LOCUS       NM_028101               2107 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus jumonji domain containing 8 (Jmjd8), mRNA.
ACCESSION   NM_028101
VERSION     NM_028101.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2107)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2107)
  AUTHORS   Li,Y., Zhang,Y., Zhou,Z., Yi,L., Ji,F., Zhang,K., Zhang,Y. and
            Xu,H.
  TITLE     JMJD8 regulates neuropathic pain by affecting spinal cord astrocyte
            differentiation
  JOURNAL   Neurosci Lett 809, 137307 (2023)
   PUBMED   37211325
  REMARK    GeneRIF: JMJD8 regulates neuropathic pain by affecting spinal cord
            astrocyte differentiation.
REFERENCE   3  (bases 1 to 2107)
  AUTHORS   Yi,J., Wang,L., Du,J., Wang,M., Shen,H., Liu,Z., Qin,Y., Liu,J.,
            Hu,G., Xiao,R., Ding,J., Chen,X., Wang,H., Huang,H., Ouyang,G. and
            Liu,W.
  TITLE     ER-localized JmjC domain-containing protein JMJD8 targets STING to
            promote immune evasion and tumor growth in breast cancer
  JOURNAL   Dev Cell 58 (9), 760-778 (2023)
   PUBMED   37054705
  REMARK    GeneRIF: ER-localized JmjC domain-containing protein JMJD8 targets
            STING to promote immune evasion and tumor growth in breast cancer.
REFERENCE   4  (bases 1 to 2107)
  AUTHORS   You,D., Chul Jung,B., Villivalam,S.D., Lim,H.W. and Kang,S.
  TITLE     JMJD8 is a Novel Molecular Nexus Between Adipocyte-Intrinsic
            Inflammation and Insulin Resistance
  JOURNAL   Diabetes (2021) In press
   PUBMED   34957483
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 2107)
  AUTHORS   Zhang,F., Zhao,X., Jiang,R., Wang,Y., Wang,X., Gu,Y., Xu,L., Ye,J.,
            Chen,C.D., Guo,S., Zhang,D. and Zhao,D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2107)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2107)
  AUTHORS   Boeckel,J.N., Derlet,A., Glaser,S.F., Luczak,A., Lucas,T.,
            Heumuller,A.W., Kruger,M., Zehendner,C.M., Kaluza,D.,
            Doddaballapur,A., Ohtani,K., Treguer,K. and Dimmeler,S.
  TITLE     JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by
            Interacting With Pyruvate Kinase M2 in Endothelial Cells
  JOURNAL   Arterioscler Thromb Vasc Biol 36 (7), 1425-1433 (2016)
   PUBMED   27199445
  REMARK    GeneRIF: Jmjd8 is upregulated during endothelial differentiation
            and regulates endothelial sprouting and metabolism by interacting
            with pyruvate kinase M2.
REFERENCE   8  (bases 1 to 2107)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK155810.1 and BE982271.1.
            
            On Sep 12, 2018 this sequence version replaced NM_028101.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155810.1, SRR7345562.4877875.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2013              AK155810.1         3-2015
            2014-2107           BE982271.1         2-95                c
FEATURES             Location/Qualifiers
     source          1..2107
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.92 cM"
     gene            1..2107
                     /gene="Jmjd8"
                     /gene_synonym="2610003J06Rik"
                     /note="jumonji domain containing 8"
                     /db_xref="GeneID:72106"
                     /db_xref="MGI:MGI:1919356"
     exon            1..121
                     /gene="Jmjd8"
                     /gene_synonym="2610003J06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..839
                     /gene="Jmjd8"
                     /gene_synonym="2610003J06Rik"
                     /note="jmjC domain-containing protein 8; jumonji
                     domain-containing protein 8"
                     /codon_start=1
                     /product="jmjC domain-containing protein 8 precursor"
                     /protein_id="NP_082377.3"
                     /db_xref="CCDS:CCDS28532.2"
                     /db_xref="GeneID:72106"
                     /db_xref="MGI:MGI:1919356"
                     /translation="MAAAGRRGLLLLFVLWMMVTVILPASGEGGWKQNGLGIAAAVME
                     EERCTVERRAHITYSEFMQHYAFLKPVILQGLTDNSKFRALCSRENLLASFGDNIVRL
                     STANTYSYQKVDLPFQEYVEQLLQPQDPASLGNDTLYFFGDNNFTEWASLFQHYSPPP
                     FRLLGTTPAYSFGIAGAGSGVPFHWHGPGFSEVIYGRKRWFLYPPEKTPEFHPNKTTL
                     AWLLEIYPSLALSARPLECTIQAGEVLYFPDRWWHATLNLDTSVFISTFLG"
     exon            122..220
                     /gene="Jmjd8"
                     /gene_synonym="2610003J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            221..269
                     /gene="Jmjd8"
                     /gene_synonym="2610003J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            270..366
                     /gene="Jmjd8"
                     /gene_synonym="2610003J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            367..435
                     /gene="Jmjd8"
                     /gene_synonym="2610003J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            436..555
                     /gene="Jmjd8"
                     /gene_synonym="2610003J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            556..623
                     /gene="Jmjd8"
                     /gene_synonym="2610003J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            624..758
                     /gene="Jmjd8"
                     /gene_synonym="2610003J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            759..2092
                     /gene="Jmjd8"
                     /gene_synonym="2610003J06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1994..1999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jmjd8"
                     /gene_synonym="2610003J06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2016
                     /gene="Jmjd8"
                     /gene_synonym="2610003J06Rik"
                     /note="major polyA site"
     polyA_site      2087
                     /gene="Jmjd8"
                     /gene_synonym="2610003J06Rik"
ORIGIN      
        1 gcgtgctgcg cgcctgcacc cgtatgttca tggcggcggc tgggcggcgc ggtctgcttt
       61 tgctctttgt actatggatg atggtgactg tgattctgcc tgcctctggc gaagggggat
      121 ggaaacagaa tgggctggga attgcagcag cagtaatgga ggaggagcgt tgcacagtgg
      181 agcgtcgggc acacatcacg tactccgaat tcatgcagca ctatgccttc ctcaagcccg
      241 tcatcttgca aggactcacg gacaactcga agttccgggc cctgtgttcc cgggaaaacc
      301 tgctagcctc gttcggggac aacattgttc gcttgagtac agccaacacc tactcctacc
      361 agaaagtgga cctgcccttc caggaatatg tggaacagct gctgcagccc caggatcctg
      421 catccctagg caatgacacc ctgtactttt ttggagacaa caacttcact gagtgggcat
      481 ccctcttcca gcactactct ccgccaccat tccgtctcct gggaaccacc cctgcttaca
      541 gctttggaat tgcaggagct ggatctgggg tacccttcca ctggcatggg cctggtttct
      601 cagaggttat ctatggtcgg aagcgctggt tcctctaccc tcctgagaag acacctgagt
      661 tccaccctaa caagaccaca ttggcctggc tgctggaaat atacccatct ctagccctgt
      721 cagcacggcc tctagaatgt accatccagg ctggtgaagt actgtatttt cctgatcggt
      781 ggtggcatgc cacactcaat ctggacacca gtgtcttcat ttctaccttc cttggctagc
      841 cagacaggca actggcaagc ccactgcacc agcacatgcc aatgtagtgc tcacagactt
      901 tattacagga cagtggcagc agcagcaacc tcagcccacc ctcacccact ctccagccca
      961 gaagggggac aagggaggct catggtccag caaggggtat gctgagaagg ggagcagttc
     1021 agaacccatc agcagggccg atgggggcag gcccagggac acaaactata cagggactgg
     1081 agcttccgtc tccagatcct cctgggccag ggtgccaggc aggacatggg gcctcaatag
     1141 tcctctaccc agccgttctc agagatgaaa gcgtcaatga cttccttcat ggccaagttg
     1201 gggatgagct gttcctgggt cagagggctc cgggtcacag ggtcaaagtg gcccacacgc
     1261 tgcaacagag tcaagagtgt tcaatggcct gagtataccg atccgggtac caaggctctc
     1321 catggcccgg tctccatggg ccctccttac ctgcaggtgc tcctcaatgt ccttgcggtc
     1381 ataggtgata ccactgggtg taatgcaggg ttcccgcatc agctcaaagc taatcttgcc
     1441 acacaagtag tcagggatat ctcgcttcta tagcacaagg ggaaaatgtc tagaactgga
     1501 gggggctgtg ggggtcacca taccagcagc agccgatgag cttccggggg tcctcacctt
     1561 tcttttctcg tccacctgag agaagagctc atccatatct gccatgtatt tatcctgcag
     1621 agttgagtgc catgtgtggg caactcctgt ctccacacag acacacacac tctgtccacc
     1681 agggcactca tgtcatgcat gggccaacag atccaccaaa ggctggggca cttttcatgc
     1741 cacacacaaa cacacacaca atgacccaca tgtggactag gggcaccctc acgtgcttgg
     1801 cctcaatgca ggcctgctgg gcccggatgt ggccatcatc ttcatgaccc tcgtggttcc
     1861 gctgacactc ctccagttcc ctgagggtta accagaagct agttggtgat ggccctgacc
     1921 aggaaatcac agagcccgcc ccatctcagg cctctttcct cctgggcttc ccatgtaccg
     1981 gttgttgtcc ttcaataaaa acacttgtgc tggtgactca gtgtctgctg ggggagggac
     2041 ccacctctct cgctcagcag caatgagcct ggtgagatat gaatgcagct caaaaaaaaa
     2101 aaaaaaa
//
