LOCUS       NM_023277               1986 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus junction adhesion molecule 3 (Jam3), mRNA.
ACCESSION   NM_023277
VERSION     NM_023277.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1986)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1986)
  AUTHORS   Sun,Q., Li,J., Ma,J., Zheng,Y., Ju,R., Li,X., Ren,X., Huang,L.,
            Chen,R., Tan,X. and Luo,L.
  TITLE     JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens
            Fiber Maturation in Murine Lens Development
  JOURNAL   Invest Ophthalmol Vis Sci 64 (15), 15 (2023)
   PUBMED   38095908
  REMARK    GeneRIF: JAM-C Is Important for Lens Epithelial Cell Proliferation
            and Lens Fiber Maturation in Murine Lens Development.
REFERENCE   3  (bases 1 to 1986)
  AUTHORS   Li,J., Tan,X., Sun,Q., Li,X., Chen,R. and Luo,L.
  TITLE     Deficiency of Jamc Leads to Congenital Nuclear Cataract and
            Activates the Unfolded Protein Response in Mouse Lenses
  JOURNAL   Invest Ophthalmol Vis Sci 63 (10), 1 (2022)
   PUBMED   36048019
REFERENCE   4  (bases 1 to 1986)
  AUTHORS   Brandl,A., Solimando,A.G., Mokhtari,Z., Tabares,P., Medler,J.,
            Manz,H., Da Via,M.C., Croci,G.A., Kurzwart,M., Thusek,S.,
            Schneider,T., Ebert,R., Jakob,F., Einsele,H. and Beilhack,A.
  TITLE     Junctional adhesion molecule C expression specifies a CD138low/neg
            multiple myeloma cell population in mice and humans
  JOURNAL   Blood Adv 6 (7), 2195-2206 (2022)
   PUBMED   34861679
  REMARK    GeneRIF: Junctional adhesion molecule C expression specifies a
            CD138low/neg multiple myeloma cell population in mice and humans.
REFERENCE   5  (bases 1 to 1986)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1986)
  AUTHORS   Muller,W.A.
  TITLE     Leukocyte-endothelial-cell interactions in leukocyte transmigration
            and the inflammatory response
  JOURNAL   Trends Immunol 24 (6), 327-334 (2003)
   PUBMED   12810109
  REMARK    Review article
REFERENCE   7  (bases 1 to 1986)
  AUTHORS   Santoso,S., Sachs,U.J., Kroll,H., Linder,M., Ruf,A., Preissner,K.T.
            and Chavakis,T.
  TITLE     The junctional adhesion molecule 3 (JAM-3) on human platelets is a
            counterreceptor for the leukocyte integrin Mac-1
  JOURNAL   J Exp Med 196 (5), 679-691 (2002)
   PUBMED   12208882
REFERENCE   8  (bases 1 to 1986)
  AUTHORS   Aurrand-Lions,M., Johnson-Leger,C., Wong,C., Du Pasquier,L. and
            Imhof,B.A.
  TITLE     Heterogeneity of endothelial junctions is reflected by differential
            expression and specific subcellular localization of the three JAM
            family members
  JOURNAL   Blood 98 (13), 3699-3707 (2001)
   PUBMED   11739175
REFERENCE   9  (bases 1 to 1986)
  AUTHORS   Palmeri,D., van Zante,A., Huang,C.C., Hemmerich,S. and Rosen,S.D.
  TITLE     Vascular endothelial junction-associated molecule, a novel member
            of the immunoglobulin superfamily, is localized to intercellular
            boundaries of endothelial cells
  JOURNAL   J Biol Chem 275 (25), 19139-19145 (2000)
   PUBMED   10779521
REFERENCE   10 (bases 1 to 1986)
  AUTHORS   Aurrand-Lions,M.A., Duncan,L., Du Pasquier,L. and Imhof,B.A.
  TITLE     Cloning of JAM-2 and JAM-3: an emerging junctional adhesion
            molecular family?
  JOURNAL   Curr Top Microbiol Immunol 251, 91-98 (2000)
   PUBMED   11036763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW106511.1, AK013156.1 and AI850297.1.
            
            On Mar 22, 2011 this sequence version replaced NM_023277.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024357.1, AK003326.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AW106511.1         1-41
            42-1742             AK013156.1         1-1701
            1743-1986           AI850297.1         1-244               c
FEATURES             Location/Qualifiers
     source          1..1986
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 12.27 cM"
     gene            1..1986
                     /gene="Jam3"
                     /gene_synonym="1110002N23Rik; JAM-3; JAM-C; Jcam3"
                     /note="junction adhesion molecule 3"
                     /db_xref="GeneID:83964"
                     /db_xref="MGI:MGI:1933825"
     exon            1..131
                     /gene="Jam3"
                     /gene_synonym="1110002N23Rik; JAM-3; JAM-C; Jcam3"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..988
                     /gene="Jam3"
                     /gene_synonym="1110002N23Rik; JAM-3; JAM-C; Jcam3"
                     /note="junction cell adhesion molecule C; junctional
                     adhesion molecule C; junctional adhesion molecule 3;
                     junction cell adhesion molecule 3"
                     /codon_start=1
                     /product="junctional adhesion molecule C precursor"
                     /protein_id="NP_075766.1"
                     /db_xref="CCDS:CCDS22939.1"
                     /db_xref="GeneID:83964"
                     /db_xref="MGI:MGI:1933825"
                     /translation="MALSRRLRLRLYARLPDFFLLLLFRGCMIEAVNLKSSNRNPVVH
                     EFESVELSCIITDSQTSDPRIEWKKIQDGQTTYVYFDNKIQGDLAGRTDVFGKTSLRI
                     WNVTRSDSAIYRCEVVALNDRKEVDEITIELIVQVKPVTPVCRIPAAVPVGKTATLQC
                     QESEGYPRPHYSWYRNDVPLPTDSRANPRFQNSSFHVNSETGTLVFNAVHKDDSGQYY
                     CIASNDAGAARCEGQDMEVYDLNIAGIIGGVLVVLIVLAVITMGICCAYRRGCFISSK
                     QDGESYKSPGKHDGVNYIRTSEEGDFRHKSSFVI"
     exon            132..197
                     /gene="Jam3"
                     /gene_synonym="1110002N23Rik; JAM-3; JAM-C; Jcam3"
                     /inference="alignment:Splign:2.1.0"
     exon            198..311
                     /gene="Jam3"
                     /gene_synonym="1110002N23Rik; JAM-3; JAM-C; Jcam3"
                     /inference="alignment:Splign:2.1.0"
     exon            312..464
                     /gene="Jam3"
                     /gene_synonym="1110002N23Rik; JAM-3; JAM-C; Jcam3"
                     /inference="alignment:Splign:2.1.0"
     exon            465..667
                     /gene="Jam3"
                     /gene_synonym="1110002N23Rik; JAM-3; JAM-C; Jcam3"
                     /inference="alignment:Splign:2.1.0"
     exon            668..767
                     /gene="Jam3"
                     /gene_synonym="1110002N23Rik; JAM-3; JAM-C; Jcam3"
                     /inference="alignment:Splign:2.1.0"
     exon            768..897
                     /gene="Jam3"
                     /gene_synonym="1110002N23Rik; JAM-3; JAM-C; Jcam3"
                     /inference="alignment:Splign:2.1.0"
     exon            898..952
                     /gene="Jam3"
                     /gene_synonym="1110002N23Rik; JAM-3; JAM-C; Jcam3"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1970
                     /gene="Jam3"
                     /gene_synonym="1110002N23Rik; JAM-3; JAM-C; Jcam3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1952..1957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Jam3"
                     /gene_synonym="1110002N23Rik; JAM-3; JAM-C; Jcam3"
                     /note="hexamer: ATTAAA"
     polyA_site      1970
                     /gene="Jam3"
                     /gene_synonym="1110002N23Rik; JAM-3; JAM-C; Jcam3"
                     /note="major polyA site"
ORIGIN      
        1 tgcgcacgag gccggttctc cgctccgagc ctgagcccct cacattcccc tcgacatggc
       61 gctgagccgg cggctgcgac ttcgactgta cgcgcggctg cctgacttct tcctgctgct
      121 gctcttcagg ggctgcatga tagaggcagt gaatctcaaa tccagcaacc gaaacccagt
      181 ggtacatgaa tttgaaagtg tggaattgtc ttgcatcatt acggactcac agacaagtga
      241 ccctaggatt gaatggaaga aaatccaaga tggccaaacc acatatgtgt attttgacaa
      301 caagattcaa ggagacctgg caggtcgcac agatgtgttt ggaaaaactt ccctgaggat
      361 ctggaatgtg acacgatcgg attcagccat ctatcgctgt gaggtcgttg ctctaaatga
      421 ccgaaaagaa gttgatgaga ttaccattga gttaattgtg caagtgaagc cagtgacccc
      481 tgtctgcaga attccagccg ctgtacctgt aggcaagacg gcaacactgc agtgccaaga
      541 gagcgagggc tatccccggc ctcactacag ctggtaccgc aatgatgtgc cactgcctac
      601 agattccaga gccaatccca ggttccagaa ttcctctttc catgtgaact cggagacagg
      661 cactctggtt ttcaatgctg tccacaagga cgactctggg cagtactact gcattgcttc
      721 caatgacgca ggtgcagcca ggtgtgaggg gcaggacatg gaagtctatg atttgaacat
      781 tgctgggatt attgggggag tccttgttgt ccttattgtt cttgctgtga ttacgatggg
      841 catctgctgt gcgtacagac gaggctgctt catcagcagt aaacaagatg gagaaagcta
      901 taagagccca gggaagcatg acggtgttaa ctacatccgg acgagtgagg agggtgactt
      961 cagacacaaa tcgtcctttg ttatctgaca cctgtcggct gggagagcac atgcaagtac
     1021 ctctgttgga agctggtcac agggctgctg tgagcccaga gctcctgaca aagccacccg
     1081 ggcagaagct ttttgttttg gccaaagttg atgactcctt ccttccttcc ttcctcttta
     1141 acaagccaca agaataaaag gaagcctcct gaagatggat gtagacacag actgttgcta
     1201 gcctgacctc attatgggga ttagggtgat cttcaaggcc tttctggtct ccgttctccc
     1261 atgcagggca atttggactg tttttgcccc aggctgttta gctgccagga caacactggc
     1321 agagagaggc tgaggcgctg ggctgcagta gcagcaggca acagcctgat gcctgtgaca
     1381 gtgccccagg aaggttttca ggcagtgcct tgctccctgg accctgaccc accgtgttgc
     1441 ctctgttgat tggccagtac tgtcatttcc atcctggaga atgtgtttgg aatcagcatt
     1501 ttataaaaaa cccaaatcag aaaggtgaaa ttgcttgctg ggaagagggc tctgacccag
     1561 gaaactctcc ttcccaagag atgccaggag ataggagaac ctgtctgtct taagtctgaa
     1621 atggtactga agtctccttt tctattggtc ttgcttattt tataaaaatt taacattcta
     1681 aattttgcta gagatgtatt ttgattactg aaaatttcta tataaactgt aaatatattg
     1741 ccatacagtg tttcaaaacg tattttttta taatgagttc aacttaaggt agaaggcttg
     1801 ggctgctagt gtttaattgg aaaataccag tagtaaagtc ttttaaggag ttttcttaag
     1861 gaggctggct gaatattcct ttgttcaaaa gaagttttag catttttcat aagaaaactt
     1921 actctgtctg accactgttg cttaggaaac cattaaagaa ttccaatcta aaaaaaaaaa
     1981 aaaaaa
//
