LOCUS       NM_010593               5009 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus junction plakoglobin (Jup), mRNA.
ACCESSION   NM_010593
VERSION     NM_010593.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5009)
  AUTHORS   Xu,T., Herkens,L., Jia,T., Klinkhammer,B.M., Kant,S., Krusche,C.A.,
            Buhl,E.M., Hayat,S., Floege,J., Strnad,P., Kramann,R., Djudjaj,S.
            and Boor,P.
  TITLE     The role of desmoglein-2 in kidney disease
  JOURNAL   Kidney Int 105 (5), 1035-1048 (2024)
   PUBMED   38395410
REFERENCE   2  (bases 1 to 5009)
  AUTHORS   Hung,M., Lo,H.F., Beckmann,A.G., Demircioglu,D., Damle,G.,
            Hasson,D., Radice,G.L. and Krauss,R.S.
  TITLE     Cadherin-dependent adhesion is required for muscle stem cell niche
            anchorage and maintenance
  JOURNAL   Development 151 (7) (2024)
   PUBMED   38456551
REFERENCE   3  (bases 1 to 5009)
  AUTHORS   Abou Azar,F., Mugabo,Y., Yuen,S., Del Veliz,S., Pare,F., Rial,S.A.,
            Lavoie,G., Roux,P.P. and Lim,G.E.
  TITLE     Plakoglobin regulates adipocyte differentiation independently of
            the Wnt/beta-catenin signaling pathway
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (4), 119690 (2024)
   PUBMED   38367915
  REMARK    GeneRIF: Plakoglobin regulates adipocyte differentiation
            independently of the Wnt/beta-catenin signaling pathway.
REFERENCE   4  (bases 1 to 5009)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 5009)
  AUTHORS   Kohler,T.N., De Jonghe,J., Ellermann,A.L., Yanagida,A., Herger,M.,
            Slatery,E.M., Weberling,A., Munger,C., Fischer,K., Mulas,C.,
            Winkel,A., Ross,C., Bergmann,S., Franze,K., Chalut,K., Nichols,J.,
            Boroviak,T.E. and Hollfelder,F.
  TITLE     Plakoglobin is a mechanoresponsive regulator of naive pluripotency
  JOURNAL   Nat Commun 14 (1), 4022 (2023)
   PUBMED   37419903
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5009)
  AUTHORS   Butz,S., Stappert,J., Weissig,H. and Kemler,R.
  TITLE     Plakoglobin and beta-catenin: distinct but closely related
  JOURNAL   Science 257 (5073), 1142-1144 (1992)
   PUBMED   1509266
REFERENCE   7  (bases 1 to 5009)
  AUTHORS   Peifer,M., McCrea,P.D., Green,K.J., Wieschaus,E. and Gumbiner,B.M.
  TITLE     The vertebrate adhesive junction proteins beta-catenin and
            plakoglobin and the Drosophila segment polarity gene armadillo form
            a multigene family with similar properties
  JOURNAL   J Cell Biol 118 (3), 681-691 (1992)
   PUBMED   1639851
REFERENCE   8  (bases 1 to 5009)
  AUTHORS   Arnemann,J., Spurr,N.K., Wheeler,G.N., Parker,A.E. and Buxton,R.S.
  TITLE     Chromosomal assignment of the human genes coding for the major
            proteins of the desmosome junction, desmoglein DGI (DSG),
            desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and
            plakoglobin DPIII (JUP)
  JOURNAL   Genomics 10 (3), 640-645 (1991)
   PUBMED   1889810
REFERENCE   9  (bases 1 to 5009)
  AUTHORS   Ozawa,M., Ringwald,M. and Kemler,R.
  TITLE     Uvomorulin-catenin complex formation is regulated by a specific
            domain in the cytoplasmic region of the cell adhesion molecule
  JOURNAL   Proc Natl Acad Sci U S A 87 (11), 4246-4250 (1990)
   PUBMED   2349235
REFERENCE   10 (bases 1 to 5009)
  AUTHORS   Ozawa,M., Baribault,H. and Kemler,R.
  TITLE     The cytoplasmic domain of the cell adhesion molecule uvomorulin
            associates with three independent proteins structurally related in
            different species
  JOURNAL   EMBO J 8 (6), 1711-1717 (1989)
   PUBMED   2788574
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD555608.1, AK145895.1 and AL590968.8.
            
            On Mar 24, 2011 this sequence version replaced NM_010593.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040757.1, AK170934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CD555608.1         1-16
            17-2858             AK145895.1         2-2843
            2859-5009           AL590968.8         85832-87982         c
FEATURES             Location/Qualifiers
     source          1..5009
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.47 cM"
     gene            1..5009
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /note="junction plakoglobin"
                     /db_xref="GeneID:16480"
                     /db_xref="MGI:MGI:96650"
     exon            1..155
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /inference="alignment:Splign:2.1.0"
     exon            156..371
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..2401
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /note="desmoplakin-3; desmoplakin III; gamma-catenin"
                     /codon_start=1
                     /product="junction plakoglobin"
                     /protein_id="NP_034723.1"
                     /db_xref="CCDS:CCDS25420.1"
                     /db_xref="GeneID:16480"
                     /db_xref="MGI:MGI:96650"
                     /translation="MEVMNLIEQPIKVTEWQQTYTYDSGIHSGVNTCVPSVSSKGIMD
                     EDDACGRQYTLKKTTTYTQGVPQNQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLL
                     ATQVEGQTTNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVT
                     KAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREG
                     LLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPL
                     LNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQGLVQIMRNYSYEKLLWTTSRV
                     LKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESV
                     LKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDD
                     ITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNL
                     ALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPYTDGVRMEEIVEGCTGA
                     LHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAE
                     GASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKHDPAAWEA
                     AQSMIPINEPYADDMDATYRPMYSSDVPLDPLDMHMDLDGDYPMDTYSDGLRPPYPTA
                     DHMLA"
     exon            372..631
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /inference="alignment:Splign:2.1.0"
     exon            632..870
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1072
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1217
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1321
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1660
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1936
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2087
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2209
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2249
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2415
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..5009
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3224..3229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /note="hexamer: AATAAA"
     polyA_site      3246
                     /gene="Jup"
                     /gene_synonym="Ctnng; D930025P04Rik; PG"
                     /note="major polyA site"
ORIGIN      
        1 ggtccctttg ccttttgttc ggttactgag ttgctgcctt ggccagagtc cggagcagcc
       61 gccgcccgag tgcgccgagc tcagttcgct gcccgcgccg gctccctccc ggccagaccc
      121 gaccccgatt cggctcagcc cggctccacg ctcagcagcc accatggagg tgatgaacct
      181 tattgagcag cccatcaagg tgacagagtg gcaacagaca tacacctacg actcgggcat
      241 ccactccggc gtcaatacct gtgtgccctc tgtaagcagc aagggcatca tggatgagga
      301 tgatgcctgc ggcagacagt acacactcaa gaagactacc acctatacac aaggggtgcc
      361 acagaaccaa ggtgacctgg aataccagat gtccacaacg gccagagcca agcgggtgcg
      421 ggaggccatg tgtccagggg tctcaggcga ggacagttct ctactgctgg ccacccaggt
      481 ggaggggcag acaaccaatc tgcagcgcct ggccgaacca tcccagttgc tcaagtcggc
      541 catcgtccat ctcatcaact accaggatga tgcagagctg gccacccggg ctctgcctga
      601 gctcaccaag ctgctcaacg atgaggaccc ggtagtggtg accaaggcgg ctatgatcgt
      661 gaaccagctg tccaagaagg aggcatcccg ccgggctcta atgggctcgc cccagctggt
      721 ggcggcggtg gtgcggacta tgcagaacac cagtgacctg gatactgccc ggtgtaccac
      781 cagcatcctg cacaacctct ctcaccaccg agagggcttg ctcgccatat tcaagtctgg
      841 aggcatccct gccctagtcc gaatgctcag ttcccccgta gaatctgtcc tgttctacgc
      901 catcaccaca ctgcacaacc tgctgctcta tcaggagggc gccaagatgg cggtgcgtct
      961 ggcagacggg ctgcagaaga tggtgcccct actcaacaag aacaacccta agttcctggc
     1021 catcactact gactgcctgc agctcctggc ctatggcaac caggagagca agctgatcat
     1081 cctggccaat gggggacccc aagggcttgt gcagatcatg aggaactaca gctacgagaa
     1141 gcttctgtgg accaccagcc gtgtgctcaa ggtgctctcc gtgtgtccta gcaacaagcc
     1201 cgccatcgtg gaggctggtg ggatgcaggc tctgggcaag cacttgacaa gcaacagtcc
     1261 ccgcctggtg cagaactgcc tgtggactct gcgcaatctc tcggatgtag ccaccaagca
     1321 ggagggcctg gagagtgtgc tgaagatcct ggtcaaccaa ctgagtgtag atgacgtcaa
     1381 cgtcctcacc tgtgccacgg gcaccctctc caacctgacc tgcaacaaca gcaaaaacaa
     1441 gacgctggtg acacagaaca gtggcgtgga ggcgctcatc cacgccatcc tgagagccgg
     1501 agacaaagat gacatcacag agcccgctgt ctgtgccctg cgccacctta ccagccgtca
     1561 ccccgaggct gagatggccc agaactctgt gcgcctcaac tatggaatcc cggccattgt
     1621 gaaactgctc aaccagccaa accagtggcc actggtcaag gcaactattg gcctgatccg
     1681 gaacctggct ctgtgcccag ccaaccatgc ccctctgcag gaggccgcgg tcattccccg
     1741 cctcgtccag ctgttggtca aggcccacca ggacgcccag cgccatgtgg ctgcaggcac
     1801 ccagcagccc tacacggatg gtgtgaggat ggaggagatc gtggaaggct gcaccggagc
     1861 cctgcacatc ctcgcccggg atcccatgaa ccgcatggag atcttccggc tcaacaccat
     1921 tcccctgttt gtccagctcc tgtactcctc tgtggagaac atccagcgtg tggctgcggg
     1981 agtgctctgc gagctggccc aggacaagga ggctgccgac gccattgatg cggagggcgc
     2041 ctctgcccct ctcatggagc tactccattc ccgcaatgag ggcaccgcga cctacgctgc
     2101 tgctgtcctg ttccgcatct ctgaggacaa gaacccagat taccgtaagc gagtgtctgt
     2161 ggagctcacc aattccctct tcaagcatga cccagctgcc tgggaggctg cccagagtat
     2221 gatcccgatc aacgaaccct atgcagacga catggatgcc acctaccgcc ccatgtactc
     2281 cagcgatgtg cctctggacc ctctggacat gcacatggac ctggatggag actaccccat
     2341 ggacacctac agtgacggcc tgaggcctcc ctaccccact gcagaccaca tgctggccta
     2401 gccagctcca cctcagcgct gtttctcacc tggaaagctc tcaagagcag actgtgggag
     2461 gagacagaaa agtacctgag ccccgggggc cggcctggac ttcctgctga acacgcgtgc
     2521 tcccgtgctc cagagagttc ctccataggg attttgggat ggtgtctgtt cctgcttttc
     2581 tgtcctgggc tggggatcca ggctcagcac tttctccccg tccccactat ggctatggcc
     2641 actaaagctt tagactcagc ctgtgtccct gcacagcaat tctctctgct gactccagct
     2701 gcctggaccc ccacccccac ccccacccag gccttccttt gttttttttc gggggccagt
     2761 tttctcactt gacctcctgg gatatccaag acacaggttc aaggccccaa cccctgacac
     2821 ccaaagcttc ttttgaaaag ttcagggacc ttcttggggg tcggtgggga gagcggagac
     2881 attaagtgcc cctgccagga cctgcccttc ccttcaggat gctaagtttt tgctttgacc
     2941 ctcccaaggg gggagctctt ggtgacgctc cctccctctc acatcactcc acactggccc
     3001 atctgctctg cagaagcgtt ctggctcacc cctctggtgt gtggtgaggg gctttcttct
     3061 ccccctcctg tttgactccc accacctcct gcacatgggt ttgggggcgg gggtggggga
     3121 ctgaaaggga agtcccctca gagagtctta ttatcaacac tttatttttt ggttattggc
     3181 ttttcttttc tttttttgtt tttgtataga ccaaagcaaa gaaaataaaa taacacagag
     3241 atccaatgga ggctgttaaa agcattatgg tgtagaggaa gtaaggggca tgcgtaatag
     3301 gtgtgacaga cctctccgtc cctgatgtcc ccacttggct gatccttgcg tgtcctcagg
     3361 gttgcagagg caaatgaaga ggagggaggg tttgaagagc aggagtccat tgaatgattt
     3421 ggtcccatgt tcacacagaa cagggacact ggatagggga cctgtaggat agctcctgct
     3481 gtagggactc caggctgtct tgctccacag gcaagctcct tgctggcttc agcctctgct
     3541 gtcctgctgt gacatcagac cgtcttctat acctcagctc tccatggccc tcggcttact
     3601 aatacaggct tcttgttggc cagaagttgg cccaccccag cccctgtcca cctctccctc
     3661 atgactcctt actgcttgca agtcagtaac actaatgctg gccagcatct tctgcacgct
     3721 atcatgcctc ctgctcaggt tgtcccctct accttttctt gctggcccat gccatctgtc
     3781 tcaaccttgc cccaggagca ctgatcctgg gctattcctg gcaccaacgg atgctgtcac
     3841 tggacacaga tatctttttg cctagtccat gtgacgcttc cccaccagca acgctaagtt
     3901 cttctttttg aagtgggctg gtcatcacgg tcctgacaaa ctctgagaac aggaaattcc
     3961 tgtagcctgc ccgtgtggag ccagacatct gcctcttata cctgcacgga gcccaggcta
     4021 ggacttgagc gtcacagtgc atcagggtaa caccctgctt ccctgcagcc aatcacattt
     4081 gaggatgaaa tgggaaaaaa cggggtcgag gaagaaagaa aaggtccagg gtggaggcag
     4141 gaagttagtt caatcaaaag atgactgggc cttcaggcag aggtgatgag agacagctga
     4201 gtgccacagg agccaccatg ggagggagag gagactcggc atacagagac cacaaggtct
     4261 ttatttaact gcccccattt tcagggcctg gctgaatgct cagcctgggt agtttgaaaa
     4321 gaatttgata aaggaagagc ataggactct gtgagtgtgt gtgggaagca gcaaggggga
     4381 gacagcacat gagcccgagg tggtgagaga agatgctagc caggtgtgga ggatacagta
     4441 ggattctgca tctgcggctg atgctccaga caggcaggct gggtcctcac tgccaaccac
     4501 tgatgctcac cgatcactga actcaagtag aaactgtaga gtgcgcttat gttatctcta
     4561 gctgcccagc ccggagcaga gtgatctaga gatgccaagg aaaacagcaa gacgtctccc
     4621 caccccagaa gaggaggtgg caatcgcatt gtgtatcccc atgacaggca gcaagggcaa
     4681 gggatcagag aaggaagtaa aactgtcaca gaaagattga aagttgattc tagccgtggc
     4741 ggagctggag ctctgagctt cccagcaggc tggccaaaaa gggcgcatta atctctgtgg
     4801 catcgatggt ccatttctgt tcttatgtag gagctatccg caaccccgag aaagcccaca
     4861 cttggaaccc tgatttcctt atctataaaa tagggctgtc atgtagcaca ggatagatca
     4921 tgagtttggt ttgtgcccag gcttttgggg tcctcacact caggacgaac cacgtccggc
     4981 ccatctgctt agtgtcagga tataacgag
//
