LOCUS       NM_133714               3617 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus KAT8 regulatory NSL complex subunit 2 (Kansl2),
            transcript variant 1, mRNA.
ACCESSION   NM_133714
VERSION     NM_133714.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3617)
  AUTHORS   Guhathakurta,S., Erdogdu,N.U., Hoffmann,J.J., Grzadzielewska,I.,
            Schendzielorz,A., Seyfferth,J., Martensson,C.U., Corrado,M.,
            Karoutas,A., Warscheid,B., Pfanner,N., Becker,T. and Akhtar,A.
  TITLE     COX17 acetylation via MOF-KANSL complex promotes mitochondrial
            integrity and function
  JOURNAL   Nat Metab 5 (11), 1931-1952 (2023)
   PUBMED   37813994
REFERENCE   2  (bases 1 to 3617)
  AUTHORS   Sheikh,B.N., Guhathakurta,S., Tsang,T.H., Schwabenland,M.,
            Renschler,G., Herquel,B., Bhardwaj,V., Holz,H., Stehle,T.,
            Bondareva,O., Aizarani,N., Mossad,O., Kretz,O., Reichardt,W.,
            Chatterjee,A., Braun,L.J., Thevenon,J., Sartelet,H., Blank,T.,
            Grun,D., von Elverfeldt,D., Huber,T.B., Vestweber,D., Avilov,S.,
            Prinz,M., Buescher,J.M. and Akhtar,A.
  TITLE     Neural metabolic imbalance induced by MOF dysfunction triggers
            pericyte activation and breakdown of vasculature
  JOURNAL   Nat Cell Biol 22 (7), 828-841 (2020)
   PUBMED   32541879
REFERENCE   3  (bases 1 to 3617)
  AUTHORS   Pessoa Rodrigues,C., Herman,J.S., Herquel,B., Valsecchi,C.I.K.,
            Stehle,T., Grun,D. and Akhtar,A.
  TITLE     Temporal expression of MOF acetyltransferase primes transcription
            factor networks for erythroid fate
  JOURNAL   Sci Adv 6 (21), eaaz4815 (2020)
   PUBMED   32671208
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3617)
  AUTHORS   Gaub,A., Sheikh,B.N., Basilicata,M.F., Vincent,M., Nizon,M.,
            Colson,C., Bird,M.J., Bradner,J.E., Thevenon,J., Boutros,M. and
            Akhtar,A.
  TITLE     Evolutionary conserved NSL complex/BRD4 axis controls transcription
            activation via histone acetylation
  JOURNAL   Nat Commun 11 (1), 2243 (2020)
   PUBMED   32382029
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3617)
  AUTHORS   Karoutas,A., Szymanski,W., Rausch,T., Guhathakurta,S.,
            Rog-Zielinska,E.A., Peyronnet,R., Seyfferth,J., Chen,H.R., de
            Leeuw,R., Herquel,B., Kimura,H., Mittler,G., Kohl,P., Medalia,O.,
            Korbel,J.O. and Akhtar,A.
  TITLE     The NSL complex maintains nuclear architecture stability via lamin
            A/C acetylation
  JOURNAL   Nat Cell Biol 21 (10), 1248-1260 (2019)
   PUBMED   31576060
  REMARK    GeneRIF: Loss of the lysine acetyltransferase MOF or its associated
            NSL-complex members KANSL2 or KANSL3 leads to a stochastic
            accumulation of nuclear abnormalities with genomic instability
            patterns including chromothripsis.
            Erratum:[Nat Cell Biol. 2023 Apr;25(4):626. doi:
            10.1038/s41556-023-01106-y.. PMID: 36849559]
REFERENCE   6  (bases 1 to 3617)
  AUTHORS   Chelmicki,T., Dundar,F., Turley,M.J., Khanam,T., Aktas,T.,
            Ramirez,F., Gendrel,A.V., Wright,P.R., Videm,P., Backofen,R.,
            Heard,E., Manke,T. and Akhtar,A.
  TITLE     MOF-associated complexes ensure stem cell identity and Xist
            repression
  JOURNAL   Elife 3, e02024 (2014)
   PUBMED   24842875
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3617)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ059354.1, AK046649.1, AK162714.1 and BI134551.1.
            
            On Jan 18, 2014 this sequence version replaced NM_133714.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Both variants 1 and 6 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162714.1, AK046649.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                CJ059354.1         2-32
            32-2447             AK046649.1         2-2417
            2448-3597           AK162714.1         2421-3570
            3598-3617           BI134551.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..3617
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.52 cM"
     gene            1..3617
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
                     /note="KAT8 regulatory NSL complex subunit 2"
                     /db_xref="GeneID:69612"
                     /db_xref="MGI:MGI:1916862"
     exon            1..368
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
                     /inference="alignment:Splign:2.1.0"
     exon            369..627
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..1837
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
                     /note="isoform a is encoded by transcript variant 1; NSL
                     complex protein NSL2; non-specific lethal 2 homolog"
                     /codon_start=1
                     /product="KAT8 regulatory NSL complex subunit 2 isoform a"
                     /protein_id="NP_598475.2"
                     /db_xref="CCDS:CCDS37190.1"
                     /db_xref="GeneID:69612"
                     /db_xref="MGI:MGI:1916862"
                     /translation="MNRIRIHVLPTNRGRITPVPRSQEPLSCSFTHRPCSQPRLEGQE
                     FCIKHILEDKNAPFKQCSYVSTKNGKRCPSAAPKPEKKDGVSFCAEHARRNALALHAQ
                     MKKSNPGPMGETLLCQLSSYAKTELGSQTPESSRSEASRILDEDSWSDGDQEPITVDQ
                     TWRGDPDSEADSIDSDQEDPLKHAGVYTAEEVALIMREKLIRLQSLYIDQFKRLQHLL
                     KEKKRRYLHNRKVEHEALGSSLLTGPEGLLAKERENLKRLKCLRRYRQRYGVEALLHR
                     QLKERRMLATDGAAQQAHTTRSSQRCLAFVDDVRCSNQSLPMTRHCLTHICQDTNQVL
                     FKCCQGSEEVPCNKPVPVSLSEDPCCPLHFQLPPQMYKPEQVLSVPDDLEAGPMDLYL
                     SAAELQPTESLPLEFSDDLDVVGDGMPCPPSPLLFDPSLTLEDHSVTESAGDAGQMQA
                     AGDGCRSQGARSVEKAAFPQRGLATANGKPEPTSIS"
     exon            628..806
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
                     /inference="alignment:Splign:2.1.0"
     exon            807..921
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1085
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1252
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1349
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1603
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1711
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..3601
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2421..2426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
                     /note="hexamer: ATTAAA"
     polyA_site      2451
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
                     /note="major polyA site"
     regulatory      3579..3584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
                     /note="hexamer: AATAAA"
     polyA_site      3601
                     /gene="Kansl2"
                     /gene_synonym="2310037I24Rik; B930009D17"
ORIGIN      
        1 aagctgcgcg gtgccgcgcg gtgggggagg taagatggcg ccgtgccggg cgcttctcct
       61 ttgctgttag gcgctgctcg ccttctctgt cagctcagcg cggcacgtcg tctcctgcag
      121 cgttggagcc tctctggttg ctaggctttc ggggagccag gttctccggt gccgggagcc
      181 gtgggacaag atggcgcttg taggacgacg gccaaggcgc tcgggtcggg gctgtgagcg
      241 ctgaggcggc cagggacaaa ggcggcgagc cggggcgtgg gggcggggcg tgccgcgccg
      301 ttgcagtggt gccgcgtggg acaggcgccg cgcttccggt ctgctgctgc ggagattcgg
      361 ccaacgtggt tttggcatga acaggattcg gattcacgtc ttgccaacga atcgggggag
      421 gatcacccca gtgcccaggt cgcaggagcc cctttcctgt tcgttcactc accgcccgtg
      481 ctctcagccg cggctggagg ggcaggagtt ctgcattaag cacattcttg aagacaagaa
      541 tgcacccttc aaacaatgta gttacgtctc gacgaagaat ggaaaaaggt gccccagtgc
      601 tgccccaaag cccgagaaga aagatggggt gtctttctgt gccgaacatg ctcgaagaaa
      661 tgccctagca cttcatgctc aaatgaagaa gagcaaccca ggccctatgg gtgaaaccct
      721 cttgtgccag ttgagctcat acgctaaaac agagctgggc tcgcagaccc cagagagcag
      781 ccgcagtgaa gccagccgga tactggatga agacagctgg agtgatgggg accaggaacc
      841 catcactgtg gatcagacat ggagaggtga ccctgacagt gaagccgata gcatagacag
      901 tgatcaagaa gatcccctga aacatgctgg tgtctataca gctgaagaag tggctcttat
      961 tatgagagaa aagctaattc gtttgcagtc tttgtacatt gatcagttta aaagactcca
     1021 acacctgctc aaagagaaga agcgccgcta tttacacaac cggaaagtgg agcacgaggc
     1081 tttaggtagt agtctcctga ctggccctga gggacttttg gccaaagaga gagagaattt
     1141 aaagcgacta aaatgtctta ggcgataccg tcaacgctat ggagtagaag ccttactaca
     1201 caggcagctg aaggaacgca gaatgctggc caccgatggg gctgctcaac aggctcacac
     1261 cactcgttcc agtcagaggt gcttagcctt tgtggatgat gtgcgctgct ccaatcagtc
     1321 tctcccaatg accagacact gccttaccca tatctgtcag gatacaaatc aggttctctt
     1381 caaatgctgc cagggatctg aagaggtccc ctgcaacaaa ccagttcctg taagcctttc
     1441 tgaggatccc tgctgccctc tgcatttcca gttgcctcct cagatgtata agcccgagca
     1501 ggtactgtct gtgccagacg atctggaagc cggccccatg gatctgtact tgagtgctgc
     1561 cgagcttcag cccactgaga gtttaccact ggagttcagt gatgacttgg atgttgtggg
     1621 tgatggcatg ccatgcccgc cgtcgccatt gctctttgat ccttcgctaa ctcttgaaga
     1681 tcattcagtc acagaaagtg ccggagacgc aggacagatg caggcggctg gggatgggtg
     1741 cagatcccag ggagctcgaa gtgtagagaa agcagcattc cctcagcgtg gattggctac
     1801 tgcgaatgga aaaccagaac ccacttctat cagttgacat tcattctggg aattgtttgc
     1861 ctttggattt gaactttcca ttcttcagac aagtgtatct ctgatcatct ctccctgaac
     1921 agggacaact cagaccacat tgcttccttt ggggctttag agcgctatag acaaacataa
     1981 tccaagtttg tgtggaatga atatttagta tataagtttt gggatttttt tttttttcaa
     2041 ggaagaatgt gaggtgatcc ctgcctttgg gatacaatgc atattggaga ctgcctggga
     2101 gagagacatt ctgtaatggg actcctaagc cacggacaga accccacatg gatgtccagg
     2161 cgggctgtgc tcgagacggt gctcggcagg cgttggccct tagtgtctgg ctagctgtat
     2221 ctaaaggcct gtatctaagc ctttcctctg ctctacatag ttgggcaata caaagcccat
     2281 tcgtttcctt gtgaactgta actgagaaaa gcagctcaca ggtctgggct ctccttactt
     2341 agttattctt gcttttaact tatgtaagtt cctgtggtga ctccatgtaa tatgtagtga
     2401 aattactgta tatagtttct attaaatgtt aaaatgctat caaagtgtaa agtgatctgg
     2461 atcgattgtg ttctcgttgg atttgagaat gttctgatgg gaaaggtgta tactacttct
     2521 attctaagac aggcactctg gagaaactca cgacagaggt ggtgcttggt acctagttcc
     2581 cagggccagg taaacttgtg tcactggaaa gctaggggtt aattcactcg agacctggca
     2641 cagagcctta ggaccttggt tcaaccccag cgaggatggt ggagtggcaa agcagacagt
     2701 gtggcggtga ggtttgtgta aagccgcttc ctaggggagc gttagacaga aatgatgagc
     2761 agttcccagg aagaagctaa taaaactgcc aaggaaagcg gcaaagctcc tccctggggt
     2821 gggcagtcat ccatttctcc ctgcaaggaa gtagactaga tcattcgctc agcccagacc
     2881 cctttcgggt gttggctgtt ctctactctt ctgttgctta tgactaagat gtaaggttcc
     2941 agaggggtta tagagcatca tggcaggatc aggaagccgt gagctcgcat ggggactact
     3001 agcatgtggg acagcacacg tacaagacac aaggtttatc tcaaagtcca tccccagtga
     3061 tcacttcctg cagcatttcg gtatcaccga gatatcccaa aactgccacc agctgggtgc
     3121 caagtgtcca agtgccagag actggcgggc atttctaatt caaataatca catcggggtt
     3181 ggccagtgga aagcacaaga gcacggtact ggaccggatt gtcagaaggg gagctggttc
     3241 aaagagcact gagggcagac cagagtacat ctcttagagc caggccaaac tgtaatcccc
     3301 ccactgctgc gacacgtgga ggccccacag tggtacccca gagtgggaag gttggatggc
     3361 tcatgggaaa tacacactat gatgacttag gagggatagt ggctcctatg tatgcgaaga
     3421 ggagactaca accagcaaac tgcaaaccac ctctcagcaa gttgtgtagg gaacaccagg
     3481 gttgtaactt ttgtgagtta tcaccatttt gggggggatg aacctatctt tcagtgatga
     3541 acctgtcttt gggtcatcca tattcctgta aacaagccaa taaaccctac agttcactga
     3601 aaaaaaaaaa aaaaaaa
//
