LOCUS       NM_021566               4235 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus junctophilin 2 (Jph2), transcript variant 1, mRNA.
ACCESSION   NM_021566
VERSION     NM_021566.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4235)
  AUTHORS   Shi,Y., Mirabdali,S., Vetter,S.W. and Guo,A.
  TITLE     Junctophilin-2 is a double-stranded RNA-binding protein that
            regulates cardiomyocyte-autonomous innate immune response
  JOURNAL   Biochem Biophys Res Commun 733, 150725 (2024)
   PUBMED   39317111
  REMARK    GeneRIF: Junctophilin-2 is a double-stranded RNA-binding protein
            that regulates cardiomyocyte-autonomous innate immune response.
REFERENCE   2  (bases 1 to 4235)
  AUTHORS   Lahiri,S.K., Lu,J., Aguilar-Sanchez,Y., Li,H., Moreira,L.M.,
            Hulsurkar,M.M., Mendoza,A., Turkieltaub Paredes,M.R.,
            Navarro-Garcia,J.A., Munivez,E., Horist,B., Moore,O.M.,
            Weninger,G., Brandenburg,S., Lenz,C., Lehnart,S.E., Sayeed,R.,
            Krasopoulos,G., Srivastava,V., Zhang,L., Karch,J.M., Reilly,S. and
            Wehrens,X.H.T.
  TITLE     Targeting calpain-2-mediated junctophilin-2 cleavage delays heart
            failure progression following myocardial infarction
  JOURNAL   J Mol Cell Cardiol 194, 85-95 (2024)
   PUBMED   38960317
  REMARK    GeneRIF: Targeting calpain-2-mediated junctophilin-2 cleavage
            delays heart failure progression following myocardial infarction.
REFERENCE   3  (bases 1 to 4235)
  AUTHORS   Lahiri,S.K., Jin,F., Zhou,Y., Quick,A.P., Kramm,C.F., Wang,M.C. and
            Wehrens,X.H.
  TITLE     Altered myocardial lipid regulation in junctophilin-2-associated
            familial cardiomyopathies
  JOURNAL   Life Sci Alliance 7 (5), e202302330 (2024)
   PUBMED   38438248
  REMARK    GeneRIF: Altered myocardial lipid regulation in
            junctophilin-2-associated familial cardiomyopathies.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4235)
  AUTHORS   Landstrom,A.P., Yang,Q., Sun,B., Perelli,R.M., Bidzimou,M.T.,
            Zhang,Z., Aguilar-Sanchez,Y., Alsina,K.M., Cao,S., Reynolds,J.O.,
            Word,T.A., van der Sangen,N.M.R., Wells,Q., Kannankeril,P.J.,
            Ludwig,A., Kim,J.J. and Wehrens,X.H.T.
  TITLE     Reduction in Junctophilin 2 Expression in Cardiac Nodal Tissue
            Results in Intracellular Calcium-Driven Increase in Nodal Cell
            Automaticity
  JOURNAL   Circ Arrhythm Electrophysiol 16 (2), e010858 (2023)
   PUBMED   36706317
  REMARK    GeneRIF: Reduction in Junctophilin 2 Expression in Cardiac Nodal
            Tissue Results in Intracellular Calcium-Driven Increase in Nodal
            Cell Automaticity.
REFERENCE   5  (bases 1 to 4235)
  AUTHORS   Yu,L., Hall,D.D., Zhao,W. and Song,L.S.
  TITLE     NMR resonance assignments of the DNA binding domain of mouse
            Junctophilin-2
  JOURNAL   Biomol NMR Assign 16 (2), 273-279 (2022)
   PUBMED   35665900
  REMARK    GeneRIF: NMR resonance assignments of the DNA binding domain of
            mouse Junctophilin-2.
REFERENCE   6  (bases 1 to 4235)
  AUTHORS   Landstrom,A.P., Weisleder,N., Batalden,K.B., Bos,J.M., Tester,D.J.,
            Ommen,S.R., Wehrens,X.H., Claycomb,W.C., Ko,J.K., Hwang,M., Pan,Z.,
            Ma,J. and Ackerman,M.J.
  TITLE     Mutations in JPH2-encoded junctophilin-2 associated with
            hypertrophic cardiomyopathy in humans
  JOURNAL   J Mol Cell Cardiol 42 (6), 1026-1035 (2007)
   PUBMED   17509612
REFERENCE   7  (bases 1 to 4235)
  AUTHORS   Minamisawa,S., Oshikawa,J., Takeshima,H., Hoshijima,M., Wang,Y.,
            Chien,K.R., Ishikawa,Y. and Matsuoka,R.
  TITLE     Junctophilin type 2 is associated with caveolin-3 and is
            down-regulated in the hypertrophic and dilated cardiomyopathies
  JOURNAL   Biochem Biophys Res Commun 325 (3), 852-856 (2004)
   PUBMED   15541368
REFERENCE   8  (bases 1 to 4235)
  AUTHORS   Komazaki,S., Ito,K., Takeshima,H. and Nakamura,H.
  TITLE     Deficiency of triad formation in developing skeletal muscle cells
            lacking junctophilin type 1
  JOURNAL   FEBS Lett 524 (1-3), 225-229 (2002)
   PUBMED   12135771
REFERENCE   9  (bases 1 to 4235)
  AUTHORS   Ito,K., Komazaki,S., Sasamoto,K., Yoshida,M., Nishi,M., Kitamura,K.
            and Takeshima,H.
  TITLE     Deficiency of triad junction and contraction in mutant skeletal
            muscle lacking junctophilin type 1
  JOURNAL   J Cell Biol 154 (5), 1059-1067 (2001)
   PUBMED   11535622
REFERENCE   10 (bases 1 to 4235)
  AUTHORS   Takeshima,H., Komazaki,S., Nishi,M., Iino,M. and Kangawa,K.
  TITLE     Junctophilins: a novel family of junctional membrane complex
            proteins
  JOURNAL   Mol Cell 6 (1), 11-22 (2000)
   PUBMED   10949023
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589876.11 and AB024447.1.
            
            On Mar 23, 2011 this sequence version replaced NM_021566.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB024447.1, SRR13948564.1157018.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AL589876.11        185011-185033       c
            24-2704             AB024447.1         1-2681
            2705-4235           AL589876.11        123302-124832       c
FEATURES             Location/Qualifiers
     source          1..4235
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 84.22 cM"
     gene            1..4235
                     /gene="Jph2"
                     /gene_synonym="1110002E14Rik; JP-2; Jp2"
                     /note="junctophilin 2"
                     /db_xref="GeneID:59091"
                     /db_xref="MGI:MGI:1891496"
     exon            1..826
                     /gene="Jph2"
                     /gene_synonym="1110002E14Rik; JP-2; Jp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             448..2538
                     /gene="Jph2"
                     /gene_synonym="1110002E14Rik; JP-2; Jp2"
                     /note="junctophilin type 2"
                     /codon_start=1
                     /product="junctophilin-2"
                     /protein_id="NP_067541.1"
                     /db_xref="CCDS:CCDS17008.1"
                     /db_xref="GeneID:59091"
                     /db_xref="MGI:MGI:1891496"
                     /translation="MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNF
                     GFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSTNS
                     GAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLR
                     TSLSSLRSEHSNGTVAPDSPAADGPMLPSPPVPRGGFALTLLATAEAARPQGLFTRGT
                     LLGRLRRSESRTSLGSQRSRLSFLKSELSSGASDAASTGSLAEGAEGPDDAAAPFDAD
                     IDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDGHREEGK
                     YRHNVLVKGTKRRVLPLKSSKVRQKVEHGVEGAQRAAAIARQKAEIAASRTSHAKAKA
                     EAAEQAALAANQESNIARTLAKELAPDFYQPGPEYQKRRLLQEILENSESLLEPPERG
                     LGTGLPERPRESPQLHERETPQPEGGPPSPAGTPPQPKRPRPGASKDGLLSPGSWNGE
                     PGGEGSRPATPSDGAGRRSPARPASEHMAIEALQPPPAPSQEPEVAMYRGYHSYAVRT
                     GPPEPPPLEDEQEPEPEPEPEVRRSDSAPPSPVSATVPEEEPPAPRSPVPAKQATLEP
                     KPIVPKAEPKAKARKTEARGLSKAGAKKKGRKEVAQAKEAEVEVEEVPNTVLICMVIL
                     LNIGLAILFVHLLT"
     exon            827..1598
                     /gene="Jph2"
                     /gene_synonym="1110002E14Rik; JP-2; Jp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1717
                     /gene="Jph2"
                     /gene_synonym="1110002E14Rik; JP-2; Jp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..2457
                     /gene="Jph2"
                     /gene_synonym="1110002E14Rik; JP-2; Jp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2552
                     /gene="Jph2"
                     /gene_synonym="1110002E14Rik; JP-2; Jp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..4235
                     /gene="Jph2"
                     /gene_synonym="1110002E14Rik; JP-2; Jp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4202..4207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jph2"
                     /gene_synonym="1110002E14Rik; JP-2; Jp2"
                     /note="hexamer: AATAAA"
     polyA_site      4235
                     /gene="Jph2"
                     /gene_synonym="1110002E14Rik; JP-2; Jp2"
                     /note="major polyA site"
ORIGIN      
        1 tggggtggat gagaaggggg ccagcggctg cttcagggtg ggtggcgaca atttagcctc
       61 ggctgggctg ctaaaccggg aactgtccct ctttgaaaag acaggacccc tcaactcctt
      121 tcgttgcttt tcttaaggag agcacaccag actccatgga agctggacct gggacgcttt
      181 gtgggaactt ggagtctctt cggtcggctt ccttttcaag ttgctgcctt gttggggtga
      241 ctgaggaggc ctcccagcca tggcactgac cagcgccccc actgctgact tggcctttgg
      301 gcttttgctg cctctgttgg catcttgctt ttttccacct ctagcccggt ggtgagtcta
      361 ggggctcaac ctgaaggtgc ctggagaaca tcaggtaccc ctacgcccaa gctggaggac
      421 ggaggagttg tcaggagcga ggatgagatg agcgggggcc gctttgactt tgatgatggc
      481 ggggcgtatt gtgggggctg ggaaggggga aaggcacacg ggcacggact gtgcaccggc
      541 cccaagggcc agggtgaata ctcgggctcc tggaattttg gctttgaagt ggcaggcgtc
      601 tatacctggc ccagtgggaa tacctttgag ggatattgga gccagggcaa acgacatggg
      661 cttggcatag agaccaaggg gcgctggctc tacaaggggg agtggacgca tggctttaag
      721 gggcgctacg gaatccggca gagcacaaac agtggtgcca agtacgaggg cacttggaat
      781 aacggcctac aggacggcta tggcacggag acctacgcag acggaggaac ctatcaaggc
      841 caattcacca acggcatgcg ccatggctac ggtgtgcgcc aaagcgtgcc ctacgggatg
      901 gcagtggtgg tgcgttctcc gctgcgcact tctctgtcct cgctgcgcag cgagcacagc
      961 aatggaacgg tggctccgga ctcaccggcg gcagatgggc ccatgctgcc ttcgccccca
     1021 gtgccgcgcg gtggtttcgc gctcactctg ctggccacag cagaggccgc gcgaccccaa
     1081 gggctgttca cgcgtggcac actgctgggt cggctgcgac gctcagaatc acgcacatca
     1141 ctgggcagcc agcggagccg cttgagcttt ctcaagagcg agctgagttc cggagccagc
     1201 gatgccgcat ccactggcag cctggccgag ggcgctgagg gccccgacga cgcggctgcg
     1261 cccttcgatg ccgacatcga cgccaccacc acggaaacct acatgggcga gtggaagaac
     1321 gacaagcgct cgggcttcgg cgtgagcgag cgttccagcg gcctgcgcta cgagggcgag
     1381 tggctggaca acctgcgcca cggctacggc cgcaccacgc tgcccgacgg ccaccgcgag
     1441 gagggcaagt accgccacaa tgtgctggtc aagggcacca agcgccgcgt gctgccgctc
     1501 aagagcagca aggtccgcca gaaggtggag cacggggtgg agggcgccca gcgcgcagca
     1561 gccatcgcgc gccagaaggc cgagattgcc gcctccagga caagccatgc caaagccaag
     1621 gcagaggcag cagaacaggc tgccctggct gccaaccagg agtccaacat cgcccgtaca
     1681 ttggccaagg agctggctcc agacttctac cagccaggtc cggagtatca gaagcgtcgg
     1741 ctgctccagg agatcctgga gaactctgag agcttgctgg agcccccaga gcggggtctg
     1801 ggcaccggcc tcccggagcg gccccgggaa agcccgcagc tgcatgagcg cgagaccccg
     1861 cagcccgagg gcggaccccc gtctccggcc gggacgcccc cgcaacccaa gaggccccgg
     1921 cccggagcgt caaaggacgg cctgctgagt ccaggctcct ggaacgggga gcccggcgga
     1981 gagggcagcc ggcccgccac gccgtcggat ggcgccggtc gtcgcagccc cgcgcgcccc
     2041 gcctcggagc acatggccat cgaggcgctg cagccgccgc ccgcgccctc gcaggagccc
     2101 gaggtagcaa tgtaccgcgg ctaccatagc tacgccgtgc gcaccgggcc acccgagcct
     2161 ccgcccttgg aggatgagca ggagcccgag ccggagcccg agcccgaggt ccggcgatcc
     2221 gactcggcgc ccccgtcccc cgtctccgcc accgtcccgg aggaggagcc ccctgcgccg
     2281 cgaagcccgg tgcctgccaa gcaagccact ctggagccca agcccatcgt ccccaaagca
     2341 gagcccaagg ccaaggcgcg caagacagag gcccgaggac tgagcaaggc cggtgccaag
     2401 aagaagggcc gtaaggaagt ggcgcaggcg aaggaggccg aggtggaggt ggaggaggta
     2461 cccaacaccg tcctcatctg tatggtgatc ttgctgaaca tcggcctggc tatcctattt
     2521 gttcacctcc tgacttgacc ctcatctacc agtgccagga gttccactga ggatggcagg
     2581 acctgtcttt ctgcagtgcc aagcaggtgt cccaggaaga tgggacttcg gacctaaaac
     2641 cttgctcaca tccactccat ggacatttaa ggaggcctcc agagagccca tgctgggtgc
     2701 cggagtgcca gaggaagaga atgtaccccc gaggtacaaa ggatgccctg agggaatagc
     2761 cctggtcccc tgagccccgt ttgctcctgc acctgttctc agccctgtcc cacctcaccc
     2821 tgccaccctt ccctgggctt ttgtgtgttt tgagagatat caggaaagca agatattaat
     2881 acagatctct ccctcttccc cctaccccgc ccccaatcta gtcctccggc tgatggcttg
     2941 aggccaccca ggaggatgag aggttcacaa gtcccttggg tagtgcagtc aaccccagcc
     3001 catgctgttc agggttctta gagttctgga gggcagcata ggaaacaaag aagcccagct
     3061 gaatatacca gcatgcaatg ttccgcatcc tccaactagt ccagttggta tcccctagga
     3121 ccagtggggg aggggtgcgg ggggggaggg gaacctgagc atctgagcct ttggctgaga
     3181 agccacctac aggggtctgg ggtggggtgc taagaaggcg aggcatgttg gtgatggccc
     3241 ctgattttga gtgtgtctga gcctgaggct ggagttcatt tagggtcatg gatgttccct
     3301 gggcattgtg taggagctct gggcccgaga gctacagcta ctgtgatatc ctaagaattg
     3361 actcatccct gtcccccatc gaagccatgg tgggatcggg ggagcatggc acggaagtct
     3421 gaggaagtca agagctgaat ccctggtgca tactctctgg cagaggctgg agacacgcgt
     3481 tatgcagggg agcaaacctg ggctctagct gggtgcagcc catgcagcaa tgattcgtgc
     3541 ttggcagaag gtttacccgc atgcacctca cttaaagaag tttgcaccac actgcgtgtc
     3601 tgggccctcg ggcttgctgg gtgtagcatg gcagcccagg actagtgggt ccccattccc
     3661 aggaggatgg aagaaaagag tttccaggcc cctccaagtt taggaaagag gaggtgatgg
     3721 catccaagct gagctggagg aagctgctga tcctctttga cttcacgtct ctggacctct
     3781 cgggcttggg catggaagcc aggcaccctc ccaggggagc cttgaactgg atattggggt
     3841 tcagcttcct tttcttctaa atccatgggc accctctcct ctagagtcac actggctgct
     3901 ctcagcactg ccggggcttg gtggcttggt tggaatcgct ttttttactg agaggagcct
     3961 gcggatgttc ctgtacctgc cggtgtaggc aggactttgc ctctggttgg gttttcctgg
     4021 attccaggga atgagggggt gggcggaggt tcctcgggag tgacaggccc taggccttgg
     4081 ttctgaggtc attgctctac tctgggtgca gtccagcccc gaggacgagc ctgtgactgt
     4141 cagagctatc agagctgttt gggggtgggg ggatgggttc aggatgccaa gtctgtgcca
     4201 aaataaatcc gcatctgctc acaggttcaa ctgca
//
