LOCUS       NM_172872               4801 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus KN motif and ankyrin repeat domains 4 (Kank4), mRNA.
ACCESSION   NM_172872
VERSION     NM_172872.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4801)
  AUTHORS   Zhang,C., He,H., Dai,J., Li,Y., He,J., Yang,W., Dai,J., Han,F.,
            Kong,W., Wang,X., Zheng,X., Zhou,J., Pan,W., Chen,Z., Singhal,M.,
            Zhang,Y., Guo,F. and Hu,J.
  TITLE     KANK4 Promotes Arteriogenesis by Potentiating VEGFR2 Signaling in a
            TALIN-1-Dependent Manner
  JOURNAL   Arterioscler Thromb Vasc Biol 42 (6), 772-788 (2022)
   PUBMED   35477278
  REMARK    GeneRIF: KANK4 Promotes Arteriogenesis by Potentiating VEGFR2
            Signaling in a TALIN-1-Dependent Manner.
REFERENCE   2  (bases 1 to 4801)
  AUTHORS   Guo,S.S., Seiwert,A., Szeto,I.Y.Y. and Fassler,R.
  TITLE     Tissue distribution and subcellular localization of the family of
            Kidney Ankyrin Repeat Domain (KANK) proteins
  JOURNAL   Exp Cell Res 398 (1), 112391 (2021)
   PUBMED   33253712
  REMARK    GeneRIF: Tissue distribution and subcellular localization of the
            family of Kidney Ankyrin Repeat Domain (KANK) proteins.
REFERENCE   3  (bases 1 to 4801)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   4  (bases 1 to 4801)
  AUTHORS   Zhu,Y., Kakinuma,N., Wang,Y. and Kiyama,R.
  TITLE     Kank proteins: a new family of ankyrin-repeat domain-containing
            proteins
  JOURNAL   Biochim Biophys Acta 1780 (2), 128-133 (2008)
   PUBMED   17996375
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670941.11.
            
            On Aug 25, 2009 this sequence version replaced NM_172872.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060737.2, AK081525.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AL670941.11        144741-144852       c
            113-195             AL670941.11        112974-113056       c
            196-2124            AL670941.11        105579-107507       c
            2125-2236           AL670941.11        104314-104425       c
            2237-2455           AL670941.11        101989-102207       c
            2456-2543           AL670941.11        100698-100785       c
            2544-2763           AL670941.11        98571-98790         c
            2764-2906           AL670941.11        92778-92920         c
            2907-3107           AL670941.11        88718-88918         c
            3108-4801           AL670941.11        82207-83900         c
FEATURES             Location/Qualifiers
     source          1..4801
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 45.6 cM"
     gene            1..4801
                     /gene="Kank4"
                     /gene_synonym="Ankrd38; C130031J23"
                     /note="KN motif and ankyrin repeat domains 4"
                     /db_xref="GeneID:242553"
                     /db_xref="MGI:MGI:3043381"
     exon            1..112
                     /gene="Kank4"
                     /gene_synonym="Ankrd38; C130031J23"
                     /inference="alignment:Splign:2.1.0"
     exon            113..195
                     /gene="Kank4"
                     /gene_synonym="Ankrd38; C130031J23"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..3230
                     /gene="Kank4"
                     /gene_synonym="Ankrd38; C130031J23"
                     /note="ankyrin repeat domain 38; ankyrin repeat
                     domain-containing protein 38"
                     /codon_start=1
                     /product="KN motif and ankyrin repeat domain-containing
                     protein 4"
                     /protein_id="NP_766460.2"
                     /db_xref="CCDS:CCDS18379.1"
                     /db_xref="GeneID:242553"
                     /db_xref="MGI:MGI:3043381"
                     /translation="MEKIDGKDQSSQGDEEKEPPKSYPYSVETPYGFHLDLDFLKYVD
                     DIEKGHTIKRIPIHRRAKQAKFSTLPRNFSLPNSGDRTYAVPPQQNWSPVVPRKISLG
                     TQEPSQPLPLGDLPQASVQGSELNYHRKALLAKDARQAEAGSLEDVGSGRPQLLRASS
                     MPATLLQNQVPEEPSLTSGPSTLLALPLLQDEGSVCDGAFDPAEGLMGFQASAQSVDR
                     ELGELEPAIPEQVWEGAEPEEGDLKASSHLSQPGPSSAVQSVPMDLEEVEIEHHMREA
                     ELVLTPGSATPSPPPLPSPILENDLSLDEIELSISEIPPPPPIEVDVRSIGIRVTEES
                     LGLLETDTSSISSLKNQVLALEDKLSGRTEELARVRAALEQQEEETKAREQRIQELEC
                     TVAHLEEKLSQERASEAPDRTDATVNTDPLQELTPRESHDKNIGVNLLNTPDPECRAP
                     RAEKNGFPWVQNNHKQSYPSPEEPVLPPQLSLPRGPEQILASSLCSCLSMELRIEEEG
                     SEQEGGQEEGAGGLSRAAGESSWSTRESAPVIREEATSELPGAERPGRPASSPQDATI
                     GQYVKKIQELLHEQWNCLEHGYPELASAIKQPASKLSSIQNQLLSSLNLLLSAYSAQA
                     PEPEPKETPAPPPSTPPPPPPPPPEISPSTSLKSIMKKKDYGFRAGGNGTKKNLQFVG
                     VNGGYETTSSEETSGEDSSPEDLSDSETEKKQDCSESREDRDLHPSCEAGQGVPEGTR
                     NSGHTSDRGEEVSHLRAERYKPSEEFLNACQTLSQHLPETGDTTKQLLRQSLNTISQE
                     WFRVSSRKLSSPEAVAAYLLEVQPHSPYLLKLLVNLADRSGNTALHYSVSHSNFAIVK
                     LLLDTGVCNVDHQNKAGYTAVMITPLASAETKEDMAVVWKLLREGNVNIQATQGGQTA
                     LMLGVSHDREDMVQALLSCQADVNLQDNDGSSALMLACHQGNADLVRLLLAHPACNSS
                     LTDKAGRTALSLVLNSPAHVEIAELLRAHSEPGRSLGPKELQKN"
     exon            196..2124
                     /gene="Kank4"
                     /gene_synonym="Ankrd38; C130031J23"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2236
                     /gene="Kank4"
                     /gene_synonym="Ankrd38; C130031J23"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2455
                     /gene="Kank4"
                     /gene_synonym="Ankrd38; C130031J23"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2543
                     /gene="Kank4"
                     /gene_synonym="Ankrd38; C130031J23"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2763
                     /gene="Kank4"
                     /gene_synonym="Ankrd38; C130031J23"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2906
                     /gene="Kank4"
                     /gene_synonym="Ankrd38; C130031J23"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3107
                     /gene="Kank4"
                     /gene_synonym="Ankrd38; C130031J23"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..4801
                     /gene="Kank4"
                     /gene_synonym="Ankrd38; C130031J23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4776..4781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kank4"
                     /gene_synonym="Ankrd38; C130031J23"
                     /note="hexamer: ATTAAA"
     polyA_site      4795
                     /gene="Kank4"
                     /gene_synonym="Ankrd38; C130031J23"
                     /note="major polyA site"
ORIGIN      
        1 cgtgccactg aagaccgtgc agctgcagct gcgtgcaccc cgaagccggg tgggagctcg
       61 cgttgctcct gcacagcggt cgcttcctgc cagaaccccg cggttcccca agaactctcc
      121 aggaatcacg cagactcggt ggatgtggag tacctgagat actgaacttt gtactcacga
      181 tggagaagat agatggcaag gaccagtcct ctcaggggga tgaagagaaa gagcctccaa
      241 agagctaccc ttactctgtg gagaccccgt atggttttca tctggacttg gacttcctca
      301 aatatgtgga tgacattgag aagggacaca ccatcaaaag gattccgatc cacagacgag
      361 ccaagcaggc taagtttagt actctgcccc gaaacttcag ccttcccaac agtggggacc
      421 gcacctatgc tgttcctccc cagcaaaact ggtctcctgt ggtacccaga aagatatccc
      481 tggggaccca ggagccatcc cagccactgc cactgggtga tctcccccag gcctcggtgc
      541 aaggcagtga gctgaactac cacaggaagg ctctcttggc aaaggatgcc aggcaggcgg
      601 aggctggttc tctggaggat gtagggagtg gacggcccca gctgttgaga gcatccagca
      661 tgcctgctac actgctgcaa aaccaggtcc ccgaagagcc cagcctgacc tcaggccctt
      721 ccacacttct tgccctccct ctgctccagg atgaaggcag tgtgtgtgat ggtgcctttg
      781 accctgcaga agggctcatg ggtttccaag catcggccca gtcagtagac agggagttgg
      841 gggaactaga gccagcaatt ccagagcagg tctgggaggg ggctgaacca gaagaaggtg
      901 acctcaaggc ttcaagtcac ctctctcagc caggtccttc ctccgcagtc cagagtgtcc
      961 ccatggatct agaggaagtg gaaattgagc accacatgag agaagcagag ctggtgttaa
     1021 cgcctggctc cgccacgccc agcccgcccc ctctgccctc ccccatcctt gagaatgatc
     1081 tctccctgga cgaaatcgag ctgagcatca gcgagatccc accccctcca cccatagaag
     1141 tggatgtgag gagcattggg atccgggtaa cggaggaaag cctgggcctg ctggagactg
     1201 ataccagcag tatctccagc ctgaagaatc aggtcctggc ccttgaggac aaattgtcgg
     1261 ggagaacaga agagcttgcc cgggtcagag ctgcccttga gcagcaggaa gaagagacca
     1321 aggctaggga acagaggatt caagagctgg agtgcactgt agcccattta gaagaaaagc
     1381 ttagtcaaga gagggccagc gaggctccgg acaggactga tgccacggtg aacactgacc
     1441 ccctacagga gctcactccc cgagagtccc atgataagaa cattggggtc aatctgctga
     1501 acactccgga tcctgaatgc cgggcaccaa gagcagaaaa gaacggcttc ccatgggtcc
     1561 aaaataatca caagcaaagc tatccgagcc ccgaagaacc cgtgctgcca ccccaactgt
     1621 cactgccaag gggacctgag cagatcctcg cctcatccct gtgcagctgc ctctccatgg
     1681 agctccggat tgaagaggag ggttctgagc aggagggagg ccaggaggag ggagctgggg
     1741 gcttgagcag ggcagcagga gagtcttcct ggagcacaag agaatctgct cccgtgatca
     1801 gggaggaggc cacctcagag ctccccggag cagagcgtcc aggaaggcca gccagttccc
     1861 cacaagatgc cacaatcggg cagtatgtga agaagattca agagcttctc catgaacagt
     1921 ggaactgcct ggagcatggc tacccggagc tggccagcgc catcaagcag cccgcctcca
     1981 agctcagcag catccagaac caactgctca gttcccttaa cctgttactc tctgcctact
     2041 cagctcaggc cccggagccg gagccgaagg aaactcctgc ccctcccccc tccaccccgc
     2101 ccccgccccc gccgccgccg ccagagatct ctccgtcgac cagccttaaa tccataatga
     2161 aaaagaaaga ctatggcttc cgtgcaggag gtaatgggac caaaaagaac cttcagtttg
     2221 ttggggttaa cggtggctat gagaccacgt ctagcgagga gaccagtggg gaggacagct
     2281 cccctgagga tttgtctgac agtgagaccg agaagaaaca ggattgctca gagtccaggg
     2341 aggacagaga cttgcatccc agctgtgagg ctgggcaggg agtccctgaa ggcaccagaa
     2401 actcaggcca cacaagtgat cgtggggagg aagtgtctca tctgagggct gagagatata
     2461 aaccctcaga ggaatttctt aacgcgtgcc agacactgag ccagcacctg ccggaaactg
     2521 gggataccac caagcagctc ctgaggcaaa gcttgaatac catcagtcag gagtggttcc
     2581 gtgtgtccag caggaagtta tctagccctg aggctgtggc tgcctacctc cttgaggtcc
     2641 agcctcactc tccatatctt ctgaagctac ttgtcaacct ggctgaccga agtgggaaca
     2701 cagcccttca ctacagtgtg tcacactcca acttcgccat tgtcaagcta ctgctggaca
     2761 caggtgtctg caatgtggat catcagaaca aagctggcta cactgctgtg atgatcactc
     2821 ccttggcttc tgctgagaca aaagaagaca tggctgttgt ctggaaactc ttaagagagg
     2881 ggaatgtgaa catacaagca actcagggag gacagactgc actgatgtta ggagtcagcc
     2941 acgaccggga ggacatggtc caagcactac tgagctgcca ggcagatgtc aacctgcagg
     3001 acaatgatgg atcttccgcc ctcatgctgg cctgtcacca aggcaacgcc gacctggtac
     3061 gactgctcct ggcacaccca gcctgcaaca gcagcctgac tgacaaggct ggccgaacag
     3121 ctttgtccct cgttctgaat tcacctgccc acgtggaaat cgcagagctt ctgcgggccc
     3181 actcagagcc gggcaggtcc ctggggccga aggagctgca gaagaattag caaccaggaa
     3241 caaaaggttc cttttctgga ctccccgctt gccctgagag agggccgggg ttacagccag
     3301 agggtcacca ttggagacag aaactatgtc aaatatgcac agtacattcc catcatataa
     3361 ttctgctcat taggatgctc ggtagtgttt tgccttaggc caagcccccc cacactacat
     3421 ggggtgcaga gtgcaggctg cagtggagtc atccagaaat tcaaaacgtc ttcggctttg
     3481 aattcctcgt gacgttgtct ttgcagtcct gtgtagcaag caggtaggtc agggcaccct
     3541 tgcacaatag aaaaagcaat actttttaca tggagtttta aagcgcactg tttttttctt
     3601 tgttttgttt ttaatcaagt gtgtatacaa atatgttcca gtgactatgc atgtctagag
     3661 agaatggcag aggagtctaa attcgggcaa agtgggacta agcccagtga tgtcagtgcc
     3721 agggtgtgac acttctaagt acccgagggg ctccattcct tctatggaag taagcagaaa
     3781 acaaatggtt aatactagtg atgcatgctt gacagagtcc agttatttca cccattccca
     3841 gcctacgaga gaagcaaatg aactggccag cttcttgctg agagtgggtc actgtagaag
     3901 tcaacattac tcacccgtcc ctagaagcac agggccccta gaagcaggta ccagctctga
     3961 gaacttcctg gctccttggt gcacagacat ccagctgggc tgcagtagca gccagccagg
     4021 gtaagataga gctttctctg gactgacatc tctcccaggg atagttcttt cctgagcatc
     4081 cgtatcccct gggtcctgta catggaaggc tcataatcat agctctgaaa atctcacgcc
     4141 aacattatat atatatatat atatatttcc tttatataaa aggaagagca tcaaaattgg
     4201 tgatctgtac actgaaaaca ctgaagcaag aattctcatt tgggctgggg tgcctatttg
     4261 tttggtaccc ctctgctaag tcacaaagct tttgtgggta acaatgtcat cgtccccaag
     4321 gtggaagcaa gtatacaacc tacctctggg agtctccata agaaacagct tataaaagtt
     4381 ttggaatctg gataacccag aaaggctgac ttcagacatt ctgtagcaaa gtccttttca
     4441 cagcatgatt tgtgagagat gcccagaatc cctcgtgtgg atgctgctta gagataggaa
     4501 ggatggcaaa acagacgagc tttaaagaat gctgtaagag gatttattcc aatgtcaaaa
     4561 cgcaaatgta aaagcaaaca cacactttta ataaacgtta gctccatgct ttacaaaggt
     4621 taatgtgtat ccagccccag ggatcttgtt atgcagcagg tctgaaagga ggcctgagtt
     4681 tctgtgtgtc taactgggcc cagaggacgt caatgcggtc agaccacagc cacgcttcga
     4741 gcagcacagc tccggcctgt cctttttgtt tataaattaa aatgttgcct ctcaattggt
     4801 c
//
