LOCUS       NM_001005421            2472 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus junction adhesion molecule like (Jaml), mRNA.
ACCESSION   NM_001005421 XM_194453
VERSION     NM_001005421.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2472)
  AUTHORS   Cheng,S., Li,M., Li,C., Dai,Y., Zhuo,J., Wang,J., Qian,J. and
            Hao,Z.
  TITLE     JAML inhibits colorectal carcinogenesis by modulating the tumor
            immune microenvironment
  JOURNAL   In Vitro Cell Dev Biol Anim 60 (4), 382-396 (2024)
   PUBMED   38625487
  REMARK    GeneRIF: JAML inhibits colorectal carcinogenesis by modulating the
            tumor immune microenvironment.
REFERENCE   2  (bases 1 to 2472)
  AUTHORS   Mraz,V., Lohmann,R.K.D., Menzel,M., Hawkes,A., Vaher,H.,
            Funch,A.B., Jee,M.H., Gadsboll,A.O., Weber,J.F., Yeung,K., Odum,N.,
            Woetmann,A., McKay,D., Witherden,D., Geisler,C. and Bonefeld,C.M.
  TITLE     The junctional adhesion molecule-like protein (JAML) is important
            for the inflammatory response during contact hypersensitivity
  JOURNAL   Contact Dermatitis 89 (5), 323-334 (2023)
   PUBMED   37619972
  REMARK    GeneRIF: The junctional adhesion molecule-like protein (JAML) is
            important for the inflammatory response during contact
            hypersensitivity.
REFERENCE   3  (bases 1 to 2472)
  AUTHORS   Huang,W., Wang,B.O., Hou,Y.F., Fu,Y., Cui,S.J., Zhu,J.H.,
            Zhan,X.Y., Li,R.K., Tang,W., Wu,J.C., Wang,Z.Y., Wang,M.,
            Wang,X.J., Zhang,Y., Liu,M., Xie,Y.S., Sun,Y. and Yi,F.
  TITLE     JAML promotes acute kidney injury mainly through a
            macrophage-dependent mechanism
  JOURNAL   JCI Insight 7 (14), e158571 (2022)
   PUBMED   35708906
  REMARK    GeneRIF: JAML promotes acute kidney injury mainly through a
            macrophage-dependent mechanism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2472)
  AUTHORS   McGraw,J.M., Thelen,F., Hampton,E.N., Bruno,N.E., Young,T.S.,
            Havran,W.L. and Witherden,D.A.
  TITLE     JAML promotes CD8 and gammadelta T cell antitumor immunity and is a
            novel target for cancer immunotherapy
  JOURNAL   J Exp Med 218 (10) (2021)
   PUBMED   34427588
  REMARK    GeneRIF: JAML promotes CD8 and gammadelta T cell antitumor immunity
            and is a novel target for cancer immunotherapy.
REFERENCE   5  (bases 1 to 2472)
  AUTHORS   Fu,Y., Sun,Y., Wang,M., Hou,Y., Huang,W., Zhou,D., Wang,Z.,
            Yang,S., Tang,W., Zhen,J., Li,Y., Wang,X., Liu,M., Zhang,Y.,
            Wang,B., Liu,G., Yu,X., Sun,J., Zhang,C. and Yi,F.
  TITLE     Elevation of JAML Promotes Diabetic Kidney Disease by Modulating
            Podocyte Lipid Metabolism
  JOURNAL   Cell Metab 32 (6), 1052-1062 (2020)
   PUBMED   33186558
  REMARK    GeneRIF: Elevation of JAML Promotes Diabetic Kidney Disease by
            Modulating Podocyte Lipid Metabolism.
REFERENCE   6  (bases 1 to 2472)
  AUTHORS   Verdino,P., Witherden,D.A., Ferguson,M.S., Corper,A.L.,
            Schiefner,A., Havran,W.L. and Wilson,I.A.
  TITLE     Molecular insights into gammadelta T cell costimulation by an
            anti-JAML antibody
  JOURNAL   Structure 19 (1), 80-89 (2011)
   PUBMED   21220118
  REMARK    GeneRIF: crystal structure of the JAML-HL4E10 Fab complex
REFERENCE   7  (bases 1 to 2472)
  AUTHORS   Verdino,P., Witherden,D.A., Havran,W.L. and Wilson,I.A.
  TITLE     The molecular interaction of CAR and JAML recruits the central cell
            signal transducer PI3K
  JOURNAL   Science 329 (5996), 1210-1214 (2010)
   PUBMED   20813955
  REMARK    GeneRIF: crystal structure of junctional adhesion molecule-like
            protein (JAML) and coxsackie and adenovirus receptor; data show how
            CAR-mediated clustering of JAML recruits phosphoinositide 3-kinase
            to a JAML intracellular sequence motif
REFERENCE   8  (bases 1 to 2472)
  AUTHORS   Witherden,D.A., Verdino,P., Rieder,S.E., Garijo,O., Mills,R.E.,
            Teyton,L., Fischer,W.H., Wilson,I.A. and Havran,W.L.
  TITLE     The junctional adhesion molecule JAML is a costimulatory receptor
            for epithelial gammadelta T cell activation
  JOURNAL   Science 329 (5996), 1205-1210 (2010)
   PUBMED   20813954
  REMARK    GeneRIF: identified an epithelial gammadelta T cell costimulatory
            molecule, junctional adhesion molecule-like protein - JAML; binding
            of JAML to CAR provides costimulation leading to cell proliferation
            and cytokine and growth factor production
REFERENCE   9  (bases 1 to 2472)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   10 (bases 1 to 2472)
  AUTHORS   Mirza,M., Petersen,C., Nordqvist,K. and Sollerbrant,K.
  TITLE     Coxsackievirus and adenovirus receptor is up-regulated in migratory
            germ cells during passage of the blood-testis barrier
  JOURNAL   Endocrinology 148 (11), 5459-5469 (2007)
   PUBMED   17690169
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122305.4, CJ139627.1, CJ141417.1, AA798428.1, AA120429.1,
            CJ231590.1 and BX520654.1.
            
            On Nov 15, 2007 this sequence version replaced NM_001005421.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY093688.1, ERR3363658.1144488.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC122305.4         89230-89276
            48-528              CJ139627.1         2-482
            529-673             CJ141417.1         284-428
            674-970             AA798428.1         193-489
            971-1322            AA120429.1         107-458
            1323-1782           CJ231590.1         8-467
            1783-2029           AC122305.4         117903-118149
            2030-2472           BX520654.1         1-443
FEATURES             Location/Qualifiers
     source          1..2472
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..2472
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /note="junction adhesion molecule like"
                     /db_xref="GeneID:270152"
                     /db_xref="MGI:MGI:2685484"
     exon            1..114
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            115..211
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            212..274
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1371
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /note="dendritic-cell specific protein Crea7; mCrea7;
                     dendritic cell-specific protein CREA7; adhesion molecule
                     AMICA; adhesion molecule, interacts with CXADR antigen 1"
                     /codon_start=1
                     /product="junctional adhesion molecule-like precursor"
                     /protein_id="NP_001005421.3"
                     /db_xref="CCDS:CCDS23128.1"
                     /db_xref="GeneID:270152"
                     /db_xref="MGI:MGI:2685484"
                     /translation="MLCLLKLIVIPVILAPVGYPQGLPGLTVSSPQLRVHVGESVLMG
                     CVVQRTEEKHVDRVDWLFSKDKDDASEYVLFYYSNLSVPTGRFQNRSHLVGDTFHNDG
                     SLLLQDVQKADEGIYTCEIRLKNESMVMKKPVELWVLPEEPKDLRVRVGDTTQMRCSI
                     QSTEEKRVTKVNWMFSSGSHTEEETVLSYDSNMRSGKFQSLGRFRNRVDLTGDISRND
                     GSIKLQTVKESDQGIYTCSIYVGKLESRKTIVLHVVQDEFQRTISPTPPTDKGQQGIL
                     NGNQLVIIVGIVCATFLLLPVLILIVKKAKWNKSSVSSMASVKSLENKEKINPEKHIY
                     SSITTWETTERGISGESEGTYMTMNPVWPSSPKASSLVRSSVRSK"
     exon            275..438
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            439..664
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            665..777
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            778..1009
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1160
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1221
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1305
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..2458
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2433..2438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /note="hexamer: AATAAA"
     polyA_site      2458
                     /gene="Jaml"
                     /gene_synonym="AMICA; Amica1; Crea7; Gm638"
                     /note="major polyA site"
ORIGIN      
        1 tctgtgttgc tttgagcctg atctcctgtg ctggcagaag tctctcagtt ggtgtgggcg
       61 atgctgtggc aggagatcgc ggtggactgt tcttcctggg cactgtcatc ttgggtgagg
      121 aagctaaggt agagtgagtc aaggacggcc tgggaaggac tgccttgggc tgttttcatt
      181 ttccaagtgg attttgttga ttggaataca gattgaaaac ttgaaaggat aatgctttgc
      241 ctcctgaaac tgattgtgat tccagtaatc ctggcccctg taggttatcc acagggcctg
      301 ccaggcttga ccgtttcctc ccctcagctg agagtgcatg tgggtgaatc agtcttgatg
      361 ggatgtgttg tccagcgcac agaagagaaa cacgtggaca gagtggattg gctcttctcg
      421 aaagataaag atgatgcgag tgaatatgtg ctgttctact attccaacct tagcgtgcct
      481 acggggcgct tccagaaccg gtcacatttg gtgggggaca ccttccataa tgatggttct
      541 ctcctgctcc aagatgttca gaaggccgat gagggaatct acacctgtga aatccgcctc
      601 aaaaatgaga gcatggtgat gaaaaagccc gtggaactgt gggtgctacc agaggaacct
      661 aaagatctca gagtccgagt aggtgataca actcagatga gatgttctat ccagagcaca
      721 gaagagaaac gggtgaccaa agtaaactgg atgttttctt caggaagcca tactgaggag
      781 gagacagtct tgagctatga ctccaacatg cgtagtggaa aattccagag cctgggccgc
      841 ttccgcaacc gtgtagacct gacaggtgac atctcccgca atgatggctc aatcaaactt
      901 caaacagtga aggagtctga ccaaggaatc tacacttgca gcatctacgt gggaaagctg
      961 gagtccagga aaaccattgt gctgcatgtg gtccaggacg aatttcaaag gacaatttca
     1021 ccaactcctc caactgataa gggtcagcag ggcatcctga atggaaatca gctggtgatc
     1081 attgtgggga tcgtctgtgc caccttcctg ctgcttccgg ttttgatatt aattgtgaag
     1141 aaagccaagt ggaataagag ctcagtaagt tctatggctt ctgtgaagag cctggagaac
     1201 aaagagaaga ttaatccaga gaagcatatc tactcctcca taactacgtg ggagacgaca
     1261 gagagaggaa taagtggaga gtcagagggc acctacatga ccatgaatcc agtttggcct
     1321 tcttccccca aagcatccag tttggtccgc tcttcagtca gatccaagta atgtggttga
     1381 aaagaaaaaa aaaaaaagtc accttgggga atttccaaaa ccgagcaaac tttctgagaa
     1441 ggaggagaga ctctttttga tggtccctgg gactactgtg ccagctattt tagacttgtg
     1501 cattccatct ggtcttggcc tccatcaaaa ggctgaagac ggagggtttg gagtctggca
     1561 ggaaggctga actgctccgg ataaccaggc actgatgagg ggagggagac ctcggacttc
     1621 tcccagaagt ggtgtgcggg ctggtgagga tggggagcag cctggtctgc cttgtgcttt
     1681 caagctctcc attggactgg atctgtaacg tgaacagtgg tttgcttgtt tgttgttcgt
     1741 ttttgcggat gagctactaa gagacacaca gagatataaa ccaaaaaaaa aaaaaattat
     1801 tttgatgaat tatccccaaa taggtgtgat ttgttggaat catctttttt tatgtcccag
     1861 atgaaggaca agtggggaaa tttgaagcat ggaactcctg agagagtgtt ctttgaggag
     1921 agccacaatg gactcagcat ctggggactg gtttggatct ggggggaaga cttaggggta
     1981 acccattgga agtgggatat gagaacagct ctgggatttc ctcgggctgg gaatctgcac
     2041 tgatggctga agctaggcct gtggagtttg gacatccatg ttttccaaat gcattgaaca
     2101 ggcttgccaa agcgaacagc caacgattga atccttggtc tgaaatatga gactcctgta
     2161 cttttcattg ttatcatgag acttaaacag gttgatctta tttaaatatt ttttttttaa
     2221 atgggagtgg tgctggagag atagcccatc agttaagaga actgactgct cttgcagaag
     2281 actggggttt gatgcccagc atccacatgg tggctcataa ctgtaactcc aattccaagg
     2341 gagctgacac cttcttctgg cctttgtggt ccctgcatgt gcaaggtaca tggacataca
     2401 tacatatata taaaagtttt ttaaaaatgg tcaataaaaa ctaaaagtgt tgatcttaaa
     2461 aaaaaaaaaa aa
//
