LOCUS       NM_177049               4489 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus junctophilin 4 (Jph4), mRNA.
ACCESSION   NM_177049
VERSION     NM_177049.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4489)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4489)
  AUTHORS   Sahu,G., Wazen,R.M., Colarusso,P., Chen,S.R.W., Zamponi,G.W. and
            Turner,R.W.
  TITLE     Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex
            to Regulate Neuronal Excitability
  JOURNAL   Cell Rep 28 (9), 2427-2442 (2019)
   PUBMED   31461656
  REMARK    GeneRIF: Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite
            Complex to Regulate Neuronal Excitability.
REFERENCE   3  (bases 1 to 4489)
  AUTHORS   Woo,J.S., Srikanth,S., Nishi,M., Ping,P., Takeshima,H. and Gwack,Y.
  TITLE     Junctophilin-4, a component of the endoplasmic reticulum-plasma
            membrane junctions, regulates Ca2+ dynamics in T cells
  JOURNAL   Proc Natl Acad Sci U S A 113 (10), 2762-2767 (2016)
   PUBMED   26929330
  REMARK    GeneRIF: Data show that junctophilin-4 (JP4) is expressed in T
            cells and localized at the endoplasmic reticulum-plasma membrane
            junctions to regulate Ca(2+) signaling.
REFERENCE   4  (bases 1 to 4489)
  AUTHORS   Quille,M.L., Carat,S., Quemener-Redon,S., Hirchaud,E., Baron,D.,
            Benech,C., Guihot,J., Placet,M., Mignen,O., Ferec,C., Houlgatte,R.
            and Friocourt,G.
  TITLE     High-throughput analysis of promoter occupancy reveals new targets
            for Arx, a gene mutated in mental retardation and
            interneuronopathies
  JOURNAL   PLoS One 6 (9), e25181 (2011)
   PUBMED   21966449
REFERENCE   5  (bases 1 to 4489)
  AUTHORS   Ikeda,A., Miyazaki,T., Kakizawa,S., Okuno,Y., Tsuchiya,S.,
            Myomoto,A., Saito,S.Y., Yamamoto,T., Yamazaki,T., Iino,M.,
            Tsujimoto,G., Watanabe,M. and Takeshima,H.
  TITLE     Abnormal features in mutant cerebellar Purkinje cells lacking
            junctophilins
  JOURNAL   Biochem Biophys Res Commun 363 (3), 835-839 (2007)
   PUBMED   17904530
  REMARK    GeneRIF: Gene expression was slightly altered in the JP-3 and JP-4
            Knockout cerebellum.
REFERENCE   6  (bases 1 to 4489)
  AUTHORS   Kakizawa,S., Kishimoto,Y., Hashimoto,K., Miyazaki,T., Furutani,K.,
            Shimizu,H., Fukaya,M., Nishi,M., Sakagami,H., Ikeda,A., Kondo,H.,
            Kano,M., Watanabe,M., Iino,M. and Takeshima,H.
  TITLE     Junctophilin-mediated channel crosstalk essential for cerebellar
            synaptic plasticity
  JOURNAL   EMBO J 26 (7), 1924-1933 (2007)
   PUBMED   17347645
REFERENCE   7  (bases 1 to 4489)
  AUTHORS   Moriguchi,S., Nishi,M., Komazaki,S., Sakagami,H., Miyazaki,T.,
            Masumiya,H., Saito,S.Y., Watanabe,M., Kondo,H., Yawo,H.,
            Fukunaga,K. and Takeshima,H.
  TITLE     Functional uncoupling between Ca2+ release and
            afterhyperpolarization in mutant hippocampal neurons lacking
            junctophilins
  JOURNAL   Proc Natl Acad Sci U S A 103 (28), 10811-10816 (2006)
   PUBMED   16809425
  REMARK    GeneRIF: Jph4 seems to have an essential role in neural
            excitability fundamental to plasticity and integrated functions.
REFERENCE   8  (bases 1 to 4489)
  AUTHORS   Nishi,M., Sakagami,H., Komazaki,S., Kondo,H. and Takeshima,H.
  TITLE     Coexpression of junctophilin type 3 and type 4 in brain
  JOURNAL   Brain Res Mol Brain Res 118 (1-2), 102-110 (2003)
   PUBMED   14559359
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157212.2 and AB099712.1.
            
            On Mar 25, 2011 this sequence version replaced NM_177049.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY341261.1, AB099712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-657               AC157212.2         164744-165400       c
            658-4489            AB099712.1         1-3832
FEATURES             Location/Qualifiers
     source          1..4489
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.07 cM"
     gene            1..4489
                     /gene="Jph4"
                     /gene_synonym="9330157P13Rik; JP-4; JPHL1"
                     /note="junctophilin 4"
                     /db_xref="GeneID:319984"
                     /db_xref="MGI:MGI:2443113"
     exon            1..945
                     /gene="Jph4"
                     /gene_synonym="9330157P13Rik; JP-4; JPHL1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1495
                     /gene="Jph4"
                     /gene_synonym="9330157P13Rik; JP-4; JPHL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1117..3003
                     /gene="Jph4"
                     /gene_synonym="9330157P13Rik; JP-4; JPHL1"
                     /note="junctophilin-like 1 protein"
                     /codon_start=1
                     /product="junctophilin-4"
                     /protein_id="NP_796023.2"
                     /db_xref="CCDS:CCDS27109.1"
                     /db_xref="GeneID:319984"
                     /db_xref="MGI:MGI:2443113"
                     /translation="MSPGGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWA
                     HGFESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWESVS
                     GLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSVPYHQAALLRSPRR
                     TSLDSGHSDPPTPPPPLPLPGDEGGSPASGSRGGFVLAGPGDADGASSRKRTPAAGGF
                     FRRSLLLSGLRAGGRRSSLGSKRGSLRSEVSSEVGSTGPPGSEASGPPIPAPPALIEG
                     SATEVYAGEWRADRRSGYGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKR
                     NRLVHGGRVRSLLPLALRRGKVKEKVDRAVEGARRAVSAARQRQEIAAARAADALLKA
                     VAASSVAEKAVEAARMAKLIAQDLQPMLEAPGRRPRQDSGGSDTEPLDEDSPGVYENG
                     LTPSEGSPELPSSPASSHQPWRAPACRSPLPPGGNWGPFSSPKAWPEEWGGPGEQAEE
                     LAGYEAEDEAGVQGPGPRDGSPLLGGCSDSSGSLREEEGEDEESLPQLRAPGGSESEP
                     VTTPVLRGLSSRGPDAGCLTEEVEEPAPTERPAQPGAANPLVVGAVALLDLSLAFLFS
                     QLLT"
     exon            1496..2267
                     /gene="Jph4"
                     /gene_synonym="9330157P13Rik; JP-4; JPHL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2386
                     /gene="Jph4"
                     /gene_synonym="9330157P13Rik; JP-4; JPHL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2919
                     /gene="Jph4"
                     /gene_synonym="9330157P13Rik; JP-4; JPHL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..4489
                     /gene="Jph4"
                     /gene_synonym="9330157P13Rik; JP-4; JPHL1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4441
                     /gene="Jph4"
                     /gene_synonym="9330157P13Rik; JP-4; JPHL1"
                     /note="major polyA site"
     regulatory      4467..4472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jph4"
                     /gene_synonym="9330157P13Rik; JP-4; JPHL1"
                     /note="hexamer: AATAAA"
     polyA_site      4485
                     /gene="Jph4"
                     /gene_synonym="9330157P13Rik; JP-4; JPHL1"
ORIGIN      
        1 gctcgtcgcg agccttattt cgctctcttc ttctccctat gtgattctgc tcccctcctt
       61 ccctccaccc ttgacttctc tccctagcta tctctcaaga gtcctggaat gggtctccct
      121 cgccatctcc catgccggct atatctcccc ctgccatagc tctcacccct gcacctcatt
      181 ctttgtattc ctctcgcact cccggtctcc ccagcatctc tcctcccccg cctggctctg
      241 gcctccccct gcctccccat cttaagactc ctccccctag ctcctctccc ctcccctccc
      301 tccacctcac tccactccct gcctgcatgc cacggtttct ttccaccgtg ggggtctctg
      361 agccttccat tctcctctcc gcctgccttc tccctcacct caggggtagc gaaccccctt
      421 tttttctgcc tgagcatcct cgcaccaccc ccactgccac tgactctctc cccaccctct
      481 cctctccgct tctctctgcc cctttaaatc tgcctggccc agcctccccc ttgatgctgg
      541 gtttggagca aacattgatt tgtgctggga tggaattgga attttgattt tttttttcct
      601 ctcccaacca taagaagaaa aaaataaaaa caccccttct tgatagcccc ctcccctttc
      661 ccatccagcc cccagctcct cttcgctgtc tccgttcaag acagattttt ttccccctac
      721 acttattctc atcccctcca ccctgccact acctcacccc ccacactagc ctgcaccttc
      781 agccgaggaa aagggactct cccatagctc ccccaccttc cttctctggg ttgtagcagt
      841 ctctccggaa gggaaggggg cttggcttgt cctggtgagg tgtgagtgga gggaccctgc
      901 catggaaact gcgcctggga ggcagcctga gccccagcac acatgccact caggatgagg
      961 gtccggccct gcctgcccgc gctggggccc ctccgcccag ccccggtcta actgcccccg
     1021 cccccaagcc tcgcccggcc cccaggcccc cagccggctc tccagcccca tgatgcgctg
     1081 agctgccggg gggctgaggc cgcgccaact acatgcatgt cccccggggg caagttcgac
     1141 tttgacgacg ggggctgcta cgtggggggc tgggaggcgg ggcgggcaca tggctacggc
     1201 gtgtgcaccg ggcccggcgc ccagggagag tacagcggct gctgggctca cggcttcgag
     1261 tcgctgggtg tcttcacggg gcccggcgga cacagttacc agggccactg gcagcagggc
     1321 aagcgcgaag ggctgggcgt ggagcgcaag agccgctgga cctaccgcgg cgagtggctg
     1381 ggcgggctga aggggcgcag cggcgtatgg gagagcgtgt ccggcctgcg ctacgccggg
     1441 ctctggaagg acggcttcca ggacggctac ggcaccgaga cctactcgga tggaggcact
     1501 taccaaggcc agtggcaagc cgggaaacgc cacggctacg gggtgcgcca aagtgtaccc
     1561 taccaccagg cggcgcttct gcgctcaccc cgccgcacct ccctggactc cggccacagc
     1621 gaccccccga cgccgcctcc acccctaccc ctaccaggag atgaaggagg cagcccagcc
     1681 tccggctccc gaggcggctt cgtgctggcg gggccagggg acgccgacgg ggcgtcttcc
     1741 cgtaagcgca ccccagcagc aggtggattc ttccgccgtt cactgctgct cagcgggctc
     1801 cgggctggtg ggcgccgcag ctccctgggc agcaagaggg gatctctacg cagcgaggtg
     1861 agcagcgaag tgggcagtac aggacccccg ggctccgagg ccagcgggcc cccaatccca
     1921 gctccacctg ccctcatcga gggctcagcc actgaggtgt acgccggtga gtggcgtgcg
     1981 gaccggcgca gtggctatgg agtgagccag agatccaacg ggctgcgcta cgaaggcgag
     2041 tggctgggca accgacgcca cggatacggg cgcaccaccc ggcccgatgg ctcccgtgag
     2101 gagggcaagt acaagcgtaa ccggctggta cacgggggac gtgtccgcag cctcctgcct
     2161 ctggccctta gacggggcaa agtcaaggag aaagtggaca gggctgtcga aggtgcccgt
     2221 cgagctgtga gtgctgcccg ccagcgccag gaaattgcgg ctgccagggc agcagacgcc
     2281 ctcctaaaag cagtggcagc cagcagcgtc gcggagaagg ctgtggaggc tgcgcggatg
     2341 gccaagctga tagcccagga tctacaaccc atgttagagg ccccaggccg cagacccaga
     2401 caggactcag gaggttctga cacagagcct ttggatgagg acagccctgg ggtatacgag
     2461 aatggactga ccccctcaga gggctctccg gaactaccca gcagccccgc ctcctcccac
     2521 caaccttggc gagcccctgc ctgccggagt ccactgcctc ctggagggaa ctggggcccc
     2581 ttctccagcc ctaaagcttg gcccgaggag tgggggggtc ctggtgagca ggcagaggaa
     2641 ctagctggct atgaggctga ggatgaggct ggggtgcagg gtccaggacc aagagatggt
     2701 tccccacttc tcggaggctg cagtgacagt tcaggaagtc ttcgagagga ggagggggaa
     2761 gacgaagagt ccttgcccca actgagggcc ccaggaggct cagagtctga gcctgtcacc
     2821 acgccagttt tgaggggcct gtcttcaagg ggtcctgatg ctgggtgcct gacagaagag
     2881 gttgaggagc ctgctcccac cgagaggcct gcccagccgg gagctgccaa ccccctggtg
     2941 gtgggagccg tggccttgct ggacctcagc ctggccttcc tgttctccca gctcctcacc
     3001 tgaggcaaca tcctggcttc cttcgggttc tggctgcctg cctctgcacc cactctgacc
     3061 ttcgacctgc cttctcttct ctcctcctcc acccacttgt gttttcccct atctccgggg
     3121 cccctttctt ttggtctctc gcttcttcct tccctctatt ctttgagatg gtctcattta
     3181 ttctggaccc gtctctggtc ttcctggttt ttctttccca ccctgacccc ttctctctct
     3241 agattgttta catatgaagg gctgttctct ctcagagttg ctctctcctc tgagatacac
     3301 aaatctaagt cagaccattg ccccccccca tgtcctcccc aaccttttct ttgaatcaaa
     3361 acttcaccaa gggtgggggt ttggtgtcct gaggaatctc ctggaatctg agtggagggg
     3421 agaaaggaaa tgcataagaa gtgattgggt ggccagacaa ggcactgcct gagccacttg
     3481 gggctcactg gccccaaggg aaagctgcag gaaaagtacc ctccactctt acctcccaga
     3541 acctacctaa gttcttgcct actttgatct tccctgaggg agaaaagggg agcgaacaac
     3601 aggaaactcc ccgtgctccc tctcctgccc tcctcaacca gtccctctcc caaccaccaa
     3661 ggatggcacg ccaagccaag agtattgaga aaagcaacga aaaaccatct ggtgcaacca
     3721 agcccgcccc tcttcagatt ctgccactca cctctctacc cttctctgcc cccctgaaaa
     3781 tttatttggt tggtctggac tcacttgtgg cctttgatta aattcctaag gggactgaag
     3841 aagacatttc tgcagagggt tagaggcgct gcagcaagcg aggaccccag tcctcagctc
     3901 tgacagttgt ggggcgaaca cgttgagggc tgaagggcag cagatgctgt cacaagtcta
     3961 gtttctaacc cctcgcgtag actcctgcga gatgggagct aacggggaat cagaggaagc
     4021 cgctgcccca cacagggcag ggcagaggtg ggtgtcaacc ccggacgaga gttgggggga
     4081 gagcctgttt gagattatgg ctgatccctg ggactaactt tccctctggg gacagaaagc
     4141 tgtacaagag gggactgtgg aaccccgggg gactttccta ccctgcatga ggcagaggca
     4201 agctgcctgc caatcaatcc cttcctcaag gaatggcctt gcccaggaat gcccaccaca
     4261 cacacactct tcttattttt ctagtcaacc tctgtttact ccctggcctg ccttcctcct
     4321 gcctcccttc cttccttcct tctcaatctt tacttctgat ttctatttca tggaatttgg
     4381 gattgaagtt atacaacagt gccgccaaca tcaagtcttg caggaaaaaa aaaataacaa
     4441 agaaatttaa caaaaaaaag tatattaata aaaaagttcc aaaaagggg
//
