LOCUS       NM_028001               1116 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus junctional sarcoplasmic reticulum protein 1 (Jsrp1),
            mRNA.
ACCESSION   NM_028001
VERSION     NM_028001.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1116)
  AUTHORS   Mosca,B., Eckhardt,J., Bergamelli,L., Treves,S., Bongianino,R., De
            Negri,M., Priori,S.G., Protasi,F. and Zorzato,F.
  TITLE     Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow
            Twitch Skeletal Muscles
  JOURNAL   J Biol Chem 291 (28), 14555-14565 (2016)
   PUBMED   27189940
  REMARK    GeneRIF: Calcium entry activated by ablation of both JP45-CASQ1 and
            JP45-CASQ2 complexes supports tetanic force development in slow
            twitch soleus muscles.
            Erratum:[J Biol Chem. 2016 Sep 23;291(39):20824. doi:
            10.1074/jbc.A115.709071.. PMID: 27664065]
REFERENCE   2  (bases 1 to 1116)
  AUTHORS   Mosca,B., Delbono,O., Laura Messi,M., Bergamelli,L., Wang,Z.M.,
            Vukcevic,M., Lopez,R., Treves,S., Nishi,M., Takeshima,H.,
            Paolini,C., Martini,M., Rispoli,G., Protasi,F. and Zorzato,F.
  TITLE     Enhanced dihydropyridine receptor calcium channel activity restores
            muscle strength in JP45/CASQ1 double knockout mice
  JOURNAL   Nat Commun 4, 1541 (2013)
   PUBMED   23443569
  REMARK    GeneRIF: Ca(2+) transients evoked by tetanic stimulation are the
            result of massive Ca(2+) influx due to enhanced Ca(v)1.1 channel
            activity, which restores muscle strength in JP45/CASQ1 double
            knockout mice.
REFERENCE   3  (bases 1 to 1116)
  AUTHORS   Delbono,O., Messi,M.L., Wang,Z.M., Treves,S., Mosca,B.,
            Bergamelli,L., Nishi,M., Takeshima,H., Shi,H., Xue,B. and
            Zorzato,F.
  TITLE     Endogenously determined restriction of food intake overcomes
            excitation-contraction uncoupling in JP45KO mice with aging
  JOURNAL   Exp Gerontol 47 (4), 304-316 (2012)
   PUBMED   22297108
REFERENCE   4  (bases 1 to 1116)
  AUTHORS   Delbono,O., Xia,J., Treves,S., Wang,Z.M., Jimenez-Moreno,R.,
            Payne,A.M., Messi,M.L., Briguet,A., Schaerer,F., Nishi,M.,
            Takeshima,H. and Zorzato,F.
  TITLE     Loss of skeletal muscle strength by ablation of the sarcoplasmic
            reticulum protein JP45
  JOURNAL   Proc Natl Acad Sci U S A 104 (50), 20108-20113 (2007)
   PUBMED   18077436
  REMARK    GeneRIF: One of the molecules involved in the development or
            maintenance of skeletal muscle strength.
REFERENCE   5  (bases 1 to 1116)
  AUTHORS   Anderson,A.A., Altafaj,X., Zheng,Z., Wang,Z.M., Delbono,O.,
            Ronjat,M., Treves,S. and Zorzato,F.
  TITLE     The junctional SR protein JP-45 affects the functional expression
            of the voltage-dependent Ca2+ channel Cav1.1
  JOURNAL   J Cell Sci 119 (Pt 10), 2145-2155 (2006)
   PUBMED   16638807
REFERENCE   6  (bases 1 to 1116)
  AUTHORS   Anderson,A.A., Treves,S., Biral,D., Betto,R., Sandona,D., Ronjat,M.
            and Zorzato,F.
  TITLE     The novel skeletal muscle sarcoplasmic reticulum JP-45 protein.
            Molecular cloning, tissue distribution, developmental expression,
            and interaction with alpha 1.1 subunit of the voltage-gated calcium
            channel
  JOURNAL   J Biol Chem 278 (41), 39987-39992 (2003)
   PUBMED   12871958
  REMARK    GeneRIF: cloning, developmental expression, localization in
            sarcoplasmic reticulum, interaction with alpha 1.1 voltage-gated
            calcium channel, and involvement in skeletal muscle
            excitation-contraction coupling
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166937.2.
            
            On Mar 25, 2011 this sequence version replaced NM_028001.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009016.1, BY708892.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC166937.2         71210-71245
            37-159              AC166937.2         72291-72413
            160-197             AC166937.2         72604-72641
            198-300             AC166937.2         74142-74244
            301-489             AC166937.2         74344-74532
            490-572             AC166937.2         75480-75562
            573-1116            AC166937.2         75669-76212
FEATURES             Location/Qualifiers
     source          1..1116
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1116
                     /gene="Jsrp1"
                     /gene_synonym="2300003C06Rik; 2310032K21Rik; JP-45; JP45"
                     /note="junctional sarcoplasmic reticulum protein 1"
                     /db_xref="GeneID:71912"
                     /db_xref="MGI:MGI:1916700"
     exon            1..36
                     /gene="Jsrp1"
                     /gene_synonym="2300003C06Rik; 2310032K21Rik; JP-45; JP45"
                     /inference="alignment:Splign:2.1.0"
     exon            37..159
                     /gene="Jsrp1"
                     /gene_synonym="2300003C06Rik; 2310032K21Rik; JP-45; JP45"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1040
                     /gene="Jsrp1"
                     /gene_synonym="2300003C06Rik; 2310032K21Rik; JP-45; JP45"
                     /note="junctional-face membrane protein of 45 kDa homolog"
                     /codon_start=1
                     /product="junctional sarcoplasmic reticulum protein 1"
                     /protein_id="NP_082277.2"
                     /db_xref="CCDS:CCDS24034.2"
                     /db_xref="GeneID:71912"
                     /db_xref="MGI:MGI:1916700"
                     /translation="MTTRGLEDLDGGLGSCLPSDDLPFLEEPASGRRPESKARGTSRR
                     ADSSDWTHVLQDPVAAGAGDAGLKKMEKELAGKESTAGKAGTSPRIVPARRKPQAPPP
                     LQPPPPPLQPPPRTPSDDLPWGDLTLNKCLVLASLVALLGSALQLCRDAVAGEVVAAP
                     HPWVPPSSPPKKEASPAPKPPVLVSPSGSPQPKPGPPQARMQDEPELPGSPEATETRV
                     ERGGSISEASGEESVPLGDRGSQEKPRKEKPSKGEKLKKEKPRREKPRREDKSQVTGE
                     PRQSLPRRWEAREGGRRPWGRDSRDLLEHGKLQAWAPRRRHDRDDRPRQKRGKGRD"
     exon            160..197
                     /gene="Jsrp1"
                     /gene_synonym="2300003C06Rik; 2310032K21Rik; JP-45; JP45"
                     /inference="alignment:Splign:2.1.0"
     exon            198..300
                     /gene="Jsrp1"
                     /gene_synonym="2300003C06Rik; 2310032K21Rik; JP-45; JP45"
                     /inference="alignment:Splign:2.1.0"
     exon            301..489
                     /gene="Jsrp1"
                     /gene_synonym="2300003C06Rik; 2310032K21Rik; JP-45; JP45"
                     /inference="alignment:Splign:2.1.0"
     exon            490..572
                     /gene="Jsrp1"
                     /gene_synonym="2300003C06Rik; 2310032K21Rik; JP-45; JP45"
                     /inference="alignment:Splign:2.1.0"
     exon            573..1116
                     /gene="Jsrp1"
                     /gene_synonym="2300003C06Rik; 2310032K21Rik; JP-45; JP45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1092..1097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jsrp1"
                     /gene_synonym="2300003C06Rik; 2310032K21Rik; JP-45; JP45"
                     /note="hexamer: AATAAA"
     polyA_site      1116
                     /gene="Jsrp1"
                     /gene_synonym="2300003C06Rik; 2310032K21Rik; JP-45; JP45"
                     /note="major polyA site"
ORIGIN      
        1 tatcttgtct ctcaagccca gctcggaggc tgtcggtctc tatgactacc agaggcctgg
       61 aggacctgga tgggggcctg ggcagctgcc tccccagtga tgacctccca tttctggagg
      121 aaccagcctc aggccggcgg ccagagagca aggctcgagg gacatccagg cgggccgact
      181 ccagtgactg gacccatgtc cttcaggacc cagttgctgc tggcgctggg gatgccgggc
      241 tcaagaagat ggaaaaagag ctagcgggca aggagagcac agctggcaaa gcgggaacaa
      301 gcccccggat cgttcctgca cgtaggaagc cgcaggctcc gcctcccctg cagccgcccc
      361 cgcctcccct gcagccgccc ccaaggacgc caagcgatga cctgccctgg ggagatctga
      421 cgctcaacaa gtgcctggta ctggcctcgc tggtggccct gctgggctcg gctcttcagc
      481 tgtgtcggga cgcagtggct ggggaggtcg tggctgcccc tcacccatgg gtcccgccca
      541 gctctccacc aaagaaggaa gcgtcgccag cgcctaagcc tccggttttg gtgtctccat
      601 ccgggtctcc tcagccgaag cctgggccac cccaggcacg gatgcaggat gagcctgagc
      661 ttcccgggag ccctgaagct acagaaaccc gggtagaacg tggagggtcc atctcggaag
      721 cctctgggga ggagagcgta ccccttgggg accgagggtc ccaggagaag ccacggaaag
      781 agaagccaag taaaggggag aaactgaaga aggagaagcc gagaagggag aagccgagga
      841 gagaggataa gtcacaggtc actggggagc cccgtcaatc actgccacgg cgctgggagg
      901 cgcgggaagg aggccgtcgg ccatggggac gggactccag ggacctcctc gagcatggga
      961 agctgcaggc ctgggctccc cggcgaaggc atgaccgtga tgaccggccc agacagaagc
     1021 gagggaaggg gcgtgactga tcctgtgtcc cctgggcgaa tcctgtgtcc cttctccctg
     1081 tagcaccagc aaataaaggc cgtgttgtga cagcaa
//
