LOCUS       NM_030887               1660 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus Jun dimerization protein 2 (Jdp2), transcript variant
            1, mRNA.
ACCESSION   NM_030887
VERSION     NM_030887.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1660)
  AUTHORS   Parahuleva,M.S., Kockskamper,J., Heger,J., Grimm,W., Scherer,A.,
            Buhler,S., Kreutz,J., Schulz,R. and Euler,G.
  TITLE     Structural, Pro-Inflammatory and Calcium Handling Remodeling
            Underlies Spontaneous Onset of Paroxysmal Atrial Fibrillation in
            JDP2-Overexpressing Mice
  JOURNAL   Int J Mol Sci 21 (23), 9095 (2020)
   PUBMED   33265909
  REMARK    GeneRIF: Structural, Pro-Inflammatory and Calcium Handling
            Remodeling Underlies Spontaneous Onset of Paroxysmal Atrial
            Fibrillation in JDP2-Overexpressing Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1660)
  AUTHORS   Avraham,S., Korin,B., Aviram,S., Shechter,D., Shaked,Y. and
            Aronheim,A.
  TITLE     ATF3 and JDP2 deficiency in cancer associated fibroblasts promotes
            tumor growth via SDF-1 transcription
  JOURNAL   Oncogene 38 (20), 3812-3823 (2019)
   PUBMED   30670778
  REMARK    GeneRIF: JDP2 regulates the expression of essential tumor promoting
            factors, such as Sdf1 expressed by cancer associated fibroblasts
            within the tumor microenvironment, and thus restrain tumor growth.
REFERENCE   3  (bases 1 to 1660)
  AUTHORS   Kalfon,R., Friedman,T., Eliachar,S., Shofti,R., Haas,T., Koren,L.,
            Moskovitz,J.D., Hai,T. and Aronheim,A.
  TITLE     JDP2 and ATF3 deficiencies dampen maladaptive cardiac remodeling
            and preserve cardiac function
  JOURNAL   PLoS One 14 (2), e0213081 (2019)
   PUBMED   30818334
  REMARK    GeneRIF: Transgenic mice with cardiac expression of either JDP2 or
            ATF3 showed maladaptive remodeling and cardiac dysfunction.
            Surprisingly, JDP2 knockout (KO) did not protect the heart
            following transverse aortic constriction. Instead, the JDP2 KO mice
            performed worse than their wild type counterparts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1660)
  AUTHORS   Wang,X.H., Liu,Q. and Shao,Z.T.
  TITLE     Deletion of JDP2 improves neurological outcomes of traumatic brain
            injury (TBI) in mice: Inactivation of Caspase-3
  JOURNAL   Biochem Biophys Res Commun 504 (4), 805-811 (2018)
   PUBMED   30217453
  REMARK    GeneRIF: JDP2 role in the traumatic brain injury and cognitive
            function.JDP2 promoted caspase-3 activation in astrocytes.
REFERENCE   5  (bases 1 to 1660)
  AUTHORS   Heger,J., Bornbaum,J., Wurfel,A., Hill,C., Brockmann,N., Gaspar,R.,
            Paloczi,J., Varga,Z.V., Sarkozy,M., Bencsik,P., Csont,T., Torok,S.,
            Kojonazarov,B., Schermuly,R.T., Bongler,K., Parahuleva,M.,
            Ferdinandy,P., Schulz,R. and Euler,G.
  TITLE     JDP2 overexpression provokes cardiac dysfunction in mice
  JOURNAL   Sci Rep 8 (1), 7647 (2018)
   PUBMED   29769710
  REMARK    GeneRIF: JDP2 overexpression is associated with heart failure
            development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1660)
  AUTHORS   Kawaida,R., Ohtsuka,T., Okutsu,J., Takahashi,T., Kadono,Y., Oda,H.,
            Hikita,A., Nakamura,K., Tanaka,S. and Furukawa,H.
  TITLE     Jun dimerization protein 2 (JDP2), a member of the AP-1 family of
            transcription factor, mediates osteoclast differentiation induced
            by RANKL
  JOURNAL   J Exp Med 197 (8), 1029-1035 (2003)
   PUBMED   12707301
  REMARK    GeneRIF: Results suggest that Jun dimerization protein 2 (JDP2) may
            play an important role in the RANK-mediated signal transduction
            system, especially in osteoclast differentiation.
REFERENCE   7  (bases 1 to 1660)
  AUTHORS   Katz,S. and Aronheim,A.
  TITLE     Differential targeting of the stress mitogen-activated protein
            kinases to the c-Jun dimerization protein 2
  JOURNAL   Biochem J 368 (Pt 3), 939-945 (2002)
   PUBMED   12225289
  REMARK    GeneRIF: characterization of binding sites for stress
            mitogen-activated protein kinases on JDP2
REFERENCE   8  (bases 1 to 1660)
  AUTHORS   Ostrovsky,O., Bengal,E. and Aronheim,A.
  TITLE     Induction of terminal differentiation by the c-Jun dimerization
            protein JDP2 in C2 myoblasts and rhabdomyosarcoma cells
  JOURNAL   J Biol Chem 277 (42), 40043-40054 (2002)
   PUBMED   12171923
  REMARK    GeneRIF: JDP2 protein plays a major role in promoting skeletal
            muscle differentiation via its involvement in cell cycle arrest and
            activation of the myogenic program
REFERENCE   9  (bases 1 to 1660)
  AUTHORS   Jin,C., Li,H., Murata,T., Sun,K., Horikoshi,M., Chiu,R. and
            Yokoyama,K.K.
  TITLE     JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex
            to inhibit the retinoic acid-induced differentiation of F9 cells
  JOURNAL   Mol Cell Biol 22 (13), 4815-4826 (2002)
   PUBMED   12052888
  REMARK    GeneRIF: JDP2, repressor of AP-1, recruits a histone deacetylase 3
            complex to inhibit the retinoic acid-induced differentiation of F9
            cells.JDP2 is key factor that controls the commitment of F9 cells
            to differentiation and shed light on AP-1 repressor functions
REFERENCE   10 (bases 1 to 1660)
  AUTHORS   Jin,C., Ugai,H., Song,J., Murata,T., Nili,F., Sun,K., Horikoshi,M.
            and Yokoyama,K.K.
  TITLE     Identification of mouse Jun dimerization protein 2 as a novel
            repressor of ATF-2
  JOURNAL   FEBS Lett 489 (1), 34-41 (2001)
   PUBMED   11231009
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115037.16.
            
            On Feb 7, 2022 this sequence version replaced NM_030887.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB077438.1, AA667990.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               AC115037.16        115951-116166
            217-449             AC115037.16        124685-124917
            450-554             AC115037.16        148197-148301
            555-1660            AC115037.16        155325-156430
FEATURES             Location/Qualifiers
     source          1..1660
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.74 cM"
     gene            1..1660
                     /gene="Jdp2"
                     /gene_synonym="Jundm2; Jundp2; TIF"
                     /note="Jun dimerization protein 2"
                     /db_xref="GeneID:81703"
                     /db_xref="MGI:MGI:1932093"
     exon            1..216
                     /gene="Jdp2"
                     /gene_synonym="Jundm2; Jundp2; TIF"
                     /inference="alignment:Splign:2.1.0"
     exon            217..449
                     /gene="Jdp2"
                     /gene_synonym="Jundm2; Jundp2; TIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..740
                     /gene="Jdp2"
                     /gene_synonym="Jundm2; Jundp2; TIF"
                     /function="transcription factor"
                     /note="c-Jun dimerization protein 2"
                     /codon_start=1
                     /product="jun dimerization protein 2"
                     /protein_id="NP_112149.2"
                     /db_xref="CCDS:CCDS26060.1"
                     /db_xref="GeneID:81703"
                     /db_xref="MGI:MGI:1932093"
                     /translation="MMPGQIPDPSVTAGSLPGLGPLTGLPSSALTTEELKYADIRNIG
                     AMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQR
                     ESERLELMNAELKTQIEELKLERQQLILMLNRHRPTCIVRTDSVRTPESEGNPLLEQL
                     DKK"
     exon            450..554
                     /gene="Jdp2"
                     /gene_synonym="Jundm2; Jundp2; TIF"
                     /inference="alignment:Splign:2.1.0"
     exon            555..1660
                     /gene="Jdp2"
                     /gene_synonym="Jundm2; Jundp2; TIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1636..1641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jdp2"
                     /gene_synonym="Jundm2; Jundp2; TIF"
                     /note="hexamer: AGTAAA"
     polyA_site      1656
                     /gene="Jdp2"
                     /gene_synonym="Jundm2; Jundp2; TIF"
                     /note="major polyA site"
ORIGIN      
        1 gccgcccgcc acagcctgcg ggagggacac tcggcggccg cgacgggggg cgctggcggc
       61 agcggacgct gcagcggcgg cggcggggct ggcgccgcgg cggctcccgg gccgggacgg
      121 gcctgggcag cgggcggcag cagcgcggag tgggcaccgc gcctgcagca gggttctggg
      181 cccggggccg ccgcctccgc cagcggcttc tgcacgcccc tccaggccgg cctgccactc
      241 ctcctgctat gatgcctggg cagatcccag acccttcagt gaccgcaggc tctctgccag
      301 ggctcggccc cctcaccgga cttcccagct ctgctctgac cacagaggag ctgaaatacg
      361 ctgacatccg caacattggg gcgatgattg cgcccttgca cttcctggag gtgaaactgg
      421 gcaagaggcc ccaacccgtg aagagtgagc tagacgagga agaagagcga aggaaaaggc
      481 gccgggaaaa gaacaaagtc gctgcagcca gatgccggaa caagaagaag gaacgcacag
      541 agtttctgca gagggagtca gagcggctgg agctcatgaa cgcagagctg aagacgcaga
      601 tagaggagct gaagctggag cggcaacagc ttatcctgat gctcaaccgc caccgcccca
      661 cctgcatcgt gcgcacagat agcgtcagga cgcccgagtc cgaaggcaac ccactgctgg
      721 agcagctgga caagaagtga ctgaaggcct ggaggaggca tcagaggaag aggaggaagg
      781 ggaggagcat aaaagagaaa gaggacgagc aaggtgacag agggcccctc ccaggcacgt
      841 gacaaactct atgatgaggc ttagcataac tagcctccag ctggctcttt tttgaaactc
      901 agccctgccg cgcaagagca agagcggact gaagaaacca gagggaccag gtgctgagac
      961 caaggttgac ccgcagatag gggctgtccc actccagggc ccagcttgaa gagcacctga
     1021 gccagagagg tgccaaacca ggtagtagcc tcaggcactc ctttggcctc tctgccaaga
     1081 cccccaccca ggggactact gagcagccaa gaaaagccat gcattgcaaa cacagtgtgg
     1141 cccgcggatg gaactcagca tagactgcaa tccacctccc cagccctgcc caagcccagt
     1201 ggaagggggt gcactgtggg gctgcaatgg cccagctgga gttggctgcg gcacagaggc
     1261 gcgggcgccc ttccaaagca catacttaat caatgaatgt ttacagactg gctgtcctgg
     1321 cggggcttcc aactgcacac ggtttttata ctttctttct ttttctttct tttttttttt
     1381 aatatttttt acaaaaaaaa agattttata caagcaatat atatatatat atatatatat
     1441 atatatatgg atttctataa tcactcgatg tgacacagta caaatatgct atggtctgtt
     1501 atggacatcc acccaccagt taaggccatt gtaattccta agtactgtag gctctgggtg
     1561 ttggggggtg gccaggcggg tgaggtacat ttccatcctt gtaacccctt cctagtaccc
     1621 agtcctgtat cgttcagtaa acattgctct taattaccca
//
