LOCUS       NM_145611               4853 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus KN motif and ankyrin repeat domains 2 (Kank2), mRNA.
ACCESSION   NM_145611
VERSION     NM_145611.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4853)
  AUTHORS   Xu,Y., Guo,C., Pan,W., Zhao,C., Ding,Y., Xie,X., Wei,Z., Sun,Y. and
            Yu,C.
  TITLE     Nephrotic-syndrome-associated mutation of KANK2 induces pathologic
            binding competition with physiological interactor KIF21A
  JOURNAL   J Biol Chem 297 (2), 100958 (2021)
   PUBMED   34274317
  REMARK    GeneRIF: Nephrotic-syndrome-associated mutation of KANK2 induces
            pathologic binding competition with physiological interactor
            KIF21A.
REFERENCE   2  (bases 1 to 4853)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4853)
  AUTHORS   Xiang,C., Frietze,K.K., Bi,Y., Li,Y., Dal Pozzo,V., Pal,S.,
            Alexander,N., Baubet,V., D'Acunto,V., Mason,C.E., Davuluri,R.V. and
            Dahmane,N.
  TITLE     RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell
            Identity and Glioblastoma Subtypes in Developing Neurons
  JOURNAL   Mol Cell Biol 41 (7), e0052620 (2021)
   PUBMED   33903225
REFERENCE   4  (bases 1 to 4853)
  AUTHORS   Guo,S.S., Seiwert,A., Szeto,I.Y.Y. and Fassler,R.
  TITLE     Tissue distribution and subcellular localization of the family of
            Kidney Ankyrin Repeat Domain (KANK) proteins
  JOURNAL   Exp Cell Res 398 (1), 112391 (2021)
   PUBMED   33253712
  REMARK    GeneRIF: Tissue distribution and subcellular localization of the
            family of Kidney Ankyrin Repeat Domain (KANK) proteins.
REFERENCE   5  (bases 1 to 4853)
  AUTHORS   Sun,Z., Tseng,H.Y., Tan,S., Senger,F., Kurzawa,L., Dedden,D.,
            Mizuno,N., Wasik,A.A., Thery,M., Dunn,A.R. and Fassler,R.
  TITLE     Kank2 activates talin, reduces force transduction across integrins
            and induces central adhesion formation
  JOURNAL   Nat Cell Biol 18 (9), 941-953 (2016)
   PUBMED   27548916
  REMARK    GeneRIF: identify Kank proteins as talin activators that decrease
            the grip between the integrin-talin complex and actomyosin to
            regulate cell migration velocity
REFERENCE   6  (bases 1 to 4853)
  AUTHORS   Xu,X., Patrakka,J., Sistani,L., Uhlen,M., Jalanko,H., Betsholtz,C.
            and Tryggvason,K.
  TITLE     Expression of novel podocyte-associated proteins sult1b1 and
            ankrd25
  JOURNAL   Nephron Exp Nephrol 117 (2), e39-e46 (2011)
   PUBMED   20720434
  REMARK    GeneRIF: sult1b1 may be involved in the sulfonylation of podocyte
            protein podocalyxin, whereas ankrd25 may contribute to controlling
            actin dynamics in podocyte foot processes.
REFERENCE   7  (bases 1 to 4853)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 4853)
  AUTHORS   Zhu,Y., Kakinuma,N., Wang,Y. and Kiyama,R.
  TITLE     Kank proteins: a new family of ankyrin-repeat domain-containing
            proteins
  JOURNAL   Biochim Biophys Acta 1780 (2), 128-133 (2008)
   PUBMED   17996375
REFERENCE   9  (bases 1 to 4853)
  AUTHORS   Yoshikawa,T., Piao,Y., Zhong,J., Matoba,R., Carter,M.G., Wang,Y.,
            Goldberg,I. and Ko,M.S.
  TITLE     High-throughput screen for genes predominantly expressed in the ICM
            of mouse blastocysts by whole mount in situ hybridization
  JOURNAL   Gene Expr Patterns 6 (2), 213-224 (2006)
   PUBMED   16325481
REFERENCE   10 (bases 1 to 4853)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049288.1, AC161371.4 and BB517655.1.
            
            On Nov 15, 2007 this sequence version replaced NM_145611.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049288.1, AK031324.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3266              AK049288.1         2-3267
            3267-4790           AC161371.4         40569-42092
            4791-4853           BB517655.1         144-206
FEATURES             Location/Qualifiers
     source          1..4853
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.88 cM"
     gene            1..4853
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /note="KN motif and ankyrin repeat domains 2"
                     /db_xref="GeneID:235041"
                     /db_xref="MGI:MGI:2384568"
     exon            1..65
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /inference="alignment:Splign:2.1.0"
     exon            66..180
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..2675
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /note="ankyrin repeat domain 25; ankyrin repeat
                     domain-containing protein 25"
                     /codon_start=1
                     /product="KN motif and ankyrin repeat domain-containing
                     protein 2"
                     /protein_id="NP_663586.3"
                     /db_xref="CCDS:CCDS22911.1"
                     /db_xref="GeneID:235041"
                     /db_xref="MGI:MGI:2384568"
                     /translation="MAQVLHVPAPFPGTPGQASPAAFPSKEPDPPYSVETPYGYRLDL
                     DFLKYVDDIEKGHTLRRVAVQRRPRLGSLPRGPGSWWTSTESLCSDASGDSRHSAYSY
                     CGRGFYPQYGALETRIGSNPRVERTLLDARRRLEDQAAAPSSGGLGSLTPSAAGSTSS
                     LAGVGLLPPTPRSSGLSTPVAPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKL
                     SVLQEEKRQLTVQLKSQKFLGHPSGTRSRSELCLDLPEAPDDPAALETRSVGTWVRER
                     DLGIPDGEAALVAKVAVLETQLKKALQELRAAQTQQVDLQPQAWPPPDTQVRVDTVRV
                     VEGPREVEVAASTAAGALAQRAQSLEPYGTGLKALTTSGGPENTLVFRSHEVVETMCP
                     LPTATTGNVHTAKKISITERSCTGAPRMTEPSSVNPRPAAASVVQPENPVPAAQDTTD
                     KKPTRPAAASQDSQAADGAGRASLATKRKEDPADPEVNQRNLQFVGVNGGYESPSEDS
                     STAENSEHESTENEGPEPPARVLSPAECPQLRPPGAAVATTSLEGPQLSQESQRVPAP
                     EVASGPDPEEEIRMDLSPDLISACLALEKYLENPNALTERELKVAYTTVLQEWLRLAC
                     RSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSG
                     VCHVDKLNRAGYSPIMLTALATLKTQDDIETILQLFRLGNVNAKASQAGQTALMLAVS
                     HGRVDVVRALLACEADVNIQDEDGSTALMCACEHGHKEITGLLLAVPSCDISLTDRDG
                     STALMVALDAGQSEIASMLYSRMNIKCSFAPMSDYESPASSSAEE"
     exon            181..1407
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1551
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1642
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1879
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1967
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2187
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2330
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2531
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2621
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..4853
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4823..4828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /note="hexamer: AATAAA"
     polyA_site      4842
                     /gene="Kank2"
                     /gene_synonym="Ankrd25"
                     /note="major polyA site"
ORIGIN      
        1 aagcttgcgg cgactgaggc ggagcgggca ggacgcctgg gacggcggag gctcgagcgt
       61 gccaggtcag cctcagctgt cagcaggctg ttggggagac tcagttccct gagtgacatc
      121 tgaggagcaa ccacagagag aggatggccc aggtcctgca tgtgcccgcc ccattcccag
      181 gaacccctgg tcaggcctcc ccagcggcct tccccagcaa ggagccagac ccaccgtact
      241 cagtggaaac gccctatggc taccgcctgg acctggattt tcttaagtac gtggatgaca
      301 ttgagaaggg ccacacactg cgcagggtgg cggtacagcg ccggccgcgc ctgggttccc
      361 tgccacgggg cccgggctcc tggtggacgt ccacagagtc tctgtgctct gatgccagtg
      421 gggacagccg gcactcggcc tactcctact gtggccgcgg cttctaccca cagtacggag
      481 ccttggagac ccgaatcggc tccaaccctc gtgtggagcg cacgctgctg gatgcgcggc
      541 gccggctgga ggaccaggcg gctgccccat cgtccggtgg cctgggctcc ctcacaccca
      601 gcgccgcggg ctccaccagc tccctggcag gcgtgggcct gctgcccccc acgcctcgca
      661 gctccggcct gtccaccccg gtggcaccca gcgctggtca cctagcccac gtgcgcgagc
      721 agatggctgg agccctgcgc aagctgcgcc agctggagga gcaggtcaag ctgatccccg
      781 ttctccaagt caagctgtca gtgctccagg aggaaaagag acagctcacc gtgcagctca
      841 agagccagaa gtttctaggt cacccctcag ggacacggag ccggagtgag ctctgcctgg
      901 accttcccga ggcccctgac gaccctgctg cactagagac ccgctcggtg ggcacctggg
      961 ttagagaacg ggacttgggc attccagatg gtgaagctgc cctggtagct aaagtggccg
     1021 tgttggagac ccagctcaaa aaagcgctac aggagctgcg ggcggctcag acccagcagg
     1081 tcgacctcca gccccaggcc tggccaccac cagacaccca ggtccgcgtg gacaccgtgc
     1141 gagtagtgga gggtccccgg gaagtggagg tggcagccag cacggcagcc ggggcccttg
     1201 cacagcgagc tcagagtctg gaaccctacg gaacagggct gaaggccctg accacatctg
     1261 ggggaccaga gaacaccctc gtgttccgca gtcatgaagt ggtggagacc atgtgcccac
     1321 tgcccacagc taccactggc aatgtgcaca cagccaagaa gatcagcatt acagaacgga
     1381 gttgcaccgg tgcacccagg atgacagagc cttcctccgt taatccacgc cctgctgcag
     1441 cctctgtggt acagcctgag aaccctgtcc cggctgccca ggacaccact gacaagaagc
     1501 ccaccaggcc agcagcagca tcgcaggact cacaagcggc tgacggagca ggcagagcct
     1561 ctttggccac gaagaggaaa gaggaccccg cagaccctga agtcaaccag aggaacctcc
     1621 agtttgtggg agtcaatggc gggtatgagt ccccctcgga ggactccagc acagcagaaa
     1681 actccgaaca cgagagcaca gagaacgagg gcccggagcc accagcaagg gttctgagcc
     1741 cagctgaatg tcctcagctc aggcctccag gggctgcagt ggccacgacc agtctggagg
     1801 ggccccagct ctcccaggaa tcccagcgtg tgcctgcacc tgaggtggcg tcaggacccg
     1861 atcctgagga ggaaattcgg atggatctga gccctgacct catatcagcc tgcttggccc
     1921 tggagaaata cctggagaac cccaatgccc tcacagagcg agaactgaaa gtggcctata
     1981 ccacagtgct tcaggagtgg ctgcgcctgg cctgccgcag tgacgcacac cctgagcttg
     2041 tgcggcgaca tctagtcacc ttcagggcca tgtctgcccg gctgctggac tacgtggtca
     2101 acatcgccga cagcaatggt aacactgccc tgcactactc agtgtcacac gccaacttcc
     2161 ctgtggtgcg gcagttgctg gacagcgggg tctgtcatgt ggacaagctg aaccgtgccg
     2221 gctacagccc tattatgctc actgccctgg ccacgttgaa gacccaggac gacattgaga
     2281 ccatccttca gctcttccgg cttgggaatg tcaatgccaa agccagccag gcaggacaga
     2341 cggccctgat gctggccgtc agccacgggc gggtggacgt ggtgagagca ttgctggcct
     2401 gtgaggcgga cgtcaacatt caggatgagg acggctccac ggccctgatg tgtgcatgtg
     2461 agcacggaca caaggagatc accgggctcc tgctggctgt gcctagctgt gacatctcac
     2521 tcactgaccg cgacgggagc acagcactga tggtggccct ggacgctggg cagagcgaga
     2581 tcgcatctat gctgtactca cgcatgaaca tcaagtgctc gttcgctccc atgtcagact
     2641 acgagagtcc ggcttcgtct tcagccgagg agtgaataca gggaggagcc agtgagtccc
     2701 ccaggaccca ccagccacaa gccacgcatc aaaccgtccc tcctccatcc ctctgtccca
     2761 ttctgcctcg gcattcctca gcccctgaac ttccctgagg gagccctgac atctaccagg
     2821 ctcaagctcc tggaagcctt tcccagcacc ctgggttcaa agccagaaag ccaagctaca
     2881 ttctcctccc agttggcacc agttgacaac gccttgggtg tgggtttctt gtaaagaaca
     2941 tagagaacaa tcagccggca attatgggag gaggaagggg gggcaagaag agaaaatact
     3001 gtattcttga gtcattgtta ggggatggga ggggtcagaa ttcagttgct aaatttgaat
     3061 gtcactggaa tgttacagtg tctattgtct cctcatcttt acagcaggtc tccacaaagc
     3121 ctgctcacca ccctttgtca cctcatttca ttgtctagtg tacaataggg tcttgtccac
     3181 tgccctccac ctccagactg tgtcttcagg gcctggggtg tctcttgtga ttgctttaca
     3241 gaataagatt gccgtacctt agccgcctgc ctccagtcag aaagcagtgt tttcatttgc
     3301 ctttttcctt tctctctctc tctctctctc tctctcacac acacacacac acacacacac
     3361 acacacacac acacacacac gcacgcgcgc gcgcgcacac atgcacaggg cttgtcatct
     3421 tgcagctgat agctgatgtc ctgtgacttg gaaatgacca acttacaaga agttatgctg
     3481 acctccctgt tccccacggg gagtgcttgg cagaggagac tacttctaga aatactttca
     3541 gacctacaga caaaaaagaa aaaaggccat tccggagtga ctcccagcat cacagcccag
     3601 aacctcctcc tcaaaggaga gtaaacagag actgtgatac tgaccaagta caggcgctcg
     3661 ctatgaagcc catatgttcc tgattaagag ctggctggcc tcagagcact cccagaacta
     3721 gcttaaagtg acaggctttg ctgaaatcca aagggacaaa agagtagttt tatgtttgtg
     3781 tgtttgtttt taatgccctg gagctcctgc tggtgacagg agagacagac aggctgcacc
     3841 tttctctaac tggggttcct ttctggcccc aggatctcag tgtggttcgt ggggggattt
     3901 tgttgttgtt tctttgtttc ttttcttcat aaagaagaaa aaggaaacaa cttctagatg
     3961 tgccttgcga tagggaggac tttgtcctct caagtctccc tgtcgtatcc agatcacagc
     4021 tgaacccact gggccttggc gccaaacctc agcagggcag cattgagact catggactaa
     4081 aggaaagtgt tcactcttct agacaagtgg gtctcttggt ttgatggagt cttactccgc
     4141 ttgagttttg tagaaggggt ttgtctaagg catagaggct tggttggcat aagaaaataa
     4201 gatggacaga tggatgggtg gatggatgga tggctgattg agtgggtggg tgggtggatg
     4261 gatgcataaa tgaatagatg gatggatgaa tgaacagata gatgaatgga tggatggaca
     4321 ggtgggtgga tggatgggtg gacggatgag tgtggggtgg gtggatggat aaatgagcaa
     4381 tggatgagaa actgggttgg ctggtgggta gatgtcatga tggagtcttt gcacgtgtat
     4441 gaaacagaaa accaaacttc aggacagaca gctgctggtg tctctggatg ctcacagcct
     4501 agggcacatt tgaaaggtcg tgctctgagc tgagccctga gttccagcct tgtagccagc
     4561 aagggagttt atttaaggtt ctggaagcat cagctatgac ccaaagcaca cgctcctcag
     4621 aaaagcccct gtttctgtcg ctgctgcttt ctgtttctct gtcggggcca ccagggccaa
     4681 acacccacca gtctctcctc tccttcccgc tatactccag ttttctttct actctgtgac
     4741 cacggtacat ccatgaagac agtgttacac gtaaatgaag tattcttttc ttgtaatcat
     4801 attttagaaa gtaaaaggac ttaataaagc tacaaataaa aacattgcct cgt
//
