LOCUS       NM_001081963            6748 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus junctional cadherin 5 associated (Jcad), mRNA.
ACCESSION   NM_001081963
VERSION     NM_001081963.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6748)
  AUTHORS   Suraya,R., Nagano,T., Yumura,M., Hara,T., Akashi,M., Yamamoto,M.,
            Tachihara,M., Nishimura,Y. and Kobayashi,K.
  TITLE     Loss of JCAD/KIAA1462 Protects the Lung from Acute and Chronic
            Consequences of Chronic Obstructive Pulmonary Disease
  JOURNAL   Int J Mol Sci 25 (17), 9492 (2024)
   PUBMED   39273437
  REMARK    GeneRIF: Loss of JCAD/KIAA1462 Protects the Lung from Acute and
            Chronic Consequences of Chronic Obstructive Pulmonary Disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6748)
  AUTHORS   Xie,L., Chen,H., Zhang,L., Ma,Y., Zhou,Y., Yang,Y.Y., Liu,C.,
            Wang,Y.L., Yan,Y.J., Ding,J., Teng,X., Yang,Q., Liu,X.P. and Wu,J.
  TITLE     JCAD deficiency attenuates activation of hepatic stellate cells and
            cholestatic fibrosis
  JOURNAL   Clin Mol Hepatol 30 (2), 206-224 (2024)
   PUBMED   38190829
  REMARK    GeneRIF: JCAD deficiency attenuates activation of hepatic stellate
            cells and cholestatic fibrosis.
REFERENCE   3  (bases 1 to 6748)
  AUTHORS   Zhang,L., Yang,Y.Y., Xie,L., Zhou,Y., Zhong,Z., Ding,J., Wang,Z.H.,
            Wang,Y.L., Liu,X.P., Yu,F.X. and Wu,J.
  TITLE     JCAD deficiency delayed liver regenerative repair through the
            Hippo-YAP signalling pathway
  JOURNAL   Clin Transl Med 14 (3), e1630 (2024)
   PUBMED   38509842
  REMARK    GeneRIF: JCAD deficiency delayed liver regenerative repair through
            the Hippo-YAP signalling pathway.
REFERENCE   4  (bases 1 to 6748)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 6748)
  AUTHORS   Liberale,L., Puspitasari,Y.M., Ministrini,S., Akhmedov,A.,
            Kraler,S., Bonetti,N.R., Beer,G., Vukolic,A., Bongiovanni,D.,
            Han,J., Kirmes,K., Bernlochner,I., Pelisek,J., Beer,J.H., Jin,Z.G.,
            Pedicino,D., Liuzzo,G., Stellos,K., Montecucco,F., Crea,F.,
            Luscher,T.F. and Camici,G.G.
  TITLE     JCAD promotes arterial thrombosis through PI3K/Akt modulation: a
            translational study
  JOURNAL   Eur Heart J 44 (20), 1818-1833 (2023)
   PUBMED   36469488
  REMARK    GeneRIF: JCAD promotes arterial thrombosis through PI3K/Akt
            modulation: a translational study.
            Erratum:[Eur Heart J. 2023 May 21;44(20):1843. doi:
            10.1093/eurheartj/ehad174.. PMID: 37171028]
REFERENCE   6  (bases 1 to 6748)
  AUTHORS   Douglas,G., Mehta,V., Al Haj Zen,A., Akoumianakis,I., Goel,A.,
            Rashbrook,V.S., Trelfa,L., Donovan,L., Drydale,E., Chuaiphichai,S.,
            Antoniades,C., Watkins,H., Kyriakou,T., Tzima,E. and Channon,K.M.
  TITLE     A key role for the novel coronary artery disease gene JCAD in
            atherosclerosis via shear stress mechanotransduction
  JOURNAL   Cardiovasc Res 116 (11), 1863-1874 (2020)
   PUBMED   31584065
  REMARK    GeneRIF: A key role for the novel coronary artery disease gene JCAD
            in atherosclerosis via shear stress mechanotransduction.
REFERENCE   7  (bases 1 to 6748)
  AUTHORS   Hara,T., Monguchi,T., Iwamoto,N., Akashi,M., Mori,K., Oshita,T.,
            Okano,M., Toh,R., Irino,Y., Shinohara,M., Yamashita,Y., Shioi,G.,
            Furuse,M., Ishida,T. and Hirata,K.I.
  TITLE     Targeted Disruption of JCAD (Junctional Protein Associated With
            Coronary Artery Disease)/KIAA1462, a Coronary Artery
            Disease-Associated Gene Product, Inhibits Angiogenic Processes In
            Vitro and In Vivo
  JOURNAL   Arterioscler Thromb Vasc Biol 37 (9), 1667-1673 (2017)
   PUBMED   28705794
  REMARK    GeneRIF: JCAD has a redundant functional role in physiological
            angiogenesis but serves a pivotal role in pathological angiogenic
            process after birth.
REFERENCE   8  (bases 1 to 6748)
  AUTHORS   Akashi,M., Higashi,T., Masuda,S., Komori,T. and Furuse,M.
  TITLE     A coronary artery disease-associated gene product, JCAD/KIAA1462,
            is a novel component of endothelial cell-cell junctions
  JOURNAL   Biochem Biophys Res Commun 413 (2), 224-229 (2011)
   PUBMED   21884682
  REMARK    GeneRIF: These results indicate that JCAD is a component of
            VE-cadherin-based cell-cell junctions in endothelial cells. This
            study also suggests the implication of endothelial cell-cell
            adhesion in coronary artery disease.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147227.4, AK220394.1 and BU757028.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.34357.1,
                                           SRR1660817.199804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC147227.4         75670-75772
            104-434             AC147227.4         89816-90146
            435-1871            AC147227.4         113256-114692
            1872-4164           AK220394.1         29-2321
            4165-6354           AC147227.4         121044-123233
            6355-6748           BU757028.1         1-394               c
FEATURES             Location/Qualifiers
     source          1..6748
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 3.01 cM"
     gene            1..6748
                     /gene="Jcad"
                     /gene_synonym="1110056P05Rik; 9430020K01Rik; Gm328;
                     mKIAA1462"
                     /note="junctional cadherin 5 associated"
                     /db_xref="GeneID:240185"
                     /db_xref="MGI:MGI:2685174"
     exon            1..103
                     /gene="Jcad"
                     /gene_synonym="1110056P05Rik; 9430020K01Rik; Gm328;
                     mKIAA1462"
                     /inference="alignment:Splign:2.1.0"
     exon            104..434
                     /gene="Jcad"
                     /gene_synonym="1110056P05Rik; 9430020K01Rik; Gm328;
                     mKIAA1462"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..4122
                     /gene="Jcad"
                     /gene_synonym="1110056P05Rik; 9430020K01Rik; Gm328;
                     mKIAA1462"
                     /note="junctional protein associated with coronary artery
                     disease"
                     /codon_start=1
                     /product="junctional cadherin 5-associated protein"
                     /protein_id="NP_001075432.1"
                     /db_xref="CCDS:CCDS37719.1"
                     /db_xref="GeneID:240185"
                     /db_xref="MGI:MGI:2685174"
                     /translation="MYSVEDLLISHGYKPARDAAAPCEDKSERCRSTRTGPRAGQGLL
                     NGYKDGATAHTHSRTSLGTGHVSNSENRISRPRGHREHQSTSRTPEARFLNQPSLAWS
                     SQPQSGRDDIYWSRGRQEGSGSLCPRDWKELESRGMAQAYSLPVHVRENLWEVAGRTE
                     HVMKNAIWEEELRMQDMSLESWKKPRELGRQASDGDGRKRPQEKFEGLYPFVHGEHTS
                     QNRKKSQSLPRALSPKSLNFTEIPVPLHDGHITGVPKVPPYPPSFPSPSEPMRNLEKA
                     SSSGPFPRPKFGKPLKTPCYSSHSQPRGEGGFQDHQHRDPRGSYPTRSKDPSHELGML
                     DPGLEPPVYVPPPSYRSPPQHIPNPYLEDPVPRHVSSNQSQQQVPEKPETSCPLPSGS
                     LAARDLYDAMPGSPPQGLPPQPYPIATHGGSIQYIPFDDPRIRHIKLAQPPEFYEEAK
                     LDDTSYNPGLLTTQEPAIGKRQYDDAPSVPRGPTPSPVNEQSSAFVHSSPRWLQGQLP
                     LGIGPGGFHGQTEHHVMGGLTTNVTDIKAEGHASSPQPQSEGTCKTYTKLRKFETGVQ
                     SKKSSKKKSNATIFCLVSIPVKSESLVLATDTNNNDFKLVADKTRGLCQGSALQEQSL
                     LSMSSTDLELQALMGSMAWRRTSPRQGLRESEDGQIDDPRILHLIKPKELQASSPWPG
                     HQYRDQQTQTSFHEDSKSSQLLPATKPGEASNVAPTPTCPDTTASEVCLHTALAFSDQ
                     NQKPSVPHLQGQTSLSPSRNSAFSRTSSAINQASMSKGTSDQLPGANPVPKPEVVKGE
                     STTGQCNSTQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEESHGGSGSEDSEAEQP
                     EDCADSRTKSWALQGTRTAQQPAGLALENVASPDRRLNDSQSWNEEPKPGHSSVHPQS
                     LGPSQEEGSRGVPVQWADGSLTAEQKSQEDLNGMCERDFSPRPVSRIAPIDTKAAPLY
                     CLSEPRGSQELTKFGDAVGSVQLGRETPTQVGNGGDTEVLPCVLLPLADKYRGHSTPD
                     FRSLELTLGQEQNAYKLECLDLENTVEVLPSESLQERAERILGIEVAVESLLPSARRT
                     EQSQLPEPDASACNPSSSREDSSHSLALPVGPKVATDAFYGRRKCGWTESPLFVGERA
                     PQASICSDVDGFPTSQATSPEPGKKDEEAKAPFKSTLFHFMEKSTNVVGPEKRLRNPS
                     KVVENLQEKLVSPPKKADSVHLIRMREVNSLSQMRCLSSKSADSVEEPDPLKVIKSSA
                     WLSEGLTSLGGKDEAWQAGHLPSVSQNENGHPEVPRDKMSDQDLWCADSYDPSRVERV
                     "
     exon            435..4087
                     /gene="Jcad"
                     /gene_synonym="1110056P05Rik; 9430020K01Rik; Gm328;
                     mKIAA1462"
                     /inference="alignment:Splign:2.1.0"
     exon            4088..6731
                     /gene="Jcad"
                     /gene_synonym="1110056P05Rik; 9430020K01Rik; Gm328;
                     mKIAA1462"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6708..6713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jcad"
                     /gene_synonym="1110056P05Rik; 9430020K01Rik; Gm328;
                     mKIAA1462"
                     /note="hexamer: AATAAA"
     polyA_site      6731
                     /gene="Jcad"
                     /gene_synonym="1110056P05Rik; 9430020K01Rik; Gm328;
                     mKIAA1462"
                     /note="major polyA site"
ORIGIN      
        1 gagcatgctc cacccggtag tagcaggctg ggtggctcgt gctggtcccc gccgggcgaa
       61 gcggcagcgg ctgtggcgcg ggacagtatg cgggaaccgg tcgtgatggg tcctgccacc
      121 gtgatggttg aagcttttga ggtttgatga cgctgcagca tgtatagtgt ggaagatctc
      181 ctgatttctc atggatacaa accagcccga gatgccgcag caccatgtga ggacaaatca
      241 gagagatgca ggtcgacaag gacaggaccc cgagctggcc aaggcctatt gaatgggtac
      301 aaggatggcg ctacagccca tacgcacagt aggacatccc tggggacagg acacgtgagc
      361 aactctgaaa accgcatcag caggccaaga ggccacaggg agcaccaaag cacttctaga
      421 actcctgagg cacggttttt aaatcaaccc tccttagcat ggtcctctca gccccaaagt
      481 ggtagagacg acatctactg gagcagagga agacaggagg gcagtggctc cctgtgtccc
      541 agggactgga aagaactgga aagcagagga atggctcagg cttacagtct gcccgtccat
      601 gtgagagaga atctgtggga agttgcagga aggacagagc atgtgatgaa gaatgccatc
      661 tgggaagaag agctgagaat gcaggacatg agcttggaaa gctggaagaa gccaagggag
      721 ttagggaggc aggcatccga tggggatgga cggaaaaggc cccaggaaaa gttcgagggt
      781 ctgtacccat ttgttcatgg ggagcacacg tctcagaaca gaaaaaaatc ccagtcattg
      841 ccccgagctc tttctcctaa gagcctgaat ttcacagaaa ttcctgttcc actacatgat
      901 ggtcacataa caggtgtccc aaaagtgcca ccatatcctc ctagcttccc atccccttcg
      961 gaacccatga ggaaccttga gaaggctagc tcctcaggcc cttttcccag gcctaagttt
     1021 gggaaacccc ttaagactcc gtgttatagc tctcactcac agcccagggg agaaggtgga
     1081 tttcaggacc accagcacag ggacccacgt ggctcctacc caacaagaag taaggatccc
     1141 agccatgagt tgggtatgct ggatcctggc ttggagcccc cagtgtatgt gcctccacct
     1201 tcatataggt caccccctca gcacattcca aacccatacc ttgaagatcc tgtgcccagg
     1261 catgtgagca gcaaccagag tcagcagcaa gtacctgaga aacctgagac cagctgtcca
     1321 cttccttctg gctctcttgc agctagggat ctctatgatg caatgcctgg ctctcctccg
     1381 caaggtcttc ctccacaacc ctatcctatt gccacccatg ggggttctat tcagtacatt
     1441 ccatttgatg atccacggat ccgacatatc aaactagctc agcccccaga attctatgaa
     1501 gaggcaaagc ttgatgatac atcctataac cctggtttac tcactaccca agagccagcc
     1561 attgggaaaa gacagtacga tgatgcccct tcggtaccac ggggcccaac gccttcacca
     1621 gtcaatgagc agagctctgc ctttgtccat tccagtcccc ggtggctgca gggccagctc
     1681 cccctgggca ttggacctgg aggcttccat ggccaaacag agcatcatgt catgggcgga
     1741 ttaacaacta atgtgacaga catcaaggca gaaggccatg cctcttcacc acagccacag
     1801 agtgagggta cctgcaaaac ctacactaag ctcagaaagt ttgaaactgg ggttcagagc
     1861 aagaaaagtt caaagaagaa aagtaacgca actatatttt gtttggtctc catcccagtt
     1921 aaatctgagt cacttgtgct agctacggat acaaacaaca atgactttaa gctggttgct
     1981 gataagaccc gagggctgtg ccagggttca gccctgcagg agcagagtct gctgagtatg
     2041 tcttccactg acctggagct gcaagccctc atgggaagca tggcttggag aagaacatct
     2101 ccaaggcaag gtctgaggga gtcagaagat ggccaaattg atgaccccag aatcctccat
     2161 ctcatcaaac ccaaagaact tcaggcttcc agcccttggc caggacacca atacagagat
     2221 caacagaccc aaaccagttt ccatgaagac tccaaaagct cacagctcct ccctgccaca
     2281 aagccaggag aggccagcaa tgtagctccg accccaacat gcccagatac cactgcctcc
     2341 gaagtatgcc tccatacagc cttagcattc agtgatcaaa atcagaagcc cagtgtacct
     2401 cacctccaag gacaaacgtc ccttagcccg tctcgaaaca gtgctttctc aaggacttcc
     2461 tcagccataa accaggcatc tatgtccaaa gggacctctg accagctccc tggtgccaac
     2521 cctgttccca agccagaggt ggtgaagggg gagtccacaa caggccagtg caatagcaca
     2581 caactcttcg gtcagtttct cttgaaacca gttagccggc ggccctggga tttgataagt
     2641 cagttagaaa gttttaacaa ggaacttcag gaagaggaag aaagccatgg tggtagtggt
     2701 agtgaggaca gtgaggcaga acagccagag gactgtgcag attccagaac caagtcctgg
     2761 gctctccagg gaactagaac agcacagcag cctgcagggc tggcgctgga gaatgtagct
     2821 tccccagata gaagacttaa tgactcacag agctggaatg aagaaccaaa gcctggccac
     2881 tcaagtgtcc atccacagtc cctgggccca tcacaggagg aaggcagcag aggtgttcca
     2941 gtccaatggg cagatggaag cctgactgca gagcagaaaa gccaggagga tttgaatggg
     3001 atgtgtgagc gagactttag cccaaggcct gtgagcagga ttgcacccat tgacacaaaa
     3061 gcagcccctt tatactgtct gtcagaacca agaggaagtc aagaactcac caaattcggc
     3121 gatgctgtag ggtctgtgca gctgggcaga gagactccca cacaggtggg taatggtggg
     3181 gacacagagg tcctaccctg tgtccttctg ccactggctg acaaatatcg aggccactca
     3241 acaccagact ttcggtcttt agagctcaca ctgggacaag aacagaatgc ctataaatta
     3301 gagtgtctgg atttagagaa caccgtggaa gtccttccaa gtgagtctct gcaggaaagg
     3361 gcagagagga tcctgggcat agaggtggcc gtggagtccc ttctgccaag tgccaggaga
     3421 acagaacaaa gccagcttcc tgagcctgat gcaagtgcct gcaacccaag ttcatccaga
     3481 gaggactcat cacacagctt ggcactacca gtggggccca aagtggccac tgacgccttc
     3541 tatggcagga ggaagtgtgg ctggactgag agtcctcttt ttgtaggaga aagggccccc
     3601 caggcttcta tatgctcaga tgtggatggc ttccctacaa gccaggccac cagtcctgag
     3661 cctgggaaaa aggatgagga ggcgaaagca cccttcaagt ccactctgtt ccatttcatg
     3721 gaaaagtcca caaatgtggt gggtcctgaa aagaggctca gaaacccttc caaagtggtt
     3781 gagaacttac aagaaaaact ggtatcaccc ccaaaaaagg cagactctgt tcacttgata
     3841 agaatgaggg aggtcaactc cttgtctcag atgaggtgtc tgagctccaa gagcgctgac
     3901 tccgtggagg agcctgaccc cttaaaggtc atcaaaagtt cagcctggct ttcagaaggc
     3961 cttacttccc tgggtggtaa agacgaagcc tggcaagcag ggcacctgcc ctctgtctct
     4021 cagaatgaaa acggacaccc cgaagtgccg agggacaaga tgtcagacca agacttgtgg
     4081 tgtgcagatt cctatgatcc aagccgagtg gagagggtgt gatggctgct ggtggagccc
     4141 ccaccacctg ctagtggaaa gctctctggt tggcccacct gtcttgctca ggcagaagct
     4201 ggaaactgtg gggtttgcag tgtcccggct cctcctttgc ctgccacccc tacagaattg
     4261 ttacgaagat aaagcagtga tctgctgaca ccatctgtct ctatagcatg gatatgtaat
     4321 ccctatattt agaacagagt atttacatca attcccttcc aggtggttag gagtgtggcc
     4381 taggagtttg gacactttga gtgtaagggg aatgtgagtg agcgagtgag taagtgagtg
     4441 agtgagtgag cgagcgagtg aatgagcgag tgagtgagtg agtgagcgag cgagtgagta
     4501 agaatgaccc atttttatta ctaacccttc ggcagcttgg agttaggtgt gagttaactg
     4561 ctgtgaactc agaatcgcgt cttggtgttc ctgaaggctc gcactcgctg taacttaccc
     4621 actccacttg gtttcaaggc aaacgtgctg tgctcgctca gctttgcact cagtcttccc
     4681 taggttttac cttctgtgtg aatgtttaga tattctttat atgaaaaata attgctgttc
     4741 taaaatagac catgctaaca aaataactat atttcttttt ataaaattgc tatttttcta
     4801 tggtatataa acagttctta ggtggcagat ttttaaggaa gtgctatttt atttaagagt
     4861 ctatccctat gtgtgtgagg gacccaagag ggcccacctt ggctctaaag cctttgtccc
     4921 tgctccaatg tcagctctgt tccttttcac tgtgtttccc aatgtcattg aagaccaatc
     4981 acatgttcat tagctctcat aaagatattt gcacagacag agctgtgaga gtacatttga
     5041 agataccgct ctcgaaatca accaacttca cggtcatttt gcatccatgt ccactagact
     5101 tgccaacccc catacttctg cctttgtatt cctatgggga atcttccccg agaagagacg
     5161 tttctcctgc ctactgcctt gctcctttaa agaaacatat atttttgtct agaatgacta
     5221 gttaatcttg catattctga aaagtgcttg ggatcagtac ctaggtggca ttctatgtgc
     5281 acacatacca tgacggaagt ataaaggggc ccgtgtttcc actattgatt ggcctgcaga
     5341 gttcgtgtat tttgtggcat ttcacccttc tgcctgtgaa aggtttttgt taactaatat
     5401 tttccaaagc ctttgtcccc ttccttcccc tcttacctct tcccctgtcc tttcctcttt
     5461 tcttcccctc accctccacc tctctttctc gattaatttt ttgagacatt tagacatttt
     5521 ctgacatgcc aaattcctgc agtatgagcc catggctggt cagtcctctg gtcctaagtt
     5581 caaacaggac tttcacagtc tcttatctcc accatatcat tttatttcct aagaacctca
     5641 catgcactga ctggactaca caaagcagag tccaagtagt ctcgatacac cttcccagat
     5701 gcacacatct acagtcttga tttgaacctg tttctcatgg ccgtccttgt ccaaagcttg
     5761 gctcacgtag ggaggggttt gagctgtaaa tctccctggg gcagtggaca aacaggtgag
     5821 tggtttgcaa tggtggttga atcatctgcg aggggccagt gaaggctaaa gtatactagt
     5881 gtctgtgtgc atgtgtatac atgtgaagac cccagtgcac gcctgtgtac ctgtgtacat
     5941 actggtgctg tactgacttc ctgtcacata acctgctacc gtctgaagac tctaggacag
     6001 agagaaggat cctgaaggaa agctgttgtg ccttatgtat ctcagtctgg aacaagctgc
     6061 acttccattt tgtcttgttt gagatcgcat catacttccc cacagctggt cagtcacata
     6121 gtgactatta tagattaact taagttttcc atattctagc ccataagcaa atcttttgga
     6181 aggaagtagt aacgttaaac ttagaaactt gaaattttga ctacaacttt tcatattcct
     6241 aggtaatgta tatctgacca aaaatgattt tgctgaggtc ttaaggtcaa tacaaaccac
     6301 catttcctat gtaaatttca gatgtgccca tgacttttgg tggaaaaaaa agtcttccat
     6361 attctgtgtt tgtaattatt tttctcatta cacatgttgg tattcaataa tttggagttt
     6421 gtgaaattaa aaattctaat ttcaaccatt tgagctaaaa agtataggag gaattgtgcc
     6481 tgtggttgtt tcagaactta aagacatgat agtgaggtgg ttgtctttgg cctcttcggg
     6541 ggaaatttcc tgaaggactg aaaatgagat attttactta ttctaatgaa tatttacaca
     6601 ttcagttgtg tttctgtaag ccctgggaaa cctctaaaga tgcaaccagt tcctgggagg
     6661 gaccatcagg attatttcca taattataaa tacatatttc ctttattaat aaagaccctg
     6721 attgtgcatc aaaaaaaaaa aaaaaaaa
//
