LOCUS       NM_024205               1976 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus JNK1/MAPK8-associated membrane protein (Jkamp),
            transcript variant 1, mRNA.
ACCESSION   NM_024205
VERSION     NM_024205.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Yan,L., Yin,H., Mi,Y., Wu,Y. and Zheng,Y.
  TITLE     Deficiency of Wdr60 and Wdr34 cause distinct neural tube
            malformation phenotypes in early embryos
  JOURNAL   Front Cell Dev Biol 11, 1084245 (2023)
   PUBMED   37228654
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Peng,S., Shi,S., Tao,G., Li,Y., Xiao,D., Wang,L., He,Q., Cai,X. and
            Xiao,J.
  TITLE     JKAMP inhibits the osteogenic capacity of adipose-derived stem
            cells in diabetic osteoporosis by modulating the Wnt signaling
            pathway through intragenic DNA methylation
  JOURNAL   Stem Cell Res Ther 12 (1), 120 (2021)
   PUBMED   33579371
  REMARK    GeneRIF: JKAMP inhibits the osteogenic capacity of adipose-derived
            stem cells in diabetic osteoporosis by modulating the Wnt signaling
            pathway through intragenic DNA methylation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   Chen,Y., Liu,K., Zhang,J., Hai,Y., Wang,P., Wang,H., Liu,Q.,
            Wong,C.C.L., Yao,J., Gao,Y., Liao,Y., Tang,X. and Wang,X.J.
  TITLE     c-Jun NH2 -Terminal Protein Kinase Phosphorylates the Nrf2-ECH
            Homology 6 Domain of Nuclear Factor Erythroid 2-Related Factor 2
            and Downregulates Cytoprotective Genes in Acetaminophen-Induced
            Liver Injury in Mice
  JOURNAL   Hepatology 71 (5), 1787-1801 (2020)
   PUBMED   31945188
  REMARK    GeneRIF: c-Jun NH2 -Terminal Protein Kinase Phosphorylates the
            Nrf2-ECH Homology 6 Domain of Nuclear Factor Erythroid 2-Related
            Factor 2 and Downregulates Cytoprotective Genes in
            Acetaminophen-Induced Liver Injury in Mice.
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Chen,G., Yao,Y., Xu,G. and Zhang,X.
  TITLE     Regional difference in microRNA regulation in the skull vault
  JOURNAL   Dev Dyn 248 (10), 1009-1019 (2019)
   PUBMED   31397024
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Tcherpakov,M., Broday,L., Delaunay,A., Kadoya,T., Khurana,A.,
            Erdjument-Bromage,H., Tempst,P., Qiu,X.B., DeMartino,G.N. and
            Ronai,Z.
  TITLE     JAMP optimizes ERAD to protect cells from unfolded proteins
  JOURNAL   Mol Biol Cell 19 (11), 5019-5028 (2008)
   PUBMED   18784250
  REMARK    GeneRIF: JAMP is an important component for coordinated clearance
            of misfolded proteins from the endoplasmic reticulum.
REFERENCE   6  (bases 1 to 1976)
  AUTHORS   Kadoya,T., Khurana,A., Tcherpakov,M., Bromberg,K.D., Didier,C.,
            Broday,L., Asahara,T., Bhoumik,A. and Ronai,Z.
  TITLE     JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein,
            regulates duration of JNK activity
  JOURNAL   Mol Cell Biol 25 (19), 8619-8630 (2005)
   PUBMED   16166642
  REMARK    GeneRIF: JAMP is a membrane-anchored regulator of the duration of
            JNK1 activity in response to diverse stress stimuli [JAMP, a Jun
            N-terminal kinase 1 (JNK1)-associated membrane protein]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974486.6.
            
            On Mar 23, 2011 this sequence version replaced NM_024205.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002238.1, BG518639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               CR974486.6         47911-48255         c
            346-437             CR974486.6         44688-44779         c
            438-592             CR974486.6         43984-44138         c
            593-799             CR974486.6         39951-40157         c
            800-981             CR974486.6         39227-39408         c
            982-1058            CR974486.6         33971-34047         c
            1059-1976           CR974486.6         32567-33484         c
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 30.2 cM"
     gene            1..1976
                     /gene="Jkamp"
                     /gene_synonym="1200003C05Rik; 2310047L11Rik; Jamp"
                     /note="JNK1/MAPK8-associated membrane protein"
                     /db_xref="GeneID:104771"
                     /db_xref="MGI:MGI:1915057"
     exon            1..345
                     /gene="Jkamp"
                     /gene_synonym="1200003C05Rik; 2310047L11Rik; Jamp"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..1277
                     /gene="Jkamp"
                     /gene_synonym="1200003C05Rik; 2310047L11Rik; Jamp"
                     /note="isoform 1 is encoded by transcript variant 1;
                     medulloblastoma antigen MU-MB-50.4 homolog"
                     /codon_start=1
                     /product="JNK1/MAPK8-associated membrane protein isoform
                     1"
                     /protein_id="NP_077167.1"
                     /db_xref="CCDS:CCDS25967.1"
                     /db_xref="GeneID:104771"
                     /db_xref="MGI:MGI:1915057"
                     /translation="MAVDIQPACLGLYCGKTLLFKNGSSEIYGECGVCPRGQRTNAQK
                     YCQPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECTMAA
                     IITLLVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFVY
                     YAFCLVLMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFP
                     YIILVLSLVTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIVSISRVDRLEH
                     DLPLLALVPTPALFYLFTAKFTEPSRILSEGANGH"
     exon            346..437
                     /gene="Jkamp"
                     /gene_synonym="1200003C05Rik; 2310047L11Rik; Jamp"
                     /inference="alignment:Splign:2.1.0"
     exon            438..592
                     /gene="Jkamp"
                     /gene_synonym="1200003C05Rik; 2310047L11Rik; Jamp"
                     /inference="alignment:Splign:2.1.0"
     exon            593..799
                     /gene="Jkamp"
                     /gene_synonym="1200003C05Rik; 2310047L11Rik; Jamp"
                     /inference="alignment:Splign:2.1.0"
     exon            800..981
                     /gene="Jkamp"
                     /gene_synonym="1200003C05Rik; 2310047L11Rik; Jamp"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1058
                     /gene="Jkamp"
                     /gene_synonym="1200003C05Rik; 2310047L11Rik; Jamp"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1976
                     /gene="Jkamp"
                     /gene_synonym="1200003C05Rik; 2310047L11Rik; Jamp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1886..1891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jkamp"
                     /gene_synonym="1200003C05Rik; 2310047L11Rik; Jamp"
                     /note="hexamer: AATAAA"
     polyA_site      1910
                     /gene="Jkamp"
                     /gene_synonym="1200003C05Rik; 2310047L11Rik; Jamp"
                     /note="major polyA site"
     regulatory      1957..1962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jkamp"
                     /gene_synonym="1200003C05Rik; 2310047L11Rik; Jamp"
                     /note="hexamer: ATTAAA"
     polyA_site      1976
                     /gene="Jkamp"
                     /gene_synonym="1200003C05Rik; 2310047L11Rik; Jamp"
ORIGIN      
        1 ggaaaaggtg gagcctctga gctcaaaccc ggaagcgaga gagagagaga gagagagaga
       61 gagagagaga gagagagaga gagaggcttc caagcctaga ttaggaaact aggtttctgg
      121 gaatcctagg cctggaagtc cgccgcgtgc acccccgaca cccctagcgg gggaagcggt
      181 ggtggggcgg gactcggagc cgaatgtagc aggggcgggg ttccagcgtg cttgccaggc
      241 tagcgggagg cggagcggct gagagcgctg tggcccggat gttcgggcgc tgcgttcgga
      301 cccgctgatc cccggcttct caggggaacc tagtgtggcc aatggctgtc gatattcaac
      361 cagcatgcct tggactctac tgtgggaaga ccctattatt taaaaatggc tcaagtgaaa
      421 tctatggaga atgtggggta tgcccaagag gacagaggac caatgcacag aagtactgtc
      481 agccttgcac agagtcccca gaactttacg actggctcta tctgggcttt atggctatgc
      541 ttcctcttgt tctgcattgg ttcttcattg aatggtactc ggggaaaaag agctccagtg
      601 ctcttttcca gcacatcacc gcgctctttg aatgcaccat ggcagctatc atcaccttac
      661 tcgtgagtga tcccgtgggc gtcctttaca tccgttcctg ccgcgttctg atgctttctg
      721 attggtacac gatgctctac aacccaagtc cagattacgt caccacggtg cactgcactc
      781 acgaagccgt ctacccactg tacaccatcg tgttcgttta ttacgcgttc tgcttggtgt
      841 taatgatgct tctgcggcct ctcctggtga agaagatcgc atgcggactc ggcaagtctg
      901 accgcttcaa aagtatttac gcagctcttt acttcttccc catcctgacc gtgctgcagg
      961 cggtcggtgg gggcctctta tattacgcct tcccgtacat tatattagtg ttatctctgg
     1021 ttaccctggc tgtatacatg tctgcttctg aaatagagaa ctgctatgat ctcctggtca
     1081 ggaagaaaag acttatcgtt ctcttcagcc actggctact gcacgcctat ggcatagtct
     1141 ccatctccag agtggacagg ctggaacacg acctaccgct tttggctttg gtacctacac
     1201 cagctctgtt ttacttgttt actgcaaaat ttaccgaacc atcacggata ctctcagaag
     1261 gggccaatgg acattgaata taaaatgcca aaaaaaaaaa aaaaaaaaaa aaaaaatccc
     1321 gaaaagtatt cttcattaaa aaaaagtaaa gaagaattaa aatgtattaa tagcattctt
     1381 tcatacatgg gaagaagatt gtccagatat tataatgctt gtgctttatc tttggattta
     1441 ttggaccttg tggttacact tggagactac agggcctcct gttactgtgc tctgcctatc
     1501 ttagctatca caccggaagc ccaaacaggc aggggtaatt gctctttgga gcacggccat
     1561 gtttttgtac acctgtgctg atggtgtctc cctgcttttt gtgaagaacc tttaacaagt
     1621 gtattctgaa ctcaattgct gtggcatcat tatgccttct gttgtctata cattaccttc
     1681 gaggaattac aaaggcagat gtgcttgtgg agtgtgatgg caaaaacaga aacaaaggat
     1741 gtctttgtca atggctattt attttcacca atacagtgtt tagtaatatt tcaaaaataa
     1801 agcataattt atataacgaa ctttctgttt agagacagtt tggttgaaga catgttcaga
     1861 ttattgttcc tgtaaagaag aaaacaataa agaatttaat tgtaaaataa ctccatgttc
     1921 tgataattct tttttgctac agtgattatg gaagtaatta aaaatgttaa gcatta
//
