LOCUS       NM_008416               1840 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus jun B proto-oncogene (Junb), mRNA.
ACCESSION   NM_008416
VERSION     NM_008416.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1840)
  AUTHORS   Sarkar,S., Taira,N., Hsieh,T.H., Chien,H.C., Hirota,M.,
            Koizumi,S.I., Sasaki,D., Tamai,M., Seto,Y., Miyagi,M. and
            Ishikawa,H.
  TITLE     JunB is required for CD8+ T cell responses to acute infections
  JOURNAL   Int Immunol (2024) In press
   PUBMED   39425978
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1840)
  AUTHORS   Diawara,M. and Martin,L.J.
  TITLE     The transcription factors NR5A1 and JUNB cooperate to activate the
            Axl promoter in mouse Sertoli cell lines
  JOURNAL   Mol Biol Rep 51 (1), 982 (2024)
   PUBMED   39271559
  REMARK    GeneRIF: The transcription factors NR5A1 and JUNB cooperate to
            activate the Axl promoter in mouse Sertoli cell lines.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1840)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1840)
  AUTHORS   Zhang,X., Ding,X., Wang,C., Le,Q., Wu,D., Song,A., Huang,G.,
            Luo,L., Luo,Y., Yang,X., Goins,A.E., Desai,S.P., Qiu,C.,
            Silva,F.D., Feldman,L.E., Zhou,J., Spafford,M.F., Boyd,N.H.,
            Prossnitz,E.R., Yang,X.O., Wang,Q.A. and Liu,M.
  TITLE     Depletion of JunB increases adipocyte thermogenic capacity and
            ameliorates diet-induced insulin resistance
  JOURNAL   Nat Metab 6 (1), 78-93 (2024)
   PUBMED   38191667
  REMARK    GeneRIF: Depletion of JunB increases adipocyte thermogenic capacity
            and ameliorates diet-induced insulin resistance.
REFERENCE   5  (bases 1 to 1840)
  AUTHORS   Ramos,R.B., Martino,N., Chuy,D., Lu,S., Zuo,M.X.G.,
            Balasubramanian,U., Di John Portela,I., Vincent,P.A. and Adam,A.P.
  TITLE     Shock drives a STAT3 and JunB-mediated coordinated transcriptional
            and DNA methylation response in the endothelium
  JOURNAL   J Cell Sci 136 (18) (2023)
   PUBMED   37667913
  REMARK    GeneRIF: Shock drives a STAT3 and JunB-mediated coordinated
            transcriptional and DNA methylation response in the endothelium.
REFERENCE   6  (bases 1 to 1840)
  AUTHORS   Bossy-Wetzel,E., Bravo,R. and Hanahan,D.
  TITLE     Transcription factors junB and c-jun are selectively up-regulated
            and functionally implicated in fibrosarcoma development
  JOURNAL   Genes Dev 6 (12A), 2340-2351 (1992)
   PUBMED   1459456
REFERENCE   7  (bases 1 to 1840)
  AUTHORS   Apel,I., Yu,C.L., Wang,T., Dobry,C., Van Antwerp,M.E., Jove,R. and
            Prochownik,E.V.
  TITLE     Regulation of the junB gene by v-src
  JOURNAL   Mol Cell Biol 12 (8), 3356-3364 (1992)
   PUBMED   1630451
REFERENCE   8  (bases 1 to 1840)
  AUTHORS   Chevray,P.M. and Nathans,D.
  TITLE     Protein interaction cloning in yeast: identification of mammalian
            proteins that react with the leucine zipper of Jun
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5789-5793 (1992)
   PUBMED   1631061
REFERENCE   9  (bases 1 to 1840)
  AUTHORS   Puga,A., Nebert,D.W. and Carrier,F.
  TITLE     Dioxin induces expression of c-fos and c-jun proto-oncogenes and a
            large increase in transcription factor AP-1
  JOURNAL   DNA Cell Biol 11 (4), 269-281 (1992)
   PUBMED   1605850
REFERENCE   10 (bases 1 to 1840)
  AUTHORS   Lord,K.A., Hoffman-Liebermann,B. and Liebermann,D.A.
  TITLE     Complexity of the immediate early response of myeloid cells to
            terminal differentiation and growth arrest includes ICAM-1, Jun-B
            and histone variants
  JOURNAL   Oncogene 5 (3), 387-396 (1990)
   PUBMED   1690380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163703.4, AK141592.1 and BY515688.1.
            
            On Mar 24, 2011 this sequence version replaced NM_008416.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: J03236.1, AK145550.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC163703.4         182553-182582
            31-1816             AK141592.1         2-1787
            1817-1840           BY515688.1         412-435
FEATURES             Location/Qualifiers
     source          1..1840
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.41 cM"
     gene            1..1840
                     /gene="Junb"
                     /note="jun B proto-oncogene"
                     /db_xref="GeneID:16477"
                     /db_xref="MGI:MGI:96647"
     exon            1..1840
                     /gene="Junb"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..1354
                     /gene="Junb"
                     /note="transcription factor jun-B; myD21; Jun-B oncogene;
                     transcription factor AP-1 subunit JunB"
                     /codon_start=1
                     /product="transcription factor JunB"
                     /protein_id="NP_032442.1"
                     /db_xref="CCDS:CCDS22488.1"
                     /db_xref="GeneID:16477"
                     /db_xref="MGI:MGI:96647"
                     /translation="MCTKMEQPFYHDDSYAAAGYGRSPGSLSLHDYKLLKPTLALNLA
                     DPYRGLKGPGARGPGPEGSGAGSYFSGQGSDTGASLKLASTELERLIVPNSNGVITTT
                     PTPPGQYFYPRGGGSGGGTGGGVTEEQEGFADGFVKALDDLHKMNHVTPPNVSLGASG
                     GPQAGPGGVYAGPEPPPVYTNLSSYSPASAPSGGSGTAVGTGSSYPTATISYLPHAPP
                     FAGGHPAQLGLSRGASAFKEEPQTVPEARSRDATPPVSPINMEDQERIKVERKRLRNR
                     LAATKCRKRKLERIARLEDKVKTLKAENAGLSSAAGLLREQVAQLKQKVMTHVSNGCQ
                     LLLGVKGHAF"
     regulatory      1814..1819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Junb"
                     /note="hexamer: AGTAAA"
     polyA_site      1839
                     /gene="Junb"
                     /note="major polyA site"
ORIGIN      
        1 tataaaagct tggggctggg gccgagcact ggggactttg agggtggcca ggccagcgta
       61 ggatcctgct gggagcgggg aactgaggga agcgacgccg agaaagcagg cgcaccacgg
      121 agggagagaa aatctccgga agcccagcag cgcctttacg cacagctgcc aactggccgc
      181 tgctgaccgt ctccagctcc cgaggacgcg cgaccggaca ccgggtcctg ccacagccga
      241 ggacagctcg ccgctcgccg cagcgaggcc cggggcggcc cttcaggggg acctttccca
      301 gatcgcccag gccgcccgga tgtgcacgaa aatggaacag cctttctatc acgacgactc
      361 ttacgcagcg gcgggatacg gtcggagccc tggcagcctg tctctacacg actacaaact
      421 cctgaaaccc accttggcgc tcaacctggc ggatccctat cggggtctca agggtcctgg
      481 ggcgcggggt ccaggcccgg agggcagtgg ggcaggcagc tacttttcgg gtcagggatc
      541 agacacaggc gcatctctga agctagcctc cacggaactg gagcgcttga tcgtccccaa
      601 cagcaacggc gtgatcacga cgacgcccac gcctccggga cagtactttt acccccgtgg
      661 gggtggcagc ggtggaggta cagggggcgg cgtcaccgag gagcaggagg gctttgcgga
      721 cggttttgtc aaagccctgg acgacctgca caagatgaac cacgtgacgc cccccaacgt
      781 gtccctgggc gccagcgggg gtccccaggc cggcccaggg ggcgtctatg ctggtccgga
      841 gccgcctccc gtctacacca acctcagcag ttactcccca gcctctgcac cctctggagg
      901 ctccgggacc gccgtcggga ctgggagctc atacccgacg gccaccatca gctacctccc
      961 acatgcacca ccctttgcgg gcggccaccc ggcacagctg ggcttgagtc gcggcgcttc
     1021 cgcctttaaa gaggaaccgc agaccgtacc ggaggcacgc agccgcgacg ccacgccgcc
     1081 tgtgtccccc atcaacatgg aagaccagga gcgcatcaaa gtggagcgaa agcggctgcg
     1141 gaacaggctg gcggccacca agtgccggaa gcggaagctg gagcgcatcg cgcgcctgga
     1201 ggacaaggtg aagacactca aggctgagaa cgcggggctg tcgagtgctg ccggtctcct
     1261 acgggagcaa gtggcgcagc tcaagcagaa ggtcatgacc catgtcagca acggctgcca
     1321 gttgctgcta ggggtcaagg gacacgcctt ctgagagcct cccttgcccc atacggacac
     1381 ccccagcctt gaaggctggg cgcctgcccc ccactggggt gaggggggca ggcgatgggc
     1441 acccgccaaa aggcctgggg cgcagctcac acactggact ccggcccgcc cgcctgcgcc
     1501 cagtccttcc acctcgaggt ttacatggcc cccttccagc gtattttgta tgtttttttt
     1561 ttctgcaaag agactgaatt catattgaat ataatatatt tgtgtattta acagggaggg
     1621 gagaaggggg ctgtcgcggc ggagctggcc ccgccgcttg gtactcagcc tgcggggata
     1681 ctagggaggg acctccgccc cctgccctcc ccctctgcat agtactgtgg agaagaaaca
     1741 cgcacttcgt gtctaaagtc tattttaaga tgtgtttgtg tgtgtgtgtt tgacttttta
     1801 ttgaatctat ttaagtaaaa aaaaaattgt ctttattaat
//
