LOCUS       NM_001310513            4741 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus KAT8 regulatory NSL complex subunit 3 (Kansl3),
            transcript variant 1, mRNA.
ACCESSION   NM_001310513 XM_006495901
VERSION     NM_001310513.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4741)
  AUTHORS   Chander,A. and Mager,J.
  TITLE     Loss of KANSL3 leads to defective inner cell mass and early
            embryonic lethality
  JOURNAL   Mol Reprod Dev 91 (5), e23760 (2024)
   PUBMED   38769918
  REMARK    GeneRIF: Loss of KANSL3 leads to defective inner cell mass and
            early embryonic lethality.
REFERENCE   2  (bases 1 to 4741)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4741)
  AUTHORS   Sheikh,B.N., Guhathakurta,S., Tsang,T.H., Schwabenland,M.,
            Renschler,G., Herquel,B., Bhardwaj,V., Holz,H., Stehle,T.,
            Bondareva,O., Aizarani,N., Mossad,O., Kretz,O., Reichardt,W.,
            Chatterjee,A., Braun,L.J., Thevenon,J., Sartelet,H., Blank,T.,
            Grun,D., von Elverfeldt,D., Huber,T.B., Vestweber,D., Avilov,S.,
            Prinz,M., Buescher,J.M. and Akhtar,A.
  TITLE     Neural metabolic imbalance induced by MOF dysfunction triggers
            pericyte activation and breakdown of vasculature
  JOURNAL   Nat Cell Biol 22 (7), 828-841 (2020)
   PUBMED   32541879
REFERENCE   4  (bases 1 to 4741)
  AUTHORS   Karoutas,A., Szymanski,W., Rausch,T., Guhathakurta,S.,
            Rog-Zielinska,E.A., Peyronnet,R., Seyfferth,J., Chen,H.R., de
            Leeuw,R., Herquel,B., Kimura,H., Mittler,G., Kohl,P., Medalia,O.,
            Korbel,J.O. and Akhtar,A.
  TITLE     The NSL complex maintains nuclear architecture stability via lamin
            A/C acetylation
  JOURNAL   Nat Cell Biol 21 (10), 1248-1260 (2019)
   PUBMED   31576060
  REMARK    GeneRIF: Loss of the lysine acetyltransferase MOF or its associated
            NSL-complex members KANSL2 or KANSL3 leads to a stochastic
            accumulation of nuclear abnormalities with genomic instability
            patterns including chromothripsis.
            Erratum:[Nat Cell Biol. 2023 Apr;25(4):626. doi:
            10.1038/s41556-023-01106-y.. PMID: 36849559]
REFERENCE   5  (bases 1 to 4741)
  AUTHORS   Chelmicki,T., Dundar,F., Turley,M.J., Khanam,T., Aktas,T.,
            Ramirez,F., Gendrel,A.V., Wright,P.R., Videm,P., Backofen,R.,
            Heard,E., Manke,T. and Akhtar,A.
  TITLE     MOF-associated complexes ensure stem cell identity and Xist
            repression
  JOURNAL   Elife 3, e02024 (2014)
   PUBMED   24842875
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4741)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   7  (bases 1 to 4741)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030079.1, BC132293.1 and AK129329.1.
            
            On Jul 15, 2015 this sequence version replaced XM_006495901.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2711404.1,
                                           SRR17784647.44663.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AK030079.1         2-98
            98-2898             BC132293.1         1-2801
            2899-4741           AK129329.1         2685-4527
FEATURES             Location/Qualifiers
     source          1..4741
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 15.22 cM"
     gene            1..4741
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /note="KAT8 regulatory NSL complex subunit 3"
                     /db_xref="GeneID:226976"
                     /db_xref="MGI:MGI:1918055"
     exon            1..77
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            78..343
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..2840
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /note="isoform 1 is encoded by transcript variant 1; NSL
                     complex protein NSL3; non-specific lethal 3 homolog"
                     /codon_start=1
                     /product="KAT8 regulatory NSL complex subunit 3 isoform 1"
                     /protein_id="NP_001297442.1"
                     /db_xref="CCDS:CCDS78561.1"
                     /db_xref="GeneID:226976"
                     /db_xref="MGI:MGI:1918055"
                     /translation="MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKP
                     WSAHPDASSARPTRMLFVTPRRQQENTIESDVPIDVETVTATPVPLYDNQKARSVMNE
                     CERHVIFARTDADAPPPPEDWEEHVNRTGWTVAQNKLFNKILKALQSDRLARLANEGA
                     CNEPVLRRVAVDKCARRVRQALASVSWDTKLTQWLHTTLVETLSLPMLAAYLDALQTL
                     KGKIPTLIDRMLVSSNTKTGAAGAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILI
                     VSSGPSSSVFPASRRHRFWQSQLSCLGKVIPVATHLLNNGSGVGVLQCLEHMIGAVRS
                     KVLEIHSHFPHKPIILIGWNTGALVACHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDP
                     LLDMKTPVLFVIGQNSLQCHPEAMEDFREKIRAENSLVVVGGADDNLRISKAKKKSEG
                     LTQSMVDRCIQDEIVDFLTGVLTRAEGHVGSEPRDQDAEKKKKPRDLTRRDLAFEIPE
                     RGSRPASPAARLPTSPSGSEDLSSVSSSPTSSPKTKVTTVTSTQKSSQIGTSQLLKRH
                     VQRTEAVLTHRQAQAQFAAFLKQNMLVRKAFPPGTSSCLFVPISSESVEDIEKEELRV
                     QLKRHHSSSPLPGAKPSKRPKIKVSLISQGDTVGGPCTLSQGGTPEAAGGKPITMTLG
                     ASAGAKELTGLLTTAKSSSSEGGGTASTTPSVASSSATPNAIHTLQSRLVATSPGSSL
                     PGTASASSLLQGLSFSLQDISSKTSGLPGSPSPGPAPQATSVKLPTPMQSLGAITTGT
                     STIVRTIPVATTLSSLGATPGGKPTAIHQLLTNGSLAKLASSLPGLAQISNQASGLKV
                     PTTITLTLRGQPSRITTLSPMGSGATPSEEPNSQMLPSSSQRLPPAP"
     exon            344..514
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            515..605
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            606..791
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            792..923
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1040
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1142
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1214
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1289
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1447
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1511
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1712
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1869
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..1947
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2139
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2221
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2352
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2462
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2685
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2819
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..4741
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4716..4721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /note="hexamer: AATAAA"
     polyA_site      4741
                     /gene="Kansl3"
                     /gene_synonym="4632411B12Rik; 4932435K23; Kiaa1310;
                     mKIAA1310"
                     /note="major polyA site"
ORIGIN      
        1 agagcccaag gcgccgggag gtaaggcgca cgcgcattgg ggtccggctc gggcgagcgc
       61 gcggccgaca actgcgggtg actagcatgc agatattcac accctgactt ggctgcttga
      121 ctactgacat ggcccaccgg ggtggggaga gggacttcca gacttcagct cggcggatgg
      181 gtacctccct gctcttccag ctttcagtgc atgagcggga actggacctc gttttcctgg
      241 atcatagcta tgcaaaaccg tggagtgccc acccagatgc cagtagtgcc cgccccaccc
      301 gcatgctctt tgtaaccccc cgtcggcagc aggagaatac tattgagtca gacgttccaa
      361 tagatgtgga gacggtcacg gcaactcctg ttccacttta tgacaatcag aaggcaagaa
      421 gtgtgatgaa cgagtgtgaa cggcacgtga tcttcgccag gacagatgca gatgctcctc
      481 ctccgccaga agactgggaa gaacatgtca acaggactgg ctggacagtg gctcagaata
      541 agctatttaa caagatcctc aaagccctgc agtctgaccg gcttgcacga ttggccaatg
      601 aaggggcttg caatgagcct gtgctgcgtc gcgtggctgt ggacaagtgt gcaaggaggg
      661 tgcggcaggc gctggcaagt gtcagctggg acaccaagct gacccagtgg ctgcacacca
      721 ccctcgtgga gaccctgagc ctgcccatgc tggctgctta cttggatgcc ctgcagacac
      781 tgaaagggaa gatcccaact ttgatagatc ggatgcttgt gtcgtccaac accaaaactg
      841 gggctgcagg agcggaggcc ttgtcccttc tcctcaagag gccctgggac cctgctgttg
      901 gtgtgctttc acataacaaa ccaagcaagc tccctggttc tcctttgatt ctcatcgtct
      961 cctctggtcc ctccagctct gtgttccctg cctcacgccg ccaccgcttc tggcagtctc
     1021 agctctcctg cttaggcaag gtcatccctg tagcgaccca tctactgaac aatggcagtg
     1081 gggtaggagt tctgcagtgc ctcgaacaca tgattggggc cgtgagaagc aaagtgctag
     1141 agattcacag ccatttccca cacaaaccca tcatcctgat tggatggaat acgggagctt
     1201 tggtggcctg tcatgtgtct gtgatggagt acgtcactgc tgttgtctgc cttgggtttc
     1261 ctctgcttac tgtggatgga cccagggggg atgtggacga tcccctcctg gacatgaaga
     1321 ctccagtcct cttcgtcatt ggtcagaatt ctctacagtg tcaccctgaa gccatggagg
     1381 acttccggga aaagattcga gcagaaaata gcttggtggt ggttggggga gctgatgata
     1441 atctcagaat aagcaaagca aagaagaaat cagagggcct gactcagagc atggtggaca
     1501 gatgtattca ggatgagatt gtagacttcc tgactggagt gctcactcgt gctgagggtc
     1561 atgtgggctc tgagcctcgg gatcaggatg ctgagaagaa gaagaaaccc cgggacttga
     1621 cccgaagaga cctggccttt gaaattcctg agcgaggcag tcgtcctgct tccccagctg
     1681 ccaggctccc cacatccccc tcaggctcag aggatctctc cagtgtgtcc agcagcccca
     1741 cctctagccc taagaccaaa gtgaccacag tgacctctac ccagaaatca agtcagattg
     1801 ggacctccca gctgctgaaa agacatgtgc agaggacaga agctgtgctg acccacagac
     1861 aagcccaagc acagtttgct gcttttctga aacaaaacat gctggtgagg aaagcttttc
     1921 ctcctggcac ctcctcctgt ctctttgttc ccatttcatc agaatcagtg gaggacatag
     1981 agaaagaaga gcttcgggtc cagcttaaga ggcaccattc ttccagtcct cttcctggag
     2041 caaagccttc caagcgacca aagatcaaag tgtccctgat ctcccaaggg gacacagttg
     2101 gaggaccttg cactctttct caaggtggaa cacctgaagc tgccggaggg aagcccatca
     2161 ccatgaccct gggagcttca gcaggagcca aggaactcac tggacttctc actacagcca
     2221 agtcaagttc ttctgaaggt ggaggtacag ccagcacaac cccatctgtg gcttccagca
     2281 gtgccacacc taatgctatc cacacgctgc agagccgctt ggtggccact tctccaggca
     2341 gctcccttcc agggaccgct tcagccagca gcctcctcca gggcctcagc ttcagcttac
     2401 aggatattag cagcaagacc tctggcctcc caggaagtcc ctccccaggg ccagccccac
     2461 aggccaccag tgtgaaattg ccaaccccca tgcagagtct gggtgccatc accacaggca
     2521 cgagcaccat tgtccgtacc atccctgtgg ccaccactct ctcctccttg ggtgccactc
     2581 ctggtgggaa gcccactgcc atccaccagc tgctgaccaa tgggagcctc gctaagttgg
     2641 caagcagcct acctggcttg gctcagattt ccaaccaagc atcaggctta aaggtcccca
     2701 ccaccattac tctgacgctg cgtggccagc caagcagaat taccacgcta agccctatgg
     2761 ggtcaggggc aacgccgtcc gaggagccca actcccagat gctaccatct agttcacagc
     2821 gcctgcctcc agcaccctga gtatgccagc aaaatgtcct taccaggttg gtgaaaactg
     2881 cctcaaggtg aaccgtgtgg tcctgctgag ccggctgagt atctgaagac atccttaaga
     2941 cagccatttt cagctctcta ctagctgtct ttggggctgg gcctctggct tgagaaaaca
     3001 ttaggccagg tgatgtaagg ccagcaagtt ggttcctggg atccccaggt ctggcatagt
     3061 tggatagttg gcatttctac cccaacactg atgtagtttg accccagtgt cagtatagaa
     3121 cggctcactg cagtttcatg atgaaggcag gaagaagtgg gctgtcagct gccagccctt
     3181 agctgctcta agatgtgggg aatggtggtt accatgtgat ggctggcccc ttcctcttcc
     3241 tcacaacatt ttgtgcaatc gcctgtagaa gagagcctgt aggtccaaaa agaggggtgg
     3301 acggcaaagg aagtagttgg caaggcacac ccaagggccc tatgctgctg gcagctcggg
     3361 cttggagctc tgcatgacac ttgagggcct aagaagagct agagaaatgg aatttaccaa
     3421 gtcagggaaa ccgcaaatcc ccgagagtct tgtgtgctgc ctggcaatga agcaattgac
     3481 cagctaccat gctatctctg ctgttgtagg aagcttgggg cactaggaca gggaaggctg
     3541 tgcttcaaag tttgtctcct ttcttagaac tctgcctttc tgcttagaag tggaaaggtt
     3601 gttgactact gtgtgaggct ctggggccag cctgagtctt gtagaccgtg gtcctggtga
     3661 tgtgggcact gacgatggag cagagcctct cattccctgt gacactgcag atggagctga
     3721 tgttcagagc cggctccttt ccctttcata cttagaaagt ttctgttaag atgagaaata
     3781 aagcaacgca agtgtgattt tggtcacggg gccatataca gctacaccaa agccctctca
     3841 cctatagtct gagtggacac agtgtggagg agcctcaggc aagtcaggtc agagacgtgt
     3901 gataggacga gagaggtctc cagtctccac acctcgcctt ggctgtggag ttgcactcag
     3961 tggttcacag agtggagctg tattctgaaa ttcagaaggc attcagagaa tttgagaagg
     4021 tatgaaatct ggatgaggcg cgcctagcgc tggggccttg atagcttcat aggtcagagc
     4081 atataaccac caaaagagag gataagactg ggagtgtctg tgaaaccttt agggattaag
     4141 ttggcagagg accctgaaca accctttgtg acttaggaga acaacttgag caacactgga
     4201 gggctgctcc tgaaagatgc tgcccctgtg ttctggaacc aaagaaaacc tgtatcctgc
     4261 tttggtggtt tatctgtgtg catcccatgg gtgacttctg aggcatggct tacatacctt
     4321 gaagaactgc aaaactgagg agggggagct gcagcacact gattgtcacc tttgagggac
     4381 tgaccaacga ggaggtgact ggagtctgta gaccatgttc ctcgggtccc atctcaaacc
     4441 acagcagttg gaatgtggag agacacttca ccccacccac ctcgtggcag acttgagggt
     4501 gtagcctcag aaggtagtac tcttatgagt atgtggaagg gtcaggaagg ctttacattc
     4561 tctttcaggc aacagagggc ttgtaaatgc ccagtggaag aggtcactga ggagcaaaga
     4621 cagcaacctt tggttgtatc actataataa tttgggttgg atgaattcat agaagtgagc
     4681 cagagcaatg tttctgatct tacgttagca aaaagaataa aatacaaaac attgaacttt
     4741 g
//
