LOCUS       NM_020605               3903 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Mus musculus junctophilin 3 (Jph3), mRNA.
ACCESSION   NM_020605 XM_916243
VERSION     NM_020605.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3903)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3903)
  AUTHORS   Li,J., Sun,L., Peng,X.L., Yu,X.M., Qi,S.J., Lu,Z.J., Han,J.J. and
            Shen,Q.
  TITLE     Integrative genomic analysis of early neurogenesis reveals a
            temporal genetic program for differentiation and specification of
            preplate and Cajal-Retzius neurons
  JOURNAL   PLoS Genet 17 (3), e1009355 (2021)
   PUBMED   33760820
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3903)
  AUTHORS   Sahu,G., Wazen,R.M., Colarusso,P., Chen,S.R.W., Zamponi,G.W. and
            Turner,R.W.
  TITLE     Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex
            to Regulate Neuronal Excitability
  JOURNAL   Cell Rep 28 (9), 2427-2442 (2019)
   PUBMED   31461656
  REMARK    GeneRIF: Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite
            Complex to Regulate Neuronal Excitability.
REFERENCE   4  (bases 1 to 3903)
  AUTHORS   Li,L., Pan,Z.F., Huang,X., Wu,B.W., Li,T., Kang,M.X., Ge,R.S.,
            Hu,X.Y., Zhang,Y.H., Ge,L.J., Zhu,D.Y., Wu,Y.L. and Lou,Y.J.
  TITLE     Junctophilin 3 expresses in pancreatic beta cells and is required
            for glucose-stimulated insulin secretion
  JOURNAL   Cell Death Dis 7 (6), e2275 (2016)
   PUBMED   27336719
  REMARK    GeneRIF: The expression of JPH isoforms was examined in human and
            mouse pancreatic tissues, and JPH3 expression was found in both the
            beta cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3903)
  AUTHORS   Ikeda,A., Miyazaki,T., Kakizawa,S., Okuno,Y., Tsuchiya,S.,
            Myomoto,A., Saito,S.Y., Yamamoto,T., Yamazaki,T., Iino,M.,
            Tsujimoto,G., Watanabe,M. and Takeshima,H.
  TITLE     Abnormal features in mutant cerebellar Purkinje cells lacking
            junctophilins
  JOURNAL   Biochem Biophys Res Commun 363 (3), 835-839 (2007)
   PUBMED   17904530
  REMARK    GeneRIF: Gene expression was slightly altered in the JP-3 and JP-4
            Knockout cerebellum.
REFERENCE   6  (bases 1 to 3903)
  AUTHORS   Moriguchi,S., Nishi,M., Komazaki,S., Sakagami,H., Miyazaki,T.,
            Masumiya,H., Saito,S.Y., Watanabe,M., Kondo,H., Yawo,H.,
            Fukunaga,K. and Takeshima,H.
  TITLE     Functional uncoupling between Ca2+ release and
            afterhyperpolarization in mutant hippocampal neurons lacking
            junctophilins
  JOURNAL   Proc Natl Acad Sci U S A 103 (28), 10811-10816 (2006)
   PUBMED   16809425
REFERENCE   7  (bases 1 to 3903)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   8  (bases 1 to 3903)
  AUTHORS   Nishi,M., Sakagami,H., Komazaki,S., Kondo,H. and Takeshima,H.
  TITLE     Coexpression of junctophilin type 3 and type 4 in brain
  JOURNAL   Brain Res Mol Brain Res 118 (1-2), 102-110 (2003)
   PUBMED   14559359
REFERENCE   9  (bases 1 to 3903)
  AUTHORS   Nishi,M., Hashimoto,K., Kuriyama,K., Komazaki,S., Kano,M.,
            Shibata,S. and Takeshima,H.
  TITLE     Motor discoordination in mutant mice lacking junctophilin type 3
  JOURNAL   Biochem Biophys Res Commun 292 (2), 318-324 (2002)
   PUBMED   11906164
  REMARK    GeneRIF: Motor discoordination in mutant mice lacking junctophilin
            type 3
REFERENCE   10 (bases 1 to 3903)
  AUTHORS   Takeshima,H., Komazaki,S., Nishi,M., Iino,M. and Kangawa,K.
  TITLE     Junctophilins: a novel family of junctional membrane complex
            proteins
  JOURNAL   Mol Cell 6 (1), 11-22 (2000)
   PUBMED   10949023
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY718602.1, AB024449.1 and AC121975.3.
            
            On Mar 24, 2011 this sequence version replaced NM_020605.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082880.1, AK045706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY718602.1         13-16
            5-2588              AB024449.1         1-2584
            2589-3903           AC121975.3         78349-79663
FEATURES             Location/Qualifiers
     source          1..3903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 70.73 cM"
     gene            1..3903
                     /gene="Jph3"
                     /gene_synonym="JP-3; Jp3"
                     /note="junctophilin 3"
                     /db_xref="GeneID:57340"
                     /db_xref="MGI:MGI:1891497"
     exon            1..446
                     /gene="Jph3"
                     /gene_synonym="JP-3; Jp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..2299
                     /gene="Jph3"
                     /gene_synonym="JP-3; Jp3"
                     /note="junctophilin type 3"
                     /codon_start=1
                     /product="junctophilin-3"
                     /protein_id="NP_065630.1"
                     /db_xref="CCDS:CCDS22728.1"
                     /db_xref="GeneID:57340"
                     /db_xref="MGI:MGI:1891497"
                     /translation="MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWS
                     HGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECTG
                     NGAKYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQSVPYGMAAVIRSPL
                     RTSINSLRSEHTNGAALHPDASPAVAGSPAVSRGGFVLVAHSDSEILKSKKKGLFRRS
                     LLSGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSTASDIHSTISLGEAEAELAVI
                     EDDIDATTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWVSNRRHGYGCMTFPDGTKE
                     EGKYKQNVLVSGKRKNLIPLRASKIREKVDRAVEAAERAATIAKQKAEIAASRTSHSR
                     AKAEAALTAAQKAQEEARIARITAKEFSPSFQHRENGLEYQRPKHQMSCDDIEVLSTG
                     TPLQQESPELYRKGTTPSDLTPDDSPLQSFPASPTSTPPPAPASRTKMAHFSRQVSVD
                     EERSGDIQMLLEGRGGDYARNSWGEEKAGASRGIRSGALRSGQPTEDFRTRGSGHKQP
                     GNPKPRERRTESPTTFSWTSHHRAGNPCSGGPKLLEPDEEQLSNYKLEMKPLLRMDAC
                     PQDTHPQRRRHSRGAGGDRGFGLQRLRSKSQNKENLRPASSAEPTVQKLESLRLGDRP
                     EPRLLRWDLTFSPPQKSLPVALESDEETGDELKSSTGSAPILVVMVILLNIGVAILFI
                     NFFI"
     exon            447..1224
                     /gene="Jph3"
                     /gene_synonym="JP-3; Jp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1349
                     /gene="Jph3"
                     /gene_synonym="JP-3; Jp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..2218
                     /gene="Jph3"
                     /gene_synonym="JP-3; Jp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..3903
                     /gene="Jph3"
                     /gene_synonym="JP-3; Jp3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2438
                     /gene="Jph3"
                     /gene_synonym="JP-3; Jp3"
                     /note="major polyA site"
     regulatory      3611..3616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jph3"
                     /gene_synonym="JP-3; Jp3"
                     /note="hexamer: AATAAA"
     polyA_site      3633
                     /gene="Jph3"
                     /gene_synonym="JP-3; Jp3"
                     /note="major polyA site"
ORIGIN      
        1 tctttttttt tttttttttt tttttttttc accgcttgcg ggattcgcaa accgcgttac
       61 atgcatgtcc agtgggggta ggtttaattt tgacgatgga gggtcctact gcggaggctg
      121 ggaggacggc aaggcgcacg gccatggcgt ctgcaccggc ccgaagggcc agggcgaata
      181 caccggctcg tggagccacg gctttgaggt gctgggcgtc tacacctggc caagcggcaa
      241 cacgtaccaa ggcacctggg cgcagggcaa gcgccacggc atcggcctgg agagcaaggg
      301 gaagtgggtg tacaagggcg agtggacgca cggatttaag gggcgctacg gggtgcggga
      361 gtgcacgggc aacggagcca aatacgaagg gacctggagc aacggactgc aggatggcta
      421 cggcacggag acctactcgg atggaggaac gtatcagggc caatgggttg gtggcatgcg
      481 ccagggctac ggtgtgcggc agagtgtccc ttatggcatg gccgcagtca tccgttcgcc
      541 cctgaggacc tccatcaact ccctgcgcag cgagcacacc aacggggcgg cactgcaccc
      601 ggacgcctcc ccggcagtgg ccggcagtcc ggccgtgtcc cgtggtggct tcgtgctggt
      661 ggcccacagt gactcggaga tcctcaagag caagaagaag ggactgttcc ggcgctcgct
      721 gctgagcggc ctgaagctac gcaagtctga gtccaagagc agcctggcca gccagcgcag
      781 caagcagagc tccttccgca gcgaggccgg aatgagcacc gtgagctcca cggccagcga
      841 catccactcc accatcagcc tgggcgaggc cgaggctgag ctggcggtca ttgaggacga
      901 catcgacgcc actaccaccg agacctacgt gggtgaatgg aagaacgaca aacgctcggg
      961 cttcggtgtg agccagcgct cggacgggct taagtatgag ggcgagtggg tcagcaaccg
     1021 ccggcatggg tacgggtgca tgactttccc cgacggcacc aaggaggagg ggaagtacaa
     1081 gcagaacgtg ctcgtgagcg gcaaacgcaa gaatctcatc ccgctgcgtg ccagcaagat
     1141 ccgggagaag gtggaccggg ccgtggaggc agccgagagg gcggccacca tcgccaagca
     1201 gaaagccgag atcgctgcgt ccaggacctc ccactcacgg gccaaggctg aggcagcact
     1261 tactgcggct cagaaagccc aggaggaagc gcggatcgcc aggatcactg ccaaagagtt
     1321 ctctccctcc ttccagcaca gggaaaacgg gcttgagtac cagaggccaa agcaccagat
     1381 gtcctgcgat gatatcgagg tgctctccac cgggacaccc ctacagcagg agagccccga
     1441 gctgtaccga aagggcacca ccccttctga tctgacccct gacgacagtc ccctgcagag
     1501 cttccccgcc agccccacat ctacccctcc gccagctcct gcctccagga ccaagatggc
     1561 ccacttctcc aggcaggtct ccgtggacga ggagcgaagc ggggacatcc agatgctcct
     1621 cgagggccgc ggaggggact atgcccgcaa cagctggggc gaggagaagg ctggggcctc
     1681 taggggtatc cgcagcggtg ccctacgcag cggccagccc actgaggact tccgcacccg
     1741 gggctcaggc cacaagcagc ctgggaaccc caagccccgg gagcggcgga cggagtcccc
     1801 caccacgttc tcatggactt cccaccaccg ggcaggcaat ccctgttctg ggggccccaa
     1861 gctgctagag ccagatgagg agcagctgag caactacaag ctggagatga agcccttact
     1921 gaggatggat gcctgtccac aggatacgca cccacagaga cggcgtcata gccggggtgc
     1981 tgggggggac aggggcttcg ggctacagag actgaggtcc aagtcccaaa acaaggagaa
     2041 ccttaggcca gcctcctctg cagaacccac ggtgcagaaa ctcgagagcc tgcggctggg
     2101 ggaccggccc gagccccgtc tgctgcgttg ggacctgacc ttctccccac cccagaagtc
     2161 cctgcctgtt gcactcgagt ctgacgagga gactggagat gagctcaagt ccagcacggg
     2221 ctcagctccc atcttggtcg tcatggtgat cctgctcaac attggagtcg ccattttgtt
     2281 tattaacttt ttcatctgac aagatcggtg tgaccacgga agcgatgatg tacaaaaggg
     2341 acgctaaaag caaaacatgg agggggctcc atgactcggg acagccccac ggcgcctgtc
     2401 cttccacaga agaacaacat gattgggtat caatcacagt ttgccttttt ttctgggtaa
     2461 tgtttttttg gattttagcc aaaattcttt gcttgtataa cacaatgctg tgtggcctgg
     2521 aaggaggagg ccggcatgcc acccgtccag cttggtgtga gcgggtccgg gcaaaccagt
     2581 ggccaaaaga tcgggacctt catgtttccc gccaggtgtg gaggaaggtg gcgccttgac
     2641 cggggtgccc ggcaagccgg gagaggggga gggcagccag ggagtgcagc tgtgtgagta
     2701 gctgggagtg tgggcccagg cccagggaca gggtgtcctg gcctctgtct ccatggagtc
     2761 tgtgctgcgt acctgtggag ggagaggaaa gcccctgctc ttcttcccag aaaagaccat
     2821 gatccctctt cttggcactg ccccaaggct ctcctaagga ggcctccttc ccacactgag
     2881 tcttaaggca aagtctgttc cctgctgtcc tccgctcact cattgttggc cctgtccagc
     2941 catcctccct ccagacccag ggaggccatg ctgcagacgt ccagggctga ccccgacctg
     3001 gccgggcaca tctgagccct gatgccaagg gggctatggc ccacatgccc cggactgcct
     3061 gacagcacgc ctgggttctg tctgagcatg tgccgttcgt tttgcaccta gtatgcagga
     3121 tgtatattca ggcttccgtg tccctggcag tggcgcccca cggaggacgt cacctctcac
     3181 tgacctccac ggggtctcac atctttgcac tgtgcctgcc tcgacttccc ctaacagata
     3241 tgcatattcc ctccagatgc ctcagagcta ctccagagag tctggtcccg ggacaggaat
     3301 gtggttgaag ccagtggcta gaatgccctg ggccccgttg catacccagc actcccggat
     3361 gtccaatgta acttgtttca gtcaaacaac aggttcctca tgtctctgcc ttctctacca
     3421 gggttgttcc ctcatccaaa caaatgaata agggatgcca gcccgcctgg cccccgtggc
     3481 tccgtcagtc tccttgggtg cgcccgcccg tctgtcttac ggactccgcc ttgctttgct
     3541 tgtgttctct gctacctttt gagcagattt ctttactaca gtgcactgga ttgctatatt
     3601 tttaaccaga aataaactac agattagagc atgttccagc gacgctcagc tttcttgttt
     3661 ccgttatcca cgctgttccc tgtccaccgc ctgtccctcc tcctggagct ggtttggatc
     3721 cggggaggtt gaagggagag tgaggttcag caggtgaccc gatgcatttc tggtttctaa
     3781 ggggttccat cttttttgta cagcgtactt ttcccttcac ctttttttaa tatcaagtgg
     3841 ttgctgcaga tctggcgtga accaaataaa gattcctgct ctttgcagcc atgagagccg
     3901 tcc
//
