LOCUS       NM_001372459            5456 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus KAT8 regulatory NSL complex subunit 1 (Kansl1),
            transcript variant 4, mRNA.
ACCESSION   NM_001372459 XM_006534445
VERSION     NM_001372459.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5456)
  AUTHORS   Guhathakurta,S., Erdogdu,N.U., Hoffmann,J.J., Grzadzielewska,I.,
            Schendzielorz,A., Seyfferth,J., Martensson,C.U., Corrado,M.,
            Karoutas,A., Warscheid,B., Pfanner,N., Becker,T. and Akhtar,A.
  TITLE     COX17 acetylation via MOF-KANSL complex promotes mitochondrial
            integrity and function
  JOURNAL   Nat Metab 5 (11), 1931-1952 (2023)
   PUBMED   37813994
REFERENCE   2  (bases 1 to 5456)
  AUTHORS   Wang,D., Li,H., Chandel,N.S., Dou,Y. and Yi,R.
  TITLE     MOF-mediated histone H4 Lysine 16 acetylation governs mitochondrial
            and ciliary functions by controlling gene promoters
  JOURNAL   Nat Commun 14 (1), 4404 (2023)
   PUBMED   37479688
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5456)
  AUTHORS   Li,T., Lu,D., Yao,C., Li,T., Dong,H., Li,Z., Xu,G., Chen,J.,
            Zhang,H., Yi,X., Zhu,H., Liu,G., Wen,K., Zhao,H., Gao,J., Zhang,Y.,
            Han,Q., Li,T., Zhang,W., Zhao,J., Li,T., Bai,Z., Song,M., He,X.,
            Zhou,T., Xia,Q., Li,A. and Pan,X.
  TITLE     Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and
            links autophagic dysfunction with Koolen-de Vries syndrome in mice
  JOURNAL   Nat Commun 13 (1), 931 (2022)
   PUBMED   35177641
  REMARK    GeneRIF: Kansl1 haploinsufficiency impairs autophagosome-lysosome
            fusion and links autophagic dysfunction with Koolen-de Vries
            syndrome in mice.
            Erratum:[Nat Commun. 2022 Mar 17;13(1):1575. doi:
            10.1038/s41467-022-29129-3.. PMID: 35301327]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5456)
  AUTHORS   Sheikh,B.N., Guhathakurta,S., Tsang,T.H., Schwabenland,M.,
            Renschler,G., Herquel,B., Bhardwaj,V., Holz,H., Stehle,T.,
            Bondareva,O., Aizarani,N., Mossad,O., Kretz,O., Reichardt,W.,
            Chatterjee,A., Braun,L.J., Thevenon,J., Sartelet,H., Blank,T.,
            Grun,D., von Elverfeldt,D., Huber,T.B., Vestweber,D., Avilov,S.,
            Prinz,M., Buescher,J.M. and Akhtar,A.
  TITLE     Neural metabolic imbalance induced by MOF dysfunction triggers
            pericyte activation and breakdown of vasculature
  JOURNAL   Nat Cell Biol 22 (7), 828-841 (2020)
   PUBMED   32541879
REFERENCE   5  (bases 1 to 5456)
  AUTHORS   Arbogast,T., Iacono,G., Chevalier,C., Afinowi,N.O., Houbaert,X.,
            van Eede,M.C., Laliberte,C., Birling,M.C., Linda,K., Meziane,H.,
            Selloum,M., Sorg,T., Nadif Kasri,N., Koolen,D.A., Stunnenberg,H.G.,
            Henkelman,R.M., Kopanitsa,M., Humeau,Y., De Vries,B.B.A. and
            Herault,Y.
  TITLE     Mouse models of 17q21.31 microdeletion and microduplication
            syndromes highlight the importance of Kansl1 for cognition
  JOURNAL   PLoS Genet 13 (7), e1006886 (2017)
   PUBMED   28704368
  REMARK    GeneRIF: Our results demonstrate the implication of KANSL1 in the
            manifestation of Koolen-de Vries syndrome phenotypes and extend
            substantially our knowledge about biological processes affected by
            these mutations. Clear differences in social behavior and gene
            expression profiles between Del/+ and Kansl1+/- mice suggested
            potential roles of other genes affected by the 17q21.31 deletion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5456)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (bases 1 to 5456)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 5456)
  AUTHORS   Poorkaj,P., Kas,A., D'Souza,I., Zhou,Y., Pham,Q., Stone,M.,
            Olson,M.V. and Schellenberg,G.D.
  TITLE     A genomic sequence analysis of the mouse and human
            microtubule-associated protein tau
  JOURNAL   Mamm Genome 12 (9), 700-712 (2001)
   PUBMED   11641718
REFERENCE   9  (bases 1 to 5456)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 5456)
  AUTHORS   Nishiguchi,S., Sakuma,R., Nomura,M., Zou,Z., Jearanaisilavong,J.,
            Joh,T., Yasunaga,T. and Shimada,K.
  TITLE     A catalogue of genes in mouse embryonal carcinoma F9 cells
            identified with expressed sequence tags
  JOURNAL   J Biochem 119 (4), 749-767 (1996)
   PUBMED   8743579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL593843.9.
            
            On Sep 3, 2019 this sequence version replaced XM_006534445.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.632384.1,
                                           SRR14777535.2653337.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-596               AL593843.9         13783-14378
            597-1968            AL593843.9         30810-32181
            1969-2110           AL593843.9         77277-77418
            2111-2209           AL593843.9         87325-87423
            2210-2325           AL593843.9         98507-98622
            2326-2518           AL593843.9         99227-99419
            2519-2684           AL593843.9         105451-105616
            2685-2867           AL593843.9         112430-112612
            2868-3056           AL593843.9         113056-113244
            3057-3205           AL593843.9         113592-113740
            3206-3327           AL593843.9         117856-117977
            3328-3385           AL593843.9         119497-119554
            3386-3498           AL593843.9         119770-119882
            3499-3751           AL593843.9         120404-120656
            3752-5456           AL593843.9         120898-122602
FEATURES             Location/Qualifiers
     source          1..5456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 67.79 cM"
     gene            1..5456
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /note="KAT8 regulatory NSL complex subunit 1"
                     /db_xref="GeneID:76719"
                     /db_xref="MGI:MGI:1923969"
     exon            1..596
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /inference="alignment:Splign:2.1.0"
     exon            597..1968
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /inference="alignment:Splign:2.1.0"
     CDS             680..3979
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /note="isoform 3 is encoded by transcript variant 4; NSL
                     complex protein NSL1; non-specific lethal 1 homolog"
                     /codon_start=1
                     /product="KAT8 regulatory NSL complex subunit 1 isoform 3"
                     /protein_id="NP_001359388.1"
                     /db_xref="CCDS:CCDS88268.1"
                     /db_xref="GeneID:76719"
                     /db_xref="MGI:MGI:1923969"
                     /translation="MAAMAPALTDAAAEAHHIRFKLAPPSSTLSPGSAENNGNANILI
                     SANGTKRKAIAAEDPSLDFRNNPTKEDLGKLQPLVASYLCSDVTSVPAKESLKLQGVF
                     SKQTVLKSHPLLSQSYELRAELLGRQPVLEFSLENLRTMNTSGQTALPQAPVNGLAKK
                     LTKSSTHSDHDNSSSLNGGKRSLTSSSLQGGEVGGPDSGNLKGGMTNCTLPHRSLDIQ
                     HTTLYSNNSTANKSSVNSMDQPALQGSSRLSPSTDSSSNLTNVKLEVKKSPLSSILFS
                     ALDSDTRITALLRRQADIEIRARRLQKRLQVVQAKQVERHLQHQLGGFLETTLSKLPN
                     LESLRSRSQLMLTRKAEAALRKAASESATSEGLSNFLKSDSISEELERFTASGIANLR
                     CSEQAFDSDVTDSSSGGESDIEEEELTRADPEQCHVPLKRRSEWRWAADRAAIVSRWN
                     WLQAHVSDLEYRIRQQTDIYKQIRANKGLIVLGEAPFPDHTTDLLSLSSEVKTDHGRD
                     KLIESVSQPSENHGILVSNITESLSTKSCGAPRPVNGVVNSLQPVLADQVPGDSSDAE
                     EQLHKKQRLNLVSSSDGTCVAARTRPVLTCKKRRLVRPSSIVPLSKKVHRNVRSGCDV
                     NPSCALCGSGSVNTMPPEIHYEAPLLERLSQLDSCVHPVLAFPDDVPTSLHFQSMLKS
                     QWQNKPFDKIKPTKKFSLKHRATMPCSLSDPVRKDRHKLVNSFLTTAKLCHQQTRPDR
                     THRQHLDGVGAVPMVERVTAPKAERLLHLPPPVHDPTHSKMRLRDHSSERSEVLKHHT
                     DMSSPSYLTATHHPPHSPLVRQLSTSSDTSTPTSSGSQVAASTSQPVRRRRGESSFDI
                     NNIVIPMSVAATTRVEKLQYKEILTPSWREVDVQSLKGSPDEENEEIEDLSDAAFAAL
                     HAKCEEMERARWLWTTSVPPQRRGSRSYRSSDGRTTPQLGSANPSTPQPASPDVSSSH
                     SLSEFSHGQSPRSPISPELHSAPLTPVARDSLRHLASEDTRCSTPELGLDEQSVQPWE
                     RRTFPLAYSPQAECEEQLDAQDTAARCTRRTSGSKTGREAEVAPTSPPVVPLKSRHLA
                     ATVTAQRPAHR"
     exon            1969..2110
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2209
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2325
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2518
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2684
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2867
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3056
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3205
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3327
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3385
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3498
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /inference="alignment:Splign:2.1.0"
     exon            3499..3751
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /inference="alignment:Splign:2.1.0"
     exon            3752..5456
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5411..5416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /note="hexamer: AAGAAA"
     polyA_site      5416
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /note="major polyA site"
     polyA_site      5432
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
     regulatory      5437..5442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
                     /note="hexamer: AATAAA"
     polyA_site      5456
                     /gene="Kansl1"
                     /gene_synonym="1700081L11Rik; 9430041J06Rik; mKIAA1267"
ORIGIN      
        1 attctccctc cgcttcagat taaagggggg gagggaaaag gagctcggcc gccattttcc
       61 cagtgccgcc gccgccaccg ccaccgctcg ctgagccggc gggagaacca agcgccgtag
      121 cgaagccgac tcgtctcgcc gcggcggctt ggggggcggc cgaagtgcgc tccccggccg
      181 ggaagaagct cccggggtgg cggccggggt gcgggcgcgg gctgcagacg gcggcgcttg
      241 tttgtgcggg gcgggggggg cagctttacc ctctgccccc gcccgcccgg ggctgcggtc
      301 cccgccgtgc ccaggccggg tcggaacgga ggaaggccgg agaaagggcc cgaaagagaa
      361 gaaaaagcag ccgctccccg ccgccgccgc cttcccctcc ccctccgcct cgcccccccg
      421 cccggaaagt cagggcggct ccgggcgccg ggggggagga gagcggcggg ccgggccgga
      481 gcagcagccg cgcgcccccg cccgctggtc ctcggcgccc aggccggggg gctgtttgca
      541 aactgcgccc attttgtggg gccgaatccg cccgggctac gctcctccat cacgtgtgtg
      601 ttctcagggg aggcagcaag gggccgtgga gctggcctca gcactgggag aggctggact
      661 tcctgtctct ctgtgctgaa tggctgcgat ggcgcccgct ctcactgacg cagcagctga
      721 agcacaccac atccggttca aactggctcc cccatcctcc accttgtccc ctggcagtgc
      781 cgaaaataac ggcaacgcca atattcttat ttctgccaac ggaaccaaaa gaaaagccat
      841 tgctgcggag gatcccagtc tagacttccg caataatcct actaaggaag acttgggaaa
      901 gctgcagcca ttggtggcat cttatctctg ctctgatgta acatctgttc ccgcaaaaga
      961 gtctttgaaa ttgcaaggcg ttttcagcaa gcagacagtc cttaagtctc atcctctttt
     1021 atctcagtcc tatgaactcc gagctgagct gctggggagg cagccagttt tggagttttc
     1081 cttagaaaac cttagaacca tgaatacaag tggtcagaca gctctgccac aagcgcctgt
     1141 aaatggattg gctaagaaat tgactaaaag ttcaacacat tcggatcatg acaattccag
     1201 ttccctcaat gggggaaaac ggtctctcac ttcgtcatct ctacaaggtg gtgaggtggg
     1261 gggacctgac tctgggaact tgaagggggg tatgaccaat tgcactcttc cacatagaag
     1321 ccttgatata caacacacaa ctctatatag caataatagc actgcaaaca aatcttctgt
     1381 taattccatg gaccagccgg cacttcaagg aagcagcagg ttatcaccta gtacagactc
     1441 cagctctaac ttgacaaatg tgaagttaga agtcaaaaag tctcctctgt cttccattct
     1501 tttcagtgct ttagactctg atacaaggat aacagcttta ctgaggcggc aggctgatat
     1561 tgagatccgt gcccgaaggt tacagaagcg attacaggtt gtgcaagcca agcaggtgga
     1621 gagacattta cagcaccaac tgggtggatt tttggagacg acattgagta aactgccaaa
     1681 cttggaatcc ttaaggtccc ggagccagtt gatgttgacc cgaaaggctg aagctgcctt
     1741 gagaaaagct gccagtgagt ctgccacttc agagggactt agcaactttt tgaaaagtga
     1801 ttcaatttca gaagaattgg agagatttac agctagtggc atagccaacc tgaggtgcag
     1861 tgagcaagcg tttgattcgg atgtcacaga cagtagttcc ggaggggagt ctgacattga
     1921 agaggaagaa ctgactcgag ctgatcctga gcaatgccat gtgcccctga aacgtaggtc
     1981 tgaatggaga tgggctgcag accgagcagc tattgtcagc cgctggaact ggcttcaggc
     2041 ccatgtttct gacttggaat atcgaattcg tcagcaaaca gatatttaca aacagatacg
     2101 tgctaataag gggttgatag tccttgggga ggcacctttc ccagatcata caacagactt
     2161 actttcactt agttctgagg tgaagacaga tcatgggaga gataaattga ttgagtctgt
     2221 ttctcagcca tcagaaaacc atggtatcct tgttagtaat attacagagt cattgtctac
     2281 caaatcatgt ggagcaccgc gacctgtcaa tggagttgtt aacagtcttc agcctgtcct
     2341 ggcagaccaa gttccaggtg acagctctga tgctgaggaa caattacata aaaagcaaag
     2401 gctgaattta gtttcttcat ctgatggcac gtgtgtcgca gcccgaaccc ggcctgtact
     2461 gacctgtaag aaacggaggc ttgttaggcc cagcagcatc gttcctcttt ctaagaaggt
     2521 tcaccgtaat gtccgctctg gctgtgatgt gaatccctct tgtgcactgt gtggttcagg
     2581 cagtgtgaac accatgcctc ctgaaataca ctatgaagca cctctcttag agcgtctttc
     2641 ccagttggac tcctgcgttc accctgtgct agcatttcca gatgatgttc ccacaagcct
     2701 gcacttccag agcatgctga agtctcagtg gcaaaacaag ccttttgaca agatcaaacc
     2761 taccaaaaag ttttctctta agcacagagc gaccatgcca tgcagtctgt cagatccagt
     2821 tcgtaaagac agacacaagt tggtcaactc cttccttaca acagccaagc tgtgccatca
     2881 gcaaacacgg cctgacagga cccacaggca gcacttagac ggcgtggggg ctgtgcccat
     2941 ggtggagcga gtgacagctc caaaagcaga gcgcttgctc cacctgccgc cacctgtgca
     3001 tgaccccacc cacagcaaaa tgagattgcg agatcattca tctgagagaa gtgaagtgtt
     3061 gaagcatcac acagacatga gcagtccgag ctacttgaca gctacccacc atccacccca
     3121 cagccccctg gtgagacagc tctccacctc atcagacacc tccacaccca ccagctcggg
     3181 ctcacaagtt gcagccagca catctcagcc agtgaggagg agaaggggag agagctcatt
     3241 tgatattaac aacattgtca tcccaatgtc tgttgctgca acaactcgtg ttgagaaact
     3301 acaatacaaa gaaatcctta ctccaagctg gcgagaggtt gatgttcagt ctctgaaggg
     3361 gagtcctgat gaagagaatg aggagatcga ggacctatct gatgcagcct ttgcggccct
     3421 gcatgccaaa tgtgaggaga tggaaagggc aaggtggctg tggaccacaa gtgtgccacc
     3481 ccagcgtcgg ggcagcaggt cttacaggtc atcagacggc cggaccaccc ctcagttggg
     3541 cagtgccaac ccctccaccc cacagcctgc gtcccctgat gtcagtagta gccactctct
     3601 gtcagaattc tcccatggtc aatctcctag gagtcccatt agcccagaac tacactcagc
     3661 ccctctcacc cctgtggctc gggacagtct gcgacacctg gccagtgaag acacccgatg
     3721 ttccacacca gagctgggac tagatgaaca gtcagtccag ccatgggaac gacggacctt
     3781 ccctctggcc tacagtcccc aggcagaatg tgaggagcag ctggatgcac aggacacggc
     3841 agcccgctgc actcgccgca cctcaggcag caagactggc cgggaggcag aggtggcacc
     3901 cacctcgcct cctgttgtcc cgctcaagag tcggcatctg gcagcaacag tcacagctca
     3961 gcgcccagct cacagatgag cggaaaatga gactatacag actcactact attggcatta
     4021 aagcttcaga aatctctgcg tttgatattc aaacatcata tgctggaaat tttcacagtt
     4081 tttagtgaat ttaaggaatt tagatcctcc tttggttggt ttggttttgt tgtttgtttt
     4141 cttgttctgt tttcatgtca cacctgagca cttcctccag ttggcagaca agttcaggaa
     4201 gagaccctgc tggcctggtc ctgcatatcc tctgcactgt tggatcactg gacttggaat
     4261 gttagatgat cacccctctc ccctgcacct gtggggtagg gtgggccagc caaatggcag
     4321 caggtagatc agcacagcct ccttagatta ggggagtaga gcaaaagcag tctgggctct
     4381 tcccttccct ctaatctgtg acttggctta gctctggttg gtcaccccct ccttggtctt
     4441 ctaggatgga gtacccttcc agccagcctc tgttggctag ttcttgtcac tgaactctgg
     4501 gccagcagga tagctggctt caccttgtca cctaaacctg gaaggcccat tttcagtttc
     4561 atctgcattt ggtcgtccgt cttggctctt tgactgcagt gccctgctgc agctgctcag
     4621 gtcaccctgc cctcccttcc ccattttttc tccctccatg ccttcacaca gataacggta
     4681 gtccttccag tcagagcttc tatgacccat tcccactccc ctacaaacta ggaagtctgt
     4741 ggagtacaca tcatcacttc tgtatcatgt tttcactgac gagttcacat gtcgtgtctc
     4801 cctcacagcc ctgtcagaca gccacttaga ccctcccact tccccacacc ccttgcctgt
     4861 ggaacgctgt tggtcctagc tgtggtttcc atcattcccc atgaacctcc tgttagcctt
     4921 gtgcctgtct tatgtataat cacatcacca aaaaagggga gggggaaagg aattttcttt
     4981 ttctgccatt ttataatcgt acaaaaatag taggcagact gcttaatggt tggggttttt
     5041 tcacaatttt caacattagt gatttttttt ttctttctgt ttgcaagtta aaaggtttgt
     5101 cattgtttct ttaaacaaca ataatgcacc atatccctat gcataaagtg cttcttctat
     5161 ttataaggtt gaaaattctg aataaccctt ttagcattgt aaaaaacaaa aacaaaacaa
     5221 aaaaaccaaa aaagacaaaa atttaaaaaa acttgtattt tgtaaatatt ttcttttcct
     5281 gctttgagct gtgtaatggc agcgaacatg tagctgtctt tgttctatag aaatgctttt
     5341 cttcagagaa gctgatcttt gttaatgtca tgattctgtt tgcaaagcac agactagtgc
     5401 ttaaaaaaaa aagaaaggaa aaatgaaaaa aataataata aaaaaagata cagaga
//
