LOCUS       NM_028792               3394 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus Josephin domain containing 1 (Josd1), mRNA.
ACCESSION   NM_028792
VERSION     NM_028792.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3394)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3394)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. doi:
            10.1038/s41467-021-23768-8.. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3394)
  AUTHORS   Seki,T., Gong,L., Williams,A.J., Sakai,N., Todi,S.V. and
            Paulson,H.L.
  TITLE     JosD1, a membrane-targeted deubiquitinating enzyme, is activated by
            ubiquitination and regulates membrane dynamics, cell motility, and
            endocytosis
  JOURNAL   J Biol Chem 288 (24), 17145-17155 (2013)
   PUBMED   23625928
  REMARK    GeneRIF: JosD1, a membrane-associated DUB whose activity is
            regulated by ubiquitination, helps regulate membrane dynamics, cell
            motility, and endocytosis.
REFERENCE   4  (bases 1 to 3394)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   5  (bases 1 to 3394)
  AUTHORS   Albrecht,M., Hoffmann,D., Evert,B.O., Schmitt,I., Wullner,U. and
            Lengauer,T.
  TITLE     Structural modeling of ataxin-3 reveals distant homology to
            adaptins
  JOURNAL   Proteins 50 (2), 355-370 (2003)
   PUBMED   12486728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118227.12.
            
            On Mar 27, 2008 this sequence version replaced NM_028792.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154799.1, AK004913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1140              AC118227.12        74952-76091         c
            1141-1269           AC118227.12        65618-65746         c
            1270-1464           AC118227.12        65316-65510         c
            1465-3394           AC118227.12        62469-64398         c
FEATURES             Location/Qualifiers
     source          1..3394
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     gene            1..3394
                     /gene="Josd1"
                     /gene_synonym="1300006C06Rik; mKIAA0063"
                     /note="Josephin domain containing 1"
                     /db_xref="GeneID:74158"
                     /db_xref="MGI:MGI:1921408"
     exon            1..1140
                     /gene="Josd1"
                     /gene_synonym="1300006C06Rik; mKIAA0063"
                     /inference="alignment:Splign:2.1.0"
     CDS             956..1564
                     /gene="Josd1"
                     /gene_synonym="1300006C06Rik; mKIAA0063"
                     /EC_number="3.4.19.12"
                     /note="josephin domain-containing protein 1"
                     /codon_start=1
                     /product="josephin-1"
                     /protein_id="NP_083068.1"
                     /db_xref="CCDS:CCDS27647.1"
                     /db_xref="GeneID:74158"
                     /db_xref="MGI:MGI:1921408"
                     /translation="MSCVPWKGDKAKAESSDLPQAAPPQIYHEKQRRELCALHALNNV
                     FQDSNAFTRETLQEIFQRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWD
                     KRRDVGVIALTNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMP
                     EWIGGESELRKFLKYHLRGKNCELLLVVPEEVEAHQSWRADV"
     exon            1141..1269
                     /gene="Josd1"
                     /gene_synonym="1300006C06Rik; mKIAA0063"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1464
                     /gene="Josd1"
                     /gene_synonym="1300006C06Rik; mKIAA0063"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..3394
                     /gene="Josd1"
                     /gene_synonym="1300006C06Rik; mKIAA0063"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3374..3379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Josd1"
                     /gene_synonym="1300006C06Rik; mKIAA0063"
                     /note="hexamer: ATTAAA"
     polyA_site      3393
                     /gene="Josd1"
                     /gene_synonym="1300006C06Rik; mKIAA0063"
                     /note="major polyA site"
ORIGIN      
        1 ggagtgaacg ccgctgacgt cgggctcagg tgcgcgtgcc cgcccgctcc gccgcctgct
       61 tgtccgcgcg tgggccaggt ggcggcccgc aagctccagg tggcggcgtc ggggagacga
      121 acagtccccg ccgggcaggc agcgggaagg agcccgggac tggcctcacg tgacagcagg
      181 aggtcgctgc ggggacggtc agcccggtgg gccaaggctg caccgggcga ggcaaggcgt
      241 ccggccgcac cctcgcgggc caggcgggac ctccccgcgg cggcgcccgg gctgccgttc
      301 ccctttccgc ggctcctccc gcgccgaggc gaagcggctc ctccgctggg ccgagtccgc
      361 cagtccgctg gcggtcatgg agcgctatcc ccggagcccc cgcgcggccc gcgacctcac
      421 gccctccgat cctcgctagc tcttggcatt gggccttttc tccgccaccc aacccggtct
      481 tcggagcctg tggtgttgtg attcggacga aatggaagaa aaggagcgat gtgacccctt
      541 cggttctgcc ctcctgcatt gaggcctagt tggcatctgc agagaggaaa acacggccag
      601 gaaagcgtgg tgtttctttt tttccaaagg gggtgggagg ggaaggcggc agccaaaggg
      661 aggaatccta cgttttatat gttttttttt tctttgttaa ttctacactt tgaaagtgtt
      721 ggctaaataa actaatccaa aagttatttt ttcctatcga gaagacagaa aaaggtagat
      781 tttttttttt gtcccttttg attccaacct ttcctcccag tgacaaagca taaatcatga
      841 acaccagaga ataaataggt gaatctcagg aatccgaaga cagaaaccta gactttcctc
      901 aggagggaag gagcggagtg tttagcggct ctgcctggaa cctaaatcga aaaacatgag
      961 ttgcgtgcca tggaaaggag acaaggccaa agctgaatcc tcggaccttc cccaagcagc
     1021 gcccccacaa atctaccatg agaagcagcg cagggagctc tgtgctcttc atgctctcaa
     1081 caacgtcttc caggacagca acgccttcac gcgggaaacg ctgcaggaga ttttccagag
     1141 gctgtctccg aacactatgg tgacgcccca caagaagagc atgctgggaa atgggaacta
     1201 tgatgtgaat gtcatcatgg cagcacttca aaccaaaggc tatgaagctg tttggtggga
     1261 caagcgaagg gacgtgggtg tcattgctct tactaatgtc atgggcttca tcatgaacct
     1321 gccctccagc ctctgctggg gtccactcaa gttgcctctc aaaagacagc actggatctg
     1381 tgttcgtgag gtgggagggg cctactacaa ccttgactcc aaactcaaga tgccagagtg
     1441 gattggaggc gagagtgagc tcaggaaatt tctaaaatac catttgcgag gtaaaaactg
     1501 tgaactccta ctggttgtac cggaagaagt ggaagcccat cagagctgga gggccgacgt
     1561 gtgacagttg tttgaccctc tttgtctcaa ccctccagac ctctttgatg tgctgtggcc
     1621 tctacagtcc acttccccaa acatctcatt gggttttccc ttcagatttg ccagtgcaat
     1681 aggacagatg tgtggactgt cacagagcca cccagcagtc tgtgcctggg ggaagaaggt
     1741 aggagctctg aacacttagg gcaagccatt gaaccctttg ctatttcaga gagggagcca
     1801 agaagggcgt cctttgaggg ggctgggtta tttctccctt tccataaggt cttgatacag
     1861 gctctgctgg tagtgtcact gatgcttcag gcttacggaa aggccgcccc ttttctctcc
     1921 tgtggcacca tggggtctga ggacacagta catgcagagc caagaaactg tcaagactcc
     1981 agcagtcaca ctgcatgtca cctgcagtcc attaggcctc ttcttggtcc ctttaaaccc
     2041 cagccagcct tggggtttta taagaggctc tgctattcca aaataggtga attgcacatc
     2101 attctagcaa gacagtggtg aaagatatgc ctaataccac gtgggtaaag ccagagtagg
     2161 gtagtcactg gtggctcttc actctaatcg tgtccctatc atttcactac attgactggg
     2221 gaggctttgg gacaagacaa tgaacaggga gagtactcat agttggccca tttttagcaa
     2281 aatcaaacac atctacactg acctaaaatt ccatagtttg ggacagagtt gggcgaggaa
     2341 ctgccatgaa ggtaagcttc agggtttgag cccggtaggc acgtcctgag ctccagagct
     2401 gtggcagcaa tctcaggttg gctgtatgca tcaagctaga gcctctgagt ttggcgtctg
     2461 tgtagtttct ttgacaaaca gggttggctt gccccacttc aactagttct agatcatttt
     2521 tttcttgtaa ttttggaaaa tgaggggaaa taattaccat acccccatac caatgtgttt
     2581 gtggtggcct tcaaggcagg tgacctggcc agcccttacc gatccatggt ctctgcaggt
     2641 ctgagagctg ccccactggc ctgcttcttc tcccttggca gcagagctac ctggggcttg
     2701 catgttaatc ctgagcaagc ttgttggggt gaaggggggc tgtctcccca ctgtgactgg
     2761 agtgcatgtt tacaccagca ctttttctgc acatgtatct tcaatccaac aaggccgttt
     2821 tttattcaag tggcagaggc ctcgagtggc tactgcactg cgctcagcca tggtcatctg
     2881 caccattttc tacaccagat ctgcttggca ccatggggaa ctctgcccct gcacaatgac
     2941 attccaatca ctaccagcca gaagttacag ccgaccttgc tgattgtcac aagcaggacc
     3001 ttgggtccat tggcactgtc ggtgatagta agccatttct tgggaagagg agactcttcc
     3061 ctacagatct gcttgggcct gtgcaaatgg cactgcaaac gagccacaca cacgtggagt
     3121 ccatgagcta gtgggatgta caaagacgct taagcatttc agggctggtt ctgttcatat
     3181 ccaattctgg tgcttaggaa cagggaccca tgttaatgcc ccagggcaaa gccccactcc
     3241 tgtgaaggaa ggggcagcct gaccctgacg cccagcaagg ggcagcccta ggctttgttt
     3301 ttcttgcttt attccctttt ctgttggcct tgtgctgggt ttgtttacaa agatgtattt
     3361 tgtttaacca aatattaaaa atgaaaagct gaac
//
