LOCUS       NM_001357360            3831 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus junctional cadherin complex regulator (Jhy),
            transcript variant 3, mRNA.
ACCESSION   NM_001357360 XM_006510599
VERSION     NM_001357360.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3831)
  AUTHORS   Muniz-Talavera,H. and Schmidt,J.V.
  TITLE     The mouse Jhy gene regulates ependymal cell differentiation and
            ciliogenesis
  JOURNAL   PLoS One 12 (12), e0184957 (2017)
   PUBMED   29211732
  REMARK    GeneRIF: work shows that JHY does not only control ciliogenesis,
            but is a crucial component of the ependymal differentiation
            process, with ciliary defects likely a consequence of altered
            ependymal differentiation
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3831)
  AUTHORS   Appelbe,O.K., Bollman,B., Attarwala,A., Triebes,L.A.,
            Muniz-Talavera,H., Curry,D.J. and Schmidt,J.V.
  TITLE     Disruption of the mouse Jhy gene causes abnormal ciliary
            microtubule patterning and juvenile hydrocephalus
  JOURNAL   Dev Biol 382 (1), 172-185 (2013)
   PUBMED   23906841
  REMARK    GeneRIF: Juvenile hydrocephalus transgenic mice (Jhy(lacZ)) inherit
            communicating hydrocephalus in an autosomal recessive fashion with
            dilation of the lateral ventricles.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159820.2.
            
            On Oct 26, 2017 this sequence version replaced XM_006510599.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (b) is
            shorter at the N-terminus compared to isoform a. Variants 2 and 3
            both encode the same isoform (b).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-829               AC159820.2         84714-85542         c
            830-1159            AC159820.2         83391-83720         c
            1160-1679           AC159820.2         66849-67368         c
            1680-1793           AC159820.2         45168-45281         c
            1794-2440           AC159820.2         39507-40153         c
            2441-2735           AC159820.2         33444-33738         c
            2736-2816           AC159820.2         20716-20796         c
            2817-2945           AC159820.2         19857-19985         c
            2946-3831           AC159820.2         17359-18244         c
FEATURES             Location/Qualifiers
     source          1..3831
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 21.68 cM"
     gene            1..3831
                     /gene="Jhy"
                     /gene_synonym="4931429I11Rik"
                     /note="junctional cadherin complex regulator"
                     /db_xref="GeneID:70989"
                     /db_xref="MGI:MGI:1918239"
     exon            1..829
                     /gene="Jhy"
                     /gene_synonym="4931429I11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1159
                     /gene="Jhy"
                     /gene_synonym="4931429I11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             831..3143
                     /gene="Jhy"
                     /gene_synonym="4931429I11Rik"
                     /note="isoform b is encoded by transcript variant 3;
                     juvenile hydrocephalus protein; uncharacterized protein
                     C11orf63 homolog"
                     /codon_start=1
                     /product="jhy protein isoform b"
                     /protein_id="NP_001344289.1"
                     /db_xref="CCDS:CCDS40592.1"
                     /db_xref="GeneID:70989"
                     /db_xref="MGI:MGI:1918239"
                     /translation="MNKYKPVPKLSSQSPVHHTNLRIPPSGRPFKKEDFLNLISKDSL
                     ESDSESLPQEAKSWSDIKDQIQDKDMEPDSLEEDSPSETEEAVNRKAAHNTNREDLSA
                     HDAGVNHSQHQVEDKYSDLRYDPNWKNKREEGQPLAGEALPGSADSSSENLPLAPLYP
                     SREPSMGLSAGKGKEKKSPQSEASLLGSEFLSPKYERSTRQNGFFSELSDSDQEEKSS
                     GLSQYLKSSSSHNDVFLPGSRGPRRRKSKQYFVEKNKLTLGLPMPKTDSYLQLHNKKR
                     GETRLEQISYPVRDTDKMTVQNDKEVENTFMDPEDKWHQRAKQLKNYQEHLSQYEDTK
                     SGNVPRGQSSDAANGQQPSRRTAKARVRKQRKHQKGLKSLGTKELVVSQNNQNNPFQQ
                     PQNQRQTADASAKHELAAQTNASNPNLQDARTLTHNPKVTSDSFVSPKQALDRALYKN
                     SISGLNANKRRGHRREEERILYQPQPIYVFSDTHLQDFNELPHRHESPSQRAPQSDHH
                     MNTHRSTKTKKPAKQPQAETKYKNIEMLWKFHSSSDMEPASASPDSRLAQIMEQHQQA
                     LMQLAEVQPSEGSLASIILPPILSRVESESQLNSERSHRHQVKMARSNSEGYLLQLER
                     GKRHRKRSSTKSSKLKGYQKRDVKLGGLGPDFASVRDKMQMLMQQKEYAQQVKDYNMK
                     ALSILSKPQTSKTESKSAISRKKALDYAKTIPKPKPPNLPDQTAKKTKNSRHSEKEGG
                     LPEISLLEILQSRHEREKQAVAAFKVLHIV"
     exon            1160..1679
                     /gene="Jhy"
                     /gene_synonym="4931429I11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1793
                     /gene="Jhy"
                     /gene_synonym="4931429I11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..2440
                     /gene="Jhy"
                     /gene_synonym="4931429I11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2735
                     /gene="Jhy"
                     /gene_synonym="4931429I11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2816
                     /gene="Jhy"
                     /gene_synonym="4931429I11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2945
                     /gene="Jhy"
                     /gene_synonym="4931429I11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3831
                     /gene="Jhy"
                     /gene_synonym="4931429I11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3362..3367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jhy"
                     /gene_synonym="4931429I11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3380
                     /gene="Jhy"
                     /gene_synonym="4931429I11Rik"
                     /note="major polyA site"
ORIGIN      
        1 caagactcca agtacagtga gcttttaaat aacaaagctg gtgtttatag agatttagat
       61 ttaaaatgtt ttcatgcttg ctgctctcta aaaatcatcc tgcaaaagga aattggtatt
      121 aaaatgtggc agagcacaat gtgtatacta aagcagagac tgattgcagg caaactaact
      181 gaaaattagg caatgatata ttggtctact aagggagctt ggagttcagc agagactggc
      241 tcatgtttgt ttaagtatga gcgctacctt ttgtctgtca tgtttgtaaa ggtgctttca
      301 tccaaggagc agactgtgtc cttggaaacc ctagcaacaa ggtcaatata ataataattc
      361 aaggaacagg aatcaggtca aggtattttt aattaaaaac tggatttgtc aaaagaacat
      421 gagccagcca gtcaaaacaa atttgagcgt agcctccagt ggtaaagctc tctctctcac
      481 acacacacac atacacacac acacacacac actactgcat aaaggcagtg acacacacac
      541 acacacacac acacacacac acacacacac acactacagc ataaaggcag tgagagagaa
      601 aataaaccaa aagagaaacc ctgggtagca gtggaaggca atcaccttcc agtcctgtgc
      661 tgattcagag cacttgttct gtaaaccatc tcatgggtca ctagaggagc ctttggcgac
      721 cctgagagtt cccttggaat cacactccta catacttaac aagggacacc tcgactccta
      781 gctgaaatgc agaccagcct cccctactca agagtagcac ctattccagg atgaataaat
      841 ataaacccgt tcccaagctc tctagccagt ctcccgtcca tcacaccaac ttgaggatcc
      901 cgccttcggg cagacccttt aagaaagaag acttcttaaa cctgatttca aaagactcct
      961 tagaatcgga ttcagaaagc ctccctcaag aggctaagtc ctggtctgat attaaggacc
     1021 aaatccagga caaagatatg gagcctgaca gcttggagga ggacagccca agtgagacag
     1081 aagaggcagt gaacagaaaa gcagcccaca acactaacag ggaagaccta agtgctcatg
     1141 atgctggtgt gaatcacagc caacatcagg tagaagacaa atactcagac ctccgatatg
     1201 atcccaactg gaagaacaaa agagaggagg ggcagccatt ggctggagaa gcattaccag
     1261 ggtctgcaga tagctcttca gaaaacctgc ctttggctcc gctctaccct tccagagagc
     1321 catccatggg actctccgct gggaaaggca aagaaaagaa gagtcctcag agcgaagcct
     1381 ccttacttgg aagcgaattt ctgagcccaa agtatgaacg tagcacccgt caaaatgggt
     1441 tcttctcaga actaagcgac agtgaccagg aggagaaatc cagcggcctg tctcagtacc
     1501 taaagagctc aagctcacac aacgacgttt tcctgccggg gtcacgtggc ccgcgcagaa
     1561 ggaagtccaa acaatatttt gtggaaaaaa acaagctgac tttggggtta cctatgccta
     1621 aaacagactc ttaccttcaa cttcacaata agaagagagg agagacccgc ctcgaacaga
     1681 tttcctaccc cgtcagagat actgacaaga tgactgtcca gaatgacaaa gaagtcgaaa
     1741 acactttcat ggatcctgag gacaaatggc atcagagagc aaagcagctc aagaattacc
     1801 aagaacatct gtctcagtac gaagatacaa aatcaggcaa tgtcccaaga ggtcagtctt
     1861 ccgatgcagc caatggccag caaccttcca gaagaactgc caaggccagg gttcggaaac
     1921 agaggaaaca ccagaaaggc ctgaaatctc ttgggacaaa agagcttgtt gtcagtcaaa
     1981 ataatcagaa taaccctttc cagcaaccac agaaccaaag gcagactgcg gatgcctcag
     2041 caaagcatga gctggctgca caaacgaacg cttctaaccc caatttacag gacgccagaa
     2101 cgctcaccca caatcccaaa gtcacctccg actctttcgt ttcacctaag caggctttag
     2161 acagagcttt atataaaaac tccatctcag gactgaacgc taataaaaga cgaggacaca
     2221 gacgtgagga agagagaatt ctgtatcagc cgcagcccat ctacgtgttt tctgatacac
     2281 atctgcagga ctttaatgaa cttcctcaca gacacgagtc cccgagccag agagcccctc
     2341 agtccgatca ccacatgaac acacacaggt caacgaagac aaagaagcca gccaaacaac
     2401 cgcaggcaga gacgaaatac aagaacatag agatgctctg gaaattccac tcttcctcag
     2461 acatggaacc cgcgagtgcc tcgccagact cccggcttgc ccagatcatg gaacagcacc
     2521 agcaagcctt gatgcagctg gcagaggtgc agcccagcga gggctctctg gccagcatca
     2581 tactcccacc tatcctgtcc agggtagaaa gtgaatcgca gctcaattca gagagaagcc
     2641 acagacacca ggtgaagatg gcccgtagta attcggaagg ctacctgctt cagctggaga
     2701 gaggaaagag acacaggaag cgaagcagca caaagagttc caagctgaaa ggctatcaga
     2761 aaagagacgt gaagcttgga ggcctgggac ctgactttgc atccgtcaga gacaaaatgc
     2821 aaatgttaat gcagcaaaaa gaatacgcac agcaagtcaa ggattacaac atgaaggccc
     2881 tgtccattct gtccaaacca cagacatcaa aaaccgagag taaatctgcg atttctcgga
     2941 agaaggcttt ggactatgct aagaccatcc ccaaacccaa accaccaaat ctacctgatc
     3001 aaacagcaaa gaaaactaag aactcaaggc acagtgaaaa agaaggaggc ttaccagaaa
     3061 tttccctgtt ggagatcctg cagagcagac acgagcggga aaagcaggct gtggctgctt
     3121 tcaaagtcct tcacatcgtc tagacagcgt ttagtgggga tcaaaagtgc tatgcaaggg
     3181 acatggagaa aaaaaagtag acagttccac agtgagtggt aagctggcac tgccgcctgc
     3241 ccgccaccct tgtctgcact gtgcagaagt taatggtggt gtgtttaacc ttctggaaag
     3301 aaaaatacat acaattattt atttcaaatc tgttagaatt tggacagata gatggctaga
     3361 caataaagcc tttggtttta tattggatct tctgatttgt caaactacct ttgcgcttct
     3421 tcataacata gcatagcata gcataacata acatatgtac atacttcagt ttttcctgaa
     3481 aatgagtttg gctgacctcg tcacagaggt aacatgtcca aaataatact tttgctttca
     3541 agtctcaaaa aagtcttata tataaagttg acaatttgaa aattcatcta gatatgcaga
     3601 ttgaaatagg aaaaaaatcc tgatctcgtt ctaacacatc actcagacta aggcattaat
     3661 cataaatccc acaagtgtag ggaaatccac cgcagatcac tttatggtca aagccactga
     3721 ctccacatct ataaatttat ggggcatctt gttatcattg tggttatctt caaatattat
     3781 taaatgcctg tacttcagag tttacgacga atgtaaatat tcatattcat t
//
