LOCUS       NM_010592               2894 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus jun D proto-oncogene (Jund), transcript variant 1,
            mRNA.
ACCESSION   NM_010592
VERSION     NM_010592.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2894)
  AUTHORS   Zhao,T., Xiao,T., Cao,D., Xia,W., Gao,L., Cheng,L., Zang,M., Li,X.
            and Xu,E.Y.
  TITLE     Sertoli cell PUMILIO proteins modulate mouse testis size through
            translational control of cell cycle regulators
  JOURNAL   Biol Reprod 107 (1), 135-147 (2022)
   PUBMED   35678316
REFERENCE   2  (bases 1 to 2894)
  AUTHORS   Gura,M.A., Relovska,S., Abt,K.M., Seymour,K.A., Wu,T., Kaya,H.,
            Turner,J.M.A., Fazzio,T.G. and Freiman,R.N.
  TITLE     TAF4b transcription networks regulating early oocyte
            differentiation
  JOURNAL   Development 149 (3) (2022)
   PUBMED   35043944
REFERENCE   3  (bases 1 to 2894)
  AUTHORS   Wang,K., Cui,Y., Lin,P., Yao,Z. and Sun,Y.
  TITLE     JunD Regulates Pancreatic beta-Cells Function by Altering Lipid
            Accumulation
  JOURNAL   Front Endocrinol (Lausanne) 12, 689845 (2021)
   PUBMED   34335468
  REMARK    GeneRIF: JunD Regulates Pancreatic beta-Cells Function by Altering
            Lipid Accumulation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2894)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2894)
  AUTHORS   Carbo,J.M., Leon,T.E., Font-Diaz,J., De la Rosa,J.V., Castrillo,A.,
            Picard,F.R., Staudenraus,D., Huber,M., Cedo,L., Escola-Gil,J.C.,
            Campos,L., Bakiri,L., Wagner,E.F., Caelles,C., Stratmann,T., Van
            Ginderachter,J.A. and Valledor,A.F.
  TITLE     Pharmacologic Activation of LXR Alters the Expression Profile of
            Tumor-Associated Macrophages and the Abundance of Regulatory T
            Cells in the Tumor Microenvironment
  JOURNAL   Cancer Res 81 (4), 968-985 (2021)
   PUBMED   33361391
REFERENCE   6  (bases 1 to 2894)
  AUTHORS   Short,J.D. and Pfarr,C.M.
  TITLE     Translational regulation of the JunD messenger RNA
  JOURNAL   J Biol Chem 277 (36), 32697-32705 (2002)
   PUBMED   12105216
  REMARK    GeneRIF: Translation initiation from alternative AUG and non-AUG
            sites in human, mouse and rat.
REFERENCE   7  (bases 1 to 2894)
  AUTHORS   Puga,A., Nebert,D.W. and Carrier,F.
  TITLE     Dioxin induces expression of c-fos and c-jun proto-oncogenes and a
            large increase in transcription factor AP-1
  JOURNAL   DNA Cell Biol 11 (4), 269-281 (1992)
   PUBMED   1605850
REFERENCE   8  (bases 1 to 2894)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
REFERENCE   9  (bases 1 to 2894)
  AUTHORS   Kahn,T., Friesl,H., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Gissmann,L., Kramer,J. and zur Hausen,H.
  TITLE     Molecular cloning, analysis, and chromosomal localization of a
            mouse genomic sequence related to the human papillomavirus type 18
            E5 region
  JOURNAL   Mol Carcinog 6 (2), 88-99 (1992)
   PUBMED   1326990
REFERENCE   10 (bases 1 to 2894)
  AUTHORS   Howard,T.A., Rochelle,J.M., Saunders,A.M. and Seldin,M.F.
  TITLE     A linkage map of mouse chromosome 8: further definition of
            homologous linkage relationships between mouse chromosome 8 and
            human chromosomes 8, 16, and 19
  JOURNAL   Genomics 10 (1), 207-213 (1991)
   PUBMED   1675193
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD354239.1, BE651959.1,
            BE995638.1, AI844316.1, CK621709.1, BE648283.1, BQ177858.1,
            AA177918.1 and BQ176138.1.
            
            On Nov 20, 2013 this sequence version replaced NM_010592.4.
            
            Summary: The protein encoded by this intronless gene is a member of
            the JUN family, and a functional component of the AP1 transcription
            factor complex. This protein has been proposed to protect cells
            from p53-dependent senescence and apoptosis. Alternative
            translation initiation site usage results in the production of
            different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013].
            
            Transcript Variant: This variant (1) encodes two isoforms resulting
            from the use of alternative in-frame translation initiation codons.
            The longer isoform (JunD-FL) is derived from an upstream AUG (S1
            ORF, PMID:12105216), while the shorter isoform (deltaJunD) is
            derived from a downstream AUG (S3 ORF, PMID:12105216). This RefSeq
            represents the longer isoform (JunD-FL).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-396               CD354239.1         1-396               c
            397-747             BE651959.1         65-415
            748-1066            BE995638.1         1-319               c
            1067-1404           AI844316.1         8-345
            1405-1774           CK621709.1         193-562
            1775-2046           BE648283.1         1-272               c
            2047-2654           BQ177858.1         70-677
            2655-2854           AA177918.1         46-245
            2855-2894           BQ176138.1         1-40                c
FEATURES             Location/Qualifiers
     source          1..2894
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..2894
                     /gene="Jund"
                     /gene_synonym="Jund1"
                     /note="jun D proto-oncogene"
                     /db_xref="GeneID:16478"
                     /db_xref="MGI:MGI:96648"
     exon            1..2877
                     /gene="Jund"
                     /gene_synonym="Jund1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1319..2344
                     /gene="Jund"
                     /gene_synonym="Jund1"
                     /note="isoform JunD-FL is encoded by transcript variant 1;
                     transcription factor jun-D; Jun proto-oncogene related
                     gene d; Jun proto-oncogene related gene d1; transcription
                     factor AP-1 subunit JunD; transcription factor JunD"
                     /codon_start=1
                     /product="transcription factor JunD isoform JunD-FL"
                     /protein_id="NP_034722.1"
                     /db_xref="CCDS:CCDS40375.1"
                     /db_xref="GeneID:16478"
                     /db_xref="MGI:MGI:96648"
                     /translation="METPFYGEEALSGLAAGASSVAGATGAPGGGGFAPPGRAFPGAP
                     PTSSMLKKDALTLSLAEQGAAGLKPGSATAPSALRPDGAPDGLLASPDLGLLKLASPE
                     LERLIIQSNGLVTTTPTSTQFLYPKVAASEEQEFAEGFVKALEDLHKQSQLGAATAAT
                     SGAPAPPAPADLAATPGATETPVYANLSSFAGGAGPPGGAATVAFAAEPVPFPPPPGA
                     LGPPPPPHPPRLAALKDEPQTVPDVPSFGDSPPLSPIDMDTQERIKAERKRLRNRIAA
                     SKCRKRKLERISRLEEKVKTLKSQNTELASTASLLREQVAQLKQKVLSHVNSGCQLLP
                     QHQVPAY"
     regulatory      2857..2862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jund"
                     /gene_synonym="Jund1"
                     /note="hexamer: AGTAAA"
     polyA_site      2877
                     /gene="Jund"
                     /gene_synonym="Jund1"
                     /note="major polyA site"
ORIGIN      
        1 caaggcacaa tggcatatat tagtcatcca gaagcctgag gtgagatttt ggggggttcg
       61 ggaggtcatt ctggggtaca gagtgagatt ctgtttcaaa acgtcccaat ccagggccat
      121 agggtaggct tagaaagtaa acgtgactgc acccaagtcg gacagccaga gtgccacacc
      181 ggggagaaca gactcccaac tctcctctga ccttcctgga cacacacaca cacaaagcac
      241 agatacctac acagacaaac acagatacac aaccacacag acaaacacac cagcatgtaa
      301 aataaaaacc gagatctgta ggccgaggtt aagagactca ggcctgttac tgccacactt
      361 gggaatatga aacaggggga ctgaagttaa gttcatgaat agcggagtct agaggatgag
      421 atcctgtctt gacccaaaac aaagattaaa aaaatttttt ttcaccgaga tcaagaaaaa
      481 aacctacaac tgatggctac cctggctgca gttggactcc acacatccca tcctcagttt
      541 ccccaaggaa aaggcaggag gtcagctttt agggcgttcg actccaccct gtgaaactga
      601 caaggagcta agtagttgtg gggactctcc aagggaccct cctctgcctc ccccttcctg
      661 cccacacctg ccagctccca gccggaggaa ccctggccgg cgcccggccc ccgaggggcg
      721 tgccttcggt gggcgtgacg cggggcgtgg cttcacagag ggcctgggtt tatgaggctc
      781 cacacatcac gccacagaag tgccagagac aggggagaga tagacgcaca gatgaggtcc
      841 agtttgagaa acagagaggc aagatctaga gggaagtaaa gaggggagga agagaaaggg
      901 aggagaggca agaaacagca gggtagggac agagcctgcc cggcaatcca agctgggcgt
      961 ggtgacccgg ccaaaccgcg ttcagcccca cccccatgac gtcaacccac aatgcagcgc
     1021 gttgttgtgc catgtagcga gcgtcgctct tggcaacagc ggccgccacc aggcgagggc
     1081 gtcccgctcc cgccccttta tgcaaatcaa cgacgtcacc tcgcgccaat ggcgagcggg
     1141 ggcggtgagc tcatcgcggg ggccgaggct ataagagtgc gcgcgggcgg cgcggggcag
     1201 agcggccggc atcggagccg gtctgtacgg gcagcggact ggggggcata cggggccccc
     1261 cggggaggcc gcggccactc cccccgcccc ggggccgagc gcggcggggg aggtggggat
     1321 ggaaacgccc ttctatggcg aggaggcgct gagcggcctg gctgcgggtg cgtcgagcgt
     1381 cgctggtgct actggggccc ccggcggtgg tggcttcgcg cccccgggcc gcgctttccc
     1441 cggggcgccc ccgacgagca gcatgctgaa gaaagacgcg ctgacgctca gcctggcgga
     1501 gcagggagcg gcgggattga aaccagggtc ggccactgca ccttctgcgc tgcgccccga
     1561 cggcgccccc gacgggctgc tggcttcgcc ggatcttggg ctgctcaaac tcgcgtcgcc
     1621 ggagctggag aggctgatca tccagtccaa cgggctggtg accactaccc cgaccagtac
     1681 gcagttcctc tacccgaagg tggcagctag cgaggagcag gagttcgccg aaggcttcgt
     1741 caaggcgctg gaggacctgc acaagcaaag ccagctgggt gcggccaccg cggccacctc
     1801 aggggctccc gcgcctcccg cgcccgccga cctggccgcc acccccgggg ccacggagac
     1861 cccggtctac gccaacctga gcagtttcgc gggtggcgcc gggccccctg ggggcgcggc
     1921 caccgtggct ttcgccgcgg agccagtgcc cttcccgccg cccccgggcg cgctggggcc
     1981 gccgccacct ccgcatccac cgcgcctggc cgcgctcaag gacgagccgc agaccgtgcc
     2041 ggacgtgccg agcttcggcg acagccctcc gctgtcgccc atcgacatgg acacgcaaga
     2101 acgcatcaag gcggagcgca agaggctgcg caaccgcatc gccgcctcca aatgccgcaa
     2161 gcgcaagctg gagcgtatct cgcgcctgga ggagaaagtc aagaccctca aaagccagaa
     2221 caccgagctg gcgtccaccg ccagcctgct gcgcgagcag gtggcgcagc tcaaacagaa
     2281 agtcctcagc cacgtcaaca gcggctgcca gctgctgccc cagcaccagg tcccggcgta
     2341 ctgagcccga gcgcggggcg catgcgcgga ctagctgcgg tgggggggcg ccccggactc
     2401 tttcgagact cggtgccccc ggactcgaca agccggaccc cccttaactc tggatgggga
     2461 acccgagcgc acgacccccg ccctcgcgcc gcctctctac ccccagtcct gcgcgtggct
     2521 gcccctttgt acctccgagt aggggctcta aggggcgcgc agcctcacgc tctgcctttc
     2581 cttttttttt tgccttttgg aagagagaac gggagtgtcc gattccgccc tatttatgtt
     2641 tctactcggg aacaaacgtt ggttgcgtgt tgagtgtgtg tttccttgtg ttggtttttt
     2701 aaagaaacgg gaagaagaaa aaaaaaaccc tctcccctcc cccccccccc gctctctctc
     2761 ctcccgacac catcccctct ctttttgttt ggttttgttt tgctacgagt ccacattcct
     2821 gttccgtaat ccttggttcg ccggttttgt gttttcagta aagtcttcgt tacgccaaaa
     2881 aaaaaaaaaa aaaa
//
