LOCUS       NM_201374               2210 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus KASH domain containing 5 (Kash5), mRNA.
ACCESSION   NM_201374 XM_357750
VERSION     NM_201374.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2210)
  AUTHORS   Zhang,J., Ruiz,M., Bergh,P.O., Henricsson,M., Stojanovic,N.,
            Devkota,R., Henn,M., Bohlooly-Y,M., Hernandez-Hernandez,A.,
            Alsheimer,M., Boren,J., Pilon,M. and Shibuya,H.
  TITLE     Regulation of meiotic telomere dynamics through membrane fluidity
            promoted by AdipoR2-ELOVL2
  JOURNAL   Nat Commun 15 (1), 2315 (2024)
   PUBMED   38485951
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2210)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2210)
  AUTHORS   Zhang,Q., Tao,C., Gao,S., Li,S., Xu,B., Ke,H., Wang,Y., Zhang,F.,
            Qin,Y., Zhang,L. and Guo,T.
  TITLE     Homozygous Variant in KASH5 Causes Premature Ovarian Insufficiency
            by Disordered Meiotic Homologous Pairing
  JOURNAL   J Clin Endocrinol Metab 107 (9), 2589-2597 (2022)
   PUBMED   35708642
  REMARK    GeneRIF: Homozygous Variant in KASH5 Causes Premature Ovarian
            Insufficiency by Disordered Meiotic Homologous Pairing.
REFERENCE   4  (bases 1 to 2210)
  AUTHORS   Yang,C., Lin,X., Ji,Z., Huang,Y., Zhang,L., Luo,J., Chen,H., Li,P.,
            Tian,R., Zhi,E., Hong,Y., Zhou,Z., Zhang,F., Li,Z. and Yao,C.
  TITLE     Novel bi-allelic variants in KASH5 are associated with meiotic
            arrest and non-obstructive azoospermia
  JOURNAL   Mol Hum Reprod 28 (7) (2022)
   PUBMED   35674372
  REMARK    GeneRIF: Novel bi-allelic variants in KASH5 are associated with
            meiotic arrest and non-obstructive azoospermia.
REFERENCE   5  (bases 1 to 2210)
  AUTHORS   Luo,Y., Lee,I.W., Jo,Y.J., Namgoong,S. and Kim,N.H.
  TITLE     Depletion of the LINC complex disrupts cytoskeleton dynamics and
            meiotic resumption in mouse oocytes
  JOURNAL   Sci Rep 6, 20408 (2016)
   PUBMED   26842404
  REMARK    GeneRIF: Results provide evidence that SUN1 and KASH5 are essential
            factors in the regulation of meiotic resumption and spindle
            formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2210)
  AUTHORS   Abby,E., Tourpin,S., Ribeiro,J., Daniel,K., Messiaen,S., Moison,D.,
            Guerquin,J., Gaillard,J.C., Armengaud,J., Langa,F., Toth,A.,
            Martini,E. and Livera,G.
  TITLE     Implementation of meiosis prophase I programme requires a conserved
            retinoid-independent stabilizer of meiotic transcripts
  JOURNAL   Nat Commun 7, 10324 (2016)
   PUBMED   26742488
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2210)
  AUTHORS   Lee,C.Y., Horn,H.F., Stewart,C.L., Burke,B., Bolcun-Filas,E.,
            Schimenti,J.C., Dresser,M.E. and Pezza,R.J.
  TITLE     Mechanism and regulation of rapid telomere prophase movements in
            mouse meiotic chromosomes
  JOURNAL   Cell Rep 11 (4), 551-563 (2015)
   PUBMED   25892231
REFERENCE   8  (bases 1 to 2210)
  AUTHORS   Viera,A., Alsheimer,M., Gomez,R., Berenguer,I., Ortega,S.,
            Symonds,C.E., Santamaria,D., Benavente,R. and Suja,J.A.
  TITLE     CDK2 regulates nuclear envelope protein dynamics and telomere
            attachment in mouse meiotic prophase
  JOURNAL   J Cell Sci 128 (1), 88-99 (2015)
   PUBMED   25380821
  REMARK    GeneRIF: ablation of the kinase CDK2 alters the nuclear envelope in
            mouse spermatocytes, and that the proteins SUN1, KASH5 (also known
            as CCDC155) and lamin C2 show an abnormal cap-like distribution
            facing the centrosome.
REFERENCE   9  (bases 1 to 2210)
  AUTHORS   Horn,H.F., Kim,D.I., Wright,G.D., Wong,E.S., Stewart,C.L., Burke,B.
            and Roux,K.J.
  TITLE     A mammalian KASH domain protein coupling meiotic chromosomes to the
            cytoskeleton
  JOURNAL   J Cell Biol 202 (7), 1023-1039 (2013)
   PUBMED   24062341
REFERENCE   10 (bases 1 to 2210)
  AUTHORS   Morimoto,A., Shibuya,H., Zhu,X., Kim,J., Ishiguro,K., Han,M. and
            Watanabe,Y.
  TITLE     A conserved KASH domain protein associates with telomeres, SUN1,
            and dynactin during mammalian meiosis
  JOURNAL   J Cell Biol 198 (2), 165-172 (2012)
   PUBMED   22826121
  REMARK    GeneRIF: It was shown KASH5 possesses hitherto unknown KASH-related
            sequences that directly interacted with SUN1 and mediated telomere
            localization. KASH5 interacted with the microtubule-associated
            dynein- dynactin complex.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149868.2.
            
            On May 14, 2009 this sequence version replaced NM_201374.1.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus. The use of an alternative upstream start codon, which
            appears to be rodent-specific, would result in a protein that is 70
            aa longer at the N-terminal.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050196.1, AB725603.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AC149868.2         190179-190479       c
            302-442             AC149868.2         185832-185972       c
            443-547             AC149868.2         182094-182198       c
            548-734             AC149868.2         181555-181741       c
            735-799             AC149868.2         181116-181180       c
            800-866             AC149868.2         179937-180003       c
            867-1028            AC149868.2         179547-179708       c
            1029-1146           AC149868.2         179046-179163       c
            1147-1197           AC149868.2         178763-178813       c
            1198-1275           AC149868.2         175537-175614       c
            1276-1332           AC149868.2         175224-175280       c
            1333-1392           AC149868.2         174928-174987       c
            1393-1457           AC149868.2         174440-174504       c
            1458-1545           AC149868.2         174199-174286       c
            1546-1701           AC149868.2         173729-173884       c
            1702-1760           AC149868.2         172239-172297       c
            1761-1812           AC149868.2         170865-170916       c
            1813-1877           AC149868.2         169776-169840       c
            1878-1994           AC149868.2         169579-169695       c
            1995-2210           AC149868.2         169263-169478       c
FEATURES             Location/Qualifiers
     source          1..2210
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.17 cM"
     gene            1..2210
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /note="KASH domain containing 5"
                     /db_xref="GeneID:384619"
                     /db_xref="MGI:MGI:2687329"
     exon            1..301
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..2136
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /EC_number="3.1.3.48"
                     /note="coiled-coil domain-containing protein 155; KASH
                     domain-containing protein 5; coiled-coil domain containing
                     155"
                     /codon_start=1
                     /product="protein KASH5"
                     /protein_id="NP_958762.2"
                     /db_xref="CCDS:CCDS21234.2"
                     /db_xref="GeneID:384619"
                     /db_xref="MGI:MGI:2687329"
                     /translation="MHSILRSSLSSREALRMRQLKGLRKERPGRHPLGVRLRAIWTSF
                     LFPNPPHSGGKLRASTAAVEEHQEWSMDLPEGQAGGPTAQMYLWEQPEEASSRPLLSL
                     EEQILNSTFEACDPHKTGTVTVAHLLAYLEAVTGQGPQDVRLQTLARSLDPYGEGAGA
                     TVELDTFLVVMRDWIAACQLQGGLERAEETAYEGALASPHLPSVCPEAEESANLESFG
                     GEDPRPEGPATAELLSNLEDLELSNRRLAGENAKLQRSVETAEEGSARLGEEITALRK
                     QLRSTQQALQVAKALDEELEDLKTLAKSLEEQNRSLMAQARHTEKEQQHLAAEVETLQ
                     EENEKLLAERDGVKRRSEELATEKDALKRQLCECERLICQREAVLSERTRHAESLART
                     LEEYRTTTQELRQEISNLEEQLSQSQEGPEELLEGAEAGRVGWIMALPPSLDLEIQAI
                     RQEQDVASAGLSSPLYGVWQWEEVEPEPEPEPEPEPEPEPQEVEFPSEDPARQQTDLQ
                     REPVRALEGSRAPCLRLSRSQEEEEEEEESWVLADPSSPLGTYHHKLAPGSSRESCHI
                     VPEMHQALMPVVRDLVPVERSRTQHCLHPQHSPGIRISQHPLVPTPVLGLLLLLLLSI
                     LLFSQSPPPTWPHLQLYYLQPPPV"
     exon            302..442
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            443..547
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            548..734
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            735..799
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            800..866
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1028
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1146
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1197
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1275
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1332
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1392
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1457
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1545
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1701
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1760
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1812
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1877
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..1994
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2210
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2210
                     /gene="Kash5"
                     /gene_synonym="Ccdc155; Gm1434"
                     /note="major polyA site"
ORIGIN      
        1 gggcgagcca gacccaaaag aaagaacttg gttcaaagac tgacaagaag aaaaggatga
       61 acagggagtc cttcggttga actctctcct gcttggccct attttgtcaa gcagaaggaa
      121 aggatttttg taccgcagaa gaaagctgcc gataatatcg cgccatcacc gctagcccca
      181 ctagtgcgca tgcactcgat cctcaggtcc agcctatcct cccgagaagc tctacgcatg
      241 cgccagctca agggtcttcg taaggagaga cccgggcgcc atccactcgg agtgcgcttg
      301 cgagctatct ggacatcctt tcttttcccc aaccctcctc acagtggagg gaagctgaga
      361 gcttcgacag cagctgtaga ggagcatcag gagtggtcca tggacctgcc ggagggccag
      421 gctggtggtc caactgcaca gatgtacctc tgggaacagc ccgaggaagc gagttcaagg
      481 ccactgctca gcctagagga acagatcctt aactccacat ttgaagcctg tgaccctcac
      541 aagacaggca ctgtgactgt ggcccacctc ctggcctacc tggaggctgt gacaggacag
      601 ggacctcagg atgtgcgcct ccaaacactg gcccggagct tggaccctta tggagagggt
      661 gctggagcca ctgtggaact ggacaccttt ctggtggtca tgcgggactg gattgctgcc
      721 tgtcagctgc aggggggatt agagcgggca gaggagaccg cctacgaggg agccctggct
      781 tctccacacc tgccatctgt gtgcccagaa gctgaggagt cagccaactt agagagcttt
      841 ggaggagaag accccaggcc cgaggggcct gccacagctg agctgctgag caacctggag
      901 gacctagagc taagcaaccg gcgtcttgct ggtgagaatg ccaagctaca acgcagtgtg
      961 gagactgcgg aggagggctc tgcacgccta ggggaggaga tcacagccct gcgcaagcag
     1021 ctgcgaagta cccagcaggc cctgcaggtg gccaaggctt tggatgagga gctagaggac
     1081 ctgaagactc tggccaagag cctagaggag cagaatcgca gtctgatggc ccaggcccgg
     1141 cacacagaga aggagcagca gcacctggcg gctgaggtag agacgctaca ggaggagaat
     1201 gagaagctgc tagctgagag agatggagtg aaaaggcgga gtgaggagtt ggccacagag
     1261 aaggacgctt tgaagcggca gctctgtgag tgcgaacgac tcatttgcca gcgtgaagca
     1321 gtcctctcag agcgtacccg ccatgcagag agtctggccc ggaccttgga ggagtacaga
     1381 actaccaccc aggaactaag gcaagagatc tcaaacctgg aggagcagct gagtcagagc
     1441 caggaaggcc cagaggagct gctggaaggg gctgaggcag gaagagtagg ctggatcatg
     1501 gccctgcccc catcactaga cttggagatc caagctatcc gacaggagca ggatgtagcc
     1561 agtgctggcc tctctagtcc tctgtatgga gtgtggcagt gggaagaggt ggagcctgag
     1621 cctgagcctg agcctgagcc tgagcctgag cctgagccgc aggaggttga gtttccctct
     1681 gaggaccctg ctaggcaaca gacagacttg cagagagagc cagtgcgtgc tctagaagga
     1741 agcagagctc catgcttgcg gttgtccaga agccaggaag aggaggaaga agaagaggag
     1801 agctgggtcc tggctgaccc ttccagccct ctgggaacct atcaccataa acttgcccca
     1861 ggaagctctc gtgagagttg ccacattgta ccagagatgc accaagccct catgcctgtg
     1921 gtgagagacc tggtgccagt tgagaggtca cggacccagc actgtctgca tccccagcac
     1981 tccccaggga tcagaatcag ccagcaccca ctggtcccca cacccgtctt gggcctgctg
     2041 ctgctgctgc tgctctccat cctgctgttc agccagtccc cgccacccac ctggcctcac
     2101 ctgcagctct actacctaca gccgccacca gtgtgaggca cccttcccac cactatacct
     2161 cctccgtcag catgggaccc acatccctaa gttgtgttat gtgaccatga
//
