cctggcattg acctgtctga
     2521 gtgtctgcag tatccagact tcagtgttgt agtcctttat aaaaaagtca ttgttgcctt
     2581 tggcttcatg gttcctgatg tgaagtacaa cgaagcttac atctcatttc tgcttgttca
     2641 tcctgagtgg aggagagcag ggatcgccac attcatgatc tatcatctga ttcagacatg
     2701 catgggcaag gatgtgactc ttcatgtctc ggcaagcaac cccgccatgc tgctgtacca
     2761 gaagtttggc ttcaagaccg aggagtatgt tttggatttt tatgataagt attacccgct
     2821 ggagagtacg gagtgtaagc atgcattctt cctgaggctc cgacgctgag gggagctctg
     2881 ctcttcccag caaacggtgg atgctgccag agagtgggct tcagaagccc tgcaggccct
     2941 tatcctcgaa gtgggccctg gtctcctgtg ggtaatagcc tccacatggt ccagccgggt
     3001 gagtgaagcc agtggtacaa gtaggcagtt ctgccaccca gaaaccatcc agcaggcccc
     3061 gcgtggcctt ccagcagtat cgtggactcc actgtagacc agaaccaagt gactctgcca
     3121 ttctcttccc atacaatgag tgagcacaaa agagcctcta agctgaagag tttgagaatg
     3181 ggcctgctcg tcctacgtta gagctcagga agtatgaaag gtgttaaaga ttgcggtgcc
     3241 ctcgctgtcc caggacgaga ggttgtgagg gatcaggaat gattgcaacc ctgttctcag
     3301 cctgtgctgt gttgtcattg aaccccagag gactcacggg gcactgaagt ccttttgtct
     3361 ctttctgact tttgtcccgt tcaggaagaa tatactcagt gtctgtctcc acgctgcttt
     3421 acctgatcta cctgtcagca gctccttgca gggacactga cctgatacaa ggagtttact
     3481 cttggcatgg cctggaaaat agcttgagag gaacacttga gcttgccagg cccgtctcgt
     3541 gctcaggaca gttgcacaca ggagtgtcgg tgtggaacgg tgcaggcaga tctggctgcg
     3601 ctcgctgtcc acctcacgaa gctgcttcct gtgttgcaca tgtggagttg gactacaggt
     3661 atatcttaag tgcattccaa aagcatcaga tattctccaa taaaaatcct tacctgcaac
     3721 acctcacagc cagggctgca gcctagtc
//
