LOCUS       NM_178659               4445 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus jumonji domain containing 4 (Jmjd4), transcript
            variant 1, mRNA.
ACCESSION   NM_178659
VERSION     NM_178659.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4445)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4445)
  AUTHORS   Tang,Y., Feng,M., Su,Y., Ma,T., Zhang,H., Wu,H., Wang,X., Shi,S.,
            Zhang,Y., Xu,Y., Hu,S., Wei,K. and Xu,D.
  TITLE     Jmjd4 Facilitates Pkm2 Degradation in Cardiomyocytes and Is
            Protective Against Dilated Cardiomyopathy
  JOURNAL   Circulation 147 (22), 1684-1704 (2023)
   PUBMED   37066795
  REMARK    Erratum:[Circulation. 2024 Jul 9;150(2):e64. doi:
            10.1161/CIR.0000000000001268.. PMID: 38976614]
REFERENCE   3  (bases 1 to 4445)
  AUTHORS   Li,Z., Zhou,Y., Jia,K., Yang,Y., Zhang,L., Wang,S., Dong,Y.,
            Wang,M., Li,Y., Lu,S., Zhang,W., Zhang,L., Fan,Y., Zhang,D., Li,N.,
            Yu,Y., Cao,X. and Hou,J.
  TITLE     JMJD4-demethylated RIG-I prevents hepatic steatosis and
            carcinogenesis
  JOURNAL   J Hematol Oncol 15 (1), 161 (2022)
   PUBMED   36333807
  REMARK    GeneRIF: JMJD4-demethylated RIG-I prevents hepatic steatosis and
            carcinogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4445)
  AUTHORS   Zhang,F., Zhao,X., Jiang,R., Wang,Y., Wang,X., Gu,Y., Xu,L., Ye,J.,
            Chen,C.D., Guo,S., Zhang,D. and Zhao,D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4445)
  AUTHORS   Yoo,H., Son,D., Lee,Y.J. and Hong,K.
  TITLE     Mouse JMJD4 is dispensable for embryogenesis
  JOURNAL   Mol Reprod Dev 83 (7), 588-593 (2016)
   PUBMED   27147518
  REMARK    GeneRIF: Unexpectedly, Jmjd4-null ESCs exhibited normal colony
            morphology and maintained normal expression of pluripotent genes.
            Furthermore, Jmjd4-knockout embryos are born at a normal Mendelian
            ratio. Thus, JMJD4 is dispensable in murine development.
REFERENCE   6  (bases 1 to 4445)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK047586.1, BC116707.1 and AL592522.12.
            
            On Mar 23, 2011 this sequence version replaced NM_178659.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145394.1, AK079104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AK047586.1         2-70
            70-3220             BC116707.1         1-3151
            3221-4445           AL592522.12        151261-152485       c
FEATURES             Location/Qualifiers
     source          1..4445
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.71 cM"
     gene            1..4445
                     /gene="Jmjd4"
                     /gene_synonym="6430559I23"
                     /note="jumonji domain containing 4"
                     /db_xref="GeneID:194952"
                     /db_xref="MGI:MGI:2144404"
     exon            1..468
                     /gene="Jmjd4"
                     /gene_synonym="6430559I23"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1484
                     /gene="Jmjd4"
                     /gene_synonym="6430559I23"
                     /note="isoform 1 is encoded by transcript variant 1; jmjC
                     domain-containing protein 4; jumonji domain-containing
                     protein 4; lysyl-hydroxylase JMJD4; 2-oxoglutarate and
                     iron-dependent oxygenase JMJD4"
                     /codon_start=1
                     /product="2-oxoglutarate and iron-dependent oxygenase
                     JMJD4 isoform 1"
                     /protein_id="NP_848774.1"
                     /db_xref="CCDS:CCDS24768.1"
                     /db_xref="GeneID:194952"
                     /db_xref="MGI:MGI:2144404"
                     /translation="MDRETRTFAERYYRDLRDPVPSGGGGPTPSGVTFIQTPNAFSYA
                     DFVKGFLLPNLPCVFSSAFTEGWGSRRRWVTSEGKPDFEYLQQKYGDAVVPVANCGVR
                     EYNSNPKEHMSFRDYISYWKDYIQGSYSSSRGCLYLKDWHLCRDSLVNDLEDIFTLPV
                     YFSSDWLNEFWDVLNVDDYRFVYAGPRGTWSPFHADIFRSFSWSVNICGKKKWLFFPP
                     GEEEALRDCHGNLPYDVTSTELLDTHLYPKIQHHSLPIEVIQEPGEMVFVPSGWHHQV
                     YNLDDTISINHNWVNGCNLPNMWHFLQQELQAVQHEVEEWKDSMPDWHHHCQVIMKSC
                     TGINFEEFYHFLKVIAEKRLLVLEQGLKGDSGDSRSLDLGLQQAAFDIGRLADVLASV
                     VVNPDFQRVDTSAFSPQPEELLQQLEDAVAAAEAL"
     exon            469..634
                     /gene="Jmjd4"
                     /gene_synonym="6430559I23"
                     /inference="alignment:Splign:2.1.0"
     exon            635..769
                     /gene="Jmjd4"
                     /gene_synonym="6430559I23"
                     /inference="alignment:Splign:2.1.0"
     exon            770..1037
                     /gene="Jmjd4"
                     /gene_synonym="6430559I23"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1184
                     /gene="Jmjd4"
                     /gene_synonym="6430559I23"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..4445
                     /gene="Jmjd4"
                     /gene_synonym="6430559I23"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1984
                     /gene="Jmjd4"
                     /gene_synonym="6430559I23"
                     /note="major polyA site"
     regulatory      4331..4336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jmjd4"
                     /gene_synonym="6430559I23"
                     /note="hexamer: AATAAA"
     polyA_site      4349
                     /gene="Jmjd4"
                     /gene_synonym="6430559I23"
     polyA_site      4401
                     /gene="Jmjd4"
                     /gene_synonym="6430559I23"
     polyA_site      4425
                     /gene="Jmjd4"
                     /gene_synonym="6430559I23"
ORIGIN      
        1 gcgtaggcgc gcacgcgcac accctgggag ccccaaggcc cgcgttcctg ctggaatgtc
       61 gcacctgtgg cttttcgttc cgggctcttt ctctgtggtt accactccga gctgatttta
      121 gggggtttct cagcctccgg tccctatttg gggtgtagcg agaagccgga ctgggcctct
      181 ggggtcaggt ttcccggtgg atggatcggg agacacgcac ctttgccgag cggtactacc
      241 gggacctccg agacccagtc cctagcggcg gtggcggccc cacacccagc ggcgtgacct
      301 tcattcagac cccgaacgcc ttctcctatg ctgacttcgt gaagggcttc ctgctgccta
      361 acctgccctg cgtgttttct agcgccttca ccgagggctg gggcagcagg cggcgctggg
      421 tgacctcgga gggaaagcct gacttcgagt atctgcagca gaagtatgga gacgcggttg
      481 taccggttgc caactgtgga gtgcgagaat acaattcaaa ccccaaggag cacatgtcct
      541 tccgcgacta tatcagttac tggaaggact acatccaagg gagttactcc tcttcgcggg
      601 gctgcctcta cctcaaggac tggcatctgt gcagagactc cttggtgaat gacttggaag
      661 acatattcac cctgcccgtg tacttctcgt cagactggct gaatgagttc tgggacgtcc
      721 tcaatgtgga tgactatcgt tttgtctatg caggccccag gggcacctgg tctcccttcc
      781 atgcagacat cttccgctcc ttcagctggt cagtcaacat ctgtgggaag aagaaatggt
      841 tgttcttccc gccaggcgag gaggaagccc tccgggactg ccatggtaac ctgccctatg
      901 atgtgacttc cactgagctc ctggacaccc acctgtatcc caagatccag caccacagcc
      961 ttcccattga agtcatacag gagcctggtg agatggtgtt tgtgcccagc gggtggcacc
     1021 atcaagtgta caacctggat gacaccattt ctattaacca caactgggtc aatggctgca
     1081 acctgccaaa catgtggcac ttcctgcagc aagagctcca ggctgtgcag catgaggtcg
     1141 aagaatggaa ggactccatg cctgactggc accaccactg ccaggtcatc atgaagtcct
     1201 gcacagggat caattttgaa gaattttacc atttcctcaa agtcatcgcc gagaagaggc
     1261 tccttgtcct ggagcaagga ctgaaggggg attcagggga cagccggagc ctagacctgg
     1321 gcctacagca ggctgcattt gatattggcc gccttgcaga tgtgctggcc tctgtggttg
     1381 tgaatcctga ctttcagaga gtggacacca gcgcattctc accacagcca gaagagttgc
     1441 ttcagcagct ggaggacgca gtggctgctg cagaggccct ttagtatgct gtagctcaag
     1501 atgcaggaag aattctggag agcatcttct tcagaaggcc cagggccctt ctggaaattc
     1561 aggctacctt cccaaggaat aggatgtgct ccaagcctgt gccagtacag tacttgcaga
     1621 gggtgaacct tgaggaaggt ccagccaaaa tgggaattta actcttggag gctagagaga
     1681 tgttcaccca tctagcctct agcaagcctg ccaagaatgt gaattgagta gtagtcatga
     1741 aaccaggttt ctttggagcc tctcagcctc ttgtagttat cctaggactc ctgagtgatg
     1801 gacatccgac ttgcctacct cggaggtatc cctgtgtaac ctggaacata gatgtatatg
     1861 tatgtgtgca tgtatgtatg tatgtatgca gttgccctcc aagactctca tcctctagtt
     1921 ctgtcctagg agctccagac tccaactgaa ctaggaggaa ttaatcagtg tatgaaaagc
     1981 tgaaggggga gttccttttt tataaggtat ttatttatta tatgtgagta ccctgtagct
     2041 gttttcagac actccagaac agggcgtcag atctcattac agatggatgt gagccaccgt
     2101 gtggttgctg ggattttgaa ctcaggacct ctgaagagca gtcagtgctc ttaactgctg
     2161 aaccatctct ccagcctgaa gggggagttc ttaagctggg tgtcagtggc tagaggcaca
     2221 gtactaaatg gctgaaaaac ccaggttctg gtccatccaa gtccccagga tagagatgat
     2281 tgtacagaac tagggagcag tcgcattctt ctccatggca gtccttcaag gcctggcctc
     2341 ctatgctagc tcatctgcag aagtataggg agccctgtgg aggacacgga tagacccagt
     2401 ctcaggctga ccctggatga gtcagtgctt cctctgttgg ctatgctcac tgcccatgca
     2461 tgttggagac agacaattgc ttcatggcct ccatgagtcc acatgactag tgtctgcaca
     2521 ccaccatgtt ctctgtgctg tttctagaag taggggctgt ggctgagaac aggcctctga
     2581 gagcctgctg tttactctgg actgcagcat agaccaccag gatgagacac agctctaaat
     2641 aatgctgaat ttgtgaacat ctttgcagac aactgtctaa acctacagcc ttcaaggtct
     2701 gagctgaggc cttataggaa caaggaaatt ataagtagaa ttggccacaa tctttgtagg
     2761 gttcttatac aggaccttgt gccagtgaca caccctgtca tccctaagaa acccttctgg
     2821 gtaaggcctg ggaacatttc agaggagcca tgtgaggcac agctggtggt gtgctgtgct
     2881 gcaaagtagc taattcaccc tgtgagctgc aggtcctcta cagactaagt gtaagcatgt
     2941 gggtaggggc agggacacct atctttccgc cctgcctgcc acaaggagca gctctcttgg
     3001 ttgggaccac tggagagcta tgggagatta ctagcgagga gggtggcact tggtgttaga
     3061 tggagagtca gtgggaagag atttactaaa accttcaagc cctttgccag ctaaataatg
     3121 gcagcacctc ctatttcaga gcctatgcca gcattatctt agggagtcct caaacatggc
     3181 caggtagata aacttgctca gggaggttgt atctggggcc ctggttcctt tcctatgtgg
     3241 agacacttca acttcactca agtggcccag caactgaatt tacctccctt actctagact
     3301 gacaaaatta agaaaaatta acatcctagg ccttgtgtga tagatattag ctactatgta
     3361 ttcccatgac catcataact agaatgataa tagaatccca aatcagatta gcaagccagg
     3421 aggggcccgt gataaagggc tcagcaggta aaggtactta acttgctgtg caaacctgtt
     3481 gccggtttga accctagaat ccatgtcaaa gtggaggagc cccttcatgc tgcttaaata
     3541 attcattgac tgcccaaacc ctagcttgaa ccatagctgc cacaatttga aagttgttta
     3601 gtgttttgtg agatcttaaa tcatctcatt gtgttgcccc agctgccaag ggcacagcct
     3661 tagtttagtg acgtgttccc tcccaaggag ggctcagatt caacttcact caagtgggcc
     3721 agcaacttaa tttacctccc ttactctaga ctggcagaat taagaaaaat taacatccta
     3781 agattcaggg aatcctctct actcatcctt cccagtggga ggaggataca cacatgccac
     3841 tatgcctggc tgagcctgca gttaaatagt tggagaactc aagtgtagat acagattagg
     3901 ggagggtaaa ataaaaactc aagagcaaca ttagaaaata caccggagaa taccagaaat
     3961 gaagtgacaa tatacaaact atctgtaaga cagctaaagc cttacctaga gggaaaatga
     4021 taaattggca ggactaagaa caagtgtttt ggatcaatag ccaaaaaaat agaacataca
     4081 caataaatgg aaataaccag cacaagtctt tgaaatagag aatagcagtg aaaccaaaag
     4141 ttggtttata aaagaccaat aacctgggct ggagaaatgg ctcagcagtt aagagcactg
     4201 actgcttttc cagaggtcct gagttccatt cccagcaacc acatggtggc tcacaaccat
     4261 ctgtaatggg atcctttgac ctaatgtctc tgaagacagc tacagtgtgc tcacataagt
     4321 ctttattaaa aataaatagc ctgtgcatac acctgtaacc ccagcacttg ggagggtgca
     4381 gagcgccagc gcaaccctaa actctgggaa gcctttcaag gaaaatgcat gcctttattt
     4441 tcatg
//
