LOCUS       NM_010591               3187 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus jun proto-oncogene (Jun), mRNA.
ACCESSION   NM_010591
VERSION     NM_010591.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3187)
  AUTHORS   Hu,S., Tang,Y., Li,X., Li,W., Zeng,Y., Jiang,M., Chen,R., Zheng,P.,
            Yang,L., Song,Z., Xie,D., Chen,Y. and Yuan,Y.
  TITLE     Hsp90aa1/JUN/Ccl2 regulatory axis mediates migration and
            differentiation of NSPCs, promoting the onset and progression of
            early post-ischemic stroke epilepsy
  JOURNAL   Neurobiol Dis 200, 106635 (2024)
   PUBMED   39128813
  REMARK    GeneRIF: Hsp90aa1/JUN/Ccl2 regulatory axis mediates migration and
            differentiation of NSPCs, promoting the onset and progression of
            early post-ischemic stroke epilepsy.
REFERENCE   2  (bases 1 to 3187)
  AUTHORS   He,C., Wang,T., Han,Y., Zuo,C. and Wang,G.
  TITLE     Jun-activated SOCS1 enhances ubiquitination and degradation of
            CCAAT/enhancer-binding protein beta to ameliorate cerebral
            ischaemia/reperfusion injury
  JOURNAL   J Physiol 602 (19), 4959-4985 (2024)
   PUBMED   39197117
  REMARK    GeneRIF: Jun-activated SOCS1 enhances ubiquitination and
            degradation of CCAAT/enhancer-binding protein beta to ameliorate
            cerebral ischaemia/reperfusion injury.
REFERENCE   3  (bases 1 to 3187)
  AUTHORS   Hayakawa-Yano,Y., Furukawa,T., Matsuo,T., Ogasawara,T., Nogami,M.,
            Yokoyama,K., Yugami,M., Shinozaki,M., Nakamoto,C., Sakimura,K.,
            Koyama,A., Ogi,K., Onodera,O., Takebayashi,H., Okano,H. and Yano,M.
  TITLE     Qki5 safeguards spinal motor neuron function by defining the motor
            neuron-specific transcriptome via pre-mRNA processing
  JOURNAL   Proc Natl Acad Sci U S A 121 (37), e2401531121 (2024)
   PUBMED   39226364
REFERENCE   4  (bases 1 to 3187)
  AUTHORS   Khan,A.W., Aziz,M., Sourris,K.C., Lee,M.K.S., Dai,A.,
            Watson,A.M.D., Maxwell,S., Sharma,A., Zhou,Y., Cooper,M.E.,
            Calkin,A.C., Murphy,A.J., Baratchi,S. and Jandeleit-Dahm,K.A.M.
  TITLE     The Role of Activator Protein-1 Complex in Diabetes-Associated
            Atherosclerosis: Insights From Single-Cell RNA Sequencing
  JOURNAL   Diabetes 73 (9), 1495-1512 (2024)
   PUBMED   38905153
  REMARK    GeneRIF: The Role of Activator Protein-1 Complex in
            Diabetes-Associated Atherosclerosis: Insights From Single-Cell RNA
            Sequencing.
REFERENCE   5  (bases 1 to 3187)
  AUTHORS   Teng,X., He,H., Yu,H., Zhang,X., Xing,J., Shen,J., Li,C., Wang,M.,
            Shao,L., Wang,Z., Yang,H., Zhang,Y. and Wu,Q.
  TITLE     LncRNAs in the Dlk1-Dio3 Domain Are Essential for Mid-Embryonic
            Heart Development
  JOURNAL   Int J Mol Sci 25 (15), 8184 (2024)
   PUBMED   39125754
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3187)
  AUTHORS   Bossy-Wetzel,E., Bravo,R. and Hanahan,D.
  TITLE     Transcription factors junB and c-jun are selectively up-regulated
            and functionally implicated in fibrosarcoma development
  JOURNAL   Genes Dev 6 (12A), 2340-2351 (1992)
   PUBMED   1459456
REFERENCE   7  (bases 1 to 3187)
  AUTHORS   Hilberg,F. and Wagner,E.F.
  TITLE     Embryonic stem (ES) cells lacking functional c-jun: consequences
            for growth and differentiation, AP-1 activity and tumorigenicity
  JOURNAL   Oncogene 7 (12), 2371-2380 (1992)
   PUBMED   1281302
REFERENCE   8  (bases 1 to 3187)
  AUTHORS   Tomomura,M., Nakagawa,K. and Saheki,T.
  TITLE     Proto-oncogene c-jun and c-fos messenger RNAs increase in the liver
            of carnitine-deficient juvenile visceral steatosis (jvs) mice
  JOURNAL   FEBS Lett 311 (1), 63-66 (1992)
   PUBMED   1383034
REFERENCE   9  (bases 1 to 3187)
  AUTHORS   Cutting,G.R., Curristin,S., Zoghbi,H., O'Hara,B., Seldin,M.F. and
            Uhl,G.R.
  TITLE     Identification of a putative gamma-aminobutyric acid (GABA)
            receptor subunit rho2 cDNA and colocalization of the genes encoding
            rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and
            mouse chromosome 4
  JOURNAL   Genomics 12 (4), 801-806 (1992)
   PUBMED   1315307
REFERENCE   10 (bases 1 to 3187)
  AUTHORS   Le Roy,H., Simon-Chazottes,D., Montagutelli,X. and Guenet,J.L.
  TITLE     A set of anonymous DNA clones as markers for mouse gene mapping
  JOURNAL   Mamm Genome 3 (4), 244-246 (1992)
   PUBMED   1351769
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY106462.1 and AK159196.1.
            
            On Dec 11, 2007 this sequence version replaced NM_010591.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK159196.1, AK133722.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BY106462.1         2-27
            27-3187             AK159196.1         2-3162
FEATURES             Location/Qualifiers
     source          1..3187
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 43.34 cM"
     gene            1..3187
                     /gene="Jun"
                     /gene_synonym="AP-1; c-jun; Junc"
                     /note="jun proto-oncogene"
                     /db_xref="GeneID:16476"
                     /db_xref="MGI:MGI:96646"
     exon            1..3187
                     /gene="Jun"
                     /gene_synonym="AP-1; c-jun; Junc"
                     /inference="alignment:Splign:2.1.0"
     CDS             952..1956
                     /gene="Jun"
                     /gene_synonym="AP-1; c-jun; Junc"
                     /note="activator protein 1; transcription factor AP-1;
                     immediate early; AP1; AH119; jun A; proto-oncogene c-jun;
                     V-jun avian sarcoma virus 17 oncogene homolog; Jun
                     oncogene; transcription factor AP-1 subunit Jun"
                     /codon_start=1
                     /product="transcription factor Jun"
                     /protein_id="NP_034721.1"
                     /db_xref="CCDS:CCDS18364.1"
                     /db_xref="GeneID:16476"
                     /db_xref="MGI:MGI:96646"
                     /translation="MTAKMETTFYDDALNASFLQSESGAYGYSNPKILKQSMTLNLAD
                     PVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKN
                     VTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVSGAGMVAPAVASVAGAGGGGGYS
                     ASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPSQPQQQQQPPQPPHHLPQQI
                     PVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRK
                     LERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
                     "
     regulatory      2497..2502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jun"
                     /gene_synonym="AP-1; c-jun; Junc"
                     /note="hexamer: AATAAA"
     polyA_site      2525
                     /gene="Jun"
                     /gene_synonym="AP-1; c-jun; Junc"
                     /note="major polyA site"
     regulatory      2604..2609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jun"
                     /gene_synonym="AP-1; c-jun; Junc"
                     /note="hexamer: AATAAA"
     polyA_site      2625
                     /gene="Jun"
                     /gene_synonym="AP-1; c-jun; Junc"
                     /note="major polyA site"
     regulatory      2671..2676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jun"
                     /gene_synonym="AP-1; c-jun; Junc"
                     /note="hexamer: AATAAA"
     polyA_site      2689
                     /gene="Jun"
                     /gene_synonym="AP-1; c-jun; Junc"
                     /note="major polyA site"
     regulatory      3152..3157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jun"
                     /gene_synonym="AP-1; c-jun; Junc"
                     /note="hexamer: AATAAA"
     regulatory      3166..3171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jun"
                     /gene_synonym="AP-1; c-jun; Junc"
                     /note="hexamer: AATAAT"
     polyA_site      3170
                     /gene="Jun"
                     /gene_synonym="AP-1; c-jun; Junc"
                     /note="major polyA site"
     polyA_site      3182
                     /gene="Jun"
                     /gene_synonym="AP-1; c-jun; Junc"
ORIGIN      
        1 gttgagctca ggctggataa ggactcagag ttgcactgag tgtggcagag acagcctggc
       61 aggagagcgc tcaggcagac agacagacag acggacggac ttggccaacc cggtcggccg
      121 cggactccgg actgttcatc cgtttgtctt cattttctca ccaactgctt ggatccagcg
      181 cccgcggctc ctgcaccggt attttgggga gcatttggag agtcccttct cccgccttcc
      241 acggagaaga agctcacaag tccgggcgct gctgacagca tcgagagcgg ctcccgaccg
      301 cgcgaggaaa taggcgagcg gctaccggcc agcaactttc ctgacccaga ggaccggtaa
      361 caagtggccg ggagcgaact tttgcaaatc tcttctgcgc cttaaggctg ccaccgagac
      421 tgtaaagaaa agggagaaga ggaacctata ctcataccag ttcgcacagg cggctgaagt
      481 tgggcgagcg ctagccgcgg ctgcctagcg tccccctccc cctcacagcg gaggagggga
      541 cagttgtcgg aggccgggcg gcagagcccg atcgcgggct tccaccgaga attccgtgac
      601 gactggtcag caccgccgga gagccgctgt tgctgggact ggtctgcggg ctccaaggaa
      661 ccgctgctcc ccgagagcgc tccgtgagtg accgcgactt ttcaaagctc ggcatcgcgc
      721 gggagcctac caacgtgagt gctagcggag tcttaaccct gcgctccctg gagcgaactg
      781 gggaggaggg ctcaggggga agcactgccg tctggagcgc acgctcctaa acaaactttg
      841 ttacagaagc ggggacgcgc gggtatcccc ccgcttcccg gcgcgctgtt gcggccccga
      901 aacttctgcg cacagcccag gctaaccccg cgtgaagtga cggaccgttc tatgactgca
      961 aagatggaaa cgaccttcta cgacgatgcc ctcaacgcct cgttcctcca gtccgagagc
     1021 ggtgcctacg gctacagtaa ccctaagatc ctaaaacaga gcatgacctt gaacctggcc
     1081 gacccggtgg gcagtctgaa gccgcacctc cgcgccaaga actcggacct tctcacgtcg
     1141 cccgacgtcg ggctgctcaa gctggcgtcg ccggagctgg agcgcctgat catccagtcc
     1201 agcaatgggc acatcaccac tacaccgacc cccacccagt tcttgtgccc caagaacgtg
     1261 accgacgagc aggagggctt cgccgagggc ttcgtgcgcg ccctggctga actgcatagc
     1321 cagaacacgc ttcccagtgt cacctccgcg gcacagccgg tcagcggggc gggcatggtg
     1381 gctcccgcgg tggcctcagt agcaggcgct ggcggcggtg gtggctacag cgccagcctg
     1441 cacagtgagc ctccggtcta cgccaacctc agcaacttca acccgggtgc gctgagcagc
     1501 ggcggtgggg cgccctccta tggcgcggcc gggctggcct ttccctcgca gccgcagcag
     1561 cagcagcagc cgcctcagcc gccgcaccac ttgccccaac agatcccggt gcagcacccg
     1621 cggctgcaag ccctgaagga agagccgcag accgtgccgg agatgccggg agagacgccg
     1681 cccctgtccc ctatcgacat ggagtctcag gagcggatca aggcagagag gaagcgcatg
     1741 aggaaccgca ttgccgcctc caagtgccgg aaaaggaagc tggagcggat cgctcggcta
     1801 gaggaaaaag tgaaaacctt gaaagcgcaa aactccgagc tggcatccac ggccaacatg
     1861 ctcagggaac aggtggcaca gcttaagcag aaagtcatga accacgttaa cagtgggtgc
     1921 caactcatgc taacgcagca gttgcaaacg ttttgagaac agactgtcag ggctgagggg
     1981 caatggaaga aaaaaaataa cagagacaaa cttgagaact tgactggttg cgacagagaa
     2041 aaaaaaagtg tccgagtact gaagccaagg gtacacaaga tggactgggt tgcgacctga
     2101 cggcgccccc agtgtgctgg agtgggaagg acgtggcgcg cctggctttg gcgtggagcc
     2161 agagagcagc ggcctattgg ccggcagact ttgcggacgg gctgtgcccg cgcgcgacca
     2221 gaacgatgga cttttcgtta acattgacca agaactgcat ggacctaaca ttcgatctca
     2281 ttcagtatta aaggggggtg ggaggggtta caaactgcaa tagagactgt agattgcttc
     2341 tgtagtgctc cttaacacaa agcagggagg gctgggaagg ggggggaggc ttgtaagtgc
     2401 caggctagac tgcagatgaa ctcccctggc ctgcctctct caactgtgta tgtacatata
     2461 tatttttttt taatttgatg aaagctgatt actgtcaata aacagcttcc tgcctttgta
     2521 agttattcca tgtttgtttg tttgggtgtc ctgcccagtg tttgtaaata agagatttga
     2581 agcattctga gtttaccatt tgtaataaag tatataattt ttttatgttt tgtttctgaa
     2641 aatttccaga aaggatattt aagaaaatac aataaactat tgaaaagtag cccccaacct
     2701 ctttgctgca ttatccatag ataatgatag ctagatgaag tgacagctga gtgcccaata
     2761 tactagggtg aaagctgtgt cccctgtctg attgtaggaa tagataccct gcatgctatc
     2821 attggctcat actctctccc ccggcaacac acaagtccag actgtacacc agaagatggt
     2881 gtggtgtttc ttaaggctgg aagaagggct gttgcaaggg gagagggtca gcccgctgga
     2941 aagcagacac tttggttgaa agctgtatga agtggcatgt gctgtgatca tttataatca
     3001 taggaaagat ttagtaatta gctgttgatt ctcaaagcag ggacccatgg aagtttttaa
     3061 caaaaggtgt ctccttccaa ctttgaatct gacaactcct agaaaaagat gacctttgct
     3121 tgtgcatatt tataatagcg ttcgttatca caataaatgt attcaaataa tggtttttaa
     3181 aatcttg
//
