LOCUS       NM_173406               2928 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus JAZF zinc finger 1 (Jazf1), transcript variant 1,
            mRNA.
ACCESSION   NM_173406
VERSION     NM_173406.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2928)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2928)
  AUTHORS   Lee,H.Y., Jang,H.R., Li,H., Samuel,V.T., Dudek,K.D.,
            Osipovich,A.B., Magnuson,M.A., Sklar,J. and Shulman,G.I.
  TITLE     Deletion of Jazf1 gene causes early growth retardation and insulin
            resistance in mice
  JOURNAL   Proc Natl Acad Sci U S A 119 (49), e2213628119 (2022)
   PUBMED   36442127
  REMARK    GeneRIF: Deletion of Jazf1 gene causes early growth retardation and
            insulin resistance in mice.
REFERENCE   3  (bases 1 to 2928)
  AUTHORS   Wang,Q., Dong,Y. and Wang,H.
  TITLE     microRNA-19b-3p-containing extracellular vesicles derived from
            macrophages promote the development of atherosclerosis by targeting
            JAZF1
  JOURNAL   J Cell Mol Med 26 (1), 48-59 (2022)
   PUBMED   34910364
  REMARK    GeneRIF: microRNA-19b-3p-containing extracellular vesicles derived
            from macrophages promote the development of atherosclerosis by
            targeting JAZF1.
REFERENCE   4  (bases 1 to 2928)
  AUTHORS   Jeong,J., Jang,S., Park,S., Kwon,W., Kim,S.Y., Jang,S., Ko,J.,
            Park,S.J., Lim,S.G., Yoon,D., Yi,J., Lee,S., Kim,M.O., Choi,S.K.
            and Ryoo,Z.Y.
  TITLE     JAZF1 heterozygous knockout mice show altered adipose development
            and metabolism
  JOURNAL   Cell Biosci 11 (1), 161 (2021)
   PUBMED   34407873
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2928)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2928)
  AUTHORS   Li,L., Yang,Y., Yang,G., Lu,C., Yang,M., Liu,H. and Zong,H.
  TITLE     The role of JAZF1 on lipid metabolism and related genes in vitro
  JOURNAL   Metabolism 60 (4), 523-530 (2011)
   PUBMED   20580384
  REMARK    GeneRIF: These results showed that JAZF1 in adipocytes and liver
            cells reduces lipid synthesis and increases lipolysis
REFERENCE   7  (bases 1 to 2928)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   8  (bases 1 to 2928)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 2928)
  AUTHORS   Lehoczky,J.A., Williams,M.E. and Innis,J.W.
  TITLE     Conserved expression domains for genes upstream and within the HoxA
            and HoxD clusters suggests a long-range enhancer existed before
            cluster duplication
  JOURNAL   Evol Dev 6 (6), 423-430 (2004)
   PUBMED   15509224
REFERENCE   10 (bases 1 to 2928)
  AUTHORS   Nakajima,T., Fujino,S., Nakanishi,G., Kim,Y.S. and Jetten,A.M.
  TITLE     TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4
  JOURNAL   Nucleic Acids Res 32 (14), 4194-4204 (2004)
   PUBMED   15302918
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084326.5, AC107317.3 and AC117212.5.
            
            On Aug 26, 2022 this sequence version replaced NM_173406.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050474.1, SRR17784643.631120.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AC084326.5         19451-19626         c
            177-249             AC107317.3         66729-66801         c
            250-446             AC117212.5         21753-21949
            447-616             AC117212.5         56348-56517
            617-2928            AC117212.5         63672-65983
FEATURES             Location/Qualifiers
     source          1..2928
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 25.74 cM"
     gene            1..2928
                     /gene="Jazf1"
                     /gene_synonym="C820002C15; Jaz1; Tip27"
                     /note="JAZF zinc finger 1"
                     /db_xref="GeneID:231986"
                     /db_xref="MGI:MGI:2141450"
     exon            1..176
                     /gene="Jazf1"
                     /gene_synonym="C820002C15; Jaz1; Tip27"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..793
                     /gene="Jazf1"
                     /gene_synonym="C820002C15; Jaz1; Tip27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     juxtaposed with another zinc finger protein 1"
                     /codon_start=1
                     /product="juxtaposed with another zinc finger protein 1
                     isoform 1"
                     /protein_id="NP_775582.2"
                     /db_xref="CCDS:CCDS20152.1"
                     /db_xref="GeneID:231986"
                     /db_xref="MGI:MGI:2141450"
                     /translation="MTGIAAASFFSNTCRFGGCGLHFPTLADLIEHIEDNHIDTDPRV
                     LEKQELQQPTYVALSYINRFMTDAARREQESLKKKIQPKLSLTLSSSVSRGNVSTPPR
                     HSSGSLTPPVTPPITPSSSFRSSTPTGSEYDEEEVDYEESDSDESWTTESAISSEAIL
                     SSMCMNGGEEKPFACPVPGCKKRYKNVNGIKYHAKNGHRTQIRVRKPFKCRCGKSYKT
                     AQGLRHHTINFHPPVSAEMIRKMQQ"
     exon            177..249
                     /gene="Jazf1"
                     /gene_synonym="C820002C15; Jaz1; Tip27"
                     /inference="alignment:Splign:2.1.0"
     exon            250..446
                     /gene="Jazf1"
                     /gene_synonym="C820002C15; Jaz1; Tip27"
                     /inference="alignment:Splign:2.1.0"
     exon            447..616
                     /gene="Jazf1"
                     /gene_synonym="C820002C15; Jaz1; Tip27"
                     /inference="alignment:Splign:2.1.0"
     exon            617..2928
                     /gene="Jazf1"
                     /gene_synonym="C820002C15; Jaz1; Tip27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2906..2911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jazf1"
                     /gene_synonym="C820002C15; Jaz1; Tip27"
                     /note="hexamer: AATAAA"
     polyA_site      2928
                     /gene="Jazf1"
                     /gene_synonym="C820002C15; Jaz1; Tip27"
                     /note="major polyA site"
ORIGIN      
        1 ctccgcctcc gcgcgcgcgg cgctcgcaga gccgactccg gggggctctc gatgtagcac
       61 catgacaggc atcgccgccg cctccttctt ctccaacacc tgccgcttcg ggggctgcgg
      121 actccacttc cccacgctgg ccgacctcat cgagcacatc gaggacaacc acatcgacac
      181 agacccacgt gttttagaaa agcaggagct gcagcagccg acctatgtgg ccctcagtta
      241 catcaataga ttcatgacag atgctgcacg ccgagaacag gaatctctga agaagaagat
      301 tcagccgaag ctttcactaa ccctgtccag ctccgtgtct cgagggaatg tgtccactcc
      361 acctcgacat agcagtggca gccttactcc ccctgtgacc ccgcccatca cgccctcctc
      421 ttcattccgc agcagcactc caacaggcag cgagtatgat gaggaagagg tggactatga
      481 ggagtcagac agtgatgagt cctggaccac agagagcgcc atcagctctg aagcaatcct
      541 cagctccatg tgcatgaatg gaggggaaga gaagcctttc gcctgcccag ttccagggtg
      601 taaaaagaga tacaagaatg tgaatggcat aaagtaccat gctaagaatg gtcaccgaac
      661 acagattcgc gtccgcaaac cattcaaatg ccggtgtggg aagagttaca agacagctca
      721 gggcctgcgg caccacacaa tcaatttcca tcccccagtg tctgccgaga tgatcaggaa
      781 gatgcagcag tagcgtgctg gtcagaactg tgccaagaaa tcctcaccag cagttgctga
      841 ttttgaaaac agccaccttt tttcagggga agcactcagc aaccctttaa tgaaaaataa
      901 ttaaatgcat gctttaacct tttctgtact tttggaatga tgtatctttg tagttaatga
      961 ttttgtacat ttgcacatgt aatcatcacg cccatttcca ttacgttgat ataaggtgct
     1021 aaacaaaaca agctctaggt tcttcagcac attttcccca aaacaaaata aatgaagggc
     1081 atgttgcata ttgtttaacc acattgcagt gatgtcaact gggagaggag gggctggcac
     1141 tgagatgttt taagattgta atgtgattga agcttttcaa cacatcgact cacataaaac
     1201 caaaataata ccttcattat caaactggtt atcatgcctt acataatgga gttagtattt
     1261 gtgagtagaa agactttagg taatggaaat ataaataaga atgtttaaca taatatgcta
     1321 aaaatatttt catatttaaa taacatgcat aaaaggtgtg ctttcttttc tttctttttt
     1381 ttttttagtt attatcttgc cctttaagaa gctgaaattc ttgccatcga acttaccaat
     1441 cattttagtg ttctaaatgg catctttgtg caaaggactc agttcactca ttaatgctaa
     1501 cattctcatt gagtgcctgc tgggtgcaag agactgaagt tatacctaag ttacttgtgg
     1561 accaagatac cagtgaaata cttttccctg aaatgttagg aaacactttg aaatacttaa
     1621 gtgcaaattg tgtgtgtgtg aaacttagtt atagcttcat caatagatga ggttttaaag
     1681 cactttgtag ttctctattg ccaacaattt tgtttagacg ttgccaattc ttgcaactat
     1741 tgccctaaga gatctgtggg ttgcaatccg aactaaaatt cagaagtgtg tttgagcgag
     1801 gaaggttgct aagaccccta ctgccccttt cctgttcagt tgcgactttt aaaggcactt
     1861 tcctatcaca ctgtagatgt ctgcattctc attagaaatg tctgtttagc tttagaaaac
     1921 attttgccag aatatgaaaa taagccttac tgacattaag tgcttcttgc agcaggtggt
     1981 caaggaagag tgactaatag acccactaag agtggcctac atctggatcg tcctggagct
     2041 tctctcaccg acagtaccat catgtgttga gtgttctttt ctcccaagtg ctattcttta
     2101 aacaagagtt taccggttgc ctaatacgca ataaacgttg ctttgacaca gctaactgca
     2161 cacagtacaa actggtgaaa ggcagactca gattccctct aaaataacct tttcccccgt
     2221 gttcccatct gacgcagtct tacacacagc tagctagtcg tccctcctca gcattcacac
     2281 tgtgaagaca attctgttaa acagatgggt aagcttctgc atcaatccct catgatgagg
     2341 gatttaacaa tatttataaa gatgctgccc actaaaaatg tcctcagctc tgaaaagtgg
     2401 tctcggtctt gactctacag tgttagctct catggtgtta aatggatgat ccagaattca
     2461 gaatagaagt tggtgcaaaa gaaggcccta cttgctccac atctacctac agttgaccaa
     2521 aaaagttagg ccagcaatta atagttagct ttgctctttc tagtgtgaga aactgcgggc
     2581 tggatcagta gttcagcagc tacacaggca taaaaacagt cattgtgcat gttaaaaacc
     2641 tttcagtgat aaaacccagt ttctacttct tcattgtgac agtattacta aacaggtgag
     2701 gaagggatat tttgttacac cgtgtatagt gaatgtattg taccgtgtct gtgaaaaccg
     2761 tgctttaaat tatattttca tatgttttgt tggggacaga gcacattaag tttgaaagca
     2821 acagaactat cagaattgaa ggcaatttac tcaaactttc tgtcaagaaa agctgcttaa
     2881 taaatgtaca tgaaatcaca tttaaaataa actgcctctg acccaaaa
//
