LOCUS       NM_152839               2018 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus immunoglobulin joining chain (Jchain), mRNA.
ACCESSION   NM_152839
VERSION     NM_152839.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2018)
  AUTHORS   Shigesawa,I., Nakamura,A., Yamauchi,Y., Kawata,S., Miyazaki,A.,
            Nomoto,H., Kameda,H., Terauchi,Y. and Atsumi,T.
  TITLE     Effects of glucokinase haploinsufficiency on the pancreatic
            beta-cell mass and function of long-term high-fat, high-sucrose
            diet-fed mice
  JOURNAL   J Diabetes Investig 15 (12), 1732-1742 (2024)
   PUBMED   39305123
REFERENCE   2  (bases 1 to 2018)
  AUTHORS   Rossi,A.P., Tremblay,S., Castro-Rojas,C.M., Burg,A.A., Roskin,K.M.,
            Gehman,J.M., Rike-Shields,A., Alloway,R.R., Brailey,P., Allman,D.,
            Hildeman,D.A. and Woodle,E.S.
  TITLE     Effects of invivo CXCR4 blockade and proteasome inhibition on bone
            marrow plasma cells in HLA-sensitized kidney transplant candidates
  JOURNAL   Am J Transplant 23 (6), 759-775 (2023)
   PUBMED   36871629
REFERENCE   3  (bases 1 to 2018)
  AUTHORS   Wong,R., Belk,J.A., Govero,J., Uhrlaub,J.L., Reinartz,D., Zhao,H.,
            Errico,J.M., D'Souza,L., Ripperger,T.J., Nikolich-Zugich,J.,
            Shlomchik,M.J., Satpathy,A.T., Fremont,D.H., Diamond,M.S. and
            Bhattacharya,D.
  TITLE     Affinity-Restricted Memory B Cells Dominate Recall Responses to
            Heterologous Flaviviruses
  JOURNAL   Immunity 53 (5), 1078-1094 (2020)
   PUBMED   33010224
REFERENCE   4  (bases 1 to 2018)
  AUTHORS   Xu,A.Q., Barbosa,R.R. and Calado,D.P.
  TITLE     Genetic timestamping of plasma cells in vivo reveals
            tissue-specific homeostatic population turnover
  JOURNAL   Elife 9, e59850 (2020)
   PUBMED   33136000
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2018)
  AUTHORS   Oruc,Z., Oblet,C., Boumediene,A., Druilhe,A., Pascal,V., Le
            Rumeur,E., Cuvillier,A., El Hamel,C., Lecardeur,S., Leanderson,T.,
            Morelle,W., Demengeot,J., Aldigier,J.C. and Cogne,M.
  TITLE     IgA Structure Variations Associate with Immune Stimulations and IgA
            Mesangial Deposition
  JOURNAL   J Am Soc Nephrol 27 (9), 2748-2761 (2016)
   PUBMED   26825533
REFERENCE   6  (bases 1 to 2018)
  AUTHORS   Randall,T.D., Brewer,J.W. and Corley,R.B.
  TITLE     Direct evidence that J chain regulates the polymeric structure of
            IgM in antibody-secreting B cells
  JOURNAL   J Biol Chem 267 (25), 18002-18007 (1992)
   PUBMED   1517233
REFERENCE   7  (bases 1 to 2018)
  AUTHORS   Berberich,I. and Schimpl,A.
  TITLE     Regulation of immunoglobulin gene expression in normal lymphocytes.
            II. Mechanisms of down-regulation of immunoglobulin secretion after
            engagement of the B cell antigen receptor
  JOURNAL   Eur J Immunol 22 (2), 525-529 (1992)
   PUBMED   1537386
REFERENCE   8  (bases 1 to 2018)
  AUTHORS   Matsuuchi,L., Cann,G.M. and Koshland,M.E.
  TITLE     Immunoglobulin J chain gene from the mouse
  JOURNAL   Proc Natl Acad Sci U S A 83 (2), 456-460 (1986)
   PUBMED   3079912
REFERENCE   9  (bases 1 to 2018)
  AUTHORS   Cann,G.M., Zaritsky,A. and Koshland,M.E.
  TITLE     Primary structure of the immunoglobulin J chain from the mouse
  JOURNAL   Proc Natl Acad Sci U S A 79 (21), 6656-6660 (1982)
   PUBMED   6815655
REFERENCE   10 (bases 1 to 2018)
  AUTHORS   Yagi,M., D'Eustachio,P., Ruddle,F.H. and Koshland,M.E.
  TITLE     J chain is encoded by a single gene unlinked to other
            immunoglobulin structural genes
  JOURNAL   J Exp Med 155 (3), 647-654 (1982)
   PUBMED   6278047
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121585.3.
            
            On Mar 14, 2022 this sequence version replaced NM_152839.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.1587727.1, AK078865.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC121585.3         190058-190150       c
            94-214              AC121585.3         188441-188561       c
            215-295             AC121585.3         184835-184915       c
            296-2018            AC121585.3         182146-183868       c
FEATURES             Location/Qualifiers
     source          1..2018
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.7 cM"
     gene            1..2018
                     /gene="Jchain"
                     /gene_synonym="9530090F24Rik; Igj; Jch"
                     /note="immunoglobulin joining chain"
                     /db_xref="GeneID:16069"
                     /db_xref="MGI:MGI:96493"
     exon            1..93
                     /gene="Jchain"
                     /gene_synonym="9530090F24Rik; Igj; Jch"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..509
                     /gene="Jchain"
                     /gene_synonym="9530090F24Rik; Igj; Jch"
                     /note="immunoglobulin J chain; immunoglobulin joining gene
                     (not J region)"
                     /codon_start=1
                     /product="immunoglobulin J chain precursor"
                     /protein_id="NP_690052.2"
                     /db_xref="CCDS:CCDS19401.1"
                     /db_xref="GeneID:16069"
                     /db_xref="MGI:MGI:96493"
                     /translation="MKTHLLLWGVLAIFVKAVLVTGDDEATILADNKCMCTRVTSRII
                     PSTEDPNEDIVERNIRIVVPLNNRENISDPTSPLRRNFVYHLSDVCKKCDPVEVELED
                     QVVTATQSNICNEDDGVPETCYMYDRNKCYTTMVPLRYHGETKMVQAALTPDSCYPD"
     exon            94..214
                     /gene="Jchain"
                     /gene_synonym="9530090F24Rik; Igj; Jch"
                     /inference="alignment:Splign:2.1.0"
     exon            215..295
                     /gene="Jchain"
                     /gene_synonym="9530090F24Rik; Igj; Jch"
                     /inference="alignment:Splign:2.1.0"
     exon            296..2018
                     /gene="Jchain"
                     /gene_synonym="9530090F24Rik; Igj; Jch"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1202..1207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jchain"
                     /gene_synonym="9530090F24Rik; Igj; Jch"
                     /note="hexamer: ATTAAA"
     regulatory      1206..1211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jchain"
                     /gene_synonym="9530090F24Rik; Igj; Jch"
                     /note="hexamer: AATAGA"
     polyA_site      1223
                     /gene="Jchain"
                     /gene_synonym="9530090F24Rik; Igj; Jch"
                     /note="major polyA site"
     polyA_site      1236
                     /gene="Jchain"
                     /gene_synonym="9530090F24Rik; Igj; Jch"
     regulatory      1289..1294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jchain"
                     /gene_synonym="9530090F24Rik; Igj; Jch"
                     /note="hexamer: AATATA"
     polyA_site      1310
                     /gene="Jchain"
                     /gene_synonym="9530090F24Rik; Igj; Jch"
     regulatory      1996..2001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jchain"
                     /gene_synonym="9530090F24Rik; Igj; Jch"
                     /note="hexamer: AATAAA"
     polyA_site      2018
                     /gene="Jchain"
                     /gene_synonym="9530090F24Rik; Igj; Jch"
ORIGIN      
        1 ggcttcagtc tttcaacagt gaagacaaga tgaagaccca cctgcttctc tggggagtcc
       61 tggccatttt tgttaaggct gtccttgtaa caggtgacga cgaagcgacc attcttgctg
      121 acaacaaatg catgtgtacc cgagttacct ctaggatcat cccttccacc gaggatccta
      181 atgaggacat tgtggagaga aatatccgaa ttgttgtccc tttgaacaac agggagaata
      241 tctctgatcc cacctcccca ctgagaagga actttgtata ccatttgtca gacgtctgta
      301 agaaatgcga tcctgtggaa gtggagctgg aagatcaggt tgttactgcc acccagagca
      361 acatctgcaa tgaagacgat ggtgttcctg agacctgcta catgtatgac agaaacaagt
      421 gctataccac tatggtccca cttaggtatc atggtgagac caaaatggtg caagcagcct
      481 tgacccccga ttcttgctac cctgactagc ttgaatcact caccatgcag ctcgttgtcc
      541 ttagaggctc tccatttgca cccagaagtt atactcactg ctaatgaatt tgaaaccagg
      601 gttttttttt tccccctgtg gtataaaact aatgttccct ttcaatcatt agaatatcag
      661 aattgctgtc attattatgt aactctcaat tcgaagtagt aaatcctcat gtctgctcaa
      721 ggagatatgt ttaaaagttc attttccagt gtttaaaatt gtaagcaagg ggagaaagta
      781 aaattccagg agtaaaagtc aagaggttaa tgaaacccaa ccctttcctt ccttcctttg
      841 ctgtggagag ctggagcttt cgcacatcct gtactagtct ttctcttaac ctctcactgt
      901 gtagagaaaa cagccaatga acacaggaag ttacgtatct tcactagaag ttataaagga
      961 cctgttttgg aaatatttac taatatttat gaaagacttt tgttgaaagt gatataattt
     1021 gatgcacaaa tgaaaaaaaa tggatgttga tataatatat agacttggca ttagatttcc
     1081 ttgataatat ttttgacagt gagattttta tctgaaattc ttaaggggag tctttgatgt
     1141 ctcagccaaa tctaatgaaa tttgtattcc aaaatatgta ttctctagta cagtttgaac
     1201 aattaaatag agtgctaagc atatactcgt gtgaaatgac tcgttgggaa aaattttgtt
     1261 tgtgtttaac cttcttatat gtaaattaaa tataagttat tattggcaaa cagtttgtaa
     1321 gtatgataca acagtgcatt catcacttag cttatatgag tacatatttg agaaatcttt
     1381 gttaattcac aggtaaattt aagtacaaag gcagggtcca tagcatgtag cacctttcag
     1441 aagcaggaga tgtatgtact ctgtggtagg gagcttgttt atcatgttca aggccttgag
     1501 tttgatgtcc agcactgcaa acagaagaaa agcaaagcaa agcaaagcaa agcaaagcaa
     1561 agcaaagcaa agcaaagcaa agcaaagcaa agcaaagcaa agcaaagcaa agcaaagcaa
     1621 acaaccacaa acttacacag cttcatccaa gtagaaagat ctcacttaaa tggtggactt
     1681 atttcaaagt aataactttt cacatacaaa gaaatgttat ggtatgtcaa tgatgtattt
     1741 ctctaagggc actatggaaa gtagctgctg attcagaggc ggacatgaag atacttctga
     1801 tctgggaaca gggggtgcac tttctatgtc tgcgctgtat gttggcagtg tatatgaggt
     1861 ttagtaggca actctaatgg tgcaagttga agtttatatt cttacatggc tgaattaata
     1921 ctaggcaagg taactaaatg taagataatt tcttttaaaa atgaaattac aaataactat
     1981 ttcatagttt tttttaataa aaatgatgat atatccta
//
