LOCUS       NM_008415               5529 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus jerky (Jrk), mRNA.
ACCESSION   NM_008415
VERSION     NM_008415.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5529)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   2  (bases 1 to 5529)
  AUTHORS   Waldron,R. and Moore,T.
  TITLE     Complex regulation and nuclear localization of JRK protein
  JOURNAL   Biochem Soc Trans 32 (Pt 6), 920-923 (2004)
   PUBMED   15506925
  REMARK    GeneRIF: JRK protein associates with a specific chromosomal
            centromeric locus in the cell cycle G(2) phase.
REFERENCE   3  (bases 1 to 5529)
  AUTHORS   Liu,W., Seto,J., Sibille,E. and Toth,M.
  TITLE     The RNA binding domain of Jerky consists of tandemly arranged
            helix-turn-helix/homeodomain-like motifs and binds specific sets of
            mRNAs
  JOURNAL   Mol Cell Biol 23 (12), 4083-4093 (2003)
   PUBMED   12773553
  REMARK    GeneRIF: Jerky has a role in epilepsy and consists of tandemly
            arranged helix-turn-helix/homeodomain-like motifs and binds
            specific sets of mRNAs
REFERENCE   4  (bases 1 to 5529)
  AUTHORS   Liu,W., Seto,J., Donovan,G. and Toth,M.
  TITLE     Jerky, a protein deficient in a mouse epilepsy model, is associated
            with translationally inactive mRNA in neurons
  JOURNAL   J Neurosci 22 (1), 176-182 (2002)
   PUBMED   11756500
REFERENCE   5  (bases 1 to 5529)
  AUTHORS   Delgado-Escueta,A.V., Medina,M.T., Serratosa,J.M.,
            Castroviejo,I.P., Gee,M.N., Weissbecker,K., Westling,B.W.,
            Fong,C.Y., Alonso,M.E., Cordova,S., Shah,P., Khan,S., Sainz,J.,
            Rubio-Donnadieu,F. and Sparkes,R.S.
  TITLE     Mapping and positional cloning of common idiopathic generalized
            epilepsies: juvenile myoclonus epilepsy and childhood absence
            epilepsy
  JOURNAL   Adv Neurol 79, 351-374 (1999)
   PUBMED   10514826
REFERENCE   6  (bases 1 to 5529)
  AUTHORS   Toth,M. and Tecott,L.
  TITLE     Transgenic approaches to epilepsy
  JOURNAL   Adv Neurol 79, 291-296 (1999)
   PUBMED   10514821
  REMARK    Review article
REFERENCE   7  (bases 1 to 5529)
  AUTHORS   Morita,R., Miyazaki,E., Fong,C.Y., Chen,X.N., Korenberg,J.R.,
            Delgado-Escueta,A.V. and Yamakawa,K.
  TITLE     JH8, a gene highly homologous to the mouse jerky gene, maps to the
            region for childhood absence epilepsy on 8q24
  JOURNAL   Biochem Biophys Res Commun 248 (2), 307-314 (1998)
   PUBMED   9675132
  REMARK    Erratum:[Biochem Biophys Res Commun 1998 Sep 18;250(2):536]
REFERENCE   8  (bases 1 to 5529)
  AUTHORS   Donovan,G.P., Harden,C., Gal,J., Ho,L., Sibille,E., Trifiletti,R.,
            Gudas,L.J. and Toth,M.
  TITLE     Sensitivity to jerky gene dosage underlies epileptic seizures in
            mice
  JOURNAL   J Neurosci 17 (12), 4562-4569 (1997)
   PUBMED   9169517
REFERENCE   9  (bases 1 to 5529)
  AUTHORS   Toth,M., Grimsby,J., Buzsaki,G. and Donovan,G.P.
  TITLE     Epileptic seizures caused by inactivation of a novel gene, jerky,
            related to centromere binding protein-B in transgenic mice
  JOURNAL   Nat Genet 11 (1), 71-75 (1995)
   PUBMED   7550318
  REMARK    Erratum:[Nat Genet 1996 Jan;12(1):110]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK168885.1 and AC118022.12.
            
            On Mar 24, 2011 this sequence version replaced NM_008415.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042652.1, AK168885.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3378              AK168885.1         2-3379
            3379-5529           AC118022.12        132233-134383       c
FEATURES             Location/Qualifiers
     source          1..5529
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 34.26 cM"
     gene            1..5529
                     /gene="Jrk"
                     /note="jerky"
                     /db_xref="GeneID:16469"
                     /db_xref="MGI:MGI:106214"
     exon            1..76
                     /gene="Jrk"
                     /inference="alignment:Splign:2.1.0"
     exon            77..5529
                     /gene="Jrk"
                     /inference="alignment:Splign:2.1.0"
     CDS             507..2180
                     /gene="Jrk"
                     /codon_start=1
                     /product="jerky protein"
                     /protein_id="NP_032441.4"
                     /db_xref="CCDS:CCDS27524.1"
                     /db_xref="GeneID:16469"
                     /db_xref="MGI:MGI:106214"
                     /translation="MASKQAAAKGKGEKRKRVVLTLKEKIDICTRLERGESRKALMQE
                     YNVGMSTLYDIKAHKAQLLRFFASSDSRQALEQRRTLHTPKLEHLDRVLYEWFLVKRA
                     EGIPVSGPMLIEKAKDFYKQMRLTEPCVFSGGWLWRFKARHGIKKLDASSEKQAADHQ
                     AAEQFCGFFRSLAAEHGLSPEQVYSADETGLVWRCLPNSAPDDGTVPHFKQGKDRLTV
                     LMCANATGSHRIKPLAIGKGGGPRAFRGIQHLPIAYKAQGNAWVDKEIFSDWFHHIFV
                     PSVREHFRTIGLPEDSKAILLLDHSRAHSQESELVSENVFTIFLPSSVTSLLQPTEQG
                     IRRAFMRLFINPPVAFQGFPTRHNINDAIVNVARAWNAVPSQVFQRAWRKLWPTVTFT
                     EGSSSEEEAECCAIKPHKTFAHILGLVKEGPTCSGSRLQDSRVEERVVAGRDIDEAPA
                     IVAPSQATRCTKKSEKDTGETEEAAWEQAATSFEALVRFAERQPCFSVQEMGQLQALH
                     TVFRRQQQLRQPRVALRAVIKLEALQEHPGVCVATTHPTLPCSSTAGDN"
     regulatory      3359..3364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jrk"
                     /note="hexamer: ATTATA"
     polyA_site      3382
                     /gene="Jrk"
                     /note="major polyA site"
     regulatory      5078..5083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jrk"
                     /note="hexamer: AATATA"
     polyA_site      5097
                     /gene="Jrk"
ORIGIN      
        1 aggccgagaa gagcgggccg gtggagagct gcgtggctgg cgtttccggc cggtagcggc
       61 ggcacggggt ccgcagttcc tggagtgtat gggttaagca acgttgtgaa tcctcacaag
      121 gagtatctcc agcttagggc catcaaatct tcattagcct gaaacctgga cacagttgaa
      181 ggggaaagct gccacattgt gacatctgtg tggaggccgt aggctccagg tgcaccccag
      241 cagtccaggg tagctctcct gtctcctccc ctgaagagaa cagcactacc aggatctgag
      301 gcctaagtat gctagagtcc tgatactgaa ggcaaactaa ggcaagagac tgctgtagac
      361 agggtagagt caagaatgaa cttgacttaa gcctgggatc agttcctggg gcaggtagag
      421 aagagaggga gaaaccgtgg ccccaagagc cagagagaaa cataaccaag taaggacagg
      481 ggcagcctgg ctccggctgc ttcctcatgg cctccaagca ggctgcagcc aagggcaagg
      541 gggagaagcg gaagcgagtg gtgctaaccc tgaaggaaaa gattgacatc tgcacccggc
      601 tggagcgtgg ggagagtagg aaggctctga tgcaggagta taatgtgggc atgtctactc
      661 tgtatgacat caaagcccac aaggcccagc tcctcaggtt cttcgccagc tcagactctc
      721 ggcaggcgct ggaacagcga cgtaccctgc acaccccaaa gctggagcac ctggaccggg
      781 tgctctatga gtggttcctg gtaaagcgcg ctgagggcat ccctgtgtcg ggccctatgc
      841 tcatcgaaaa ggccaaggac ttctacaagc agatgcggct gacagagccc tgtgtgttct
      901 ctggagggtg gctttggcgc ttcaaggcca ggcatggcat taaaaagctg gatgcctcca
      961 gcgagaagca ggcggctgac caccaagctg ctgagcagtt ctgtggcttt ttcaggagcc
     1021 ttgcagcgga gcacgggctg tctccagagc aggtgtacag cgctgatgag actggtcttg
     1081 tctggcggtg cttgccaaat tctgccccag atgatgggac tgtgccccac ttcaaacagg
     1141 gcaaggacag gctgactgtc ttgatgtgcg ctaatgccac aggctcccac agaatcaagc
     1201 ctttggccat tgggaagggt ggcggcccca gagccttcag aggcatccag cacctgccta
     1261 ttgcttacaa ggcccagggt aatgcctggg tagacaagga gattttctca gactggttcc
     1321 atcatatttt tgtcccctcg gtgagagagc actttagaac cataggctta ccagaagaca
     1381 gcaaggcaat tctcttgctg gaccattccc gggcccactc acaggagtct gagctagtgt
     1441 cagagaacgt cttcaccatc ttcctgccct ccagcgtgac ctccttactg cagcccacag
     1501 aacaaggcat tcgcagagcc ttcatgaggc tctttattaa ccctcccgtg gccttccagg
     1561 gcttccccac ccgccacaac ataaatgacg ccatagtcaa cgtggcccgt gcctggaatg
     1621 ctgtgcctag ccaggtcttc cagcgggcct ggaggaaact gtggcccact gtcacgttca
     1681 ctgaaggctc ctcctctgag gaggaagcag agtgctgtgc catcaagcct cacaagacgt
     1741 tcgcacacat ccttgggctt gtaaaagaag ggccaacctg ttctggcagc aggcttcagg
     1801 acagcagggt tgaagagcgg gttgtggcag ggagggacat agatgaggcc cctgccattg
     1861 tggcaccatc ccaggccact aggtgtacaa aaaagtcaga gaaagatacc ggtgagactg
     1921 aggaggcagc ctgggagcag gcagccacat cctttgaggc acttgtgcgc tttgcagagc
     1981 ggcagccgtg tttcagcgtg caagagatgg ggcagctgca ggcactgcac acggtgttca
     2041 ggagacagca gcagctgagg cagccccgtg tggctctcag ggctgtgatc aaacttgagg
     2101 cccttcagga gcaccctggg gtgtgtgtgg ccacaaccca ccctaccttg ccttgctctt
     2161 ccactgcagg tgacaactaa agtaccttgt ttgcacccac tggccctctg cagctctgct
     2221 ctatggcatg tgcagctgtg gggcagagac tgcctgctag ggaggagagc atactgagat
     2281 gagcgagaga gcaagcacag gcttgggccc caggagcatg gctcttgtca gggttgctcc
     2341 ttgtttacag agggctctct atgttctggc tagtggttta actgtatctt ctagcacaga
     2401 taatctatca tttgaatggc aagagacctg gtaccctcta tctcgctact ctggagcctc
     2461 ccctagctgc agcttggttc agtgggccag ttctgtgtct ggtgttggaa aactgagcca
     2521 cattatcagg ttgaagtgcc ttgaggggtg tacctccagc ccttgggagg cttgctctcc
     2581 tcaactggtg gaccccacgc ccattcctaa gggcactggc ttcagcgttt ggcctcagtg
     2641 ttcacatccc ccactgctag ttgctgaggt atcatgccaa cctcttggtc tgcacccacc
     2701 tcatccatca acaaacaaat tcaacagcaa gctctgtagt gtccctgtca gcagcaggtc
     2761 ctacccctgg ggtccaggtc tcacagagcc actgtgctaa tctcagcatt gttcagaggc
     2821 caacatgttc tcagaagtcc gtgttcccca gaacttcaaa gtaacagcct ttatgtgaac
     2881 ggtttgcaaa gtcacagaac agaacagcac ttggtgcctt ggagctcaac atggggtagg
     2941 ggggttagca ctactccagt gggatatgtg tctgccctgg ttggttctat ggagaccagc
     3001 tgtcggagga catgactttt cctgacattg tagcattgta gccgatgagt agcactgtgg
     3061 ctgctgtgcc cgtgactccc agtgcccttt gtctgcagag gttaccttac tgttctttca
     3121 ccgtggcttt gttcttgacc ttcattccct cctggattcc tgtggctgtg ctaccacagt
     3181 cttcattcca gtggtggaca gctgctacac caagagactt ttgccgaacc tctgagagcc
     3241 agaggggttt gggcaatgtt gctttgtgtt tctgtatctg tccaaacact aaggatggcc
     3301 attgcagaca gctctagttg tggctgagtg tcgtcttgct ttacctgcat gtgtgaatat
     3361 tatacctagg ttgttttcag aagtctttgt catgattctt cagtccctgt tgaccagggt
     3421 tatgcttctt tcacaccact ttttctgtgt gtctgggtga catttgcatg ctcatgtgct
     3481 atctggtttc tggctcatac ggggctgttg tgtaactctt gtggctattt aagctgctgc
     3541 aggtcagagg tcagaagcca cacgtgcctg agcatcagtg ggcatgtgga gtgggggcat
     3601 ggggcgggac tgggggcgct cctgggccta taaggtttgt acccatcaga ccacattcta
     3661 ggaccaatgc tagctgacct tcaggacctg ttcctggtat tgccacctac tatatatgtg
     3721 atgcccccag agcacgttcc aaaacaacag cctcctttgt cttcatccct ctgtcccagg
     3781 ggagagttcc ctttgtccag tggtcactga ggccctcaga aagctctaag ctctccaggg
     3841 cagaatgttc tctggttccc cctatatact gtctgcttcc ccatcatgcc tctcagacac
     3901 ctgtgtagcc cagcctagcc tagaactggc agtcctgctt cagcctcctg tgtatcagca
     3961 ttagagacat acactgccat gcttggttca tttctgcttc ctaccacgag ctaagctatt
     4021 gttccactga tagacaggtt ttgggcactg gaatgtcaca ctgccctggc tgctcctttc
     4081 ccaccgcaga gccttttctc tctgtttatg tgtcaagaga cctttcacat cacctctcac
     4141 ttcctgggag gaggttaatt tgtcagctct gatagcaagt agagtgagat tgctccttca
     4201 ttacctctag gtgtgcacaa ggagctcata tccacagtgc cgtccagtga gaggcagatg
     4261 ctatttccgg gttgtggttt cctctgccag ggcatggtta cctgagccct acctggccct
     4321 ttgctggtgt ccaaggaaga tcatcctgct ggcatctggt cagagaaggt tgtcccctgc
     4381 ttatgagggc ctggctagga ccattctccc tcaccggcac ttgctgcttg gtggaagagc
     4441 agaagtatcc tgtcacagcc ctgtgttgtc tccatagaag tacatccaca gcaagacaag
     4501 ccacagcctt tgtcctgtgg gtggagggtg ggcaaattgg tgggttaact gggagagtgg
     4561 gtagaagagg gggctgctgc tctacccagt tacccaagta gaaatcaact caggctcccc
     4621 atgacactgg acctgggtac cacaagaaac cgggtgaggc ctgggagagg aacctcgatg
     4681 gggctgtgat ggctgctgtc actttcagta agactgggtc tgagatgatc tagaaaagaa
     4741 cccagaggga aggtccaagt ctgggaactg gagctgtgat catcctcttg tgagcctgga
     4801 cttggtgaga ggacaccttg agcttagtga ggtggaagct gtgacgtgtg ggagatgatg
     4861 gggctgtgga gtggactgcc attggtcctg gctccagctc ttttacatga tggtcctttg
     4921 cctgcttgtt cttgccttcc atcagcccca ccgccggagc attccttgca tcactaacta
     4981 gtgtcatgct gtccttgatc atggatggga cagtaagttt ttaagtaagg agttcagggt
     5041 tccctgttga gtgctagggc aagctgcaga ctggctaaat ataaggaatt aatcagagat
     5101 gcctttgtgg ttccaaagat tgtaaccccc agctcgcaga gaggcttagg tttcagggga
     5161 gggaggtaaa taagggtgtg gtgcccccta ggaggagcat cctcaggcca gaaagccatg
     5221 gaagctcttg tttgatgtgg ataagggtcc tgaggcccct tagggatgct gaaccctctg
     5281 gctggggttg atagagctcc ctctgtaggg ctccatgccc aggctctgtc cctccatcgg
     5341 tgagatcata gtctcagcct tcagtgccat cctgcctctg caccccagtg ccagagccag
     5401 cccatggagg agcttgccca gctgaaaaga gctgcctctg agagatggag aactttgtcc
     5461 acaactcaca gagggcagga ggtagaaaag acaaaagtgt ttggcggcta aatacatgaa
     5521 tgaaaatgt
//
