LOCUS       NM_207221               8552 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus jumonji domain containing 1C (Jmjd1c), transcript
            variant 1, mRNA.
ACCESSION   NM_207221 XM_907708 XM_975833
VERSION     NM_207221.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8552)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8552)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   3  (bases 1 to 8552)
  AUTHORS   Zhang,F., Zhao,X., Jiang,R., Wang,Y., Wang,X., Gu,Y., Xu,L., Ye,J.,
            Chen,C.D., Guo,S., Zhang,D. and Zhao,D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8552)
  AUTHORS   Viscarra,J.A., Wang,Y., Nguyen,H.P., Choi,Y.G. and Sul,H.S.
  TITLE     Histone demethylase JMJD1C is phosphorylated by mTOR to activate de
            novo lipogenesis
  JOURNAL   Nat Commun 11 (1), 796 (2020)
   PUBMED   32034158
  REMARK    GeneRIF: JMJD1C promotes lipogenesis to increase hepatic and plasma
            triglyceride levels, showing its role in metabolic adaption for
            activation of the lipogenic program in response to feeding/insulin,
            and its contribution to development of hepatosteatosis resulting in
            insulin resistance.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8552)
  AUTHORS   Staehle,H.F., Heinemann,J., Gruender,A., Omlor,A.M., Pahl,H.L. and
            Jutzi,J.S.
  TITLE     Jmjd1c is dispensable for healthy adult hematopoiesis and
            Jak2V617F-driven myeloproliferative disease initiation in mice
  JOURNAL   PLoS One 15 (2), e0228362 (2020)
   PUBMED   32017785
  REMARK    GeneRIF: Findings support the conclusion that Jmjd1c is dispensable
            for a Jak2V617F-driven myeloproliferative disease. Also, the strong
            embryonic Jmjd1c expression in developing muscle tissues suggests
            additional roles for JMJD1C in organs besides the hematopoietic
            system.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8552)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 8552)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 8552)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 8552)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 8552)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156272.6 and AC155712.8.
            
            On Jun 20, 2019 this sequence version replaced NM_207221.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849381, SAMN00849382
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               AC156272.6         65737-66071
            336-500             AC156272.6         96556-96720
            501-614             AC156272.6         128385-128498
            615-720             AC156272.6         153919-154024
            721-845             AC156272.6         155632-155756
            846-989             AC156272.6         156687-156830
            990-1182            AC156272.6         156926-157118
            1183-2864           AC156272.6         157603-159284
            2865-3037           AC156272.6         162658-162830
            3038-5217           AC156272.6         163386-165565
            5218-5419           AC155712.8         14036-14237
            5420-5634           AC155712.8         16160-16374
            5635-5787           AC155712.8         17559-17711
            5788-5877           AC155712.8         22296-22385
            5878-6005           AC155712.8         22995-23122
            6006-6216           AC155712.8         23437-23647
            6217-6431           AC155712.8         24050-24264
            6432-6710           AC155712.8         24851-25129
            6711-6879           AC155712.8         27960-28128
            6880-6970           AC155712.8         28971-29061
            6971-7101           AC155712.8         29694-29824
            7102-7224           AC155712.8         30222-30344
            7225-7364           AC155712.8         32199-32338
            7365-7541           AC155712.8         33818-33994
            7542-7673           AC155712.8         38640-38771
            7674-8552           AC155712.8         39636-40514
FEATURES             Location/Qualifiers
     source          1..8552
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 34.85 cM"
     gene            1..8552
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /note="jumonji domain containing 1C"
                     /db_xref="GeneID:108829"
                     /db_xref="MGI:MGI:1918614"
     exon            1..335
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..7763
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /EC_number="1.14.11.65"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable JmjC domain-containing histone demethylation
                     protein 2C; jumonji domain-containing protein 1C"
                     /codon_start=1
                     /product="probable JmjC domain-containing histone
                     demethylation protein 2C isoform 1"
                     /protein_id="NP_997104.2"
                     /db_xref="CCDS:CCDS56707.1"
                     /db_xref="GeneID:108829"
                     /db_xref="MGI:MGI:1918614"
                     /translation="MAVETRPELVGKRFLCVAAGEDARPERGQSGCGRGWRAGVIRAV
                     SHRDRGHPDLAVYVEFDDLEWDKREWVRVYEDFSTFLVEYHLIWAKRKDPSQTQGSKS
                     RQIQWPALTFKPLVENSIPSSITAVEFLIDKQLDFLTEDSAFQPYQDDIDSLKPVLRD
                     NPQLHAEVKVWVKEQKVQEIFMQGPYSLNGYRVRVYRQDSATQWFTGIITHHDLFTRT
                     MIVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRASQNISTVHGHY
                     TRAQANSPRPAMNSQAAVPKQNTHQQQQQRSIRPNKRKGSDSSIPDEEKMKEDKYDCV
                     SRGENPKGKNKHVVTKRRKPEEAEKRLSMKRLRTDNASDASESSDAESSSKRVTETSS
                     SEPMPEYEPKNKVTSKVNGEEGQSQAAEEAGEETLIDTRPPWDQMQEDKNHNEGEKPK
                     STDSHLQDKMTLRSSEQATVADHNSNDSVLQECNVENQRTVELLPKDRLVSRTPTPKC
                     VTDIKNDTHSERAAQENLNTFGLQTPENMDPNVSDSKHSNAKYLETAKQDCDQSWVSD
                     VVKVDLTQSSVTNAPSGSDKRDTEKERNHYVSYMSSLSAVSVTEDQLHKRSPPPETIK
                     AKLTTSVDTQKAKSSSSPEVVKPKITHSPDSVKSKAAYGNSQAVGERRLANKIEHELS
                     RGSFHPVPTRGSALETTKSPLIIDKNEHFTVYRDPALIGSETGANHISPFLSQHPFSL
                     HSSSHRTCLNPGTHHPALTPGPHLLAGSTSQTPLPTINTHPLTSGPHHPVHHPHLLPT
                     VLPGVPTASLLGGHPRLESAHASSLSHLALAHQQQQQLLQHQSPHLLGQAHPSASYNQ
                     LGLYPIIWQYPNGTHAYSGLGLPSSKWVHPENAVNAEASLRRNSPSPWLHQPTPVTSA
                     DGIGLLSHIPVRPSSAEPHRPHKITVHSSPPLTKTLADHHKEELERKAFMEPLRSNAS
                     TSVKGDLDLNRSQAGKDCHLHRHFVGPRPPQETGERLNKYKEEHRRILQESIDVAPFT
                     TKIKGHEVERENYSRVVPSSSSPKSHAIKQDKDVDRSVSEIYKMKHSVPQSLPQSNYF
                     TTLSNSVVNEPPRSYPSKEVSNIYTEKQNNNLSATANPQTHSFISSLSKPPPLIKHQP
                     ESESLVGKIPDHLPHQSASHSVTTFRSDCRSPTHLTVSSTNALRSMPALHRAPVFHPP
                     IHHSLERKESSYSSLSPPTLTPVMPVNAGGKVQESQKPPTLIPEPKDSQSNFKNSSDQ
                     SLTEMWRSNNNLNREKAEWPVEKSSGKSQAAVASVIVRPPSSTKVDSVPSVPLASKDR
                     VCERSSSGANKTDYLKPEAGETGRIILPNVNLESAHVKSEKNFEAVSQGNVPVSVMSA
                     VNVVSTTKADVFTSAATTTSVSSLSSAETSYSLSNTISASTPFECTSSKSVVSQAVAQ
                     AKDCTVSTAVPGTLACSKTGSAVQPGSGFSGTTDFIHLKKHKAALAAAQFKNSSVSEA
                     ELNTVRNQTVAASLPLDSTMTCTASNKAISVGNGPAAQSSQPNYHTKLKKAWLTRHSE
                     EDKNTNKMENSGNSVSEIIKPCSVNLIASTSNDIENRADGRVAVDKYGRDEKVSRRKA
                     KRTYESGSESGDSDESESKSEQRTKRQPKPTYKKKQNDLQKRKGEVEEDSKPNGVLSR
                     SAKDKSKLKLQNSNTGVPRSVLKDWRKVKKLKQTGESFLQDDSCCEIGPNLQKCRECR
                     LIRSKKGEESTHSPVFCRFYYFRRLSFSKNGVVRIDGFSSPDQYDDEAMSLWTHENYE
                     DDEVDVETSKYILDIIGDKFCQLVTSEKTALSWVKKDAKIAWKRAVRGVREMCDACEA
                     TLFNVHWVCRKCGFVACLDCYKAKERKSSRDKELYAWMKCVKGQPHDHKHLMLTQIIP
                     GSVLTDLLDAMHILREKYGIKSHCHCTNRQNLQGGNVPTMNGVSQVLQNVLHHSNKTS
                     VSLPESQQQNSPQKSQTNGNSSPGSASTDSRLTPPESQSPLHWLADLAEQKSREEKQE
                     NKEFTLEREIKEDGDQDASDSPNGSTSPPASQSNEQGSTLRDLLTTTAGKLRVGSTDA
                     GIAFAPVYSMGTSSGKGGRTMPNILDDIIASVVENKIPPNKTSKINIKSEPNEEPKES
                     SLPATDESNKSYRDIPHSWICDQHILWLKDYKNSNNWKLFKECWKQGQPAVVSGVHKK
                     MNISLWKAESISLDFGDHQADLLNCKDSIVSNANVKEFWDGFEEVSKRQKNKGGETVV
                     LKLKDCPSGEDFKAMMPTRYEDFLRCLPLPEYCNPEGKFNLASHLPGFFVRPDLGPRL
                     CSAYGVAAAKDHDIGTTNLHIEASDVVNVLVYVGIAKGNGVLSKAGILKKFEEEELDD
                     VLRKRLKDSSEIPGALWHIYAGKDVDKIREFLQKISKEQGLEVLPEHDPIRDQSWYVN
                     RKLRQRLLEEYGVRACTLIQFLGDAIVLPAGTLHQVQNFHSCVQVTEDFVSPEHLVQS
                     FHLTQELRLLKEEINYDDKLQVKNILYHAVKEMVRALKMHEDEVEDMEDT"
     exon            336..500
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            501..614
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            615..720
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            721..845
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            846..989
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1182
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..2864
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            2865..3037
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..5217
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            5218..5419
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            5420..5634
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            5635..5787
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            5788..5877
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            5878..6005
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            6006..6216
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            6217..6431
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            6432..6710
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            6711..6879
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            6880..6970
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            6971..7101
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            7102..7224
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            7225..7364
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            7365..7541
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            7542..7673
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            7674..8552
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8526..8531
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /note="hexamer: ATTAAA"
     polyA_site      8546
                     /gene="Jmjd1c"
                     /gene_synonym="5430433L24Rik; D630035I23Rik; Jmjdic;
                     TRIP8"
                     /note="major polyA site"
ORIGIN      
        1 attcctgtca gtttgcctgt gggccgcgcg tgaggtcgtg ggcggcgcgg ctccgggtcg
       61 tcgagcgtgc aggggcgctc tcgctcgcgg gccgcctcgc ctgcggtcgg ctcctcggca
      121 tgggcggccg gtaggagcgg gctgcgctcg tccccggcgc agtggcggcc atggcggtgg
      181 agacgcggcc cgagctggtg gggaagcggt tcctgtgcgt ggcggccggc gaggacgcgc
      241 gtccggagcg cgggcagagc ggctgcgggc gcggctggcg ggcgggggtc atccgagccg
      301 tgtcccaccg cgaccgcggc cacccggacc tggcggtcta cgtggaattt gatgaccttg
      361 agtgggataa acgggagtgg gttagagttt atgaagattt ttcaactttc ttggtggaat
      421 atcacttaat ctgggccaaa aggaaggacc ctagccagac tcagggatca aagagcagac
      481 aaattcagtg gcctgcactg accttcaaac cattggttga aaatagtata cctagttcta
      541 tcactgcagt agaattcctt atagataagc aactggattt tttaacagaa gatagtgcct
      601 ttcagccata ccaggacgac atagacagct taaagcccgt actcagggac aacccacagc
      661 tgcacgcgga agtgaaagtc tgggtgaagg aacagaaggt ccaggagatt tttatgcaag
      721 gtccttattc attaaatgga tacagagtga gagtctatag acaagattct gccacccagt
      781 ggtttactgg cataattact catcatgatc tcttcacccg caccatgatc gttatgaatg
      841 atcaggtact agaaccacag aatgtcgatc cttctatggt tcaaatgacc tttctagatg
      901 atgtcgttca ctctttgtta aaaggtgaaa atattggcat tacatcacgg cgaaggtctc
      961 gtgccagtca aaatatcagc actgttcacg gtcattatac acgtgctcaa gcaaatagtc
     1021 ccagaccagc aatgaactct caagctgctg taccaaaaca gaacacacac cagcaacagc
     1081 aacaaagaag tattcgtcca aataagagga agggttcaga tagcagcata cccgatgaag
     1141 agaagatgaa ggaagataaa tatgattgtg tatcacgagg agaaaatcct aaaggtaaga
     1201 acaagcacgt ggtgacaaaa cggcggaaac ctgaggaggc cgagaagagg ctgagcatga
     1261 aaaggctccg gacagacaat gcctctgacg cctccgagag cagtgacgca gagagctcca
     1321 gcaagagagt gactgagact tcctcctctg aaccaatgcc agagtatgaa ccgaaaaata
     1381 aagtcacctc aaaggtaaat ggagaggagg gacagtccca ggctgctgaa gaggcaggag
     1441 aagagaccct gatagatact cggcctccct gggaccagat gcaggaagat aaaaaccaca
     1501 acgaagggga gaagcccaag tccacggaca gccaccttca agacaaaatg actctccgtt
     1561 catctgagca agccacagtt gctgaccaca attctaatga ttcagtcctt caagaatgca
     1621 atgtggaaaa ccaacgcaca gtggaattat taccaaagga caggttagtg tccagaacac
     1681 cgacacccaa atgtgttacg gatatcaaga acgacactca ttctgagagg gcggctcagg
     1741 aaaatttaaa tacttttggc ctccagacac ctgagaacat ggatccaaat gttagtgatt
     1801 ccaaacattc aaatgctaaa tacctagaaa cagcaaagca agattgtgac cagagctggg
     1861 tcagtgatgt agtgaaagtg gatttaactc agtcaagtgt tacaaatgct ccttcaggaa
     1921 gtgataagcg cgatacggag aaagagagaa atcactatgt ctcatacatg tcttcattaa
     1981 gtgcagtttc tgtcacagag gatcagctac ataaacgaag tccaccccca gaaactataa
     2041 aagctaaact aactacttca gtagataccc agaaggcaaa atccagttct tcacctgaag
     2101 ttgttaaacc caagatcact cattctcctg attctgtgaa gtctaaagct gcttatggga
     2161 acagtcaagc tgttggtgag cgaaggctgg caaataaaat agagcatgag ttatccagag
     2221 gtagtttcca tccagttcct actcgaggca gtgctttgga aactacaaag agccctctta
     2281 tcattgataa aaacgagcac ttcacagtct atagggatcc tgctcttatt ggatcagaaa
     2341 caggagctaa tcacatttca ccttttttga gccagcatcc tttttctctt cattcctcat
     2401 cccatagaac ctgtttaaac ccaggtaccc atcaccctgc cttaacgcca ggaccccact
     2461 tactagctgg gtcaactagt caaactccat tacctaccat taacactcac cctctcacta
     2521 gtggtccaca ccatcctgtc catcaccctc atttgcttcc cactgtgtta cctggagtgc
     2581 ctactgcctc tttactcggt ggccacccac gtctagagag tgctcatgca agcagcttga
     2641 gccatttagc actagcacac cagcagcagc aacagttgtt acagcaccag tcacctcatc
     2701 ttcttggaca agcccatcct tccgcttcat ataatcagct tggactttat ccaattattt
     2761 ggcaatatcc gaatggaaca catgcatact caggacttgg tctcccttct tctaagtggg
     2821 ttcacccaga aaatgcagtt aatgctgaag cttcattaag gaggaattct cccagtcctt
     2881 ggctacatca acccactcct gtgacctcag cggatggtat tggattactt agtcacattc
     2941 ctgtcagacc ttccagtgca gagcctcatc gacctcacaa gattacagtg cattccagtc
     3001 ccccactgac aaagacatta gcagatcacc acaaagaaga attggagagg aaagctttta
     3061 tggaaccatt acggtctaat gcatccacat cagtaaaagg tgacctggat cttaataggt
     3121 cacaggcagg aaaagattgt cacttgcata ggcattttgt gggtccaagg ccaccccagg
     3181 agactggaga gagactgaac aaatacaagg aggaacatcg tcggattctt caggagagta
     3241 ttgatgtggc tccatttaca accaaaatca agggtcatga ggttgaaaga gagaattact
     3301 ccagagtagt accatcatct tctagtccta aaagccatgc tatcaaacaa gataaagacg
     3361 tagaccgctc cgtgtcagag atttataaga tgaagcactc agtgcctcag agtttgcccc
     3421 agagtaacta cttcactact ttatctaata gtgtggtcaa tgagccacca agatcctacc
     3481 catccaaaga agtttccaac atttacactg agaaacaaaa taataacctt tctgcaacag
     3541 ccaatcctca aactcattct tttatatcat ctctttcgaa gcctccacct ttgattaaac
     3601 accaaccaga aagtgaaagt ttagtgggca agataccaga ccatcttccc catcagagtg
     3661 catctcactc agtaacaacg ttcagaagtg attgtcggag ccctacccat ctgactgttt
     3721 cttctactaa tgcactccgc agcatgcctg ctctgcacag ggcaccagta ttccatccac
     3781 caatccacca cagtttggaa agaaaggaaa gcagctacag tagcctttcc cctccaacac
     3841 tgacaccggt gatgccagta aatgctggtg gcaaagttca agaatctcag aagcctccaa
     3901 ctctaattcc tgagccaaaa gactctcagt caaattttaa gaattcttct gatcagagtc
     3961 taacggaaat gtggagatct aataacaacc tcaacagaga gaaagctgag tggcccgtgg
     4021 aaaagagtag tggaaagtcc caggctgctg tggcatctgt cattgttcgt ccaccttcta
     4081 gtacaaaagt tgatagtgtg ccatctgtac cattagcttc caaagatcga gtttgtgaaa
     4141 gatcttcatc tggggcaaat aaaacagatt acctcaaacc agaagccgga gagactggaa
     4201 gaattattct accaaatgtg aatttagaaa gtgctcatgt gaaatctgaa aaaaactttg
     4261 aagctgtctc ccagggcaac gttcctgttt cagtcatgtc tgctgtaaat gtagtctcta
     4321 ctaccaaagc agatgtgttc acatctgctg ccactaccac cagtgtctcc agcttgagta
     4381 gtgcagaaac aagttattct ttatcaaata ccatttcggc ctctacaccc ttcgaatgta
     4441 cttcttcaaa aagtgttgtt agtcaggcag tggcgcaagc aaaggactgc acagtcagca
     4501 ccgcggttcc aggcactctg gcctgtagta agacaggaag tgctgttcag cccggctctg
     4561 gcttctcagg cacaactgat tttattcatt taaaaaagca caaggcagcg ttggctgcag
     4621 ctcagtttaa aaatagtagt gtcagtgagg ctgaacttaa tactgtgaga aatcagacag
     4681 tggcagcctc tcttcccctg gatagcacca tgacctgcac tgcaagtaac aaagcaatct
     4741 ctgtaggaaa tgggccagca gcccagtcca gtcagcccaa ctaccacact aaactgaaga
     4801 aggcctggct caccagacat tcagaagaag ataaaaatac taataaaatg gaaaattcag
     4861 ggaattctgt atccgaaatt attaagccat gttctgtcaa cttaatagcc tctacatcta
     4921 atgatataga aaatcgtgca gatggcagag tcgctgtaga taaatatgga agagatgaga
     4981 aagtcagcag gagaaaagcc aaaagaactt acgaatctgg ctctgaaagt ggagactcag
     5041 atgagagcga aagcaagtcg gagcagagga ctaaacggca gccgaagcca acttataaaa
     5101 agaagcagaa cgacctgcag aagaggaaag gcgaggtcga agaggactcg aagcctaatg
     5161 gagttctcag caggagcgcc aaggacaaaa gtaaactgaa gttgcagaac agtaatactg
     5221 gcgttcctcg ttccgtgctg aaagactggc ggaaggtcaa gaagctgaag caaactggag
     5281 aatcatttct gcaggatgac tcctgctgtg agataggtcc caacttacag aagtgccgag
     5341 agtgcagact tatccggagt aagaaggggg aagaatcaac tcactcaccg gtgttttgta
     5401 gattttacta ctttaggaga ttgtccttta gtaagaatgg agtagtcaga atagatggtt
     5461 tctcttctcc tgatcaatac gatgatgaag ccatgagttt atggacccat gaaaattatg
     5521 aagatgatga agtagatgtt gaaacctcta agtatatctt ggacataata ggtgataagt
     5581 tctgtcagtt agtaacgtct gagaaaacag cgttgtcctg ggtgaaaaag gatgccaaaa
     5641 ttgcatggaa aagggcagtt cgaggtgtcc gggagatgtg tgatgcgtgc gaggccacac
     5701 tgttcaacgt ccactgggtt tgccgcaagt gtggatttgt ggcttgcttg gactgttaca
     5761 aggccaagga aaggaagagt tctagagata aagagctgta tgcttggatg aagtgtgtga
     5821 aaggccagcc ccatgaccat aagcatctga tgctgactca gattatccct ggctctgtgt
     5881 tgacagacct tcttgatgcc atgcacattc ttagggaaaa atatggtatt aaatcccatt
     5941 gtcactgtac aaacagacag aatttacaag gtggaaatgt tcctacaatg aatggtgtgt
     6001 ctcaagttct acagaatgtt cttcaccaca gtaataagac ttctgtgtcc ctgcctgagt
     6061 ctcagcagca gaacagccct cagaaatctc agactaacgg caacagtagc cctggaagtg
     6121 caagtacaga cagcaggttg acacctccag agtcccagtc accgctgcac tggctagctg
     6181 atcttgctga gcagaaatcc agagaggaaa aacaagaaaa caaagaattt actcttgaaa
     6241 gggaaatcaa agaagatgga gaccaagatg cctctgattc tccaaatggc agcacatcac
     6301 ctccagcatc ccagagcaac gaacagggtt caaccctacg tgatttgctg accacaacag
     6361 ctggcaagct tcgtgtgggc tctacagatg ctggcattgc ctttgcgcca gtatattcaa
     6421 tgggaacctc aagtggcaaa ggtggccgga ctatgcctaa cattcttgat gacatcattg
     6481 cttcagttgt tgaaaacaaa attccaccaa ataaaacctc caagatcaat ataaaatcag
     6541 aacctaatga agaacccaaa gaaagcagtc tgcctgccac ggatgaaagc aataagtctt
     6601 atcgtgacat accacattct tggatctgtg accagcatat tttatggctt aaagattaca
     6661 agaatagtaa taactggaag cttttcaaag agtgctggaa acaaggacag cctgcagtgg
     6721 tttccggtgt gcataagaaa atgaacatta gcttgtggaa ggcagaatca attagtctgg
     6781 attttggaga ccaccaagct gatctcctca actgcaaaga cagcattgtt tccaatgcca
     6841 acgttaagga gttctgggat ggttttgaag aagtgtcaaa acgtcaaaaa aacaaaggtg
     6901 gagaaacagt agtattaaag ttgaaagact gcccatctgg ggaggacttc aaggccatga
     6961 tgccaacaag atatgaagac tttttaagat gtctgccatt accagaatat tgcaacccag
     7021 aagggaagtt caatttggcc tcccatttgc cagggttctt tgtacgccct gatctaggac
     7081 ccaggctgtg cagtgcctat ggtgttgctg ctgctaagga tcatgatata ggaaccacaa
     7141 atcttcacat tgaagcttct gatgttgtca atgtcctagt ctatgtcggc atagcaaaag
     7201 gaaatggcgt cctctcaaaa gcaggaatac ttaagaaatt tgaagaagaa gaattagatg
     7261 atgttttaag aaaaagatta aaggattcga gtgaaatccc tggtgctcta tggcatattt
     7321 atgctggaaa agatgttgac aagataaggg aatttcttca aaagatttca aaagaacaag
     7381 gccttgaagt tctgccagag catgatccaa tccgggacca aagctggtat gtgaatagaa
     7441 agctccgcca gagactgctt gaggaatatg gggtgagagc ctgcactctg attcagttcc
     7501 ttggtgatgc cattgttttg ccagcaggaa cacttcacca ggtacaaaat tttcacagct
     7561 gtgttcaggt gaccgaagac tttgtctctc cagaacatct tgtacagtcg tttcacttaa
     7621 cacaggagct gaggcttttg aaggaagaaa tcaattacga tgataaactc caggttaaga
     7681 atatcttgta tcatgcagtc aaggaaatgg tgagagctct gaagatgcat gaagatgaag
     7741 tagaggatat ggaagacacc taattgcggt tggaactggg atgccccttg agtgacgcta
     7801 ggtctgactt aagctccatt aaaccatcag tgccaagaaa ttctctttgt agtaattact
     7861 tgctactgac accataccag tatagcatta tgccacagcc cctgtgattc aatgctagct
     7921 ataaaccaag ctaaatttaa aagcagtact atatagctgt tcctgtatca tagtgtatat
     7981 gatgtttgtg aagatgccag atttaaaatg atgtatttat ttttggtaaa aaaaaaaatc
     8041 tatgctatat tgttgatcaa gtgtaaatgt gctgttgtac agtttaataa aataactgat
     8101 atttttcact acattgagac agttactgtg agactaggac acaccagctg ttgcctgcgt
     8161 ttgggaaatt gctggattgc acagcagtca cgtcataatc agaaaattac tgccaaataa
     8221 ttgtaaaatg tgtaaaatac aaagtacata aagtagatac taaactcaga cacttcaata
     8281 ttttgttgaa gctattgact gtacaattaa acgttttcaa aaggtgtaat ttatttaaaa
     8341 ttgtctcatt ttggtaaaat ttatgtgaag ttttaaagct aaatattaaa cttaatatgc
     8401 tatgtaaata tatacatata tacatttaag gatgtatttt tttaaaacat tggcttgctt
     8461 ttgttaaagt gcaagtgtta catatggctt tgtacattac agttgaaagg ggttttacat
     8521 tttccattaa aagactttat caagaagctg ga
//
