LOCUS       NM_010594                608 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus kidney androgen regulated protein (Kap), mRNA.
ACCESSION   NM_010594
VERSION     NM_010594.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 608)
  AUTHORS   Naganuma,H., Miike,K., Ohmori,T., Tanigawa,S., Ichikawa,T.,
            Yamane,M., Eto,M., Niwa,H., Kobayashi,A. and Nishinakamura,R.
  TITLE     Molecular detection of maturation stages in the developing kidney
  JOURNAL   Dev Biol 470, 62-73 (2021)
   PUBMED   33197428
REFERENCE   2  (bases 1 to 608)
  AUTHORS   Grande,M.T., Pascual,G., Riolobos,A.S., Clemente-Lorenzo,M.,
            Bardaji,B., Barreiro,L., Tornavaca,O., Meseguer,A. and
            Lopez-Novoa,J.M.
  TITLE     Increased oxidative stress, the renin-angiotensin system, and
            sympathetic overactivation induce hypertension in kidney
            androgen-regulated protein transgenic mice
  JOURNAL   Free Radic Biol Med 51 (10), 1831-1841 (2011)
   PUBMED   21906672
  REMARK    GeneRIF: transgenic mice overexpressing protein specifically in
            kidney show hypertension associated with oxidative stress
REFERENCE   3  (bases 1 to 608)
  AUTHORS   Insinna,C., Humby,M., Sedmak,T., Wolfrum,U. and Besharse,J.C.
  TITLE     Different roles for KIF17 and kinesin II in photoreceptor
            development and maintenance
  JOURNAL   Dev Dyn 238 (9), 2211-2222 (2009)
   PUBMED   19384852
REFERENCE   4  (bases 1 to 608)
  AUTHORS   Tornavaca,O., Pascual,G., Barreiro,M.L., Grande,M.T., Carretero,A.,
            Riera,M., Garcia-Arumi,E., Bardaji,B., Gonzalez-Nunez,M.,
            Montero,M.A., Lopez-Novoa,J.M. and Meseguer,A.
  TITLE     Kidney androgen-regulated protein transgenic mice show hypertension
            and renal alterations mediated by oxidative stress
  JOURNAL   Circulation 119 (14), 1908-1917 (2009)
   PUBMED   19332469
  REMARK    GeneRIF: Overexpression of this gene induces hypertension and
            chronic renal disease.
REFERENCE   5  (bases 1 to 608)
  AUTHORS   Fan,L., Hardy,D.O., Catteral,J.F., Zhao,J. and Li,S.
  TITLE     Identification and characterization of the minimal
            androgen-regulated kidney-specific kidney androgen-regulated
            protein gene promoter
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 40 (12), 979-988 (2008)
   PUBMED   19089304
  REMARK    GeneRIF: defined the minimal Kap147 promoter that may be a good
            model for the study of kidney PTC-specific expression and molecular
            mechanisms that lead to an androgen-specific responsiveness in vivo
REFERENCE   6  (bases 1 to 608)
  AUTHORS   Jones,C.M., Simon-Chazottes,D., Guenet,J.L. and Hogan,B.L.
  TITLE     Isolation of Vgr-2, a novel member of the transforming growth
            factor-beta-related gene family
  JOURNAL   Mol Endocrinol 6 (11), 1961-1968 (1992)
   PUBMED   1480182
REFERENCE   7  (bases 1 to 608)
  AUTHORS   Meseguer,A. and Catterall,J.F.
  TITLE     Effects of pituitary hormones on the cell-specific expression of
            the KAP gene
  JOURNAL   Mol Cell Endocrinol 89 (1-2), 153-162 (1992)
   PUBMED   1338721
REFERENCE   8  (bases 1 to 608)
  AUTHORS   Melanitou,E., Tronik,D. and Rougeon,F.
  TITLE     Two isoforms of the kidney androgen-regulated protein are encoded
            by two alleles of a single gene in OF1 mice
  JOURNAL   Genet Res 59 (2), 117-124 (1992)
   PUBMED   1352760
REFERENCE   9  (bases 1 to 608)
  AUTHORS   Melanitou,E., Simon-Chazottes,D., Guenet,J.L. and Rougeon,F.
  TITLE     The gene coding for the kidney androgen-regulated protein (Kap),
            maps between the Gapd and Kras-2 genes on mouse chromosome 6
  JOURNAL   Mamm Genome 1 (3), 191-192 (1991)
   PUBMED   1686731
REFERENCE   10 (bases 1 to 608)
  AUTHORS   Toole,J.J., Hastie,N.D. and Held,W.A.
  TITLE     An abundant androgen-regulated mRNA in the mouse kidney
  JOURNAL   Cell 17 (2), 441-448 (1979)
   PUBMED   455472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142506.1 and AV000934.1.
            
            On Nov 10, 2006 this sequence version replaced NM_010594.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI956209.1, AI317440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-606               AK142506.1         2-607
            607-608             AV000934.1         624-625
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 64.03 cM"
     gene            1..608
                     /gene="Kap"
                     /gene_synonym="FKSG22"
                     /note="kidney androgen regulated protein"
                     /db_xref="GeneID:16483"
                     /db_xref="MGI:MGI:96653"
     exon            1..117
                     /gene="Kap"
                     /gene_synonym="FKSG22"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..410
                     /gene="Kap"
                     /gene_synonym="FKSG22"
                     /note="ARP"
                     /codon_start=1
                     /product="kidney androgen-regulated protein precursor"
                     /protein_id="NP_034724.1"
                     /db_xref="CCDS:CCDS20635.1"
                     /db_xref="GeneID:16483"
                     /db_xref="MGI:MGI:96653"
                     /translation="MMLFKVLVITVFCGLTVAFPLSELVSINKELQNSIIDLLNSVFD
                     QLGSYRGTKAPLEDYTDDDLSTDSEQIMDFTPAANKQNSEFSTDVETVSSGFLEEFTE
                     NTDITVKIPLAGNPVSPTS"
     exon            118..294
                     /gene="Kap"
                     /gene_synonym="FKSG22"
                     /inference="alignment:Splign:2.1.0"
     exon            295..357
                     /gene="Kap"
                     /gene_synonym="FKSG22"
                     /inference="alignment:Splign:2.1.0"
     exon            358..608
                     /gene="Kap"
                     /gene_synonym="FKSG22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      587..592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kap"
                     /gene_synonym="FKSG22"
                     /note="putative"
     polyA_site      606
                     /gene="Kap"
                     /gene_synonym="FKSG22"
                     /note="putative"
ORIGIN      
        1 aatttctttc tcctgttcac tggttgcctt aaccctacta aagcatgatg cttttcaagg
       61 tcctggtgat cactgtcttc tgtggtctga ctgtggcttt ccccctgtca gaattagttt
      121 caatcaataa agaactacag aattcaatca ttgacctact aaactcagtc tttgaccaac
      181 tgggatcata cagagggaca aaagctcctc tagaggatta tacagatgat gatttaagca
      241 ctgactctga gcagatcatg gacttcacgc cagccgcaaa caaacagaat tctgagttct
      301 ctactgatgt tgagacagtc tcctccggct ttctggaaga attcactgag aacacagaca
      361 tcacagtgaa aattccatta gctgggaatc cagtctcccc tacttcctga gaagactcca
      421 actttgaaat aaacctgcga ctgccattca ggatattgtc tttgtagaaa atgatataaa
      481 tctaagatgc tcccagcaaa gaagaaagaa cgaggaagtg atcctggatg agaaatgctg
      541 tgccaggcat ctctaagctc tgcccttact ctgtgtgggt ttaagaaata aacgttcatt
      601 tgaattgc
//
