LOCUS       NM_001122738            4655 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus KAT8 regulatory NSL complex subunit 1-like (Kansl1l),
            transcript variant 1, mRNA.
ACCESSION   NM_001122738
VERSION     NM_001122738.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4655)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ177470.1, AK145440.1, AK138707.1, AK082897.1 and BB793048.1.
            
            [WARNING] On Jul 12, 2024 this sequence was replaced by
            NM_001122738.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            CDS exon combination :: AK082897.1, SRR13861890.206904.1
                                    [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               CJ177470.1         2-294
            294-963             AK145440.1         265-934
            964-1180            AK138707.1         795-1011
            1181-4650           AK082897.1         1-3470
            4651-4655           BB793048.1         370-374
FEATURES             Location/Qualifiers
     source          1..4655
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 33.61 cM"
     gene            1..4655
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /note="KAT8 regulatory NSL complex subunit 1-like"
                     /db_xref="GeneID:68691"
                     /db_xref="MGI:MGI:1915941"
     exon            1..222
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /inference="alignment:Splign:2.1.0"
     exon            223..1342
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..3122
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /note="isoform 1 is encoded by transcript variant 1; KAT8
                     regulatory NSL complex subunit 1-like protein"
                     /codon_start=1
                     /product="KAT8 regulatory NSL complex subunit 1-like
                     protein isoform 1"
                     /protein_id="NP_001116210.1"
                     /db_xref="GeneID:68691"
                     /db_xref="MGI:MGI:1915941"
                     /translation="MTPALKEATTKGICFSSLPNTMESDKMLCMESPRTVDEKLKGGD
                     TFSQMLGFPTPEPTLNTNFVNLKHFASPQASKHFQTVLLMSSNSTLNKYNENYNQKKV
                     MESNCSKLKNVLCNGSSIQLSKICPSHSENEFIKKELSDTTSQCMKDIQIVLDSNLTK
                     DANVDRLHLQNCKWYQKNALLDKFTDTKIKKGLLQCTQKKIGPSHSDVPTSSSAAEKE
                     QEVNARLLHCVSKQKILLSQARRTQKHLQMLLAKHVVKHYGQQMKFSMKHQLPTMKIF
                     HEPTTVLSNSLLEHTEIKPEVNILASENKFWDDTNNGFSQCTAAEIQRFALSATGLLS
                     HVEEGLDSDATDSSSDDELDEYTIRKNVAVNSSTEWKWLVDRAQVGSRWTWLQAQISE
                     LEYKIQQLTDIHRQIRASKVPQRSEEPLPEHDFEMSPSSPTLLLRNIEKQSAQLTEII
                     NSLIAPLNLSPTSSPLSSKSCSHKCLANGISRSASENLDELSSSSSWLLNQKHSKKRR
                     KDRTRLKSPSLAIMSTAARTRPLQSFHKRKLYRLSPTFYWTPETLPSKEAFLSSTQTP
                     YTGSPFSWDNWEQSSRSHLLREQVSKLDSSFHPVLSLPSEIPLHLHFETLFKKTDMKG
                     ELAENQFVGDCLISPPPVQGTSSLNQWRNGYSPICKPQIRSQPSVQLLQGRKKRHLSE
                     TALAGERTRFEEFAFQRSEPGSHCNFTAVSNANVTSRTQNPSSQNTSRRRLRSESSYD
                     IDNIVIPMSLVAPAKLEKLQYKEILTPRWRKVVLQPLDEHNLNKEEIEDLSDDVFSLR
                     HRKYEEREQARWSLWEQSKWHRRNNRAYSKNVEGQDLVLKEHSSELGSAQQGTAESPF
                     ELPAESHSLCAQDSLSLNDGQEDKSLRWERRAFPLKDEDTAALLCQDERKDQTGGTST
                     AFHDEVFCSTTPESGHPPKMQLDGMEEYKSFGIGVTNVKRNR"
     exon            1343..1484
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1577
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1699
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1904
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2067
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2175
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2307
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2429
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2554
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2609
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2722
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2891
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..4655
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4519..4524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /note="hexamer: ATTAAA"
     polyA_site      4536
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
                     /note="major polyA site"
     polyA_site      4651
                     /gene="Kansl1l"
                     /gene_synonym="1110028C15Rik; 1190030G24; C430010P07Rik;
                     mKIAA4189"
ORIGIN      
        1 gtagggttcc gtcccccgag cgcccggagc tgcgggcagc gggcggactg ttaaaccgcg
       61 gcggcggcgt cagccggggc gggagcgggg cgcgctctgg agacgagtcg gcggcgcccc
      121 gggtgggggg aggcgggcgg acagctagag atcgcctcgg cggcccccac cacggccgga
      181 ccgaaggtgc ggcggcggag ggcagccagg gcgccccagc aggcttccag taattatctc
      241 caggattcgc catgacccca gctctgaagg aggcaacaac aaagggtatc tgcttttcat
      301 ctttgccaaa taccatggaa tctgacaaga tgctgtgcat ggaaagtccg agaactgtag
      361 atgaaaagct taagggagga gacactttct ctcagatgct gggatttccg actcctgaac
      421 ctactctaaa tactaatttt gtgaatttaa aacattttgc ctcccctcag gcttcaaaac
      481 attttcagac agttctttta atgagttcta attcaacact aaataagtat aatgagaatt
      541 ataaccaaaa gaaagtaatg gagtccaact gcagtaaact gaaaaatgta ctgtgcaatg
      601 gcagcagcat tcagctcagt aagatctgcc cttctcactc cgaaaacgag ttcatcaaaa
      661 aggaactctc ggataccaca agccagtgca tgaaagatat acaaatcgtt ctggattcaa
      721 atctcaccaa agacgctaat gtagacagac tacatctgca aaactgtaaa tggtaccaaa
      781 agaatgcact tttggataaa ttcactgata ctaagattaa aaagggttta ttgcaatgta
      841 ctcaaaagaa aattggacct agccactcag atgtgcctac tagttcctca gctgctgaaa
      901 aagagcagga agtgaatgct cgtttacttc attgtgtgag taaacagaaa attttactta
      961 gccaggctag aagaactcag aaacacttgc agatgctcct ggcaaagcat gttgttaagc
     1021 actatggtca acagatgaaa ttttctatga aacatcagct gcccacaatg aagatctttc
     1081 atgaacccac aacagttctg agtaatagtt tacttgaaca cactgaaatt aagccagaag
     1141 tcaacatatt ggcttcagag aataagtttt gggatgatac aaacaatggc ttttctcagt
     1201 gtacagctgc agaaatccaa agatttgcac tgtctgctac agggctgttg tctcatgttg
     1261 aagagggtct ggactctgac gccaccgata gcagctcaga tgacgagttg gatgaatata
     1321 ccattagaaa aaatgtggca gtcaactcta gtactgaatg gaagtggctt gtagacagag
     1381 cacaagttgg cagccgatgg acttggcttc aagctcagat ttcagagctg gaatacaaaa
     1441 tccagcagct aacagatatc cacaggcaga ttcgtgcctc taaggttccc cagaggagtg
     1501 aagagccttt accagaacac gattttgaga tgtcaccaag cagccctaca ctacttcttc
     1561 gaaacataga gaaacagagt gcacagttga ctgagatcat taacagtttg attgcccctc
     1621 tcaacttgtc tccaacttca tcacccctct cttccaaatc ctgtagccac aaatgtctgg
     1681 ctaatggcat ttccagaagt gcttcagaga atttagatga gctctcttcc tccagtagct
     1741 ggttacttaa tcagaagcac agtaagaaaa ggagaaaaga caggacaaga ttgaaatctc
     1801 catccttggc tatcatgagt acagctgcgc gaacaaggcc ccttcaaagt ttccataaga
     1861 gaaaactcta cagattgagt cccacttttt actggactcc cgagacttta ccttcaaaag
     1921 aagcattttt aagtagcaca cagacgcctt acacgggatc accgttcagt tgggacaact
     1981 gggaacagag ttccaggtct cacctgttaa gagaacaggt ttccaaactc gattcctcct
     2041 tccatcctgt tttgtcattg ccatcagaaa ttccccttca tcttcatttt gagaccttat
     2101 tcaagaagac cgacatgaaa ggagagcttg ctgaaaatca atttgtaggt gactgtctca
     2161 tatcaccgcc acctgtacaa ggtacttctt ctctgaatca gtggagaaat ggatattcac
     2221 ctatatgtaa gcctcaaata aggtcacaac catctgtaca actattacag ggaagaaaaa
     2281 aaagacattt aagtgaaaca gcattagcag gagaaagaac tagatttgaa gaatttgctt
     2341 ttcaacgttc agaaccagga tctcattgca attttactgc tgtctctaat gccaatgtca
     2401 catcaagaac ccagaatcca tcctcacaaa atacttcacg acggaggtta agaagtgaga
     2461 gctcttatga tatagataac attgtgattc ccatgtcatt agtagcacca gccaaattag
     2521 agaaactcca gtataaagaa atacttactc cacgctggag gaaggttgtt cttcagcccc
     2581 ttgatgagca taacttaaac aaagaagaga tagaagatct ttctgatgat gtcttctccc
     2641 taagacacag aaaatatgaa gagagagagc aagctaggtg gtcactgtgg gaacaaagca
     2701 aatggcacag aagaaataac agagcttaca gtaaaaatgt ggaagggcag gacttggttc
     2761 tgaaggaaca ctcaagtgaa cttggcagtg ctcagcaggg tactgcagaa agtccttttg
     2821 aactcccagc agaaagccac agtctgtgtg ctcaggactc cctttcttta aatgatggtc
     2881 aagaagacaa gtctttgcgg tgggagcggc gagcatttcc actgaaggat gaggatacag
     2941 cagccttatt gtgccaagat gaaagaaagg atcagactgg ggggacaagc acagccttcc
     3001 acgatgaagt cttctgtagt actacacctg agagtggcca ccctccaaag atgcagttag
     3061 atggaatgga agaatataaa agctttggta taggagttac taatgttaaa agaaataggt
     3121 gacagggaac gtattaagaa aaatatgtaa ctgaaaggaa aagaggaaaa agcctacaac
     3181 cctctctgct ggatccatcc ccacctcctc cggtcagggt tccagaacag gaggaggccc
     3241 acatgcatcc atctttcatg ttcagggaac atgccgatgt cttttttttc ttcctgaatc
     3301 acagaagtag ctagcttctt acctacacaa atgctagtaa cttgtgtttg ccaataatac
     3361 aaatcacaag cactaagata ttaactgctg caatttgatg acaaatcaca cctcggggca
     3421 tttgttgagg tacgagcccc tccctgatag tactgttgat ttgcatcaaa tgacaactat
     3481 tctttgtttc tattctcatg gcagttcact aaaactgcct caataatatg agaatatgct
     3541 agtgtgtata cagaatatat acacatacag tgcacacata tgtagtctta aaactgcatg
     3601 tatgaattac tctatgcaat ataagttgcc atgaatacct agcacaggtg ctgacttata
     3661 gcagacacct gaaagctttg actgtggaga gggagttgtt ttttctttta ttctaaacat
     3721 tgtttaacca atataagtta tttatggaaa ttcttatatc agataacgca atattcattt
     3781 atttgaaatc actgttctct cctgaactaa ccacaggctt tctgcttact cctaacagaa
     3841 ttaagagaag caacttaaga gtttaatata ttgatacatt taaaactatt gtcgttggga
     3901 attcaccgag tttacttgct ttatggacct cctcaagaca gcaatttaaa gtgtaaaaca
     3961 gcacacaaat cataatatgg ctgtatttct agctgatgta cagctagaag cttctaattt
     4021 ggtttttcct taccatagct ttcataaata cctatgctta caggcatcct agatcaagaa
     4081 ttcaagtttt ccaagaccaa aactttaata tagaatactg aggagtgtac attaaggaaa
     4141 attctttttg aagccatacc attttttttt cctagatgaa agttaaggac aatttgtatc
     4201 aaccactttt tgttatgcaa agaaaggtta ctcaatttgt agttcccata ctactgaaaa
     4261 tcctggccac tgagcttgga ctctatggga ttagatatat aaggttttgt tgaggattag
     4321 aaattaaact gatccctgca gaaggggggt ggggaaccat ttaaattcaa tacttacaaa
     4381 cttttgctta tagttttact gtacatttat ttttaaagaa aaagataaca aaagccagaa
     4441 aaatacaagt tgtcccaaca aataatttca aatctttgtc atgactgata ttataacctt
     4501 ctacatagtt tttttttaat taaagttatt tctatatgcc ttgtattgtg tgatttgatt
     4561 aaatgcacaa acctttcgta agctaaaata aaaacaagta ttaataaact tttatcttac
     4621 agggcaggaa aaagcccaag caagctctct attcc
//
